ATE389659T1 - Benzoxazepinderivate und deren verwendung als stimulatoren des ampa-rezeptors - Google Patents

Benzoxazepinderivate und deren verwendung als stimulatoren des ampa-rezeptors

Info

Publication number: ATE389659T1
Authority: AT; Austria
Prior art keywords: ampa receptor; benzoxazepine derivatives; receptor stimulators; stimulators; benzoxazepine
Prior art date: 2001-06-11

Application number

AT02740691T

Other languages

English (en)

Inventor

Simon James Anthony Grove

Mingqiang Zhang

Mohammad Shahid

Original Assignee

Organon Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-11

Filing date

2002-06-05

Publication date

2008-04-15

2002-06-05 Application filed by Organon Nv filed Critical Organon Nv

2008-04-15 Application granted granted Critical

2008-04-15 Publication of ATE389659T1 publication Critical patent/ATE389659T1/de

Links

ZCXLTWVZYXBHJS-UHFFFAOYSA-N 1,2-benzoxazepine Chemical class O1N=CC=CC2=CC=CC=C12 ZCXLTWVZYXBHJS-UHFFFAOYSA-N 0.000 title 1
239000000774 AMPA receptor agonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Gynecology & Obstetrics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

AT02740691T 2001-06-11 2002-06-05 Benzoxazepinderivate und deren verwendung als stimulatoren des ampa-rezeptors ATE389659T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP01202215		2001-06-11

Publications (1)

Publication Number	Publication Date
ATE389659T1 true ATE389659T1 (de)	2008-04-15

Family

ID=8180450

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02740691T ATE389659T1 (de)	2001-06-11	2002-06-05	Benzoxazepinderivate und deren verwendung als stimulatoren des ampa-rezeptors

Country Status (29)

Country	Link
US (2)	US7307073B2 (de)
EP (1)	EP1399450B1 (de)
JP (1)	JP4435561B2 (de)
KR (1)	KR100863255B1 (de)
CN (1)	CN1257908C (de)
AR (1)	AR036092A1 (de)
AT (1)	ATE389659T1 (de)
AU (1)	AU2002314144B2 (de)
BR (1)	BR0210222A (de)
CA (1)	CA2450274C (de)
CO (1)	CO5550447A2 (de)
CZ (1)	CZ300052B6 (de)
DE (1)	DE60225689T2 (de)
EC (1)	ECSP034891A (de)
ES (1)	ES2301651T3 (de)
HR (1)	HRP20031007A2 (de)
HU (1)	HUP0400154A3 (de)
IL (2)	IL158905A0 (de)
IS (1)	IS2526B (de)
MX (1)	MXPA03011563A (de)
NO (1)	NO328705B1 (de)
NZ (1)	NZ529670A (de)
PE (1)	PE20030097A1 (de)
PL (1)	PL366721A1 (de)
RU (1)	RU2279434C2 (de)
SK (1)	SK287150B6 (de)
TW (1)	TWI232863B (de)
WO (1)	WO2002100865A1 (de)
ZA (1)	ZA200309382B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2002320841B2 (en)	2001-06-14	2008-02-28	Merck Sharp & Dohme B.V.	(Pyrido/thieno)-[f]-oxazepin-5-one derivatives as positive modulators of the AMPA receptor
US20110218190A1 (en) *	2008-11-10	2011-09-08	The Regents Of The University Of California	Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction
RU2654068C1 (ru) *	2009-09-28	2018-05-16	Ф.Хоффманн-Ля Рош Аг	Бензоксазепиновые ингибиторы pi3 и способы применения
FR2964969B1 (fr)	2010-09-16	2012-08-24	Servier Lab	Nouveaux derives dihydrobenzoxathiazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2014201411A1 (en)	2013-06-13	2014-12-18	Veroscience Llc	Compositions and methods for treating metabolic disorders
WO2018009256A1 (en)	2016-03-29	2018-01-11	Respirerx Pharmaceuticals, Inc.	Compositions and methods for treating attention deficit disorders
US10821103B2 (en)	2016-11-07	2020-11-03	Arbutus Biopharma Corporation	Substituted pyridinone-containing trycyclic compounds, and methods using same
TWI801517B (zh)	2018-03-12	2023-05-11	加拿大商愛彼特生物製藥公司	經取代的2-吡啶酮三環化合物、其類似物及其使用方法
EP3773584A4 (de)	2018-04-12	2022-01-05	Arbutus Biopharma Corporation	Verfahren zur herstellung von substituierten pyridinonhaltigen tricyclischen verbindungen
EP3885349B1 (de)	2018-11-22	2023-08-23	Fujian Akeylink Biotechnology Co., Ltd.	Kristallform des hepatitis-b-oberflächenantigen-inhibitors
EP4121072A1 (de) *	2020-03-20	2023-01-25	Amathus Therapeutics, Inc.	Cyclische sulfonamidderivate als trap1-modulatoren und verwendungen davon

