ATE329908T1 - Arylethene-sulfonamid derivate, deren herstellung und deren verwendung als endothelin-antagonisten - Google Patents

Arylethene-sulfonamid derivate, deren herstellung und deren verwendung als endothelin-antagonisten

Info

Publication number: ATE329908T1
Authority: AT; Austria
Prior art keywords: arylethene; preparation; sulfonamide derivatives; endothelin antagonists; endothelin
Prior art date: 2000-07-21

Application number

AT01960485T

Other languages

English (en)

Inventor

Christoph Boss

Martin Bolli

Martine Clozel

Walter Fischli

Thomas Weller

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-21

Filing date

2001-07-10

Publication date

2006-07-15

2001-07-10 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2006-07-15 Application granted granted Critical

2006-07-15 Publication of ATE329908T1 publication Critical patent/ATE329908T1/de

Links

102000002045 Endothelin Human genes 0.000 title 1
108050009340 Endothelin Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
229940124530 sulfonamide Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pulmonology (AREA)
Hematology (AREA)
Obesity (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT01960485T 2000-07-21 2001-07-10 Arylethene-sulfonamid derivate, deren herstellung und deren verwendung als endothelin-antagonisten ATE329908T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP0007006		2000-07-21

Publications (1)

Publication Number	Publication Date
ATE329908T1 true ATE329908T1 (de)	2006-07-15

Family

ID=8164031

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01960485T ATE329908T1 (de)	2000-07-21	2001-07-10	Arylethene-sulfonamid derivate, deren herstellung und deren verwendung als endothelin-antagonisten

Country Status (21)

Country	Link
US (1)	US6951856B2 (de)
EP (1)	EP1309564B1 (de)
JP (1)	JP4832706B2 (de)
KR (1)	KR100826332B1 (de)
CN (1)	CN100562518C (de)
AR (1)	AR030247A1 (de)
AT (1)	ATE329908T1 (de)
AU (2)	AU2001281970B2 (de)
BR (1)	BR0112614A (de)
CA (1)	CA2416785C (de)
DE (1)	DE60120711T2 (de)
ES (1)	ES2266233T3 (de)
HU (1)	HUP0300965A3 (de)
IL (2)	IL153471A0 (de)
MX (1)	MXPA03000430A (de)
MY (1)	MY140724A (de)
NO (1)	NO324771B1 (de)
NZ (1)	NZ523304A (de)
TW (1)	TWI289553B (de)
WO (1)	WO2002008200A2 (de)
ZA (1)	ZA200300137B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1725540E (pt)	2004-03-05	2012-11-29	Hoffmann La Roche	Diaminopirimidinas como antagonistas de p2x3 e p2x2/3
ES2612890T3 (es)	2005-09-01	2017-05-19	F. Hoffmann-La Roche Ag	Diaminopirimidinas como moduladores de P2X3 y P2X2/3
ES2562056T3 (es)	2005-09-01	2016-03-02	F. Hoffmann-La Roche Ag	Diaminopirimidinas como moduladores P2X3 y P2X2/3
AU2006286576B2 (en)	2005-09-01	2012-06-14	F. Hoffmann-La Roche Ag	Diaminopyrimidines as P2X3 and P3X2/3 modulators
TWI331523B (en) *	2005-12-08	2010-10-11	Nat Health Research Institutes	Vinylsulfonate compounds
US20110257163A1 (en) *	2007-08-07	2011-10-20	Schering Corporation	Gamma secretase modulators
WO2009104152A1 (en) *	2008-02-20	2009-08-27	Actelion Pharmaceuticals Ltd	Combination treatment for ovarian cancer
IT1393136B1 (it) *	2009-03-11	2012-04-11	Sifa Vitor S R L	Procedimento per la preparazione del bosentan
US20100256371A1 (en) *	2009-04-02	2010-10-07	Glenmark	Processes for the preparation of bosentan and its intermediates thereof
AU2018332634A1 (en)	2017-09-12	2020-04-30	Agency For Science, Technology And Research	Compounds useful as inhibitors of isoprenylcysteine carboxyl methyltransferase
CN110885328B (zh) *	2018-09-10	2022-08-12	成都康弘药业集团股份有限公司	作为钠通道阻滞剂的磺酰胺类化合物及其用途
CN118201908A (zh)	2021-11-08	2024-06-14	正大天晴药业集团股份有限公司	氮杂联苯类化合物及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2086544C1 (ru)	1991-06-13	1997-08-10	Хоффманн-Ля Рош АГ	Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
TW287160B (de) *	1992-12-10	1996-10-01	Hoffmann La Roche
TW394761B (en)	1993-06-28	2000-06-21	Hoffmann La Roche	Novel Sulfonylamino Pyrimidines
IL111959A (en)	1993-12-17	2000-07-16	Tanabe Seiyaku Co	N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them
JP2790065B2 (ja) *	1993-12-17	1998-08-27	田辺製薬株式会社	ベンゼンスルホンアミド誘導体及びその製法
US5739333A (en)	1995-05-16	1998-04-14	Tanabe Seiyaku Co., Ltd.	Sulfonamide derivative and process for preparing the same
KR100456650B1 (ko)	1995-12-20	2005-06-20	야마노우치세이야쿠 가부시키가이샤	아릴에텐설폰아미드유도체
TWI284642B (en)	1999-01-18	2007-08-01	Hoffmann La Roche	Novel heterocyclic sulfonamides
US6417360B1 (en)	1999-03-03	2002-07-09	Hoffmann-La Roche Inc.	Heterocyclic sulfonamides

