NO20065582L - (1,lOB-dihydro-2-(amtnokarbonyl-fenyl)-SH-pyrazolo[1,5-C][1,3]benzoksazin-5-yl)fenylmetanonderivater som HIV-virusreplikasjonsinhibitorer - Google Patents

(1,lOB-dihydro-2-(amtnokarbonyl-fenyl)-SH-pyrazolo[1,5-C][1,3]benzoksazin-5-yl)fenylmetanonderivater som HIV-virusreplikasjonsinhibitorer

Info

Publication number
NO20065582L
NO20065582L NO20065582A NO20065582A NO20065582L NO 20065582 L NO20065582 L NO 20065582L NO 20065582 A NO20065582 A NO 20065582A NO 20065582 A NO20065582 A NO 20065582A NO 20065582 L NO20065582 L NO 20065582L
Authority
NO
Norway
Prior art keywords
benzoxazin
pyrazolo
aminocarbonyl
dihydro
phenyl
Prior art date
Application number
NO20065582A
Other languages
English (en)
Inventor
Dominique Louis Nest Surleraux
Abdellah Tahri
Lieve Emma Jan Michiels
Koenraad Lodewijk August Acker
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of NO20065582L publication Critical patent/NO20065582L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Foreliggende oppfinnelse vedrører 5H-pyrazolo[l,5-c][l,3]benzoksazin-5-yl)fenylmetanonderivater som inhibitorer av vimsreplikasjonen av HIV-vimset, fremgangsmåter for deres fremstilling samt farmasøytiske sammensetninger, deres anvendelse som legemidler og diagnostiske kit omfattende dem. Foreliggende oppfinnelse vedrører også kombinasjoner av foreliggende oppfinnelse HTV-inhibitorer med andre antirefrovimsmidler. Den vedrører ytterligere deres anvendelse i assayer som referanseforbindelser eller som reagenser. Forbindelsene ifølge foreliggende oppfinnelse er nyttige for å forhindre eller behandle infeksjon med HTV og for å behandle AIDS.
NO20065582A 2004-05-04 2006-12-04 (1,lOB-dihydro-2-(amtnokarbonyl-fenyl)-SH-pyrazolo[1,5-C][1,3]benzoksazin-5-yl)fenylmetanonderivater som HIV-virusreplikasjonsinhibitorer NO20065582L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04101913 2004-05-04
US60427504P 2004-08-25 2004-08-25
PCT/EP2005/052041 WO2005105810A2 (en) 2004-05-04 2005-05-04 (1,10b-dihydro-2-(aminocarbonyl-phenyl)-5h-pyrazolo[1,5- c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as hiv viral replication inhibitors

Publications (1)

Publication Number Publication Date
NO20065582L true NO20065582L (no) 2006-12-04

Family

ID=35058129

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20065582A NO20065582L (no) 2004-05-04 2006-12-04 (1,lOB-dihydro-2-(amtnokarbonyl-fenyl)-SH-pyrazolo[1,5-C][1,3]benzoksazin-5-yl)fenylmetanonderivater som HIV-virusreplikasjonsinhibitorer

Country Status (20)

