ATE381575T1 - Veränderte borrelia burgdorferi ospa - Google Patents

Veränderte borrelia burgdorferi ospa

Info

Publication number
ATE381575T1
ATE381575T1 AT01964163T AT01964163T ATE381575T1 AT E381575 T1 ATE381575 T1 AT E381575T1 AT 01964163 T AT01964163 T AT 01964163T AT 01964163 T AT01964163 T AT 01964163T AT E381575 T1 ATE381575 T1 AT E381575T1
Authority
AT
Austria
Prior art keywords
ospa
modified
alteration
borrelia burgdorferi
ospa polypeptide
Prior art date
Application number
AT01964163T
Other languages
English (en)
Inventor
Benjamin Luft
John Dunn
Catherine I Lawson
Shohei Koide
Original Assignee
Univ New York State Res Found
Brookhaven Sciences Ass Llc
Univ Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York State Res Found, Brookhaven Sciences Ass Llc, Univ Rochester filed Critical Univ New York State Res Found
Application granted granted Critical
Publication of ATE381575T1 publication Critical patent/ATE381575T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Beans For Foods Or Fodder (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Fats And Perfumes (AREA)
  • Saccharide Compounds (AREA)
AT01964163T 2000-08-18 2001-08-17 Veränderte borrelia burgdorferi ospa ATE381575T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22648400P 2000-08-18 2000-08-18

Publications (1)

Publication Number Publication Date
ATE381575T1 true ATE381575T1 (de) 2008-01-15

Family

ID=22849087

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01964163T ATE381575T1 (de) 2000-08-18 2001-08-17 Veränderte borrelia burgdorferi ospa

Country Status (9)

Country Link
US (3) US20040023325A1 (de)
EP (1) EP1311540B1 (de)
AT (1) ATE381575T1 (de)
AU (1) AU2001285049A1 (de)
DE (1) DE60131982T2 (de)
DK (1) DK1311540T3 (de)
ES (1) ES2298249T3 (de)
PT (1) PT1311540E (de)
WO (1) WO2002016421A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7008625B2 (en) * 1993-11-01 2006-03-07 Research Foundation Of The State University Of New York Recombinant constructs of Borrelia burgdorferi
EP1311540B1 (de) 2000-08-18 2007-12-19 Research Foundation Of State University Of New York Veränderte borrelia burgdorferi ospa
EP2283031B1 (de) * 2008-05-02 2017-04-12 Virginia Commonwealth University Impfstoff gegen die lyme-krankheit
SI2569008T1 (sl) 2010-05-14 2020-02-28 Baxalta Incorporated Himere OSPA in njihova uporaba v cepivih
WO2013067448A2 (en) 2011-11-03 2013-05-10 Vca Antech Inc. Compositions and methods to detect various infectious organisms
US8986704B2 (en) * 2012-07-06 2015-03-24 Valneva Austria Gmbh Mutant fragments of OspA and methods and uses relating thereto
JP2015524802A (ja) 2012-07-27 2015-08-27 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ キメラｏｓｐａ分子を含む組成物およびその使用方法
SI3092246T1 (sl) 2014-01-09 2019-08-30 Valneva Austria Gmbh Mutantni fragmenti OSPA ter z njimi povezani postopki in uporabe
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US12018054B2 (en) 2017-04-13 2024-06-25 Valneva Austria Gmbh Multivalent OspA polypeptides and methods and uses relating thereto
WO2019195314A2 (en) 2018-04-03 2019-10-10 Sanofi Antigenic epstein barr virus polypeptides
CA3095174A1 (en) * 2018-04-03 2019-10-10 Sanofi Antigenic ospa polypeptides
WO2019195316A1 (en) 2018-04-03 2019-10-10 Sanofi Ferritin proteins
MX2020010199A (es) 2018-04-03 2021-01-08 Sanofi Sa Polipeptidos antigenicos del virus sincitial respiratorio.
US10749235B2 (en) 2018-09-07 2020-08-18 International Business Machines Corporation Well thermalized microstrip formation for flexible cryogenic microwave lines in quantum applications
CN115698044A (zh) 2020-04-09 2023-02-03 瓦尔尼瓦奥地利有限责任公司 用于医学用途的包含三种OspA融合蛋白的组合物

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK590288D0 (da) 1988-10-24 1988-10-24 Symbicom Ab Kemiske forbindelser
US5246844A (en) 1991-10-22 1993-09-21 Board Of Regents, The University Of Texas System Virulence associated proteins in borrelia burgdorferi (bb)
US5777095A (en) * 1988-10-24 1998-07-07 Symbicom Aktiebolag Osp A and B Sequence of Borrelia burgdonferi strains ACA1 and IP90
DE4015911A1 (de) 1989-09-19 1991-03-28 Max Planck Gesellschaft Impfstoff gegen die lyme-krankheit
DK0506868T4 (da) 1989-12-22 2004-04-26 Mikrogen Molekularbiol Entw Immunologisk aktive proteiner fra Borrelia burgdorferi, tilhørende testkits og vaccine
US5217872A (en) * 1990-02-27 1993-06-08 The United States Of America As Represented By The Department Of Health And Human Services Method for detection of borrelia burgdorferi antigens
US5470712A (en) * 1990-03-05 1995-11-28 Us Health Antigenic proteins of Borrelia burgdorferi
EP0524958B1 (de) 1990-03-05 1996-09-18 THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE Antigen-wirkende proteine von borrelia burgdorferi
CA2084413A1 (en) 1990-06-15 1991-12-16 Richard A. Flavell Compositions and methods for the prevention and diagnosis of lyme disease
ATE196425T1 (de) 1990-07-06 2000-10-15 American Home Prod Impfstoff gegen die lyme-krankheit
CA2057536C (en) 1990-12-21 1999-10-26 John J. Dunn Cloning and expression of borrelia lipoproteins
US6221363B1 (en) 1991-07-11 2001-04-24 Baxter Aktiengesellschaft Vaccine for the prevention of lyme disease
DK0598816T3 (da) * 1991-08-15 1999-11-22 Deutsches Krebsforsch Osp A-proteiner fra Borrelia Burgdorferi-undergrupper, hvilke proteiner koder for gener og vacciner
WO1993008299A1 (en) 1991-10-18 1993-04-29 Connaught Laboratories Inc. Preparation of recombinant borrelia proteins
EP0540457A1 (de) 1991-10-22 1993-05-05 Symbicom Ab Verbesserungen der Diagnose und der Prophylaxe von Borrelia burgdorferi
EP0614488A1 (de) 1991-11-12 1994-09-14 The Regents Of The University Of Minnesota Rekombinanter impfstoff gegen die lymekrankheit
CA2157004A1 (en) 1993-02-26 1994-09-01 Cambridge Biotech Corporation Methods of inducing immunity to lyme disease and a colorimetric assay for borreliacidal activity of antisera
AU6366894A (en) 1993-03-11 1994-09-26 Regents Of The University Of California, The Methods, compositions, and kits for diagnosing lyme disease
EP0701612B1 (de) 1993-04-29 1998-01-21 IMMUNO Aktiengesellschaft Ospc-antigen-impfstoffe immunogene zusammensetzung zur vorbeugung und behandlung von lyme-krankheit und rekombinante verfahren zur herstellung von derartige antigene
US6248562B1 (en) * 1993-11-01 2001-06-19 Research Foundation State University Of New York Chimeric proteins comprising borrelia polypeptides and uses therefor
CA2175567C (en) * 1993-11-01 2010-08-10 John J. Dunn Chimeric proteins comprising borrelia polypeptides: uses therefor
US7008625B2 (en) * 1993-11-01 2006-03-07 Research Foundation Of The State University Of New York Recombinant constructs of Borrelia burgdorferi
US5620862A (en) * 1993-11-24 1997-04-15 University Of Connecticut Methods for diagnosing early Lyme disease
AU721954B2 (en) 1995-06-07 2000-07-20 Connaught Laboratories Inc. Expression of lipoproteins
US6251405B1 (en) 1995-06-07 2001-06-26 Connaught Laboratories, Inc. Immunological combination compositions and methods
CA2253374C (en) 1996-05-02 2004-07-20 Marianne Jartved Mathiesen Novel osp-c derived peptide fragments
AUPO069996A0 (en) 1996-06-27 1996-07-18 Australian National University, The Manipulation of plant cellulose
DE19740735A1 (de) 1997-09-16 1999-03-18 Max Planck Gesellschaft Arzneimittel zur Therapie einer manifesten Lyme-Borreliose
EP1100922B1 (de) 1998-07-31 2008-02-20 Gundersen Lutheran Medical Foundation, Inc. Verwendungen eines borreliaziden epitops des aussermembranproteins c von borrelia burgdorferi (ospc) als impstoff
EP1311540B1 (de) 2000-08-18 2007-12-19 Research Foundation Of State University Of New York Veränderte borrelia burgdorferi ospa

Also Published As

Publication number Publication date
DE60131982T2 (de) 2008-12-11
PT1311540E (pt) 2008-03-20
DE60131982D1 (de) 2008-01-31
DK1311540T3 (da) 2008-04-28
ES2298249T3 (es) 2008-05-16
WO2002016421A9 (en) 2003-09-04
US20040023325A1 (en) 2004-02-05
US20140030285A1 (en) 2014-01-30
WO2002016421A3 (en) 2003-03-06
AU2001285049A1 (en) 2002-03-04
US20090326200A1 (en) 2009-12-31
WO2002016421A8 (en) 2002-07-11
WO2002016421A2 (en) 2002-02-28
EP1311540B1 (de) 2007-12-19
EP1311540A2 (de) 2003-05-21
US8992936B2 (en) 2015-03-31
US8680236B2 (en) 2014-03-25

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