2001
- 2001-07-09 MY MYPI20013244A patent/MY140724A/en unknown
- 2001-07-10 AU AU2001281970A patent/AU2001281970B2/en not_active Ceased
- 2001-07-10 ES ES01960485T patent/ES2266233T3/es not_active Expired - Lifetime
- 2001-07-10 US US10/332,247 patent/US6951856B2/en not_active Expired - Fee Related
- 2001-07-10 CA CA002416785A patent/CA2416785C/en not_active Expired - Fee Related
- 2001-07-10 NZ NZ523304A patent/NZ523304A/en unknown
- 2001-07-10 EP EP01960485A patent/EP1309564B1/de not_active Expired - Lifetime
- 2001-07-10 CN CNB018126693A patent/CN100562518C/zh not_active Expired - Fee Related
- 2001-07-10 HU HU0300965A patent/HUP0300965A3/hu unknown
- 2001-07-10 MX MXPA03000430A patent/MXPA03000430A/es active IP Right Grant
- 2001-07-10 AU AU8197001A patent/AU8197001A/xx active Pending
- 2001-07-10 KR KR1020037000256A patent/KR100826332B1/ko not_active Expired - Fee Related
- 2001-07-10 JP JP2002514106A patent/JP4832706B2/ja not_active Expired - Fee Related
- 2001-07-10 DE DE60120711T patent/DE60120711T2/de not_active Expired - Lifetime
- 2001-07-10 AT AT01960485T patent/ATE329908T1/de active
- 2001-07-10 BR BR0112614-8A patent/BR0112614A/pt not_active Application Discontinuation
- 2001-07-10 WO PCT/EP2001/007922 patent/WO2002008200A2/en not_active Ceased
- 2001-07-10 IL IL15347101A patent/IL153471A0/xx active IP Right Grant
- 2001-07-16 AR ARP010103391A patent/AR030247A1/es active IP Right Grant
- 2001-07-23 TW TW090117915A patent/TWI289553B/zh not_active IP Right Cessation
2002
- 2002-12-16 IL IL153471A patent/IL153471A/en not_active IP Right Cessation
2003
- 2003-01-06 ZA ZA200300137A patent/ZA200300137B/en unknown
- 2003-01-20 NO NO20030274A patent/NO324771B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE60120711D1 (de)	2006-07-27
DE60120711T2 (de)	2007-06-06
KR100826332B1 (ko)	2008-05-02
EP1309564B1 (de)	2006-06-14
HUP0300965A2 (hu)	2003-10-28
TWI289553B (en)	2007-11-11
CA2416785C (en)	2009-11-10
CN100562518C (zh)	2009-11-25
EP1309564A2 (de)	2003-05-14
NO324771B1 (no)	2007-12-10
ZA200300137B (en)	2004-04-06
CA2416785A1 (en)	2002-01-31
NO20030274L (no)	2003-01-20
JP2004504385A (ja)	2004-02-12
NZ523304A (en)	2005-02-25
US6951856B2 (en)	2005-10-04
IL153471A0 (en)	2003-07-06
AU2001281970B2 (en)	2006-03-16
US20030220359A1 (en)	2003-11-27
WO2002008200A3 (en)	2002-05-10
KR20030016382A (ko)	2003-02-26
AU8197001A (en)	2002-02-05
HUP0300965A3 (en)	2004-01-28
BR0112614A (pt)	2003-06-10
JP4832706B2 (ja)	2011-12-07
CN1441788A (zh)	2003-09-10
ES2266233T3 (es)	2007-03-01
WO2002008200A2 (en)	2002-01-31
MY140724A (en)	2010-01-15
MXPA03000430A (es)	2003-06-24
IL153471A (en)	2007-09-20
AR030247A1 (es)	2003-08-13
NO20030274D0 (no)	2003-01-20

Legal Events

Date

Code

Title

Description

2007-04-15

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