ATE380826T1 - Hybrid-hepatozyten-wachstumsfaktorgen mit hoher expressionseffizienz von zwei hepatozyten- wachstumsfaktor-heterotypen - Google Patents
Hybrid-hepatozyten-wachstumsfaktorgen mit hoher expressionseffizienz von zwei hepatozyten- wachstumsfaktor-heterotypenInfo
- Publication number
- ATE380826T1 ATE380826T1 AT03744561T AT03744561T ATE380826T1 AT E380826 T1 ATE380826 T1 AT E380826T1 AT 03744561 T AT03744561 T AT 03744561T AT 03744561 T AT03744561 T AT 03744561T AT E380826 T1 ATE380826 T1 AT E380826T1
- Authority
- AT
- Austria
- Prior art keywords
- growth factor
- hepatocyte growth
- gene
- heterotypes
- high expression
- Prior art date
Links
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 title abstract 7
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 title abstract 6
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 108700024394 Exon Proteins 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 208000023589 ischemic disease Diseases 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020020015074A KR100562824B1 (ko) | 2002-03-20 | 2002-03-20 | 유전자 발현효율이 높으며 간세포 성장인자의 두 가지이형체를 동시에 발현하는 하이브리드 간세포 성장인자유전자 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE380826T1 true ATE380826T1 (de) | 2007-12-15 |
Family
ID=28036130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03744561T ATE380826T1 (de) | 2002-03-20 | 2003-03-20 | Hybrid-hepatozyten-wachstumsfaktorgen mit hoher expressionseffizienz von zwei hepatozyten- wachstumsfaktor-heterotypen |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US7812146B2 (de) |
| EP (1) | EP1490492B1 (de) |
| JP (1) | JP4057537B2 (de) |
| KR (1) | KR100562824B1 (de) |
| CN (1) | CN100378219C (de) |
| AT (1) | ATE380826T1 (de) |
| AU (1) | AU2003210053A1 (de) |
| BR (1) | BRPI0303570B8 (de) |
| DE (1) | DE60318026T2 (de) |
| DK (1) | DK1490492T3 (de) |
| ES (1) | ES2298538T3 (de) |
| PT (1) | PT1490492E (de) |
| WO (1) | WO2003078568A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100562824B1 (ko) * | 2002-03-20 | 2006-03-23 | 주식회사 바이로메드 | 유전자 발현효율이 높으며 간세포 성장인자의 두 가지이형체를 동시에 발현하는 하이브리드 간세포 성장인자유전자 |
| EP1954714A2 (de) * | 2005-11-10 | 2008-08-13 | Receptor Biologix, Inc. | Fusionsproteine mit dem hepatocyten wachstumsfaktor intron |
| US20090202606A1 (en) | 2008-01-25 | 2009-08-13 | Viromed Co., Ltd. | Treatment and Prevention of Cardiac Conditions Using Two or More Isoforms of Hepatocyte Growth Factor |
| KR101290322B1 (ko) * | 2008-04-09 | 2013-07-26 | 주식회사 바이로메드 | 플라스미드 ｄｎａ의 발현 증강용 동결건조 ｄｎａ 제제 |
| EP2216399A1 (de) * | 2009-01-30 | 2010-08-11 | Université de la Méditerranée | Humanes, lösliches CD146, Herstellung und Verwendungen |
| CN102120047A (zh) * | 2010-01-11 | 2011-07-13 | 上海优益绩国际贸易有限公司 | 血运重建基因药物靶向投递缓释支架 |
| CN105682676B (zh) | 2013-10-22 | 2020-10-23 | 赫利世弥斯株式会社 | 利用肝细胞生长因子的两种以上的异构体的肌萎缩性侧索硬化症预防或治疗用组合物 |
| CN107073078B (zh) * | 2014-09-26 | 2021-07-06 | 赫利世弥斯株式会社 | 利用肝细胞生长因子和基质细胞衍生因子1α的用于预防或治疗外周动脉疾病的组合物 |
| US20190038717A1 (en) * | 2016-02-04 | 2019-02-07 | Slbigen Inc. | Mesenchymal stem cell expressing hepatocyte growth factor, and use thereof |
| CA3086046C (en) * | 2017-12-29 | 2023-02-21 | Helixmith Co., Ltd. | Adeno-associated virus (aav) vector having hybrid hgf gene introduced thereto |
| KR102245539B1 (ko) | 2018-02-12 | 2021-04-29 | 주식회사 지앤피바이오사이언스 | 코어-쉘 구조의 마이크로 입자를 유효성분으로 포함하는 성장인자 유전자 발현 증가용 조성물 |
| CN108611367B (zh) * | 2018-04-24 | 2019-11-19 | 北京诺思兰德生物技术股份有限公司 | 一类通过质粒载体介导的基因治疗重组载体 |
| JP7235230B2 (ja) * | 2018-05-17 | 2023-03-08 | ヘリックスミス カンパニー， リミテッド | 化学療法－誘発末梢神経病症と関連した神経病症性痛みの治療 |
| US11510999B2 (en) * | 2018-07-17 | 2022-11-29 | Helixmith Co., Ltd | Treatment of neuropathy with DNA constructs expressing IGF-1 isoforms |
| EP3823677A4 (de) | 2018-07-19 | 2022-06-01 | Helixmith Co., Ltd. | Lyophilisierte pharmazeutische zusammensetzungen für nackte dna-gentherapie |
| CN109535243B (zh) | 2019-01-07 | 2019-09-24 | 北京诺思兰德生物技术股份有限公司 | 人肝细胞生长因子突变体及其应用 |
| CN110747214B (zh) * | 2019-03-13 | 2021-12-31 | 深圳市臻质医疗科技有限公司 | DNA片段、具有长效表达和细胞特异性结合能力的mRNA-抗体融合分子及其制备方法 |
| KR20210035126A (ko) | 2021-03-18 | 2021-03-31 | 주식회사 지앤피바이오사이언스 | 코어-쉘 구조의 마이크로 입자를 유효성분으로 포함하는 성장인자 유전자 발현 증가용 조성물 |
| KR20220135215A (ko) * | 2021-03-29 | 2022-10-06 | 주식회사 헬릭스미스 | 샤르코-마리-투스병 예방 또는 치료용 약제학적 조성물 |
| US12134776B2 (en) | 2021-10-06 | 2024-11-05 | G&P Bioscience Co., Ltd. | Development of optimized recombinant expression construct |
| KR20230152503A (ko) | 2022-04-27 | 2023-11-03 | 주식회사 헬릭스미스 | 척수강 내 투여에 최적화 된 간세포 성장인자 유전자가 도입된 aav 벡터 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ232813A (en) | 1989-03-10 | 1992-08-26 | Snow Brand Milk Products Co Ltd | Human fibroblast glycoprotein, cell differentiation, blood vessel endothelial cell growth factor, cellular immunology inforcing factor of 78 or 74 thousand daltons plus or minus two thousand daltons |
| US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US6673776B1 (en) * | 1989-03-21 | 2004-01-06 | Vical Incorporated | Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human |
| US5693622A (en) * | 1989-03-21 | 1997-12-02 | Vical Incorporated | Expression of exogenous polynucleotide sequences cardiac muscle of a mammal |
| CA2022752C (en) | 1989-08-11 | 1998-07-07 | Naomi Kitamura | Hepatic parenchymal cell growth factor, gene encoding the same, process for producing the factor, and transformants producing the factor |
| US6706694B1 (en) * | 1990-03-21 | 2004-03-16 | Vical Incorporated | Expression of exogenous polynucleotide sequences in a vertebrate |
| EP0539590B1 (de) | 1990-07-13 | 1999-03-31 | Snow Brand Milk Products Co., Ltd. | Plasmid das für die aminosäuresequenz von tcf-ii kodierende dns enthalt, transformierte zelle und produktion einer physiologisch aktiven substanz mit ihrer verwendung |
| US5661133B1 (en) | 1991-11-12 | 1999-06-01 | Univ Michigan | Collateral blood vessel formation in cardiac muscle by injecting a dna sequence encoding an angiogenic protein |
| US6498144B1 (en) * | 1993-10-18 | 2002-12-24 | North Shore - Long Island Jewish Research Institute | Use of scatter factor to enhance angiogenesis |
| US5837676A (en) * | 1993-10-18 | 1998-11-17 | Long Island Jewish Medical Center | Use of scatter factor to enhance angiogenesis |
| US5652225A (en) * | 1994-10-04 | 1997-07-29 | St. Elizabeth's Medical Center Of Boston, Inc. | Methods and products for nucleic acid delivery |
| US20030148968A1 (en) | 1995-02-28 | 2003-08-07 | Hammond H. Kirk | Techniques and compositions for treating cardiovascular disease by in vivo gene delivery |
| KR100765687B1 (ko) | 1995-08-29 | 2007-10-11 | 안제스에무지 가부시키가이샤 | Ｈｇｆ 유전자를 함유하는 약제 |
| US5830879A (en) | 1995-10-02 | 1998-11-03 | St. Elizabeth's Medical Center Of Boston, Inc. | Treatment of vascular injury using vascular endothelial growth factor |
| US6121246A (en) | 1995-10-20 | 2000-09-19 | St. Elizabeth's Medical Center Of Boston, Inc. | Method for treating ischemic tissue |
| KR20010012313A (ko) | 1997-05-06 | 2001-02-15 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 혈관형성성 트랜스유전자의 생체내 송달에 의한 심장 질환및 심실 리모델링을 치료하기 위한 방법 및 조성물 |
| JPH11246433A (ja) | 1998-03-03 | 1999-09-14 | Sumitomo Pharmaceut Co Ltd | 心筋梗塞治療剤 |
| US20040228834A1 (en) | 1998-03-09 | 2004-11-18 | Jeffrey Isner | Compositions and methods for modulating vascularization |
| CA2322559C (en) | 1998-03-09 | 2012-07-17 | St. Elizabeth's Medical Center | Compositions and methods for modulating vascularization |
| US6887477B1 (en) * | 1998-08-05 | 2005-05-03 | Tomokazu Nagano | Method of treating ischemic disease by intramuscular administration of Hepatocyte growth factor |
| EP1142590B8 (de) * | 1999-10-29 | 2008-11-26 | AnGes MG, Inc. | Gentherapie für diabetische ischämie |
| CA2389524A1 (en) | 1999-11-05 | 2001-05-17 | The Regents Of The University Of California | Techniques and compositions for treating cardiovascular disease by in vivo gene delivery |
| CN1142272C (zh) * | 2000-02-02 | 2004-03-17 | 中国人民解放军军事医学科学院百环生物医学研究中心 | 携带人肝细胞生长因子基因的重组腺病毒的用途 |
| WO2002000258A1 (en) | 2000-06-27 | 2002-01-03 | Anges Mg, Inc. | Medicinal compositions for angiogenic therapy |
| EP1361896A2 (de) * | 2001-01-23 | 2003-11-19 | Boston Scientific Corporation | Methode zur lokalen myocardialen injektion zur behandlung ischämischen myocardiums |
| KR100562824B1 (ko) | 2002-03-20 | 2006-03-23 | 주식회사 바이로메드 | 유전자 발현효율이 높으며 간세포 성장인자의 두 가지이형체를 동시에 발현하는 하이브리드 간세포 성장인자유전자 |
| WO2006121532A2 (en) * | 2005-03-31 | 2006-11-16 | Mytogen, Inc. | Treatment for heart disease |
