ATE394373T1 - Synthese von indolthiazolverbindungen als liganden des ah-rezeptors - Google Patents
Synthese von indolthiazolverbindungen als liganden des ah-rezeptorsInfo
- Publication number
- ATE394373T1 ATE394373T1 AT03707863T AT03707863T ATE394373T1 AT E394373 T1 ATE394373 T1 AT E394373T1 AT 03707863 T AT03707863 T AT 03707863T AT 03707863 T AT03707863 T AT 03707863T AT E394373 T1 ATE394373 T1 AT E394373T1
- Authority
- AT
- Austria
- Prior art keywords
- synthesis
- indolthiazole
- ligands
- receptor
- compounds
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 150000008365 aromatic ketones Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000002194 synthesizing effect Effects 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35658502P | 2002-02-12 | 2002-02-12 | |
| US10/074,102 US6916834B2 (en) | 2001-02-14 | 2002-02-12 | Preparations and use of an Ah receptor ligand, 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE394373T1 true ATE394373T1 (de) | 2008-05-15 |
Family
ID=27736819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03707863T ATE394373T1 (de) | 2002-02-12 | 2003-02-11 | Synthese von indolthiazolverbindungen als liganden des ah-rezeptors |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7002019B2 (de) |
| EP (1) | EP1480951B1 (de) |
| JP (1) | JP4445266B2 (de) |
| CN (2) | CN1915991B (de) |
| AT (1) | ATE394373T1 (de) |
| AU (1) | AU2003209130B2 (de) |
| CA (1) | CA2475331C (de) |
| DE (1) | DE60320766D1 (de) |
| MX (1) | MXPA04007767A (de) |
| WO (1) | WO2003068742A1 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ527430A (en) * | 2001-02-14 | 2005-03-24 | Wisconsin Alumni Res Found | Preparations and use of an Ah receptor ligand, 2-(1'H-Indole-3'-Carbonyl)-thiazole-4-carboxylic acid methyl ester |
| TWI224101B (en) | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| US7074817B2 (en) | 2001-06-20 | 2006-07-11 | Wyeth | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| JP4445266B2 (ja) * | 2002-02-12 | 2010-04-07 | ウイスコンシン アラムナイ リサーチ フオンデーシヨン | Ａｈ受容体のリガンドとしてのインドールチアゾール化合物の合成 |
| EP1569900B1 (de) | 2002-12-10 | 2006-06-28 | Wyeth | Substituierte 3-carbonyl-1-yl essigsäure derivate als plasminogen aktivator inhibitor(pai-1) inhibitoren |
| DE60324183D1 (en) | 2002-12-10 | 2008-11-27 | Wyeth Corp | Aryl-, aryloxy- und alkyloxysubstituierte 1h-indol-3-yl-glyoxylsäurederivateals inhibitoren des plasminogenaktivatorinhibitors-1 (pai-1) |
| UA80453C2 (en) | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
| CA2509170A1 (en) | 2002-12-10 | 2004-06-24 | Wyeth | Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| CA2509222A1 (en) | 2002-12-10 | 2004-06-24 | Wyeth | Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| US7230133B2 (en) | 2003-05-01 | 2007-06-12 | Bristol-Myers Squibb Company | Malonamides and malonamide derivatives as modulators of chemokine receptor activity |
| US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
| US7163954B2 (en) | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
| US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7342039B2 (en) | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
| US7582773B2 (en) | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| US7446201B2 (en) | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
| US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7411083B2 (en) | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
| US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| US7534894B2 (en) | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
| US7141592B2 (en) | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| AU2005277137A1 (en) | 2004-08-23 | 2006-03-02 | Wyeth | Pyrrolo-naphthyl acids as PAI-1 inhibitors |
| CN101044127A (zh) | 2004-08-23 | 2007-09-26 | 惠氏公司 | 用作纤溶酶原激活剂抑制剂－1的噻唑基－萘基酸 |
| WO2006023865A1 (en) | 2004-08-23 | 2006-03-02 | Wyeth | Oxazolo-naphthyl acids as plaminogen activator inhibtor type-1 (pai-1) modulators useful in the treatment of thrombosis and cardiovascular diseases |
| BRPI0614340A2 (pt) | 2005-08-17 | 2011-04-12 | Wyeth Corp | indóis substituìdos e métodos de seu uso |
| EP2082736A1 (de) | 2008-01-23 | 2009-07-29 | Jean Hilaire Saurat | Pharmazeutische Zusammensetzung zur lokalen Anwendung |
