ATE493490T1 - Verfahren zur biologischen herstellung von 1,3- propandiol mit hoher ausbeute - Google Patents

Verfahren zur biologischen herstellung von 1,3- propandiol mit hoher ausbeute

Info

Publication number
ATE493490T1
ATE493490T1 AT03777548T AT03777548T ATE493490T1 AT E493490 T1 ATE493490 T1 AT E493490T1 AT 03777548 T AT03777548 T AT 03777548T AT 03777548 T AT03777548 T AT 03777548T AT E493490 T1 ATE493490 T1 AT E493490T1
Authority
AT
Austria
Prior art keywords
propanediol
high yield
biologically producing
produce
microorganism
Prior art date
Application number
AT03777548T
Other languages
English (en)
Inventor
Marguerite Cervin
Phillipe Soucaille
Fernando Valle
Original Assignee
Du Pont
Genencor Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont, Genencor Int filed Critical Du Pont
Application granted granted Critical
Publication of ATE493490T1 publication Critical patent/ATE493490T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C12P7/20—Glycerol

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT03777548T 2002-10-04 2003-10-06 Verfahren zur biologischen herstellung von 1,3- propandiol mit hoher ausbeute ATE493490T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41619202P 2002-10-04 2002-10-04
PCT/US2003/031805 WO2004033646A2 (en) 2002-10-04 2003-10-06 Process for the biological production of 1,3-propanediol with high yield

Publications (1)

Publication Number Publication Date
ATE493490T1 true ATE493490T1 (de) 2011-01-15

Family

ID=32093824

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03777548T ATE493490T1 (de) 2002-10-04 2003-10-06 Verfahren zur biologischen herstellung von 1,3- propandiol mit hoher ausbeute

Country Status (13)

Country Link
US (2) US7371558B2 (de)
EP (1) EP1576123B1 (de)
JP (1) JP4592418B2 (de)
KR (1) KR101148255B1 (de)
CN (1) CN100471946C (de)
AT (1) ATE493490T1 (de)
AU (1) AU2003287028B2 (de)
BR (2) BR0314498A (de)
CA (1) CA2501574C (de)
DE (1) DE60335574D1 (de)
ES (1) ES2356526T3 (de)
MX (1) MXPA05003382A (de)
WO (1) WO2004033646A2 (de)

Families Citing this family (180)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003205041A1 (en) * 2002-07-12 2004-01-29 Ajinomoto Co., Inc. Method for producing target substance by fermentation
US20050079617A1 (en) * 2003-10-03 2005-04-14 Cervin Marguerite A. Glucose transport mutants for production of biomaterial
EP2428573A3 (de) * 2002-10-04 2012-06-27 Genecor International, Inc. Verbesserte Herstellung von Bakterienstämmen sowie Querverweis auf verwandte Anmeldungen
US7524660B2 (en) * 2005-05-05 2009-04-28 E.I. Du Pont De Nemours And Company Utilization of fructose in microbial production strains
JP2007082476A (ja) * 2005-09-22 2007-04-05 Nippon Shokubai Co Ltd グリセリンから３−ヒドロキシプロピオン酸を製造する方法
US9297028B2 (en) 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
US20080274526A1 (en) 2007-05-02 2008-11-06 Bramucci Michael G Method for the production of isobutanol
EP3301182B1 (de) 2005-10-26 2020-03-18 Butamax (TM) Advanced Biofuels LLC Fermentative Herstellung von Alkoholen mit vier Kohlenstoffatomen
US8962298B2 (en) 2006-05-02 2015-02-24 Butamax Advanced Biofuels Llc Recombinant host cell comprising a diol dehydratase