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1238719A (de)	1968-11-01	1971-07-07
ES2174851T3 (es)	1992-07-24	2002-11-16	Univ California	Farmacos que aumentan las respuestas sinapticas mediadas por receptores ampa.
AU4296196A (en)	1995-01-06	1996-07-24	F. Hoffmann-La Roche Ag	Hydroxymethylimidazodiazepines and their esters
US5650409A (en) *	1995-06-02	1997-07-22	Cortex Pharmaceuticals, Inc.	Benzoyl piperidines/pyrrolidines for enhancing synaptic response
US5736543A (en)	1996-04-03	1998-04-07	The Regents Of The University Of California	Benzoxazines for enhancing synaptic response
ATE303997T1 (de)	1997-06-09	2005-09-15	Pfizer Prod Inc	Chinazolin-4-on ampa antagonisten
US5985871A (en) *	1997-12-24	1999-11-16	Cortex Pharmaceuticals, Inc.	Benzoxazine compounds for enhancing synaptic response
HUP0101280A3 (en) *	1998-02-18	2003-02-28	Neurosearch As	Positive ampa receptor modulator compounds and their use
US6124278A (en)	1998-04-03	2000-09-26	The Regents Of The University Of California	Acylbenzoxazines for enhancing synaptic response

2002
- 2002-05-31 TW TW091111746A patent/TWI232863B/zh not_active IP Right Cessation
- 2002-06-05 IL IL15890502A patent/IL158905A0/xx unknown
- 2002-06-05 CA CA2450274A patent/CA2450274C/en not_active Expired - Lifetime
- 2002-06-05 AU AU2002314144A patent/AU2002314144B2/en not_active Expired
- 2002-06-05 BR BR0210222-6A patent/BR0210222A/pt not_active Application Discontinuation
- 2002-06-05 ES ES02740691T patent/ES2301651T3/es not_active Expired - Lifetime
- 2002-06-05 CN CNB028116410A patent/CN1257908C/zh not_active Expired - Lifetime
- 2002-06-05 US US10/480,623 patent/US7307073B2/en not_active Expired - Lifetime
- 2002-06-05 SK SK1518-2003A patent/SK287150B6/sk not_active IP Right Cessation
- 2002-06-05 EP EP02740691A patent/EP1399450B1/de not_active Expired - Lifetime
- 2002-06-05 JP JP2003503632A patent/JP4435561B2/ja not_active Expired - Lifetime
- 2002-06-05 MX MXPA03011563A patent/MXPA03011563A/es active IP Right Grant
- 2002-06-05 WO PCT/EP2002/006185 patent/WO2002100865A1/en not_active Ceased
- 2002-06-05 HR HR20031007A patent/HRP20031007A2/xx not_active Application Discontinuation
- 2002-06-05 AT AT02740691T patent/ATE389659T1/de active
- 2002-06-05 NZ NZ529670A patent/NZ529670A/en unknown
- 2002-06-05 DE DE60225689T patent/DE60225689T2/de not_active Expired - Lifetime
- 2002-06-05 KR KR1020037016150A patent/KR100863255B1/ko not_active Expired - Fee Related
- 2002-06-05 HU HU0400154A patent/HUP0400154A3/hu unknown
- 2002-06-05 CZ CZ20033376A patent/CZ300052B6/cs not_active IP Right Cessation
- 2002-06-05 RU RU2004100310/04A patent/RU2279434C2/ru not_active IP Right Cessation
- 2002-06-05 PL PL02366721A patent/PL366721A1/xx not_active IP Right Cessation
- 2002-06-10 PE PE2002000495A patent/PE20030097A1/es not_active Application Discontinuation
- 2002-06-10 AR ARP020102171A patent/AR036092A1/es unknown
2003
- 2003-11-13 IS IS7036A patent/IS2526B/is unknown
- 2003-11-17 IL IL158905A patent/IL158905A/en not_active IP Right Cessation
- 2003-12-02 ZA ZA200309382A patent/ZA200309382B/en unknown
- 2003-12-04 CO CO03107046A patent/CO5550447A2/es not_active Application Discontinuation
- 2003-12-10 NO NO20035486A patent/NO328705B1/no not_active IP Right Cessation
- 2003-12-11 EC EC2003004891A patent/ECSP034891A/es unknown
2007
- 2007-10-25 US US11/924,451 patent/US7504390B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
SK287150B6 (sk)	2010-01-07
US7504390B2 (en)	2009-03-17
IL158905A (en)	2008-12-29
JP2004533466A (ja)	2004-11-04
CZ300052B6 (cs)	2009-01-21
KR100863255B1 (ko)	2008-10-15
HRP20031007A2 (en)	2005-10-31
NO328705B1 (no)	2010-05-03
US20080139529A1 (en)	2008-06-12
CA2450274C (en)	2010-12-21
CZ20033376A3 (en)	2004-04-14
HUP0400154A3 (en)	2007-05-02
PE20030097A1 (es)	2003-02-08
IS2526B (is)	2009-07-15
ECSP034891A (es)	2004-01-28
RU2004100310A (ru)	2005-06-10
EP1399450A1 (de)	2004-03-24
NZ529670A (en)	2006-02-24
TWI232863B (en)	2005-05-21
ZA200309382B (en)	2005-03-02
NO20035486D0 (no)	2003-12-10
AR036092A1 (es)	2004-08-11
JP4435561B2 (ja)	2010-03-17
DE60225689D1 (de)	2008-04-30
US7307073B2 (en)	2007-12-11
US20040171605A1 (en)	2004-09-02
KR20040006030A (ko)	2004-01-16
SK15182003A3 (sk)	2004-05-04
IL158905A0 (en)	2004-05-12
BR0210222A (pt)	2004-04-13
RU2279434C2 (ru)	2006-07-10
PL366721A1 (en)	2005-02-07
CO5550447A2 (es)	2005-08-31
AU2002314144B2 (en)	2008-01-31
WO2002100865A1 (en)	2002-12-19
ES2301651T3 (es)	2008-07-01
HK1061858A1 (en)	2004-10-08
CA2450274A1 (en)	2002-12-19
EP1399450B1 (de)	2008-03-19
DE60225689T2 (de)	2008-07-17
MXPA03011563A (es)	2004-03-18
CN1257908C (zh)	2006-05-31
CN1514835A (zh)	2004-07-21
IS7036A (is)	2003-11-13
HUP0400154A2 (hu)	2004-07-28

