ATE394393T1 - Neue polymorphe formen eines 1-pyrrol-derivates, zwischenprodukt zur herstellung von atorvastatin - Google Patents
Neue polymorphe formen eines 1-pyrrol-derivates, zwischenprodukt zur herstellung von atorvastatinInfo
- Publication number
- ATE394393T1 ATE394393T1 AT02758667T AT02758667T ATE394393T1 AT E394393 T1 ATE394393 T1 AT E394393T1 AT 02758667 T AT02758667 T AT 02758667T AT 02758667 T AT02758667 T AT 02758667T AT E394393 T1 ATE394393 T1 AT E394393T1
- Authority
- AT
- Austria
- Prior art keywords
- new
- atorvastatin
- phenyl
- polymorphoic
- production
- Prior art date
Links
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 title abstract 2
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 title abstract 2
- 229960005370 atorvastatin Drugs 0.000 title abstract 2
- 239000005515 coenzyme Substances 0.000 abstract 1
- 229940125532 enzyme inhibitor Drugs 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- -1 hydroxymethyl-glutaryl Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000012450 pharmaceutical intermediate Substances 0.000 abstract 1
- NPPZOMYSGNZDKY-ROJLCIKYSA-N tert-butyl 2-[(4r,6r)-6-[2-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@H]2OC(C)(C)O[C@@H](CC(=O)OC(C)(C)C)C2)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 NPPZOMYSGNZDKY-ROJLCIKYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0103702A HU227124B1 (en) | 2001-09-14 | 2001-09-14 | Polymorphs of 1-pyrrole derivative, intermediate for the preparation of atorvastatin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE394393T1 true ATE394393T1 (de) | 2008-05-15 |
Family
ID=89979680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02758667T ATE394393T1 (de) | 2001-09-14 | 2002-09-13 | Neue polymorphe formen eines 1-pyrrol-derivates, zwischenprodukt zur herstellung von atorvastatin |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7186848B2 (de) |
| EP (1) | EP1430049B1 (de) |
| JP (1) | JP2005505572A (de) |
| KR (1) | KR20040029482A (de) |
| AT (1) | ATE394393T1 (de) |
| CY (1) | CY1108235T1 (de) |
| CZ (1) | CZ2004469A3 (de) |
| DE (1) | DE60226463D1 (de) |
| DK (1) | DK1430049T3 (de) |
| EA (1) | EA007104B1 (de) |
| ES (1) | ES2306778T3 (de) |
| HU (1) | HU227124B1 (de) |
| PL (1) | PL217253B1 (de) |
| PT (1) | PT1430049E (de) |
| SK (1) | SK1722004A3 (de) |
| UA (1) | UA76496C2 (de) |
| WO (1) | WO2003024959A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050119270A1 (en) * | 2000-08-04 | 2005-06-02 | Mason R. P. | Synergistic effect of amlodipine and atorvastatin on aortic endothelial cell nitric oxide release |
| EP1711489B1 (de) * | 2003-12-29 | 2012-12-26 | LEK Pharmaceuticals d.d. | Verfahren zur herstellung von amorpher (4r-cis)-6-[2-[3-phenyl-4-(phenylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methyl)-pyrrol-1-yl]-2,2-dimethyl-[1,3]-dioxan-4-yl-essigsäure |
| WO2006032959A2 (en) * | 2004-08-06 | 2006-03-30 | Glenmark Pharmaceuticals Limited | Processes for the preparation of pyrrole derivatives |
| KR101255204B1 (ko) * | 2012-07-23 | 2013-04-23 | 주식회사 베프스 | 보안 기능을 갖는 저장 장치 리더기 및 이를 이용한 보안 방법 |
| CN106938996B (zh) * | 2016-01-05 | 2019-11-19 | 天方药业有限公司 | 一种阿托伐他汀钙中间体的制备方法 |
| CN111362856B (zh) * | 2020-04-29 | 2023-08-18 | 福建海西新药创制股份有限公司 | 一种利用微反应装置生产阿托伐他汀钙的方法 |
| WO2026006786A1 (en) * | 2024-06-28 | 2026-01-02 | Osanni Bio, Inc. | Compound, compositions, and methods of use thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5003080A (en) * | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