JP5130811B2 (ja) * 2006-07-19 2013-01-30 東レ株式会社 連続発酵による１，３−プロパンジオールの製造方法
BRPI0622099A2 (pt) * 2006-10-31 2011-12-27 Metabolic Explorer Sa processo para a produÇço biolàgica de 1,3-propanodiol a partir de glicerol com alto rendimento
WO2008052596A1 (en) * 2006-10-31 2008-05-08 Metabolic Explorer Process for the biological production of n-butanol with high yield
CA2675026A1 (en) * 2007-01-12 2008-07-24 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms
WO2008091627A2 (en) * 2007-01-22 2008-07-31 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
CA2688450C (en) * 2007-03-23 2016-10-25 Metabolic Explorer Microorganisms and methods for production of 1,2-propanediol and acetol
TW200904984A (en) 2007-03-23 2009-02-01 Metabolic Explorer Sa New micro-organisms for the production of 1,2-propanediol obtained by a combination of evolution and rational design
WO2008116851A1 (en) * 2007-03-23 2008-10-02 Metabolic Explorer Metabolically engineered microorganism useful for the production of acetol
JP2010521190A (ja) * 2007-03-23 2010-06-24 メタボリック エクスプローラー １，２−プロパンジオールの製造に有用な、代謝的に操作された微生物
CN101130782B (zh) * 2007-07-23 2011-01-26 江南大学 以葡萄糖为底物产1,3-丙二醇重组酿酒酵母的构建方法
WO2009045637A2 (en) * 2007-08-10 2009-04-09 Genomatica, Inc. Methods for the synthesis of acrylic acid and derivatives from fumaric acid
US8048624B1 (en) 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
DK2235190T3 (en) 2007-12-13 2018-07-23 Danisco Us Inc COMPOSITIONS AND PROCEDURES FOR PRODUCING ISOPRENE
CN107090424A (zh) 2008-01-22 2017-08-25 基因组股份公司 利用合成气或其它气态碳源和甲醇的方法和有机体
AR072446A1 (es) * 2008-03-02 2010-09-01 Dow Global Technologies Inc Proceso de hidrogenacion mejorado
EP3450550A1 (de) 2008-03-05 2019-03-06 Genomatica, Inc. Primäre, alkohole produzierende organismen
PL2265709T3 (pl) * 2008-03-27 2018-05-30 Genomatica, Inc. Mikroorganizmy do produkcji kwasu adypinowego i innych związków
JP2011518564A (ja) 2008-04-23 2011-06-30 ダニスコ・ユーエス・インク 改良された微生物によるイソプレン産出用のイソプレンシンターゼ変異体
WO2009135074A2 (en) 2008-05-01 2009-11-05 Genomatica, Inc. Microorganisms for the production of methacrylic acid
WO2009155382A1 (en) * 2008-06-17 2009-12-23 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
CA2729302A1 (en) 2008-06-30 2010-01-14 The Goodyear Tire & Rubber Company Polymers of isoprene from renewable resources
SG167566A1 (en) 2008-07-02 2011-01-28 Danisco Us Inc Compositions and methods for producing isoprene free of C5 hydrocarbons under decoupling conditions and/or safe operating ranges
US9340768B2 (en) 2008-07-16 2016-05-17 The Texas A&M University System Transformation of glycerol and cellulosic materials into high energy fuels
BRPI0918882A2 (pt) * 2008-07-23 2019-02-26 Opx Biotechnologies Inc métodos, sistemas e composições para tolerância aumentada de microorganismo para produção de ácido 3-hidroxipropiônico (3-hp)
US20100021978A1 (en) * 2008-07-23 2010-01-28 Genomatica, Inc. Methods and organisms for production of 3-hydroxypropionic acid
WO2010031079A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Systems using cell culture for production of isoprene
MY169163A (en) 2008-09-15 2019-02-19 Danisco Us Inc Increased isoprene production using the archaeal lower mevalonate pathway
