ATE389660T1 - (1,10b-dihydro-2-(aminocarbonylphenyl)-5h- pyrazolo(1,5-c)(1,3)benzoxazin-5- yl)phenylmethanonderivate als inhibitoren der viralen hiv-replikation - Google Patents

(1,10b-dihydro-2-(aminocarbonylphenyl)-5h- pyrazolo(1,5-c)(1,3)benzoxazin-5- yl)phenylmethanonderivate als inhibitoren der viralen hiv-replikation

Info

Publication number: ATE389660T1
Authority: AT; Austria
Prior art keywords: aminocarbonylphenyl; benzoxazine; pyrazolo; dihydro; inhibitors
Prior art date: 2004-05-04

Application number

AT05740229T

Other languages

English (en)

Inventor

Abdellah Tahri

Lieve Michiels

Acker Koenraad Van

Dominique Surleraux

Original Assignee

Tibotec Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-05-04

Filing date

2005-05-04

Publication date

2008-04-15

2005-05-04 Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd

2008-04-15 Application granted granted Critical

2008-04-15 Publication of ATE389660T1 publication Critical patent/ATE389660T1/de

Links

CBJVVHOEVDZONM-UHFFFAOYSA-N 2-(5-benzoyl-5,10b-dihydro-1h-pyrazolo[1,5-c][1,3]benzoxazin-2-yl)benzamide Chemical class NC(=O)C1=CC=CC=C1C1=NN2C(C(=O)C=3C=CC=CC=3)OC3=CC=CC=C3C2C1 CBJVVHOEVDZONM-UHFFFAOYSA-N 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
230000029812 viral genome replication Effects 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT05740229T 2004-05-04 2005-05-04 (1,10b-dihydro-2-(aminocarbonylphenyl)-5h- pyrazolo(1,5-c)(1,3)benzoxazin-5- yl)phenylmethanonderivate als inhibitoren der viralen hiv-replikation ATE389660T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP04101913		2004-05-04
US60427504P	2004-08-25	2004-08-25

Publications (1)

Publication Number	Publication Date
ATE389660T1 true ATE389660T1 (de)	2008-04-15

Family

ID=35058129

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05740229T ATE389660T1 (de)	2004-05-04	2005-05-04	(1,10b-dihydro-2-(aminocarbonylphenyl)-5h- pyrazolo(1,5-c)(1,3)benzoxazin-5- yl)phenylmethanonderivate als inhibitoren der viralen hiv-replikation

Country Status (20)

Country	Link
US (1)	US7326703B2 (de)
EP (1)	EP1778696B1 (de)
JP (1)	JP4929162B2 (de)
KR (1)	KR20070015547A (de)
CN (1)	CN1950380B (de)
AP (1)	AP2006003759A0 (de)
AR (1)	AR048650A1 (de)
AT (1)	ATE389660T1 (de)
AU (1)	AU2005238235B2 (de)
BR (1)	BRPI0510612A (de)
CA (1)	CA2563959C (de)
DE (1)	DE602005005490T2 (de)
ES (1)	ES2303244T3 (de)
IL (1)	IL178082A (de)
MX (1)	MXPA06012755A (de)
NO (1)	NO20065582L (de)
PL (1)	PL1778696T3 (de)
RU (1)	RU2382789C2 (de)
WO (1)	WO2005105810A2 (de)
ZA (1)	ZA200609178B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7122185B2 (en)	2002-02-22	2006-10-17	Progenics Pharmaceuticals, Inc.	Anti-CCR5 antibody
TW200710091A (en) *	2005-04-11	2007-03-16	Tibotec Pharm Ltd	(1,10B-dihydro-2-(aminoalkyl-phenyl)-5H-pyrazolo [1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as HIV viral replication inhibitors
CA2616189C (en) *	2005-07-22	2019-03-26	Progenics Pharmaceuticals, Inc.	Methods for reducing viral load in hiv-1-infected patients
JP2010531301A (ja) *	2007-06-25	2010-09-24	テイボテク・フアーマシユーチカルズ	ダルナビル及びエトラビリンを含んでなる組み合わせ調剤
US8592487B2 (en) *	2007-10-26	2013-11-26	Concert Pharmaceuticals, Inc.	Deuterated darunavir
WO2009134401A2 (en) *	2008-04-29	2009-11-05	Progenics Pharmaceuticals, Inc.	Methods of inhibiting infection by diverse subtypes of drug-resistant hiv-1

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5145684A (en)	1991-01-25	1992-09-08	Sterling Drug Inc.	Surface modified drug nanoparticles
DE4210939A1 (de) *	1992-04-02	1993-10-07	Bayer Ag	Verwendung von 7-Oxo-7H-pyrido[1,2,3-de][1,4]benzoxacin-6-carbonsäuren und -estern als Arzneimittel
IL106507A (en) *	1992-08-07	1997-11-20	Merck & Co Inc	Pharmaceutical compositions containing benzoxazinones and some novel compounds of this type
PH30929A (en)	1992-09-03	1997-12-23	Janssen Pharmaceutica Nv	Beads having a core coated with an antifungal and a polymer.
PT721331E (pt)	1993-10-01	2002-05-31	Astrazeneca Ab	Processo i
WO1997044014A1 (en)	1996-05-20	1997-11-27	Janssen Pharmaceutica N.V.	Antifungal compositions with improved bioavailability
ES2203790T3 (es) *	1996-10-02	2004-04-16	Bristol-Myers Squibb Pharma Company	1,4-dihidro-2h-3,1-benzoxacin-2-onas 4,4-disustituidas utiles como inhibidores de la transcriptasa reversa del hiv e intermedios y procedimientos para su preparacion.
SK284813B6 (sk)	1997-03-26	2005-12-01	Janssen Pharmaceutica N. V.	Peleta obsahujúca itrakonazol, spôsob jej prípravy a farmaceutická dávková forma s jej obsahom
BR9815899A (pt) *	1998-05-20	2001-02-20	Lilly Co Eli	Compostos antivirais
IL157875A0 (en) *	2001-04-10	2004-03-28	Pfizer	Pyrazole derivatives for treating hiv

2005
- 2005-05-03 AR ARP050101767A patent/AR048650A1/es unknown
- 2005-05-04 WO PCT/EP2005/052041 patent/WO2005105810A2/en not_active Ceased
- 2005-05-04 PL PL05740229T patent/PL1778696T3/pl unknown
- 2005-05-04 AU AU2005238235A patent/AU2005238235B2/en not_active Ceased
- 2005-05-04 ES ES05740229T patent/ES2303244T3/es not_active Expired - Lifetime
- 2005-05-04 DE DE602005005490T patent/DE602005005490T2/de not_active Expired - Lifetime
- 2005-05-04 JP JP2007512194A patent/JP4929162B2/ja not_active Expired - Fee Related
- 2005-05-04 RU RU2006142705/04A patent/RU2382789C2/ru not_active IP Right Cessation
- 2005-05-04 US US11/568,380 patent/US7326703B2/en not_active Expired - Fee Related
- 2005-05-04 CA CA2563959A patent/CA2563959C/en not_active Expired - Fee Related
- 2005-05-04 BR BRPI0510612-5A patent/BRPI0510612A/pt not_active IP Right Cessation
- 2005-05-04 AT AT05740229T patent/ATE389660T1/de not_active IP Right Cessation
- 2005-05-04 MX MXPA06012755A patent/MXPA06012755A/es active IP Right Grant
- 2005-05-04 KR KR1020067022005A patent/KR20070015547A/ko not_active Withdrawn
- 2005-05-04 CN CN2005800140097A patent/CN1950380B/zh not_active Expired - Fee Related
- 2005-05-04 EP EP05740229A patent/EP1778696B1/de not_active Expired - Lifetime
- 2005-05-04 AP AP2006003759A patent/AP2006003759A0/xx unknown
2006
- 2006-09-14 IL IL178082A patent/IL178082A/en not_active IP Right Cessation
- 2006-11-03 ZA ZA200609178A patent/ZA200609178B/xx unknown
- 2006-12-04 NO NO20065582A patent/NO20065582L/no unknown

Also Published As

Publication number	Publication date
CN1950380A (zh)	2007-04-18
JP4929162B2 (ja)	2012-05-09
AP2006003759A0 (en)	2006-10-31
DE602005005490T2 (de)	2009-04-23
ES2303244T3 (es)	2008-08-01
EP1778696A2 (de)	2007-05-02
US20070248624A1 (en)	2007-10-25
RU2382789C2 (ru)	2010-02-27
JP2007536346A (ja)	2007-12-13
AU2005238235B2 (en)	2011-07-07
DE602005005490D1 (de)	2008-04-30
BRPI0510612A (pt)	2007-10-30
CN1950380B (zh)	2010-12-08
IL178082A0 (en)	2006-12-31
EP1778696B1 (de)	2008-03-19
CA2563959A1 (en)	2005-11-10
AU2005238235A1 (en)	2005-11-10
MXPA06012755A (es)	2007-01-16
IL178082A (en)	2012-06-28
KR20070015547A (ko)	2007-02-05
AR048650A1 (es)	2006-05-10
ZA200609178B (en)	2008-08-27
WO2005105810A2 (en)	2005-11-10
CA2563959C (en)	2014-07-15
PL1778696T3 (pl)	2008-08-29
RU2006142705A (ru)	2008-06-20
NO20065582L (no)	2006-12-04
WO2005105810A3 (en)	2006-03-02
US7326703B2 (en)	2008-02-05

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Legal Events

Date	Code	Title	Description
2008-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties