ATE394509T1 - Molekulare stäbchen enthaltende oligonukleotide - Google Patents

Molekulare stäbchen enthaltende oligonukleotide

Info

Publication number: ATE394509T1
Authority: AT; Austria
Prior art keywords: oligonucleotides containing; containing molecular; molecular rods; nucleotide residue; oligonucleotides
Prior art date: 2003-12-02

Application number

AT04028280T

Other languages

English (en)

Inventor

Dieter Heindl

Astrid Reiser

Karim Tabiti

Martina Junius

Alexander Hauber

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-02

Filing date

2004-11-30

Publication date

2008-05-15

2004-11-30 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2008-05-15 Application granted granted Critical

2008-05-15 Publication of ATE394509T1 publication Critical patent/ATE394509T1/de

Links

108091034117 Oligonucleotide Proteins 0.000 title abstract 3
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title abstract 2
239000002073 nanorod Substances 0.000 abstract 2
125000003729 nucleotide group Chemical group 0.000 abstract 2
238000011880 melting curve analysis Methods 0.000 abstract 1
238000003753 real-time PCR Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/808—Automated or kit

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)

AT04028280T 2003-12-02 2004-11-30 Molekulare stäbchen enthaltende oligonukleotide ATE394509T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP03027753		2003-12-02

Publications (1)

Publication Number	Publication Date
ATE394509T1 true ATE394509T1 (de)	2008-05-15

Family

ID=34610060

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04028280T ATE394509T1 (de)	2003-12-02	2004-11-30	Molekulare stäbchen enthaltende oligonukleotide

Country Status (7)

Country	Link
US (1)	US7541448B2 (de)
EP (1)	EP1538221B1 (de)
JP (1)	JP2005200405A (de)
AT (1)	ATE394509T1 (de)
CA (1)	CA2494571C (de)
DE (1)	DE602004013520D1 (de)
ES (1)	ES2305652T3 (de)

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JP5493117B2 (ja) *	2006-02-15	2014-05-14	国立大学法人岐阜大学	オリゴヌクレオチド誘導体及びその利用
US20090181391A1 (en) *	2007-11-01	2009-07-16	Zymo Research Corporation	Methods for analysis of dna methylation percentage
WO2010135917A1 (zh) *	2009-05-26	2010-12-02	厦门大学	一种检测核酸序列变异的方法
SG10201408401RA (en)	2009-09-16	2015-01-29	Genentech Inc	Coiled coil and/or tether containing protein complexes and uses thereof
US9506057B2 (en)	2010-03-26	2016-11-29	Integrated Dna Technologies, Inc.	Modifications for antisense compounds
AU2011230496B2 (en)	2010-03-26	2015-09-17	Integrated Dna Technologies, Inc.	Methods for enhancing nucleic acid hybridization
AR080793A1 (es)	2010-03-26	2012-05-09	Roche Glycart Ag	Anticuerpos biespecificos
AU2011299233B2 (en)	2010-09-07	2016-09-15	Integrated Dna Technologies, Inc.	Modifications for antisense compounds
EP2655413B1 (de)	2010-12-23	2019-01-16	F.Hoffmann-La Roche Ag	Polypeptid-polynukleotid-komplex und verwendung bei der gezielten effektorrest-bereitstellung
CA2817448C (en)	2010-12-23	2019-01-22	F. Hoffmann-La Roche Ag	Binding agent
CN103384825B (zh)	2010-12-23	2017-05-24	霍夫曼-拉罗奇有限公司	通过二价结合剂检测经翻译后修饰的多肽
CN104105711B (zh)	2012-02-10	2018-11-30	弗·哈夫曼-拉罗切有限公司	单链抗体及其他异多聚体
HK1207864A1 (zh)	2012-06-27	2016-02-12	F. Hoffmann-La Roche Ag	用於选择并产生含有至少两种不同结合实体的定制高度选择性和多特异性靶向实体的方法及其用途
MX2014014804A (es)	2012-06-27	2015-02-12	Hoffmann La Roche	Metodo para la elaboracion de conjugados de la region fc de anticuerpos que comprenden por lo menos una entidad de union que se une especificamente a un objetivo y usos del mismo.
ES2764111T3 (es)	2014-12-03	2020-06-02	Hoffmann La Roche	Anticuerpos multiespecíficos

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US5118801A (en) *	1988-09-30	1992-06-02	The Public Health Research Institute	Nucleic acid process containing improved molecular switch
US5141837A (en) *	1990-02-23	1992-08-25	Eastman Kodak Company	Method for preparing coating compositions containing photoconductive perylene pigments
US5210015A (en) *	1990-08-06	1993-05-11	Hoffman-La Roche Inc.	Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5290925A (en) *	1990-12-20	1994-03-01	Abbott Laboratories	Methods, kits, and reactive supports for 3' labeling of oligonucleotides
US5538848A (en) *	1994-11-16	1996-07-23	Applied Biosystems Division, Perkin-Elmer Corp.	Method for detecting nucleic acid amplification using self-quenching fluorescence probe
CZ274596A3 (en) *	1994-03-18	1997-03-12	Lynx Therapeutics	Oligonucleotide n3 - p5 phosphoramidates and process of their synthesis and hybridization
US5700923A (en) *	1994-09-29	1997-12-23	Hybridon, Inc.	Finderons and methods of their preparation and use
US5770715A (en) *	1995-03-22	1998-06-23	Toagosei Co., Ltd.	Hammerhead-like nucleic acid analogues and their synthesis
JPH08319295A (ja) *	1995-03-22	1996-12-03	Toagosei Co Ltd	核酸化合物及びその合成方法
US6017700A (en) *	1995-08-04	2000-01-25	Bayer Corporation	Cationic oligonucleotides, and related methods of synthesis and use
JP4281877B2 (ja)	1996-06-04	2009-06-17	ユニバーシティオブユタリサーチファウンデーション	生物学的プロセスを実行し且つモニタリングするためのシステムと方法
EP0912766B2 (de)	1996-06-04	2011-12-14	University of Utah Research Foundation	Überwachung der hybridisierung während pcr
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GB0130868D0 (en) *	2001-12-24	2002-02-06	Univ Strathclyde	New compounds

2004
- 2004-11-19 CA CA2494571A patent/CA2494571C/en not_active Expired - Fee Related
- 2004-11-30 DE DE602004013520T patent/DE602004013520D1/de not_active Expired - Lifetime
- 2004-11-30 ES ES04028280T patent/ES2305652T3/es not_active Expired - Lifetime
- 2004-11-30 AT AT04028280T patent/ATE394509T1/de active
- 2004-11-30 EP EP04028280A patent/EP1538221B1/de not_active Expired - Lifetime
- 2004-12-01 JP JP2004348896A patent/JP2005200405A/ja active Pending
- 2004-12-02 US US11/001,785 patent/US7541448B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1538221A1 (de)	2005-06-08
ES2305652T3 (es)	2008-11-01
JP2005200405A (ja)	2005-07-28
CA2494571A1 (en)	2005-06-02
US7541448B2 (en)	2009-06-02
US20050142598A1 (en)	2005-06-30
DE602004013520D1 (de)	2008-06-19
CA2494571C (en)	2010-02-09
EP1538221B1 (de)	2008-05-07

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2008-12-15

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