WO2010031068A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Reduction of carbon dioxide emission during isoprene production by fermentation
US8476049B2 (en) 2008-09-15 2013-07-02 Danisco Us Inc. Conversion of prenyl derivatives to isoprene
WO2010031083A2 (en) * 2008-09-15 2010-03-18 Opx Biotechnologies, Inc. Methods, systems and compositions related to reduction of conversions of microbially produced 3-hydroxypropionic acid (3-hp) to aldehyde metabolites
GB0820631D0 (en) * 2008-11-11 2008-12-17 London School Hygiene & Tropical Medicine Vectors
US20100184173A1 (en) * 2008-11-14 2010-07-22 Genomatica, Inc. Microorganisms for the production of methyl ethyl ketone and 2-butanol
CN102395671B (zh) * 2008-12-03 2014-06-25 韩国生命工学研究院 用于制造1，3-丙二醇的丙三醇氧化途径中阻隔的突变体
CA2746952A1 (en) * 2008-12-16 2010-06-24 Genomatica, Inc. Microorganisms and methods for conversion of syngas and other carbon sources to useful products
EP2382312A2 (de) * 2008-12-30 2011-11-02 Danisco US Inc. Verfahren zur herstellung von isopren und einem beiprodukt
EP2379730B1 (de) * 2008-12-31 2015-07-22 Metabolic Explorer Verfahren zur herstellung von diolen
CN102686735A (zh) 2009-03-05 2012-09-19 佛罗里达大学研究基金会有限公司 产乙醇细菌及它们在乙醇生产中的应用
CN102388141A (zh) * 2009-03-12 2012-03-21 韩国生命工学研究院 使用丙三醇氧化途径被阻断的重组菌株生产1,3-丙二醇的方法
EP2233562A1 (de) * 2009-03-24 2010-09-29 Metabolic Explorer Verfahren zur Herstellung großer Mengen Glycolsäure durch Fermentation
US8518686B2 (en) 2009-04-23 2013-08-27 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
BRPI1013505A2 (pt) 2009-04-30 2018-02-14 Genomatica Inc organismos para a produção de isopropanol, n-butanol, e isobutanol
EP3865569B1 (de) * 2009-04-30 2023-10-04 Genomatica, Inc. Organismen zur herstellung von 1,3-butandiol
WO2010129936A1 (en) 2009-05-07 2010-11-11 Genomatica, Inc. Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid
KR20120036851A (ko) * 2009-05-15 2012-04-18 게노마티카 인코포레이티드 사이클로헥사논의 제조를 위한 유기체
WO2010144746A2 (en) * 2009-06-10 2010-12-16 Genomatica, Inc. Microorganisms and methods for carbon-efficient biosynthesis of mek and 2-butanol
US20110144377A1 (en) * 2009-06-16 2011-06-16 E. I. Du Pont Nemours And Company Process for the biological production of 3-hydroxypropionic acid with high yield
TW201412988A (zh) 2009-06-17 2014-04-01 Danisco Us Inc 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造
TWI434921B (zh) 2009-06-17 2014-04-21 Danisco Us Inc 從生物異戊二烯組合物製造燃料成分之方法及系統
WO2011012697A2 (en) 2009-07-30 2011-02-03 Metabolic Explorer Mutant yqhd enzyme for the production of a biochemical by fermentation
DK2462221T3 (en) 2009-08-05 2017-05-22 Genomatica Inc SEMISYNTHETIC TEREPHTHALIC ACID BY MICRO-ORGANISMS PRODUCING MUCONIC ACID
US8715971B2 (en) 2009-09-09 2014-05-06 Genomatica, Inc. Microorganisms and methods for the co-production of isopropanol and 1,4-butanediol
JP5932648B2 (ja) 2009-09-23 2016-06-15 ダニスコ・ユーエス・インク 新規なグリコシルヒドロラーゼ酵素及びその用途
CA2775390C (en) 2009-09-27 2021-06-29 Opx Biotechnologies, Inc. Method for producing 3-hydroxypropionic acid and other products
US8809027B1 (en) 2009-09-27 2014-08-19 Opx Biotechnologies, Inc. Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase
AU2010306785B2 (en) 2009-10-13 2016-01-14 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA, putrescine and related compounds, and methods related thereto
US8852903B2 (en) 2009-10-23 2014-10-07 E I Du Pont De Nemours And Company Co-metabolism of fructose and glucose in microbial production strains
US20110097767A1 (en) * 2009-10-23 2011-04-28 Priti Pharkya Microorganisms for the production of aniline
CN102933715B (zh) * 2009-10-29 2015-04-29 韩国生命工学研究院 从甘油生产3-羟基丙酸的方法
EP2501797A4 (de) 2009-11-18 2013-04-17 Myriant Corp Technisierung von mikroben zur wirksamen herstellung von chemikalien
AU2010349739B2 (en) 2009-11-18 2014-10-16 Ptt Global Chemical Public Company Limited Metabolic evolution of Escherchia coli strains that produce organic acids
US10017793B2 (en) 2009-11-18 2018-07-10 Myriant Corporation Metabolic evolution of Escherichia coli strains that produce organic acids
CA2781400A1 (en) * 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Production of an organic acid and/or related chemicals
US20110136190A1 (en) 2009-12-04 2011-06-09 E. I. Du Pont De Nemours And Company Recombinant bacteria for producing glycerol and glycerol-derived products from sucrose
CN102753698A (zh) * 2009-12-10 2012-10-24 基因组股份公司 合成气或其他气态碳源和甲醇转化为1,3-丁二醇的方法和有机体
CA2783976A1 (en) 2009-12-18 2011-06-23 Danisco Us Inc. Purification of isoprene from renewable resources
WO2011075748A1 (en) 2009-12-22 2011-06-23 Danisco Us Inc. Membrane bioreactor for increased production of isoprene gas
PH12012500999A1 (en) 2009-12-23 2013-02-11 Danisco Us Inc Methods for improving the efficiency of simultaneous saccharification and fermentation reactions
SG181856A1 (en) 2009-12-23 2012-07-30 Danisco Us Inc Compositions and methods for the increased production of isoprene and other products with 6 - phosphogluconolactonase (pgl)
CN102834508A (zh) * 2010-01-29 2012-12-19 基因组股份公司 用于生物合成对甲苯甲酸和对苯二甲酸的微生物和方法
US8048661B2 (en) * 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US8637286B2 (en) 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
KR20190006103A (ko) 2010-05-05 2019-01-16 게노마티카 인코포레이티드 부타디엔을 생합성하기 위한 미생물 및 방법
KR101220499B1 (ko) * 2010-05-25 2013-01-10 한국생명공학연구원 글리세롤로부터 3-하이드록시프로피온산을 고수율로 제조하는 방법
EP2582649A1 (de) 2010-06-17 2013-04-24 Danisco US Inc. Brennstoffzusammensetzungen mit isoprenderivaten
TWI500768B (zh) * 2010-07-05 2015-09-21 Metabolic Explorer Sa 由蔗糖製備１，３－丙二醇之方法
WO2012018624A2 (en) 2010-07-26 2012-02-09 Genomatica, Inc. Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene
WO2012019169A1 (en) 2010-08-06 2012-02-09 Danisco Us Inc. Production of isoprene under neutral ph conditions
KR101247881B1 (ko) * 2010-08-27 2013-03-26 주식회사 씨티씨바이오 비타민 ｂ―１２ 생성능을 갖는 재조합 미생물 및 상기 재조합 미생물을 이용한 ３―하이드록시프로피온산의 제조방법
CN103443271A (zh) 2010-10-27 2013-12-11 丹尼斯科美国公司 用于增加异戊二烯产量的异戊二烯合酶变体
US8129170B1 (en) 2010-12-06 2012-03-06 E.I. Du Pont De Nemours And Company Recombinant bacteria having the ability to metabolize sucrose
EP2655597A1 (de) 2010-12-22 2013-10-30 Danisco US Inc. Biologische herstellung von pentosezuckern unter verwendung rekombinanter zellen
JP2014504497A (ja) 2010-12-22 2014-02-24 ダニスコ・ユーエス・インク ２種類のｉｓｐｇ酵素を用いてイソプレン生産を向上させる組成物及び方法
MX2013010512A (es) 2011-03-17 2013-10-07 Danisco Inc Metodo para reducir la viscosidad en un proceso de sacarificacion.
