ATE391711T1 - Arylpiperazinderivate und deren verwendung als für den dopamin-d3-rezeptor selektive liganden - Google Patents

Arylpiperazinderivate und deren verwendung als für den dopamin-d3-rezeptor selektive liganden

Info

Publication number: ATE391711T1
Authority: AT; Austria
Prior art keywords: nrr; alkylene; polyfluoro; alkyl; dopamine
Prior art date: 2004-12-01

Application number

AT05822892T

Other languages

English (en)

Inventor

Marc Capet

Denis Danvy

Catherine Dartois

Nicolas Levoin

Marcel Morvan

Isabelle Berrebi-Bertrand

Thierry Calmels

Philippe Robert

Jean-Charles Schwartz

Jeanne-Marie Lecomte

Original Assignee

Bioprojet Soc Civ

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-01

Filing date

2005-11-29

Publication date

2008-04-15

2005-11-29 Application filed by Bioprojet Soc Civ filed Critical Bioprojet Soc Civ

2008-04-15 Application granted granted Critical

2008-04-15 Publication of ATE391711T1 publication Critical patent/ATE391711T1/de

Links

102000004073 Dopamine D3 Receptors Human genes 0.000 title abstract 3
108090000525 Dopamine D3 Receptors Proteins 0.000 title abstract 3
239000003446 ligand Substances 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004414 alkyl thio group Chemical group 0.000 abstract 2
125000003709 fluoroalkyl group Chemical group 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
KOAGTIYEJARZPM-UHFFFAOYSA-N 1-(5-methoxy-1,3-dihydroisoindol-2-yl)-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]hexan-1-one Chemical compound C1C2=CC(OC)=CC=C2CN1C(=O)CCCCCN(CC1)CCN1C1=CC=CC(C(F)(F)F)=C1 KOAGTIYEJARZPM-UHFFFAOYSA-N 0.000 abstract 1
230000002075 anti-alcohol Effects 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
230000000648 anti-parkinson Effects 0.000 abstract 1
230000002738 anti-smoking effect Effects 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
239000000729 antidote Substances 0.000 abstract 1
239000000939 antiparkinson agent Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
210000005260 human cell Anatomy 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000003176 neuroleptic agent Substances 0.000 abstract 1
230000000701 neuroleptic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
General Health & Medical Sciences (AREA)
Addiction (AREA)
Psychiatry (AREA)
Psychology (AREA)
Gynecology & Obstetrics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT05822892T 2004-12-01 2005-11-29 Arylpiperazinderivate und deren verwendung als für den dopamin-d3-rezeptor selektive liganden ATE391711T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0412763A FR2878524B1 (fr)	2004-12-01	2004-12-01	Nouveaux derives d'arylpiperazine

Publications (1)

Publication Number	Publication Date
ATE391711T1 true ATE391711T1 (de)	2008-04-15

Family

ID=34951009

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05822892T ATE391711T1 (de)	2004-12-01	2005-11-29	Arylpiperazinderivate und deren verwendung als für den dopamin-d3-rezeptor selektive liganden

Country Status (12)

Country	Link
US (1)	US20080214542A1 (de)
EP (1)	EP1828125B1 (de)
AT (1)	ATE391711T1 (de)
DE (1)	DE602005006018T2 (de)
DK (1)	DK1828125T3 (de)
ES (1)	ES2302254T3 (de)
FR (1)	FR2878524B1 (de)
HR (1)	HRP20080187T3 (de)
PL (1)	PL1828125T3 (de)
PT (1)	PT1828125E (de)
SI (1)	SI1828125T1 (de)
WO (1)	WO2006058993A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2006072608A2 (en) *	2005-01-03	2006-07-13	Universitá Degli Studi Di Siena	Aryl piperazine derivatives for the treatment of neuropsychiatric disorders
EP1870405A1 (de) *	2006-06-22	2007-12-26	Bioprojet	Carbonylierte (Aza)cyclohexane als Dopamin D3 Rezeptorliganden
WO2009095438A1 (en) *	2008-02-01	2009-08-06	Neurosearch A/S	Novel aryl piperazine derivatives useful as modulators of dopamine and serotonin receptors
US20110085978A1 (en) *	2008-03-14	2011-04-14	Neurosearch A/S	Novel quinolinylamide derivatives useful as modulators of dopamine and serotonin receptors
CN102264733B (zh)	2008-10-10	2014-07-30	中国人民解放军军事医学科学院毒物药物研究所	新型多巴胺d3受体配体，其制备方法及其医药用途
US9227944B2 (en)	2008-10-10	2016-01-05	Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China	Dopamine D3 receptor ligands and preparation and medical uses of the same
WO2014079504A1 (en) *	2012-11-22	2014-05-30	Biofordrug S.R.L.	Polycyclic ligands of 5-ht7 receptor and use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0654023B1 (de) *	1992-08-06	1998-09-16	Smithkline Beecham Plc	5-(2-oxyphenyl)-pyrrol-derivate als dopamin-d3-rezeptor-antagonisten
US5523229A (en) *	1994-03-22	1996-06-04	Trustees Of The University Of Pennsylvania	Antibodies specific for oncofetal fibronectin
EP1464641B1 (de) *	1999-12-30	2008-05-14	H. Lundbeck A/S	4-Phenylpiperazinyl, -piperidinyl und -tetrahydropyridyl-Derivate als Dopamin D4-Antagonisten
MXPA04007920A (es) *	2002-02-13	2004-11-26	Glaxo Group Ltd	Derivados de bencensulfonamida como agentes antisicoticos.
US20040204422A1 (en) *	2003-04-14	2004-10-14	Abbott Gmbh & Co. Kg.	N-[(Piperazinyl)hetaryl]arylsulfonamide compounds

2004
- 2004-12-01 FR FR0412763A patent/FR2878524B1/fr not_active Expired - Fee Related
2005
- 2005-11-29 SI SI200530267T patent/SI1828125T1/sl unknown
- 2005-11-29 DK DK05822892T patent/DK1828125T3/da active
- 2005-11-29 PL PL05822892T patent/PL1828125T3/pl unknown
- 2005-11-29 EP EP05822892A patent/EP1828125B1/de not_active Expired - Lifetime
- 2005-11-29 HR HR20080187T patent/HRP20080187T3/xx unknown
- 2005-11-29 ES ES05822892T patent/ES2302254T3/es not_active Expired - Lifetime
- 2005-11-29 US US11/720,526 patent/US20080214542A1/en not_active Abandoned
- 2005-11-29 AT AT05822892T patent/ATE391711T1/de not_active IP Right Cessation
- 2005-11-29 DE DE602005006018T patent/DE602005006018T2/de not_active Expired - Fee Related
- 2005-11-29 WO PCT/FR2005/002964 patent/WO2006058993A1/fr not_active Ceased
- 2005-11-29 PT PT05822892T patent/PT1828125E/pt unknown

Also Published As

Publication number	Publication date
EP1828125B1 (de)	2008-04-09
EP1828125A1 (de)	2007-09-05
PT1828125E (pt)	2008-08-22
DE602005006018D1 (de)	2008-05-21
HRP20080187T3 (hr)	2008-05-31
DE602005006018T2 (de)	2008-07-10
FR2878524B1 (fr)	2007-01-19
US20080214542A1 (en)	2008-09-04
FR2878524A1 (fr)	2006-06-02
WO2006058993A1 (fr)	2006-06-08
PL1828125T3 (pl)	2008-09-30
DK1828125T3 (da)	2008-08-04
ES2302254T3 (es)	2008-07-01
SI1828125T1 (sl)	2008-08-31

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2008-10-15

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2010-08-15

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