| US20090202606A1 (en) | 2008-01-25 | 2009-08-13 | Viromed Co., Ltd. | Treatment and Prevention of Cardiac Conditions Using Two or More Isoforms of Hepatocyte Growth Factor |
| KR101290322B1 (ko) | 2008-04-09 | 2013-07-26 | 주식회사 바이로메드 | 플라스미드 ｄｎａ의 발현 증강용 동결건조 ｄｎａ 제제 |
-
2002
- 2002-03-20 KR KR1020020015074A patent/KR100562824B1/ko not_active Expired - Lifetime
-
2003
- 2003-03-20 DK DK03744561T patent/DK1490492T3/da active
- 2003-03-20 WO PCT/KR2003/000548 patent/WO2003078568A2/en not_active Ceased
- 2003-03-20 BR BRPI0303570A patent/BRPI0303570B8/pt not_active IP Right Cessation
- 2003-03-20 EP EP03744561A patent/EP1490492B1/de not_active Expired - Lifetime
- 2003-03-20 PT PT03744561T patent/PT1490492E/pt unknown
- 2003-03-20 DE DE60318026T patent/DE60318026T2/de not_active Expired - Lifetime
- 2003-03-20 JP JP2003576563A patent/JP4057537B2/ja not_active Expired - Lifetime
- 2003-03-20 ES ES03744561T patent/ES2298538T3/es not_active Expired - Lifetime
- 2003-03-20 AT AT03744561T patent/ATE380826T1/de active
- 2003-03-20 AU AU2003210053A patent/AU2003210053A1/en not_active Abandoned
- 2003-03-20 CN CNB038065347A patent/CN100378219C/zh not_active Expired - Lifetime
-
2004
- 2004-09-20 US US10/944,277 patent/US7812146B2/en active Active
-
2007
- 2007-12-14 US US11/957,170 patent/US7838505B2/en not_active Expired - Lifetime
-
2009
- 2009-12-31 US US12/650,860 patent/US7745174B2/en not_active Ceased
-
2010
- 2010-10-20 US US12/908,765 patent/US8338385B2/en not_active Expired - Fee Related
-
2017
- 2017-07-05 US US15/642,307 patent/USRE48404E1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| HK1080895A1 (zh) | 2006-05-04 |
| US7812146B2 (en) | 2010-10-12 |
| BRPI0303570B8 (pt) | 2021-05-25 |
| EP1490492B1 (de) | 2007-12-12 |
| US20120010273A1 (en) | 2012-01-12 |
| US7838505B2 (en) | 2010-11-23 |
| AU2003210053A8 (en) | 2003-09-29 |
| PT1490492E (pt) | 2008-03-25 |
| WO2003078568A3 (en) | 2003-11-27 |
| BRPI0303570B1 (pt) | 2018-04-24 |
| KR100562824B1 (ko) | 2006-03-23 |
| US20100105878A1 (en) | 2010-04-29 |
| JP2005520512A (ja) | 2005-07-14 |
| KR20030075718A (ko) | 2003-09-26 |
| AU2003210053A1 (en) | 2003-09-29 |
| US7745174B2 (en) | 2010-06-29 |
| DE60318026T2 (de) | 2008-11-20 |
| US8338385B2 (en) | 2012-12-25 |
| WO2003078568A2 (en) | 2003-09-25 |
| JP4057537B2 (ja) | 2008-03-05 |
| DE60318026D1 (de) | 2008-01-24 |
| USRE48404E1 (en) | 2021-01-26 |
| BR0303570A (pt) | 2005-07-19 |
| US20090131350A1 (en) | 2009-05-21 |
| US20050079581A1 (en) | 2005-04-14 |
| DK1490492T3 (da) | 2008-03-17 |
| EP1490492A2 (de) | 2004-12-29 |
| EP1490492A4 (de) | 2006-05-31 |
| ES2298538T3 (es) | 2008-05-16 |
| CN100378219C (zh) | 2008-04-02 |
| CN1643149A (zh) | 2005-07-20 |
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| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification |
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