RU2013146341A (ru) 2011-03-17 2015-04-27 ДАНИСКО ЮЭс ИНК Композиции целлюлазы и способы их применения для улучшенного превращения лигноцеллюлозной биомассы в ферментируемые сахара
JP2014519811A (ja) 2011-04-29 2014-08-21 ダニスコ・ユーエス・インク チオラーゼ、ＨＭＧ−ＣｏＡ合成酵素及びＨＭＧ−ＣｏＡ還元酵素活性を有するポリペプチドをコードしている遺伝子を使用するメバロン酸、イソプレン、及びイソプレノイドの生産
EP2702140B1 (de) 2011-04-29 2018-10-31 Danisco US Inc. Rekombinante mikroorganismen zur erhöhten produktion von mevalonat, isopren und isoprenoiden
EP2540834A1 (de) 2011-06-29 2013-01-02 Metabolic Explorer Verfahren zur Herstellung von 1,3-Propandiol
JP2013013353A (ja) * 2011-07-01 2013-01-24 Daicel Corp １，３−プロパンジオールの製造方法
RS54444B1 (sr) 2011-07-12 2016-06-30 Scientist Of Fortune S.A. Rekombinantni mikroorganizmi za proizvodnju korisnih metabolita
US20130034658A1 (en) * 2011-08-01 2013-02-07 E. I. Du Pont De Nemours And Company Poly-trimethylene terephthalate solid core fibrillation-resistant filament having a substantially triangular cross section, a spinneret for producing the filament, and a carpet made therefrom
BR112014002661A2 (pt) 2011-08-04 2019-09-24 Danisco Us Inc produção de isopreno, precursores de isoprenoide, e isoprenoides com o uso de acetoacetil-coa sintase
EP2739742A1 (de) 2011-08-05 2014-06-11 Danisco US Inc. Herstellung von isoprenoiden unter neutralen ph-bedingungen
JP2013070675A (ja) * 2011-09-28 2013-04-22 Daicel Corp アルキルジオールを産生する組換え菌の培養方法
BR112014008278A2 (pt) 2011-10-07 2017-04-18 Danisco Us Inc utilização de fosfocetolase na produção de mevalonato, precursores isoprenoides e isopreno
WO2013063528A2 (en) 2011-10-27 2013-05-02 Danisco Us Inc. Isoprene synthase variants with improved solubility for production of isoprene
WO2013096917A1 (en) 2011-12-23 2013-06-27 Danisco Us Inc. Production of isoprene under reduced oxygen inlet levels
EP2794863A1 (de) 2011-12-23 2014-10-29 Danisco US Inc. Erhöhte produktion von isopren anhand von wirtszellen mit verminderter ispa-aktivität
US20130316416A1 (en) 2012-02-23 2013-11-28 Massachusetts Institute Of Technology Engineering microbes and metabolic pathways for the production of ethylene glycol
US9017961B2 (en) 2012-03-05 2015-04-28 E.I. Du Pont De Nemours And Company Recombinant bacteria comprising novel sucrose transporters
US8686114B2 (en) 2012-03-05 2014-04-01 E I Du Pont De Nemours And Company Variant sucrose transporter polypeptides
US9315831B2 (en) 2012-03-30 2016-04-19 Danisco Us Inc. Direct starch to fermentable sugar as feedstock for the production of isoprene, isoprenoid precursor molecules, and/or isoprenoids
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
US8895277B2 (en) 2012-05-02 2014-11-25 Danisco Us Inc. Legume isoprene synthase for production of isoprene
CN104736695B (zh) 2012-07-20 2017-05-24 普瑞特克微生物有限责任公司 非致病性f18大肠杆菌菌株及其用途
CN109182238A (zh) 2012-08-10 2019-01-11 嘉吉有限公司 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法
EP2708598A1 (de) * 2012-09-14 2014-03-19 Basf Se Serinolherstellung in glycerolkatabolismusdefizienten Escherichia Coli-Strängen
EP2914717A1 (de) 2012-10-31 2015-09-09 Danisco US Inc. Beta-glucosidase aus magnaporthe grisea
CA2888757A1 (en) 2012-10-31 2014-05-08 Danisco Us Inc. Compositions and methods of use
MX2015005424A (es) 2012-10-31 2015-08-05 Danisco Inc Beta-glucosidasa de neurospora crassa.
