CN1191243C - 用作抗炎剂的二氢苯并呋喃和相关化合物 - Google Patents

用作抗炎剂的二氢苯并呋喃和相关化合物 Download PDF

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Publication number
CN1191243C
CN1191243C CNB951948911A CN95194891A CN1191243C CN 1191243 C CN1191243 C CN 1191243C CN B951948911 A CNB951948911 A CN B951948911A CN 95194891 A CN95194891 A CN 95194891A CN 1191243 C CN1191243 C CN 1191243C
Authority
CN
China
Prior art keywords
methyl
butyl
tert
dihydrobenzo
furan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB951948911A
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English (en)
Chinese (zh)
Other versions
CN1156993A (zh
Inventor
M·W·舍尔茨
R·S·马修斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vanderbilt University
Original Assignee
Vanderbilt University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/481,727 external-priority patent/US5656661A/en
Application filed by Vanderbilt University filed Critical Vanderbilt University
Publication of CN1156993A publication Critical patent/CN1156993A/zh
Application granted granted Critical
Publication of CN1191243C publication Critical patent/CN1191243C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB951948911A 1994-07-27 1995-07-19 用作抗炎剂的二氢苯并呋喃和相关化合物 Expired - Fee Related CN1191243C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28089294A 1994-07-27 1994-07-27
US08/280,892 1994-07-27
US08/481,727 1995-06-07
US08/481,727 US5656661A (en) 1994-07-27 1995-06-07 Dihydrobenzofuran and related compounds useful as anti-inflammatory agents

Publications (2)

Publication Number Publication Date
CN1156993A CN1156993A (zh) 1997-08-13
CN1191243C true CN1191243C (zh) 2005-03-02

Family

ID=26960588

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB951948911A Expired - Fee Related CN1191243C (zh) 1994-07-27 1995-07-19 用作抗炎剂的二氢苯并呋喃和相关化合物

Country Status (11)

Country Link
EP (1) EP0773939B1 (de)
JP (1) JPH10506615A (de)
CN (1) CN1191243C (de)
AT (1) ATE385496T1 (de)
AU (1) AU704085B2 (de)
BR (1) BR9508436A (de)
CA (1) CA2196054C (de)
ES (1) ES2301161T3 (de)
IL (1) IL114698A (de)
NZ (1) NZ290080A (de)
WO (1) WO1996003396A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5821250A (en) * 1996-02-01 1998-10-13 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5672620A (en) * 1996-02-01 1997-09-30 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5686471A (en) * 1996-02-01 1997-11-11 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5684031A (en) * 1996-02-01 1997-11-04 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5750543A (en) * 1996-02-01 1998-05-12 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5618835A (en) * 1996-02-01 1997-04-08 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
FR2744452B1 (fr) * 1996-02-06 1998-03-06 Cird Galderma Composes biaryles heterocycliques, compositions pharmaceutiques et cosmetiques les contenant et utilisations
FR2754260B1 (fr) * 1996-10-04 1998-10-30 Adir Nouveaux derives substitues de biphenyle ou de phenylpyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5985930A (en) 1996-11-21 1999-11-16 Pasinetti; Giulio M. Treatment of neurodegenerative conditions with nimesulide
EP2641903B1 (de) 2012-03-19 2014-10-22 Symrise AG Dihydrobenzofuran-Derivate als Riech- und/oder Aromastoffe
KR101592560B1 (ko) * 2013-06-21 2016-02-05 제주대학교 산학협력단 신규 플라보노이드 및 그 용도

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3551456A (en) * 1968-04-18 1970-12-29 Universal Oil Prod Co Acetyl derivatives of substituted chromans and coumarans
FR2370472A2 (fr) * 1976-11-10 1978-06-09 Continental Pharma Amino-alcool heterocyclique, son sel et son procede de preparation
EP0026593A1 (de) * 1979-09-15 1981-04-08 Pfizer Limited Bicyclische Keto- und Aminosäuren, Ester und Amide und deren pharmazeutische Zusammensetzungen
HUT36107A (en) * 1982-12-04 1985-08-28 Lilly Industries Ltd Process for production of new aurone-derivatives and medical preparatives consisting of such compounds
EP0117675B1 (de) * 1983-02-19 1986-07-23 Beecham Group Plc Benzofuran- und Benzothiophencarbonsäurederivate
FI842738A7 (fi) * 1983-07-14 1985-01-15 Syntex Inc Aroyylibentsofuraani- ja bentsotiofeenietikka- ja propionihapot.
US4613611A (en) * 1983-10-14 1986-09-23 American Cyanamid Company Method of treating diabetes mellitus using arylglyoxals
AU4261285A (en) * 1984-06-01 1985-12-05 Tokyo Tanabe Company Limited 1-propanone derivatives
FR2613365B1 (fr) * 1987-04-01 1989-07-28 Adir Nouveaux derives de l'amino tetrahydro-5, 6, 7, 8 naphto (2, 3b) furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2613364B1 (fr) * 1987-04-01 1989-06-09 Adir Nouvelles amines tricycliques derivees du tetrahydro-5, 6, 7, 8 naphto (2, 3b) dihydro-2, 3 furanne, et du tetrahydro-6, 7, 8, 9 5h-benzocyclohepta (2, 3b) dihydro-2, 3 furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US4849428A (en) * 1987-11-23 1989-07-18 The Procter & Gamble Company Cyclic anti-inflammatory derivatives of di-tert-butylphenol compounds, compositions and use
IL88674A0 (en) * 1987-12-18 1989-07-31 Norwich Eaton Pharma Preparation of certain substituted aromatic compounds
GB8906166D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
JP2808460B2 (ja) * 1989-11-16 1998-10-08 大正製薬株式会社 イミダゾール誘導体
JPH03215485A (ja) * 1990-01-11 1991-09-20 Taisho Pharmaceut Co Ltd ベンゾチエニルイミダゾール誘導体
TW197435B (de) * 1990-11-22 1993-01-01 Takeda Pharm Industry Co Ltd
JPH06263733A (ja) * 1993-01-14 1994-09-20 Sankyo Co Ltd ベンゼン誘導体

Also Published As

Publication number Publication date
ATE385496T1 (de) 2008-02-15
JPH10506615A (ja) 1998-06-30
AU704085B2 (en) 1999-04-15
BR9508436A (pt) 1998-07-14
CN1156993A (zh) 1997-08-13
EP0773939B1 (de) 2008-02-06
CA2196054A1 (en) 1996-02-08
CA2196054C (en) 2001-04-17
ES2301161T3 (es) 2008-06-16
NZ290080A (en) 1999-04-29
AU3071195A (en) 1996-02-22
WO1996003396A1 (en) 1996-02-08
IL114698A0 (en) 1995-11-27
IL114698A (en) 2001-03-19
EP0773939A1 (de) 1997-05-21

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Address before: Ohio, USA

Applicant before: THE PROCTER & GAMBLE Co.

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