| US8236849B2 (en) * | 2008-10-15 | 2012-08-07 | Ohio Northern University | Model for glutamate racemase inhibitors and glutamate racemase antibacterial agents |
| AU2010313622B2 (en) | 2009-11-02 | 2014-08-14 | Ahr Pharmaceuticals, Inc. | ITE for cancer intervention and eradication |
| US10632106B2 (en) | 2009-11-02 | 2020-04-28 | Ariagen, Inc. | Methods of cancer treatment with 2-(1′H-Indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester |
| CN102775399A (zh) * | 2011-12-27 | 2012-11-14 | 盛世泰科生物医药技术(苏州)有限公司 | arylhydrocarbon受体(AHR)的内源性配体,2-(1’H3’-吲哚羰基)噻唑-4-羧酸甲酯的合成新方法 |
| WO2015013510A1 (en) * | 2013-07-25 | 2015-01-29 | Ecole Polytechnique Federale De Lausanne Epfl | High aspect ratio nanofibril materials |
| AU2015315132B2 (en) * | 2014-09-12 | 2020-04-09 | Ariagen, Inc. | Efficient and scalable systhesis of 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester and its structural analogs |
| CN108239083B (zh) * | 2016-12-26 | 2021-08-17 | 阿里根公司 | 芳香烃受体调节剂 |
| EP3713937A2 (de) | 2017-11-20 | 2020-09-30 | Ariagen, Inc. | Indolverbindungen als modulatoren des aryl-kohlenwasserstoff-rezeptors (ahr) |
| IL287177B2 (en) | 2019-04-15 | 2026-04-01 | Ariagen Inc | Indole-based chiral thiazole derivatives and their use |
| US11136318B2 (en) | 2019-06-21 | 2021-10-05 | Noramco, Llc | Processes for the preparation of aryl hydrocarbon receptor ligands |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3265931A (en) * | 1964-09-21 | 1966-08-09 | Martin E Gerry | Magnetic ignition distributor |
| US3285931A (en) | 1964-12-21 | 1966-11-15 | Union Carbide Corp | Preparation of substituted pyrrole derivatives |
| US5366685A (en) | 1989-07-18 | 1994-11-22 | Idemitsu Petrochemical Co., Ltd. | Process of molding thermoplastic sheet by plug assist vacuum forming |
| US6323228B1 (en) * | 2000-09-15 | 2001-11-27 | Abbott Laboratories | 3-substituted indole angiogenesis inhibitors |
| US6523228B1 (en) * | 2000-10-26 | 2003-02-25 | Avery Dennison Corporation | Tamper-proof tie |
| NZ527430A (en) * | 2001-02-14 | 2005-03-24 | Wisconsin Alumni Res Found | Preparations and use of an Ah receptor ligand, 2-(1'H-Indole-3'-Carbonyl)-thiazole-4-carboxylic acid methyl ester |
| CA2460345A1 (en) * | 2001-09-13 | 2003-03-20 | Synta Pharmaceuticals Corp. | 2-aroylimidazole compounds for treating cancer |
| JP4445266B2 (ja) * | 2002-02-12 | 2010-04-07 | ウイスコンシン アラムナイ リサーチ フオンデーシヨン | Ａｈ受容体のリガンドとしてのインドールチアゾール化合物の合成 |
-
2003
- 2003-02-11 JP JP2003567873A patent/JP4445266B2/ja not_active Expired - Lifetime
- 2003-02-11 US US10/364,253 patent/US7002019B2/en not_active Expired - Lifetime
- 2003-02-11 AU AU2003209130A patent/AU2003209130B2/en not_active Expired
- 2003-02-11 WO PCT/US2003/004205 patent/WO2003068742A1/en not_active Ceased
- 2003-02-11 CN CN2006100915364A patent/CN1915991B/zh not_active Expired - Fee Related
- 2003-02-11 AT AT03707863T patent/ATE394373T1/de not_active IP Right Cessation
- 2003-02-11 CN CNA038063808A patent/CN1642910A/zh active Pending
- 2003-02-11 MX MXPA04007767A patent/MXPA04007767A/es active IP Right Grant
- 2003-02-11 DE DE60320766T patent/DE60320766D1/de not_active Expired - Fee Related
- 2003-02-11 CA CA2475331A patent/CA2475331C/en not_active Expired - Lifetime
- 2003-02-11 EP EP03707863A patent/EP1480951B1/de not_active Expired - Lifetime
-
2005
- 2005-11-23 US US11/286,537 patent/US7241900B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005525340A (ja) | 2005-08-25 |
| US7241900B2 (en) | 2007-07-10 |
| CN1915991B (zh) | 2010-05-26 |
| DE60320766D1 (de) | 2008-06-19 |
| CA2475331C (en) | 2012-06-12 |
| CN1642910A (zh) | 2005-07-20 |
| CN1915991A (zh) | 2007-02-21 |
| US20040204588A1 (en) | 2004-10-14 |
| EP1480951B1 (de) | 2008-05-07 |
| MXPA04007767A (es) | 2004-10-15 |
| AU2003209130A1 (en) | 2003-09-04 |
| CA2475331A1 (en) | 2003-08-21 |
| US20060079692A1 (en) | 2006-04-13 |
| EP1480951A1 (de) | 2004-12-01 |
| US7002019B2 (en) | 2006-02-21 |
| WO2003068742A1 (en) | 2003-08-21 |
| EP1480951A4 (de) | 2006-03-22 |
| AU2003209130B2 (en) | 2008-06-05 |
| JP4445266B2 (ja) | 2010-04-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |