ATE381561T1 - Verfahren zur herstellung von chiralen propionsäurederivaten - Google Patents
Verfahren zur herstellung von chiralen propionsäurederivatenInfo
- Publication number
- ATE381561T1 ATE381561T1 AT04765444T AT04765444T ATE381561T1 AT E381561 T1 ATE381561 T1 AT E381561T1 AT 04765444 T AT04765444 T AT 04765444T AT 04765444 T AT04765444 T AT 04765444T AT E381561 T1 ATE381561 T1 AT E381561T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- propionic acid
- acid derivatives
- formula
- producing chiral
- Prior art date
Links
- 229940111131 antiinflammatory and antirheumatic product propionic acid derivative Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000005599 propionic acid derivatives Chemical class 0.000 title 1
- VURFVHCLMJOLKN-UHFFFAOYSA-N diphosphane Chemical compound PP VURFVHCLMJOLKN-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000003446 ligand Substances 0.000 abstract 2
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 238000009876 asymmetric hydrogenation reaction Methods 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052703 rhodium Inorganic materials 0.000 abstract 1
- 239000010948 rhodium Substances 0.000 abstract 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 abstract 1
- 229910052707 ruthenium Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03021700 | 2003-09-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE381561T1 true ATE381561T1 (de) | 2008-01-15 |
Family
ID=34354426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04765444T ATE381561T1 (de) | 2003-09-29 | 2004-09-21 | Verfahren zur herstellung von chiralen propionsäurederivaten |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7262303B2 (de) |
| EP (1) | EP1670792B1 (de) |
| JP (2) | JP4627299B2 (de) |
| KR (1) | KR100854886B1 (de) |
| CN (1) | CN1860115B (de) |
| AT (1) | ATE381561T1 (de) |
| CA (1) | CA2539176C (de) |
| DE (1) | DE602004010830T2 (de) |
| DK (1) | DK1670792T3 (de) |
| ES (1) | ES2297463T3 (de) |
| IL (1) | IL174360A (de) |
| MX (1) | MXPA06003365A (de) |
| TW (1) | TWI333491B (de) |
| WO (1) | WO2005030764A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7262303B2 (en) * | 2003-09-29 | 2007-08-28 | Hoffman-La Roche Inc. | Process for the production of chiral propionic acid derivatives |
| ATE453622T1 (de) * | 2006-04-03 | 2010-01-15 | Hoffmann La Roche | Verfahren zur herstellung von enantiomeren angereicherten cyclischen beta-aryl- oder heteroarylcarbonsäuren |
| ATE513702T1 (de) * | 2008-02-23 | 2011-07-15 | Gm Global Tech Operations Inc | Kondensatablaufrohr für heizungs-, lüftungs- und/oder klimaanlage und verfahren für die montage eines kondensatablaufrohrs |
| WO2010069793A1 (en) * | 2008-12-16 | 2010-06-24 | F. Hoffmann-La Roche Ag | Process for the preparation of pyrollidine-3-carboxylic acids |
| ES2397558T3 (es) * | 2009-01-23 | 2013-03-07 | F. Hoffmann-La Roche Ag | Composición farmacéutica que comprende aleglitazar |
| US8450496B2 (en) * | 2009-03-24 | 2013-05-28 | Hoffman-La Roche Inc. | Process for the preparation of propionic acid derivatives |
| WO2011070179A1 (en) * | 2009-12-07 | 2011-06-16 | F. Hoffmann-La Roche Ag | Process for the preparation of propionic acid derivatives |
| WO2013181384A1 (en) | 2012-05-31 | 2013-12-05 | Ratiopharm Gmbh | Solid state forms of aleglitazar sodium |
| WO2014016369A1 (en) | 2012-07-27 | 2014-01-30 | Ratiopharm Gmbh | Pharmaceutical formulation comprising aleglitazar and complexing agent |
| MX2015002095A (es) * | 2012-09-12 | 2015-05-11 | Hoffmann La Roche | Formas solidas de acido (s)-2-metoxi-3-{4-[2-(5-metil-2-fenil-oxaz ol-4-il)-etoxi]benzo[b]tiofen-7-il}propionico y de sales del mismo. |