Country Link
US (1) US7326703B2 (no)
EP (1) EP1778696B1 (no)
JP (1) JP4929162B2 (no)
KR (1) KR20070015547A (no)
CN (1) CN1950380B (no)
AP (1) AP2006003759A0 (no)
AR (1) AR048650A1 (no)
AT (1) ATE389660T1 (no)
AU (1) AU2005238235B2 (no)
BR (1) BRPI0510612A (no)
CA (1) CA2563959C (no)
DE (1) DE602005005490T2 (no)
ES (1) ES2303244T3 (no)
IL (1) IL178082A (no)
MX (1) MXPA06012755A (no)
NO (1) NO20065582L (no)
PL (1) PL1778696T3 (no)
RU (1) RU2382789C2 (no)
WO (1) WO2005105810A2 (no)
ZA (1) ZA200609178B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7122185B2 (en) 2002-02-22 2006-10-17 Progenics Pharmaceuticals, Inc. Anti-CCR5 antibody
AR056652A1 (es) * 2005-04-11 2007-10-17 Tibotec Pharm Ltd Derivados de (1,10-b dihidro-2-(aminoalquil-fenil) -5h-pirazolo (1,5-c) (1,3)benzoxazin-5-il) fenilmetanona y su uso en la fabricacion de un medicamento
EP1910573B1 (en) * 2005-07-22 2013-09-04 CytoDyn, Inc. Methods for reducing viral load in hiv-1-infected patients
JP2010531301A (ja) * 2007-06-25 2010-09-24 テイボテク・フアーマシユーチカルズ ダルナビル及びエトラビリンを含んでなる組み合わせ調剤
US8592487B2 (en) * 2007-10-26 2013-11-26 Concert Pharmaceuticals, Inc. Deuterated darunavir
WO2009134401A2 (en) * 2008-04-29 2009-11-05 Progenics Pharmaceuticals, Inc. Methods of inhibiting infection by diverse subtypes of drug-resistant hiv-1

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
DE4210939A1 (de) * 1992-04-02 1993-10-07 Bayer Ag Verwendung von 7-Oxo-7H-pyrido[1,2,3-de][1,4]benzoxacin-6-carbonsäuren und -estern als Arzneimittel
IL106507A (en) * 1992-08-07 1997-11-20 Merck & Co Inc Pharmaceutical compositions containing benzoxazinones and some novel compounds of this type
PH30929A (en) 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
ES2166786T3 (es) 1993-10-01 2002-05-01 Astrazeneca Ab Procedimiento i.
US6509038B2 (en) 1996-05-20 2003-01-21 Janssen Pharmaceutica N.V. Antifungal compositions with improved bioavailability
DE69724630T2 (de) * 1996-10-02 2004-07-29 Bristol-Myers Squibb Pharma Co. 4,4-disubstituierte 1,4-dihydro-2h-3,1-benzoxazin-2-one die anwendbar sind als hiv-reverstranskriptase-inhibitoren, zwischenprodukte und verfahren zu ihrer herstellung
CZ295502B6 (cs) 1997-03-26 2005-08-17 Janssen Pharmaceutica N. V. Antifungální peleta, způsob její přípravy a farmaceutická dávková forma s obsahem těchto pelet
JP2002515433A (ja) * 1998-05-20 2002-05-28 イーライ・リリー・アンド・カンパニー 抗ウイルス化合物
SI1762567T1 (sl) * 2001-04-10 2012-08-31 Pfizer Derivati pirazola za zdravljenje HIV-a

Also Published As

Publication number Publication date
WO2005105810A2 (en) 2005-11-10
CN1950380A (zh) 2007-04-18
US20070248624A1 (en) 2007-10-25
MXPA06012755A (es) 2007-01-16
AU2005238235A1 (en) 2005-11-10
EP1778696B1 (en) 2008-03-19
RU2006142705A (ru) 2008-06-20
AR048650A1 (es) 2006-05-10
BRPI0510612A (pt) 2007-10-30
EP1778696A2 (en) 2007-05-02
WO2005105810A3 (en) 2006-03-02
JP4929162B2 (ja) 2012-05-09
PL1778696T3 (pl) 2008-08-29
CN1950380B (zh) 2010-12-08
IL178082A0 (en) 2006-12-31
JP2007536346A (ja) 2007-12-13
DE602005005490D1 (de) 2008-04-30
KR20070015547A (ko) 2007-02-05
ZA200609178B (en) 2008-08-27
ES2303244T3 (es) 2008-08-01
ATE389660T1 (de) 2008-04-15
US7326703B2 (en) 2008-02-05
AU2005238235B2 (en) 2011-07-07
DE602005005490T2 (de) 2009-04-23
CA2563959C (en) 2014-07-15
AP2006003759A0 (en) 2006-10-31
IL178082A (en) 2012-06-28
RU2382789C2 (ru) 2010-02-27
CA2563959A1 (en) 2005-11-10

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