ATE391792T1 - Carbonyl reduktase, gene und methoden zu deren expression, sowie verwendung derselben zur herstellung optisch aktiver alkohole - Google Patents

Carbonyl reduktase, gene und methoden zu deren expression, sowie verwendung derselben zur herstellung optisch aktiver alkohole

Info

Publication number: ATE391792T1
Authority: AT; Austria
Prior art keywords: present; optical purity; enzyme; high optical; dimethoxyphenylacetone
Prior art date: 2003-04-17

Application number

AT04009125T

Other languages

English (en)

Inventor

Norihiro Kimoto

Hiroaki Yamamoto

Takanori Nakajima

Original Assignee

Daicel Chem

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-17

Filing date

2004-04-16

Publication date

2008-04-15

2004-04-16 Application filed by Daicel Chem filed Critical Daicel Chem

2008-04-15 Application granted granted Critical

2008-04-15 Publication of ATE391792T1 publication Critical patent/ATE391792T1/de

Links

238000000034 method Methods 0.000 title abstract 3
108010031132 Alcohol Oxidoreductases Proteins 0.000 title abstract 2
102000005751 Alcohol Oxidoreductases Human genes 0.000 title abstract 2
150000001298 alcohols Chemical class 0.000 title abstract 2
108090000623 proteins and genes Proteins 0.000 title 1
UMYZWICEDUEWIM-UHFFFAOYSA-N 1-(3,4-dimethoxyphenyl)propan-2-one Chemical compound COC1=CC=C(CC(C)=O)C=C1OC UMYZWICEDUEWIM-UHFFFAOYSA-N 0.000 abstract 4
108090000790 Enzymes Proteins 0.000 abstract 4
102000004190 Enzymes Human genes 0.000 abstract 4
230000003287 optical effect Effects 0.000 abstract 4
KWJDGWGMDAQESJ-QMMMGPOBSA-N (2s)-1-(3,4-dimethoxyphenyl)propan-2-ol Chemical compound COC1=CC=C(C[C@H](C)O)C=C1OC KWJDGWGMDAQESJ-QMMMGPOBSA-N 0.000 abstract 3
241000894006 Bacteria Species 0.000 abstract 1
ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 abstract 1
108090000854 Oxidoreductases Proteins 0.000 abstract 1
102000004316 Oxidoreductases Human genes 0.000 abstract 1
108091007187 Reductases Proteins 0.000 abstract 1
235000018370 Saccharomyces delbrueckii Nutrition 0.000 abstract 1
244000288561 Torulaspora delbrueckii Species 0.000 abstract 1
235000014681 Torulaspora delbrueckii Nutrition 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
239000005515 coenzyme Substances 0.000 abstract 1
229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 abstract 1
238000006722 reduction reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT04009125T 2003-04-17 2004-04-16 Carbonyl reduktase, gene und methoden zu deren expression, sowie verwendung derselben zur herstellung optisch aktiver alkohole ATE391792T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2003113402		2003-04-17
JP2003163015A JP4213524B2 (ja)	2003-04-17	2003-06-06	新規なカルボニル還元酵素、その酵素をコードするｄｎａを含むポリヌクレオチド、その製造方法、およびこれを利用した光学活性アルコールの製造方法

Publications (1)

Publication Number	Publication Date
ATE391792T1 true ATE391792T1 (de)	2008-04-15

Family

ID=32911489

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04009125T ATE391792T1 (de)	2003-04-17	2004-04-16	Carbonyl reduktase, gene und methoden zu deren expression, sowie verwendung derselben zur herstellung optisch aktiver alkohole

Country Status (5)

Country	Link
US (1)	US7083962B2 (de)
EP (1)	EP1469079B8 (de)
JP (1)	JP4213524B2 (de)
AT (1)	ATE391792T1 (de)
DE (1)	DE602004012918T8 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20080233621A1 (en) *	2004-02-04	2008-09-25	Api Corporation	Method For Producing Alcohol and Carboxylic Acid Having Optical Activity
JP2007274901A (ja) *	2004-05-12	2007-10-25	Taisho Pharmaceut Co Ltd	光学活性プロパルギルアルコールの製造方法
DE102005038606A1 (de) *	2005-08-16	2007-03-01	Consortium für elektrochemische Industrie GmbH	Verfahren zur enzymatischen Herstellung von chiralen 1-acylierten 1,2-Diolen
DE102005063191A1 (de) *	2005-12-30	2007-07-05	Basf Ag	Verfahren zur enzymatischen Herstellung von Citronellal
CN101528917B (zh)	2006-10-02	2015-07-29	科德克希思公司	用于制备立体异构纯的他汀类及其合成中间体的组合物和方法
KR101502634B1 (ko)	2007-02-08	2015-03-16	코덱시스, 인코포레이티드	케토 환원 효소 및 이의 용도
EP2195443B1 (de)	2007-08-24	2015-01-07	Codexis, Inc.	Verbesserte ketoreduktase-polypeptide zur stereoselektiven produktion von (r)-3-hydroxythiolan
CN101855342B (zh)	2007-09-13	2013-07-10	科德克希思公司	用于还原苯乙酮的酮还原酶多肽
CN101889081B (zh) *	2007-09-28	2014-06-18	科德克希思公司	酮还原酶多肽及其用途
JP5646328B2 (ja)	2007-10-01	2014-12-24	コデクシス，インコーポレイテッド	アゼチジノンの生産のためのケトレダクターゼポリペプチド
ES2560459T3 (es)	2008-08-27	2016-02-19	Codexis, Inc.	Polipéptidos cetorreductasa para la producción de una 3-aril-3-hidroxipropanamina a partir de una 3-aril-3-cetopropanamina
WO2010025287A2 (en) *	2008-08-27	2010-03-04	Codexis, Inc.	Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
SG10201404330VA (en)	2008-08-29	2014-10-30	Codexis Inc	Ketoreductase Polypeptides For The Stereoselective Production Of (4S)-3[(5S)-5(4-Fluorophenyl)-5-Hydroxypentanoyl]-4-Phenyl-1,3-Oxazolidin-2-One
BRPI0924997B1 (pt) *	2009-06-22	2024-01-16	Sk Biopharmaceuticals Co., Ltd	Método para preparar um composto de éster do ácido 1-aril-2- tetrazoil etil carbâmico
WO2011022548A2 (en)	2009-08-19	2011-02-24	Codexis, Inc.	Ketoreductase polypeptides for the preparation of phenylephrine
US8404461B2 (en)	2009-10-15	2013-03-26	SK Biopharmaceutical Co. Ltd.	Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
EP2566497B1 (de)	2010-05-04	2015-07-29	Codexis, Inc.	Biokatalysatoren zur ezetimib-synthese
WO2015009558A1 (en)	2013-07-16	2015-01-22	International Flavors & Fragrances Inc.	Compositions and methods for the biosynthesis of vanillin or vanillin beta-d-glucoside
CN115725524B (zh) *	2018-05-31	2024-12-31	中国科学院天津工业生物技术研究所	羰基还原酶突变体及其在环戊二酮类化合物还原中的应用
CN113025506B (zh) *	2019-12-24	2022-12-09	中国科学院天津工业生物技术研究所	一种生产乙醇的重组丝状真菌及其构建和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3593362B2 (ja)	1993-06-04	2004-11-24	ダイセル化学工業株式会社	光学活性１−フェニル−２−置換プロパン誘導体およびその製造法
US5508461A (en)	1993-06-04	1996-04-16	Daicel Chemical Industries, Ltd.	Optically active 1-phenyl-2-substituted propane derivatives and methods of producing the same
JP3696638B2 (ja)	1993-11-18	2005-09-21	ダイセル化学工業株式会社	光学活性２−アミノ−１−フェニルエタノール誘導体の製造方法
US5629200A (en)	1993-11-18	1997-05-13	Daicel Chemical Industries, Ltd.	Production of optically active 2-amino-1-phenylethanol derivatives by asymetrical assimilation
JP3587569B2 (ja)	1994-09-30	2004-11-10	株式会社カネカ	光学活性な１−（３，４−ジメトキシフェニル）−２−プロパノールの製造法
AU1302999A (en)	1997-11-04	1999-05-24	Eli Lilly And Company	Ketoreductase gene and protein from yeast
US6531308B2 (en)	1997-11-04	2003-03-11	Eli Lilly And Company	Ketoreductase gene and protein from yeast
JP4154182B2 (ja)	2002-07-16	2008-09-24	ダイセル化学工業株式会社	α−ケト酸還元酵素、その製造方法、およびこれを利用した光学活性α−ヒドロキシ酸の製造方法

2003
- 2003-06-06 JP JP2003163015A patent/JP4213524B2/ja not_active Expired - Fee Related
2004
- 2004-04-15 US US10/826,081 patent/US7083962B2/en not_active Expired - Fee Related
- 2004-04-16 DE DE602004012918T patent/DE602004012918T8/de active Active
- 2004-04-16 EP EP04009125A patent/EP1469079B8/de not_active Expired - Lifetime
- 2004-04-16 AT AT04009125T patent/ATE391792T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP1469079B1 (de)	2008-04-09
DE602004012918T2 (de)	2008-07-10
US7083962B2 (en)	2006-08-01
EP1469079A1 (de)	2004-10-20
DE602004012918T8 (de)	2009-08-06
DE602004012918D1 (de)	2008-05-21
JP4213524B2 (ja)	2009-01-21
US20050148057A1 (en)	2005-07-07
JP2005000002A (ja)	2005-01-06
EP1469079B8 (de)	2008-10-29

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Legal Events

Date	Code	Title	Description
2008-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties