ATE389659T1 - Benzoxazepinderivate und deren verwendung als stimulatoren des ampa-rezeptors - Google Patents

Benzoxazepinderivate und deren verwendung als stimulatoren des ampa-rezeptors

Info

Publication number
ATE389659T1
ATE389659T1 AT02740691T AT02740691T ATE389659T1 AT E389659 T1 ATE389659 T1 AT E389659T1 AT 02740691 T AT02740691 T AT 02740691T AT 02740691 T AT02740691 T AT 02740691T AT E389659 T1 ATE389659 T1 AT E389659T1
Authority
AT
Austria
Prior art keywords
ampa receptor
benzoxazepine derivatives
receptor stimulators
stimulators
benzoxazepine
Prior art date
Application number
AT02740691T
Other languages
English (en)
Inventor
Simon James Anthony Grove
Mingqiang Zhang
Mohammad Shahid
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Application granted granted Critical
Publication of ATE389659T1 publication Critical patent/ATE389659T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D515/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT02740691T 2001-06-11 2002-06-05 Benzoxazepinderivate und deren verwendung als stimulatoren des ampa-rezeptors ATE389659T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01202215 2001-06-11

Publications (1)

Publication Number Publication Date
ATE389659T1 true ATE389659T1 (de) 2008-04-15

Family

ID=8180450

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02740691T ATE389659T1 (de) 2001-06-11 2002-06-05 Benzoxazepinderivate und deren verwendung als stimulatoren des ampa-rezeptors

Country Status (29)

Country Link
US (2) US7307073B2 (de)
EP (1) EP1399450B1 (de)
JP (1) JP4435561B2 (de)
KR (1) KR100863255B1 (de)
CN (1) CN1257908C (de)
AR (1) AR036092A1 (de)
AT (1) ATE389659T1 (de)
AU (1) AU2002314144B2 (de)
BR (1) BR0210222A (de)
CA (1) CA2450274C (de)
CO (1) CO5550447A2 (de)
CZ (1) CZ300052B6 (de)
DE (1) DE60225689T2 (de)
EC (1) ECSP034891A (de)
ES (1) ES2301651T3 (de)
HR (1) HRP20031007A2 (de)
HU (1) HUP0400154A3 (de)
IL (2) IL158905A0 (de)
IS (1) IS2526B (de)
MX (1) MXPA03011563A (de)
NO (1) NO328705B1 (de)
NZ (1) NZ529670A (de)
PE (1) PE20030097A1 (de)
PL (1) PL366721A1 (de)
RU (1) RU2279434C2 (de)
SK (1) SK287150B6 (de)
TW (1) TWI232863B (de)
WO (1) WO2002100865A1 (de)
ZA (1) ZA200309382B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1255413C (zh) 2001-06-14 2006-05-10 阿克佐诺贝尔公司 作为ampa受体正性调节剂的(吡啶并/噻吩并)－[f]－氧杂吖庚因－5－酮衍生物
US20110218190A1 (en) * 2008-11-10 2011-09-08 The Regents Of The University Of California Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction
TWI423980B (zh) * 2009-09-28 2014-01-21 Hoffmann La Roche 苯并氧氮呯ｐｉ３ｋ抑制劑化合物及使用方法
FR2964969B1 (fr) * 2010-09-16 2012-08-24 Servier Lab Nouveaux derives dihydrobenzoxathiazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP3311842A1 (de) 2013-06-13 2018-04-25 VeroScience LLC Zusammensetzungen und verfahren zur behandlung von stoffwechselstörungen
EP3436021B1 (de) 2016-03-29 2026-07-29 RespireRx Pharmaceuticals, Inc. Zusammensetzungen mit niedrig wirkenden ampakinen zur behandlung von aufmerksamkeitsdefizitstörungen
JP7113009B2 (ja) 2016-11-07 2022-08-04 アービュタス バイオファーマ コーポレイション 置換ピリジノン含有三環式化合物およびそれを使用する方法
TWI801517B (zh) 2018-03-12 2023-05-11 加拿大商愛彼特生物製藥公司 經取代的2-吡啶酮三環化合物、其類似物及其使用方法
TW202010499A (zh) 2018-04-12 2020-03-16 加拿大商愛彼特生物製藥公司 經取代的吡啶酮之三環化合物的製備方法
CA3120532C (en) 2018-11-22 2023-09-26 Fujian Cosunter Pharmaceutical Co., Ltd. Crystal form of hepatitis b surface antigen inhibitor
US20230218632A1 (en) * 2020-03-20 2023-07-13 Amathus Therapeutics, Inc. Cyclic sulfonamide derivatives as trap1 modulators and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1238719A (de) 1968-11-01 1971-07-07
DE69331761T2 (de) 1992-07-24 2002-09-12 The Regents Of The University Of California, Oakland Arzneimittel, die den durch ampa rezeptoren vermittelten synaptischen respons erhöhen
CN1168140A (zh) 1995-01-06 1997-12-17 弗·哈夫曼-拉罗切有限公司 羟甲基咪唑并二氮杂䓬及其酯
US5650409A (en) * 1995-06-02 1997-07-22 Cortex Pharmaceuticals, Inc. Benzoyl piperidines/pyrrolidines for enhancing synaptic response
US5736543A (en) * 1996-04-03 1998-04-07 The Regents Of The University Of California Benzoxazines for enhancing synaptic response
ES2245015T3 (es) 1997-06-09 2005-12-16 Pfizer Products Inc. Quinazolin-4-onas como antagonistas de ampa.
US5985871A (en) * 1997-12-24 1999-11-16 Cortex Pharmaceuticals, Inc. Benzoxazine compounds for enhancing synaptic response
RU2214405C2 (ru) * 1998-02-18 2003-10-20 НьюроСёрч А/С Новые соединения и их применение в качестве положительных модуляторов амра-рецепторов
US6124278A (en) 1998-04-03 2000-09-26 The Regents Of The University Of California Acylbenzoxazines for enhancing synaptic response