| CN112480179B (zh) * | 2020-11-24 | 2025-11-14 | 苏州鹏旭医药科技有限公司 | 一种取代二茂铁基二膦均相催化剂配体 |
| US20240270731A1 (en) * | 2021-08-13 | 2024-08-15 | Alebund Pharmaceuticals (Hong Kong) Limited | Deuterated compounds |
| CN114669333B (zh) * | 2022-04-25 | 2023-06-23 | 中山大学 | 一种催化α-季碳醛脱羰氢化的催化剂体系和催化方法 |
| CN118480034B (zh) * | 2023-02-13 | 2025-02-11 | 礼邦医药(香港)有限公司 | 氘代化合物的晶型或盐 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE203242T1 (de) * | 1992-05-18 | 2001-08-15 | Hoffmann La Roche | Asymmetrische hydrierung |
| US6222039B1 (en) * | 1998-07-13 | 2001-04-24 | Hoffman-La Roche Inc. | Process for the preparation of chiral lactones |
| JP2002543194A (ja) * | 1999-04-28 | 2002-12-17 | ドクター・レディーズ・ラボラトリーズ・リミテッド | 置換二環系ヘテロ環化合物、その製造方法、並びに抗肥満症及び抗高コレステロール血症剤としてのこれらの使用 |
| ME01310B (me) | 2001-05-15 | 2011-10-10 | Hoffmann La Roche | Derivati oksazola koji su supstituisani karboksilnom kiselinom za primenu kao ppar-alfa-1-gama aktivatori u lečenju dijabetesa |
| TWI343915B (en) * | 2002-10-07 | 2011-06-21 | Hoffmann La Roche | Chirale ppar agonists |
| US7262303B2 (en) * | 2003-09-29 | 2007-08-28 | Hoffman-La Roche Inc. | Process for the production of chiral propionic acid derivatives |
-
2004
- 2004-09-02 US US10/933,176 patent/US7262303B2/en not_active Expired - Lifetime
- 2004-09-21 WO PCT/EP2004/010568 patent/WO2005030764A1/en not_active Ceased
- 2004-09-21 CN CN2004800281762A patent/CN1860115B/zh not_active Expired - Fee Related
- 2004-09-21 DK DK04765444T patent/DK1670792T3/da active
- 2004-09-21 KR KR1020067006097A patent/KR100854886B1/ko not_active Expired - Fee Related
- 2004-09-21 CA CA002539176A patent/CA2539176C/en not_active Expired - Fee Related
- 2004-09-21 JP JP2006530000A patent/JP4627299B2/ja not_active Expired - Fee Related
- 2004-09-21 EP EP04765444A patent/EP1670792B1/de not_active Expired - Lifetime
- 2004-09-21 DE DE602004010830T patent/DE602004010830T2/de not_active Expired - Lifetime
- 2004-09-21 MX MXPA06003365A patent/MXPA06003365A/es active IP Right Grant
- 2004-09-21 ES ES04765444T patent/ES2297463T3/es not_active Expired - Lifetime
- 2004-09-21 AT AT04765444T patent/ATE381561T1/de active
- 2004-09-27 TW TW093129276A patent/TWI333491B/zh not_active IP Right Cessation
-
2006
- 2006-03-16 IL IL174360A patent/IL174360A/en active IP Right Grant
-
2007
- 2007-06-08 US US11/811,071 patent/US7365207B2/en not_active Expired - Fee Related
-
2010
- 2010-10-13 JP JP2010230320A patent/JP5279789B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1860115B (zh) | 2011-09-07 |
| IL174360A (en) | 2011-10-31 |
| CN1860115A (zh) | 2006-11-08 |
| JP2007506800A (ja) | 2007-03-22 |
| US20050070714A1 (en) | 2005-03-31 |
| TW200524919A (en) | 2005-08-01 |
| US20070249842A1 (en) | 2007-10-25 |
| JP2011037886A (ja) | 2011-02-24 |
| KR20060056405A (ko) | 2006-05-24 |
| EP1670792B1 (de) | 2007-12-19 |
| JP5279789B2 (ja) | 2013-09-04 |
| WO2005030764A1 (en) | 2005-04-07 |
| MXPA06003365A (es) | 2006-06-08 |
| DE602004010830T2 (de) | 2008-12-24 |
| CA2539176A1 (en) | 2005-04-07 |
| CA2539176C (en) | 2010-01-05 |
| KR100854886B1 (ko) | 2008-08-28 |
| DK1670792T3 (da) | 2008-04-21 |
| JP4627299B2 (ja) | 2011-02-09 |
| EP1670792A1 (de) | 2006-06-21 |
| IL174360A0 (en) | 2006-08-01 |
| TWI333491B (en) | 2010-11-21 |
| US7262303B2 (en) | 2007-08-28 |
| US7365207B2 (en) | 2008-04-29 |
| DE602004010830D1 (de) | 2008-01-31 |
| ES2297463T3 (es) | 2008-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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