ATE389653T1 - 4-substituierte derivate von pyrazolo 3,4-d pyrimidin und deren verwendungen - Google Patents

4-substituierte derivate von pyrazolo 3,4-d pyrimidin und deren verwendungen

Info

Publication number: ATE389653T1
Authority: AT; Austria
Prior art keywords: pyrazolo; pyrimidine; substituted derivatives; nhch2c6h5; nhc4h9
Prior art date: 2003-05-28

Application number

AT04734885T

Other languages

English (en)

Inventor

Francesco Bondavalli

Maurizio Botta

Olga Bruno

Fabrizio Manetti

Silvia Schenone

Fabio Carraro

Original Assignee

Univ Siena

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-05-28

Filing date

2004-05-26

Publication date

2008-04-15

2003-05-28 Priority claimed from IT000263A external-priority patent/ITRM20030263A1/it

2003-05-28 Priority claimed from IT000264A external-priority patent/ITRM20030264A1/it

2004-05-26 Application filed by Univ Siena filed Critical Univ Siena

2008-04-15 Application granted granted Critical

2008-04-15 Publication of ATE389653T1 publication Critical patent/ATE389653T1/de

Links

CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
-1 NHcyclohexyl Chemical group 0.000 abstract 2
125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
QUKPALAWEPMWOS-UHFFFAOYSA-N 1h-pyrazolo[3,4-d]pyrimidine Chemical compound C1=NC=C2C=NNC2=N1 QUKPALAWEPMWOS-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Hematology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT04734885T 2003-05-28 2004-05-26 4-substituierte derivate von pyrazolo 3,4-d pyrimidin und deren verwendungen ATE389653T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT000263A ITRM20030263A1 (it)	2003-05-28	2003-05-28	Derivati 4-sostituiti della 1-(2-cloro-2-feniletil)-
IT000264A ITRM20030264A1 (it)	2003-05-28	2003-05-28	Derivati 4-sostituiti della 1-(2-cloro-2-feniletil)-

Publications (1)

Publication Number	Publication Date
ATE389653T1 true ATE389653T1 (de)	2008-04-15

Family

ID=33492308

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04734885T ATE389653T1 (de)	2003-05-28	2004-05-26	4-substituierte derivate von pyrazolo 3,4-d pyrimidin und deren verwendungen

Country Status (8)

Country	Link
US (1)	US7589086B2 (de)
EP (1)	EP1638966B1 (de)
JP (1)	JP4642766B2 (de)
AT (1)	ATE389653T1 (de)
CA (1)	CA2527496C (de)
DE (1)	DE602004012559T2 (de)
ES (1)	ES2304252T3 (de)
WO (2)	WO2004106340A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1746099A1 (de)	2004-12-23	2007-01-24	DeveloGen Aktiengesellschaft	Mnk1 or Mnk2 Inhibitoren
JP5274842B2 (ja) *	2004-12-28	2013-08-28	エグゼリクシス，インコーポレイテッド	免疫疾患、炎症疾患および増殖疾患の処置のためのセリン−スレオニンキナーゼモジュレーター（ｐ７０Ｓ６Ｋ、Ａｋｔ−１およびＡｋｔ−２）としての［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジンまたは［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジン化合物
US7558755B2 (en) *	2005-07-13	2009-07-07	Mott Antony R	Methods and systems for valuing investments, budgets and decisions
GB0524436D0 (en) *	2005-11-30	2006-01-11	Novartis Ag	Organic compounds
CA2651898A1 (en)	2006-04-07	2007-10-18	Develogen Aktiengesellschaft	Thienopyrimidines having mnk1/mnk2 inhibiting activity for pharmaceutical compositions
EP1889847A1 (de)	2006-07-10	2008-02-20	DeveloGen Aktiengesellschaft	Pyrrolopyrimidine zur pharmazeutischen Anwendung
EP2201013B1 (de) *	2007-09-14	2014-11-19	Universita Degli Studi di Siena	Neue 4-substituierte derivate von pyrazolo[3,4-d]pyrimidin und pyrrolo[2,3-d]pyrimidin und anwendungen davon
UY32072A (es)	2008-08-26	2010-03-26	Boehringer Ingelheim Int	Tienopirimidinas para composiciones farmacéuticas
MX2012009851A (es)	2010-02-26	2012-09-12	Boehringer Ingelheim Int	Tienopirimidinas que contienen un grupo alquilo sustituido para composiciones farmaceuticas.
UY33241A (es)	2010-02-26	2011-09-30	Boehringer Ingelheim Int	?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?.
JP5575274B2 (ja)	2010-02-26	2014-08-20	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	医薬組成物のためのｍｎｋｌ／ｍｎｋ２阻害活性を有する４−［シクロアルキルオキシ（ヘテロ）アリールアミノ］チエノ「２，３−ｄ］ピリミジン
US9290499B2 (en)	2010-05-19	2016-03-22	The University Of North Carolina At Chapel Hill	Pyrazolopyrimidine compounds for the treatment of cancer
EP2632920A1 (de)	2010-10-27	2013-09-04	Dynamix Pharmaceuticals Ltd.	Sulfonamide zur modulation von pkm2
MX2014004086A (es)	2011-10-03	2014-09-22	Univ North Carolina	Compuestos de pirrolopirimidina para el tratamiento del cancer.
AU2013266438B2 (en)	2012-05-22	2017-09-07	The University Of North Carolina At Chapel Hill	Pyrimidine compounds for the treatment of cancer
CN103570723B (zh) *	2012-07-27	2016-07-13	广西梧州制药（集团）股份有限公司	吡唑并嘧啶衍生物及其制备方法和在药物制备中的用途
EP2909211A4 (de)	2012-10-17	2016-06-22	Univ North Carolina	Pyrazolopyrimidinverbindungen zur krebsbehandlung
EP2925752A4 (de)	2012-11-27	2016-06-01	Univ North Carolina	Pyrimidinverbindungen zur krebsbehandlung
US9555031B2 (en)	2014-04-11	2017-01-31	The University Of North Carolina At Chapel Hill	Therapeutic uses of selected pyrrolopyrimidine compounds with anti-mer tyrosine kinase activity
US10709708B2 (en)	2016-03-17	2020-07-14	The University Of North Carolina At Chapel Hill	Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS58208293A (ja) *	1982-05-20	1983-12-03	Lion Corp	１Ｈ−ピラゾロ〔３，４−ｄ〕ピリミジン誘導体及び該化合物を含有する抗腫瘍剤
CA2214086C (en) *	1995-04-03	2008-07-29	Novartis Ag	Pyrazole derivatives and processes for the preparation thereof
WO2003029209A2 (en) *	2001-10-02	2003-04-10	Smithkline Beecham Corporation	Chemical compounds

2004
- 2004-05-26 ES ES04734885T patent/ES2304252T3/es not_active Expired - Lifetime
- 2004-05-26 WO PCT/IT2004/000303 patent/WO2004106340A2/en not_active Ceased
- 2004-05-26 WO PCT/IT2004/000302 patent/WO2004106339A2/en not_active Ceased
- 2004-05-26 US US10/558,553 patent/US7589086B2/en not_active Expired - Fee Related
- 2004-05-26 EP EP04734885A patent/EP1638966B1/de not_active Expired - Lifetime
- 2004-05-26 CA CA2527496A patent/CA2527496C/en not_active Expired - Fee Related
- 2004-05-26 JP JP2006531028A patent/JP4642766B2/ja not_active Expired - Fee Related
- 2004-05-26 DE DE602004012559T patent/DE602004012559T2/de not_active Expired - Lifetime
- 2004-05-26 AT AT04734885T patent/ATE389653T1/de active

Also Published As

Publication number	Publication date
DE602004012559T2 (de)	2009-04-30
JP2007500206A (ja)	2007-01-11
EP1638966B1 (de)	2008-03-19
DE602004012559D1 (de)	2008-04-30
EP1638966A2 (de)	2006-03-29
US20070010510A1 (en)	2007-01-11
WO2004106340A2 (en)	2004-12-09
JP4642766B2 (ja)	2011-03-02
WO2004106340A3 (en)	2005-02-17
US7589086B2 (en)	2009-09-15
ES2304252T3 (es)	2008-10-01
WO2004106339A3 (en)	2005-02-17
WO2004106339A2 (en)	2004-12-09
CA2527496A1 (en)	2004-12-09
CA2527496C (en)	2012-08-14

Legal Events

Date

Code

Title

Description

2009-01-15

UEP

Publication of translation of european patent specification

Ref document number: 1638966

Country of ref document: EP

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ATE389653T1 (de)	2008-04-15	4-substituierte derivate von pyrazolo 3,4-d pyrimidin und deren verwendungen
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