Also Published As

Publication number Publication date
CZ20033376A3 (en) 2004-04-14
NZ529670A (en) 2006-02-24
IL158905A (en) 2008-12-29
CO5550447A2 (es) 2005-08-31
CN1257908C (zh) 2006-05-31
CA2450274A1 (en) 2002-12-19
HUP0400154A2 (hu) 2004-07-28
IS2526B (is) 2009-07-15
JP2004533466A (ja) 2004-11-04
NO328705B1 (no) 2010-05-03
WO2002100865A1 (en) 2002-12-19
ES2301651T3 (es) 2008-07-01
ECSP034891A (es) 2004-01-28
TWI232863B (en) 2005-05-21
NO20035486D0 (no) 2003-12-10
PE20030097A1 (es) 2003-02-08
ZA200309382B (en) 2005-03-02
JP4435561B2 (ja) 2010-03-17
US7307073B2 (en) 2007-12-11
HUP0400154A3 (en) 2007-05-02
CN1514835A (zh) 2004-07-21
KR100863255B1 (ko) 2008-10-15
MXPA03011563A (es) 2004-03-18
AR036092A1 (es) 2004-08-11
US20040171605A1 (en) 2004-09-02
RU2279434C2 (ru) 2006-07-10
US7504390B2 (en) 2009-03-17
DE60225689T2 (de) 2008-07-17
AU2002314144B2 (en) 2008-01-31
HRP20031007A2 (en) 2005-10-31
US20080139529A1 (en) 2008-06-12
HK1061858A1 (en) 2004-10-08
PL366721A1 (en) 2005-02-07
IL158905A0 (en) 2004-05-12
SK287150B6 (sk) 2010-01-07
SK15182003A3 (sk) 2004-05-04
KR20040006030A (ko) 2004-01-16
EP1399450A1 (de) 2004-03-24
DE60225689D1 (de) 2008-04-30
IS7036A (is) 2003-11-13
CA2450274C (en) 2010-12-21
BR0210222A (pt) 2004-04-13
CZ300052B6 (cs) 2009-01-21
EP1399450B1 (de) 2008-03-19
RU2004100310A (ru) 2005-06-10

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