Legal Events

Date

Code

Title

Description

2008-10-15

UEP

Publication of translation of european patent specification

Ref document number: 1399450

Country of ref document: EP

Publication	Publication Date	Title
DE60113719D1 (de)	2006-02-09	Chinuclidincarbamat derivate und deren verwendung als m3 antagonisten
DE60009116D1 (de)	2004-04-22	Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten
DE60005386D1 (de)	2003-10-23	Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten
DE60036803D1 (de)	2007-11-29	Arylmethyl-carbonylamino-thiazolderivate und ihre verwendung als antitumormittel
ATE418543T1 (de)	2009-01-15	Substituierte 1,4-dipiperidin-4-yl- piperazinderivate und deren verwendung als neurokininantagonisten
DE60015296D1 (de)	2004-12-02	Indolderivate und ihre verwendung als mcp-1 rezeptor antagonisten
DE60208351D1 (de)	2006-02-02	Glukopyranosyloxybenzylbenzolderivate und deren medizinische verwendung
ATE332294T1 (de)	2006-07-15	Dihydro-1,3,5-triazin-diamin-derivate und ihre therapeutische verwendung
ATE348805T1 (de)	2007-01-15	2-acyl-indolderivate und deren verwendung als antitumormittel
DE60135239D1 (de)	2008-09-18	Indolinderivate und deren verwendung als 5-ht2 rezeptor liganden
DE60133897D1 (de)	2008-06-19	Substituierte chinazolin-derivate und deren verwendung als aurora-2-kinase inhibitoren
ATE280158T1 (de)	2004-11-15	3-phenylpyridinderivative und deren verwendung als nk-1 rezeptorantagonisten
ATE458717T1 (de)	2010-03-15	Beta-amino-alpha-cyanoacrylate und deren verwendung als herbizide
DE60106607D1 (de)	2004-11-25	Substituierte 1-aminoalkyl-lactame und ihre verwendung als muscarinrezeptor antagonisten
DE60114413D1 (de)	2005-12-01	Substituierte 1-aminoalkyl-lactame und deren verwendung als muscarinrezeptor-antagonisten
DE60320457D1 (de)	2008-05-29	Tetrahydrochinolinderivate und deren verwendung als modulatoren des fsh rezeptors
DE60021507D1 (de)	2005-09-01	Uracilverbindungen und deren Verwendung
DE60107603D1 (de)	2005-01-05	Pyrimidinverbindungen und deren verwendung als pestizide
ATE389659T1 (de)	2008-04-15	Benzoxazepinderivate und deren verwendung als stimulatoren des ampa-rezeptors
DE50206476D1 (de)	2006-05-24	Cyanoanthranylamid-derivate und deren verwendung als arzneimittel
ATE401333T1 (de)	2008-08-15	1-oxa-3,9-diazaspiroc5.5üundecan-2-onderivate und deren verwendung als antagonisten des neurokininrezeptors
ATE353881T1 (de)	2007-03-15	1,4-diazepan-2,5-dion-derivate und deren verwendung als nk-1 rezeptorantagonisten
DE60311277D1 (de)	2007-03-08	Benzotriazabicyclische derivate und deren verwendung als beta-lactamaseinhibitoren und antibakterielle mittel
DE50004104D1 (de)	2003-11-20	Indolderivate und deren verwendung als 5ht2a liganden
DE60036885D1 (de)	2007-12-06	Succinimidverbindungen und deren verwendung