DK2929022T3 (en) 2012-12-07 2017-02-13 Danisco Us Inc COMPOSITIONS AND METHODS OF USE
BR112015012968A2 (pt) 2012-12-07 2017-09-12 Danisco Us Inc composições e métodos de uso
EP2935364A2 (de) 2012-12-21 2015-10-28 Danisco US Inc. Herstellung von isopren, isoprenoid und isoprenoidvorläufern mittels eines alternativen unteren mevalonatpfades
CN103146740B (zh) * 2013-03-06 2014-08-20 中国科学院南海海洋研究所 一株生产1,3-丙二醇的工程菌及其构建方法
WO2014146026A1 (en) 2013-03-15 2014-09-18 Opx Biotechnologies, Inc. Bioproduction of chemicals
WO2014145096A1 (en) 2013-03-15 2014-09-18 Cindy Hoppe Flash evaporation for production purification and recovery
EP3425049A1 (de) 2013-04-10 2019-01-09 Danisco US Inc. Phosphoketolasen zur verbesserten herstellung von aus dem acetylcoenzym a-abgeleiteten metaboliten, isopren, isoprenoidvorläufern und isoprenoiden
US9926568B2 (en) 2013-06-21 2018-03-27 Danisco Us Inc. Compositions and methods for clostridial transformation
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
JP6603658B2 (ja) 2013-07-19 2019-11-06 カーギル インコーポレイテッド 脂肪酸及び脂肪酸誘導体の製造のための微生物及び方法
WO2015034948A1 (en) 2013-09-03 2015-03-12 Myriant Corporation A process for manufacturing acrylic acid, acrylonitrile and 1,4-butanediol from 1,3-propanediol
CN105829530A (zh) 2013-12-04 2016-08-03 丹尼斯科美国公司 包含β-葡萄糖苷酶多肽的组合物及其使用方法
CN103642765B (zh) * 2013-12-25 2015-11-18 南京工业大学 醇脱氢酶突变体及其应用
JP6744819B2 (ja) 2014-02-20 2020-08-19 ダニスコ・ユーエス・インク メバロン酸、イソプレン、イソプレノイド前駆体、イソプレノイド、およびアセチルＣｏＡ由来産物の生産向上のための組換え微生物
KR20150110144A (ko) 2014-03-24 2015-10-02 삼성전자주식회사 글리세롤, 3-hp, 또는 아크릴산 생산능을 갖는 재조합 미생물 및 그를 이용하여 글리세롤, 3-hp, 또는 아크릴산을 생산하는 방법
EP2993228B1 (de) 2014-09-02 2019-10-09 Cargill, Incorporated Herstellung von fettsäureestern
EP3201330A1 (de) 2014-09-30 2017-08-09 Danisco US Inc. Zusammensetzungen mit beta-mannanase und verfahren zur verwendung
EP3201334A1 (de) 2014-09-30 2017-08-09 Danisco US Inc. Zusammensetzungen mit beta-mannanase und verfahren zur verwendung
WO2016054185A1 (en) 2014-09-30 2016-04-07 Danisco Us Inc Compositions comprising beta-mannanase and methods of use
EP3201332A1 (de) 2014-09-30 2017-08-09 Danisco US Inc. Zusammensetzungen mit beta-mannanase und verfahren zur verwendung
WO2016054168A1 (en) 2014-09-30 2016-04-07 Danisco Us Inc Compositions comprising beta mannanase and methods of use
BR112017008595A2 (pt) 2014-10-27 2017-12-19 Danisco Us Inc composições e métodos referentes à beta-glucosidase
CN105734002B (zh) * 2014-12-10 2019-06-25 中粮集团有限公司 一种重组谷氨酸生产菌株及其制备方法与应用
EP3050970B1 (de) 2015-01-28 2019-09-18 Metabolic Explorer Modifizierter Mikroorganismus zur optimierten Herstellung von 1,4-Butandiol
KR101748930B1 (ko) * 2015-02-09 2017-06-20 지에스칼텍스 주식회사 다이올 생산용 재조합 미생물
AU2017291975B2 (en) * 2016-07-08 2021-06-03 Metabolic Explorer Method for the fermentative production of molecules of interest by microorganisms comprising genes coding sugar phosphotransferase system (PPS)
CN106399217B (zh) * 2016-12-06 2019-10-18 江南大学 一种敲除arcA提高克雷伯氏菌1,3-丙二醇产量的方法
WO2018144701A2 (en) 2017-02-02 2018-08-09 Cargill Incorporated Genetically modified cells that produce c6-c10 fatty acid derivatives
EP3577220A2 (de) 2017-02-06 2019-12-11 Zymergen, Inc. Manipulierte biosynthesewege zur herstellung von tyramin durch fermentation
SG11201910019PA (en) 2017-04-27 2019-11-28 Univ California Microorganisms and methods for producing cannabinoids and cannabinoid derivatives
WO2019036140A1 (en) 2017-07-17 2019-02-21 Zymergen Inc. METALLO-ORGANIC STRESS MATERIALS
CN111479853A (zh) 2017-10-05 2020-07-31 齐默尔根公司 光学透明的聚酰亚胺
KR20200095534A (ko) 2017-12-07 2020-08-10 지머젠 인코포레이티드 발효에 의한 (6e)-8-히드록시제라니올의 제조를 위해 조작된 생합성 경로
WO2019126778A1 (en) 2017-12-21 2019-06-27 Zymergen Inc. Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone
KR102053330B1 (ko) 2018-04-23 2019-12-06 한국과학기술연구원 글리세롤을 포함하는 미생물 발효용 조성물 및 이를 이용한 부티르산의 생산방법
CN110656075B (zh) * 2018-06-28 2022-11-11 中国科学院青岛生物能源与过程研究所 一种合成乙酰辅酶a衍生产品的通用性底盘细胞及其构建方法与应用
IL280749B2 (en) * 2018-08-10 2025-08-01 Metabolic Explorer Sa Microorganisms with improved 1,3-propanediol and butyric acid production
WO2020069142A1 (en) 2018-09-26 2020-04-02 Demetrix, Inc. Optimized expression systems for expressing berberine bridge enzyme and berberine bridge enzyme-like polypeptides
CN109321610B (zh) * 2018-11-01 2022-11-04 上海交通大学 微生物发酵法高效制备2-氨基-1,3-丙二醇
CN109609426B (zh) * 2019-01-04 2022-02-15 花安堂生物科技集团有限公司 一种以甲醇/甲醛和葡萄糖为共底物生产1,3-丙二醇的方法
US12152062B2 (en) * 2019-02-24 2024-11-26 Oncosimis Biotech Privated Limited Method for continuous production of recombinant GLP-1 peptide by bacteria
CA3140079A1 (en) 2019-05-22 2020-11-26 Demetrix, Inc. Optimized cannabinoid synthase polypeptides
KR102802031B1 (ko) * 2019-09-04 2025-04-29 주식회사 엘지화학 Crispr 시스템을 이용한 포도당으로부터 글리세롤로의 전환률 향상 방법
CN115038786A (zh) 2019-09-18 2022-09-09 德美崔克斯公司 优化的四氢大麻酚酸(thca)合酶多肽
WO2021183448A1 (en) 2020-03-09 2021-09-16 Demetrix, Inc. Optimized olivetolic acid cyclase polypeptides
US20230357806A1 (en) * 2020-09-30 2023-11-09 Genomium, Inc. Fermentation process to produce bioacrolein and bioacrylic acid
US20230348942A1 (en) * 2020-11-05 2023-11-02 Lg Chem, Ltd. Microorganisms having capability of producing 3-hydroxypropionic acid from glucose and uses thereof
IT202000031979A1 (it) 2020-12-22 2022-06-22 Novamont Spa Processo di purificazione di una miscela comprendente dioli e acetali
CN114806981B (zh) * 2021-01-18 2023-05-23 中国科学院上海高等研究院 克雷伯氏菌工程菌在生产1,3-丙二醇中的应用