| US5103024A (en) * | 1990-10-17 | 1992-04-07 | Warner-Lambert Company | Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
| US5217453A (en) * | 1991-03-18 | 1993-06-08 | Wilk Peter J | Automated surgical system and apparatus |
| EP0688536B1 (de) * | 1994-03-23 | 2000-08-02 | Erbe Elektromedizin GmbH | Multifunktionales Instrument für die Ultraschall-Chirurgie |
| US5526822A (en) * | 1994-03-24 | 1996-06-18 | Biopsys Medical, Inc. | Method and apparatus for automated biopsy and collection of soft tissue |
| GEP20002029B (en) * | 1995-07-17 | 2000-04-10 | Warner Lambert Company Us | (54) Crystalline [R-(R*,R*,]–2-(4-Fluorophenyl)-Beta,Delta-Dihydroxy-5-(1-Methyl-Ethyl)-3-Phenyl–4-{Phenylamino) Carbonyl} - 1H - Pyrrole - 1 - Heptanoic Acid Hemi Calcium Salt (Atorvastatin) |
| US5871495A (en) * | 1996-09-13 | 1999-02-16 | Eclipse Surgical Technologies, Inc. | Method and apparatus for mechanical transmyocardial revascularization of the heart |
| SI20814A (sl) * | 2001-01-23 | 2002-08-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Priprava amorfnega atorvastatina |
-
2001
- 2001-09-14 HU HU0103702A patent/HU227124B1/hu not_active IP Right Cessation
-
2002
- 2002-09-13 US US10/489,686 patent/US7186848B2/en not_active Expired - Fee Related
- 2002-09-13 EA EA200400391A patent/EA007104B1/ru not_active IP Right Cessation
- 2002-09-13 PT PT02758667T patent/PT1430049E/pt unknown
- 2002-09-13 SK SK172-2004A patent/SK1722004A3/sk unknown
- 2002-09-13 JP JP2003528806A patent/JP2005505572A/ja active Pending
- 2002-09-13 KR KR10-2004-7003753A patent/KR20040029482A/ko not_active Ceased
- 2002-09-13 AT AT02758667T patent/ATE394393T1/de active
- 2002-09-13 EP EP02758667A patent/EP1430049B1/de not_active Expired - Lifetime
- 2002-09-13 ES ES02758667T patent/ES2306778T3/es not_active Expired - Lifetime
- 2002-09-13 WO PCT/HU2002/000088 patent/WO2003024959A1/en not_active Ceased
- 2002-09-13 DE DE60226463T patent/DE60226463D1/de not_active Expired - Lifetime
- 2002-09-13 DK DK02758667T patent/DK1430049T3/da active
- 2002-09-13 PL PL369227A patent/PL217253B1/pl unknown
- 2002-09-13 UA UA20040402706A patent/UA76496C2/uk unknown
- 2002-09-13 CZ CZ2004469A patent/CZ2004469A3/cs unknown
-
2008
- 2008-07-31 CY CY20081100812T patent/CY1108235T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK1722004A3 (en) | 2004-08-03 |
| HU0103702D0 (en) | 2001-11-28 |
| PL217253B1 (pl) | 2014-06-30 |
| ES2306778T3 (es) | 2008-11-16 |
| UA76496C2 (uk) | 2006-08-15 |
| EP1430049A1 (de) | 2004-06-23 |
| EP1430049B1 (de) | 2008-05-07 |
| US20040249168A1 (en) | 2004-12-09 |
| EA007104B1 (ru) | 2006-06-30 |
| DK1430049T3 (da) | 2008-09-01 |
| HUP0103702A3 (en) | 2007-08-28 |
| HUP0103702A2 (hu) | 2003-06-28 |
| DE60226463D1 (de) | 2008-06-19 |
| CY1108235T1 (el) | 2014-02-12 |
| WO2003024959A1 (en) | 2003-03-27 |
| JP2005505572A (ja) | 2005-02-24 |
| EA200400391A1 (ru) | 2005-02-24 |
| HU227124B1 (en) | 2010-07-28 |
| KR20040029482A (ko) | 2004-04-06 |
| PT1430049E (pt) | 2008-08-08 |
| US7186848B2 (en) | 2007-03-06 |
| CZ2004469A3 (cs) | 2004-08-18 |
| PL369227A1 (en) | 2005-04-18 |
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Legal Events
| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification |
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