KR20240004255A (ko) 2021-03-08 2024-01-11 엑소폴리머, 인코포레이티드 국소 사용을 위한 바이오폴리머
IT202100006419A1 (it) 2021-03-17 2022-09-17 Novamont Spa Recupero di dioli da una miscela
CN113881614B (zh) * 2021-09-10 2023-07-28 江苏清大智兴生物技术有限公司 一种提升1,3-丙二醇生产菌株性能的工程菌及其应用
WO2023076358A1 (en) 2021-10-26 2023-05-04 Exopolymer, Inc. Heat stable and/or heat activated biopolymers
CN114149955B (zh) * 2021-12-09 2023-09-26 齐鲁工业大学 一种高效生产甘油的基因工程菌及其构建方法与应用
CN115820519B (zh) * 2022-08-26 2024-07-19 天津大学 一种高效定向电子通量至电子转移链的重组希瓦氏菌株的构建方法及用途
EP4586997A2 (de) 2022-09-14 2025-07-23 Exopolymer, Inc. Biopolymere zur ophthalmischen verwendung
WO2024059627A1 (en) 2022-09-14 2024-03-21 Exopolymer, Inc. Biopolymers for use in wound care
WO2024259559A1 (en) 2023-06-19 2024-12-26 Hangzhou Enhe Biotechnology Co., Ltd. Fusion polypeptides for production of 7-dehydrocholesterol and methods of use thereof
CN118086444B (zh) * 2024-04-28 2024-06-28 山东德普新材料科技有限公司 一种发酵联产1,3-丙二醇和3-羟基丙酸的方法
WO2026096945A1 (en) 2024-11-02 2026-05-07 Exopolymer, Inc. Non-petrochemical biopolymers for rheology modification
CN119709886A (zh) * 2024-12-18 2025-03-28 天津大学 一种利用光酶还原sam自由基酶生物合成1,3-丙二醇的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5702401A (en) * 1993-06-23 1997-12-30 Shaffer; Benjamin Intra-articular measuring device
WO1996034961A1 (en) 1995-05-05 1996-11-07 Genencor International, Inc. Application of glucose transport mutants for production of aromatic pathway compounds
US5686276A (en) 1995-05-12 1997-11-11 E. I. Du Pont De Nemours And Company Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
BR9712761B1 (pt) 1996-11-13 2010-02-23 mÉtodo para a produÇço de 1,3- propanodiol e microorganismo hospedeiro transformado.
CN1202253C (zh) 1997-12-02 2005-05-18 纳幕尔杜邦公司 用重组生物体生产甘油的方法
US6432686B1 (en) 1998-05-12 2002-08-13 E. I. Du Pont De Nemours And Company Method for the production of 1,3-propanediol by recombinant organisms comprising genes for vitamin B12 transport
US6613552B1 (en) * 1999-01-29 2003-09-02 Board Of Trustees Operating Michigan State University Biocatalytic synthesis of shikimic acid
EP1204755B1 (de) * 1999-08-18 2006-08-09 E.I. Du Pont De Nemours And Company Verfahren zur biologischen herstellung von 1,3-propandiol
JP4380029B2 (ja) 2000-07-05 2009-12-09 味の素株式会社 微生物を利用した物質の製造法
JP4776146B2 (ja) 2001-01-10 2011-09-21 ザ・ペン・ステート・リサーチ・ファンデーション 細胞代謝をモデル化する方法及びシステム
CA2441774A1 (en) 2001-04-20 2002-10-31 E.I. Du Pont De Nemours And Company A product removal process for use in a biofermentation system
US8192959B2 (en) 2002-04-22 2012-06-05 Genencor International Inc Promoter and plasmid system for genetic engineering

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