ATE395362T1 - Monoklonale antikörper zur apoptosis-induzierung - Google Patents

Monoklonale antikörper zur apoptosis-induzierung

Info

Publication number
ATE395362T1
ATE395362T1 AT98941848T AT98941848T ATE395362T1 AT E395362 T1 ATE395362 T1 AT E395362T1 AT 98941848 T AT98941848 T AT 98941848T AT 98941848 T AT98941848 T AT 98941848T AT E395362 T1 ATE395362 T1 AT E395362T1
Authority
AT
Austria
Prior art keywords
antibody
monoclonal antibodies
associated proteins
human integrin
apoptosis
Prior art date
Application number
AT98941848T
Other languages
English (en)
Inventor
Naoshi Fukushima
Shinsuke Uno
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE395362T1 publication Critical patent/ATE395362T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT98941848T 1997-09-11 1998-09-11 Monoklonale antikörper zur apoptosis-induzierung ATE395362T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP26485397 1997-09-11

Publications (1)

Publication Number Publication Date
ATE395362T1 true ATE395362T1 (de) 2008-05-15

Family

ID=17409137

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98941848T ATE395362T1 (de) 1997-09-11 1998-09-11 Monoklonale antikörper zur apoptosis-induzierung

Country Status (14)

Country Link
US (1) US20030157100A1 (de)
EP (1) EP1035132B1 (de)
KR (2) KR20040106585A (de)
CN (1) CN1198845C (de)
AT (1) ATE395362T1 (de)
AU (1) AU740225B2 (de)
CA (1) CA2303072A1 (de)
DE (1) DE69839492D1 (de)
HU (1) HUP0003513A3 (de)
NO (1) NO20001238L (de)
PL (1) PL339265A1 (de)
RU (1) RU2212413C2 (de)
SK (1) SK3232000A3 (de)
WO (1) WO1999012973A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ294359B6 (cs) * 1993-09-03 2004-12-15 Chugai Seiyaku Kabushiki Kaisha Monoklonální protilátka způsobující apoptózu buněk kostní dřeně, její fragment, hybridom ji produkující a farmaceutický prostředek, který ji obsahuje
US7531643B2 (en) 1997-09-11 2009-05-12 Chugai Seiyaku Kabushiki Kaisha Monoclonal antibody inducing apoptosis
AU2940900A (en) * 1999-03-10 2000-09-28 Chugai Seiyaku Kabushiki Kaisha Single-stranded fv inducing apoptosis
US7696325B2 (en) 1999-03-10 2010-04-13 Chugai Seiyaku Kabushiki Kaisha Polypeptide inducing apoptosis
TWI241345B (en) * 2000-03-10 2005-10-11 Chugai Pharmaceutical Co Ltd Apoptosis inducing polypeptide
WO2001079494A1 (fr) * 2000-04-17 2001-10-25 Chugai Seiyaku Kabushiki Kaisha Anticorps agonistes
US20040058393A1 (en) * 2000-04-17 2004-03-25 Naoshi Fukishima Agonist antibodies
RU2430927C2 (ru) * 2000-10-20 2011-10-10 Тугаи Сейяку Кабусики Кайся Агонистическое соединение, способное специфически узнавать и поперечно сшивать молекулу клеточной поверхности или внутриклеточную молекулу
US20040242847A1 (en) * 2000-10-20 2004-12-02 Naoshi Fukushima Degraded agonist antibody
WO2002033072A1 (fr) * 2000-10-20 2002-04-25 Chugai Seiyaku Kabushiki Kaisha Anticorps degrade, agoniste de tpo
AU1091802A (en) * 2000-10-20 2002-04-29 Chugai Pharmaceutical Co Ltd Degraded agonist antibody
US8034903B2 (en) 2000-10-20 2011-10-11 Chugai Seiyaku Kabushiki Kaisha Degraded TPO agonist antibody
US20050069549A1 (en) 2002-01-14 2005-03-31 William Herman Targeted ligands
AU2003271175A1 (en) 2002-10-11 2004-05-04 Masahiro Abe Cell death-inducing agent
JP2004279086A (ja) 2003-03-13 2004-10-07 Konica Minolta Holdings Inc 放射線画像変換パネル及び放射線画像変換パネルの製造方法
EP1609803A4 (de) * 2003-03-31 2006-05-24 Chugai Pharmaceutical Co Ltd Modifizierter antikörper gegen cd22 und anwendungen dafür
US8613922B2 (en) 2003-04-24 2013-12-24 The University Of North Carolina At Chapel Hill Methods for inhibiting diabetic retinopathy with an antibody against integrin associated protein (IAP)
CA2545166A1 (en) * 2003-11-11 2005-05-19 Chugai Seiyaku Kabushiki Kaisha Humanized anti-cd47 antibody
US20070280951A1 (en) * 2003-12-12 2007-12-06 Naoki Kimura Cell Death Inducing Agents
TW200530269A (en) 2003-12-12 2005-09-16 Chugai Pharmaceutical Co Ltd Anti-Mpl antibodies
TW200530266A (en) * 2003-12-12 2005-09-16 Chugai Pharmaceutical Co Ltd Method of reinforcing antibody activity
US20070281327A1 (en) * 2003-12-12 2007-12-06 Kiyotaka Nakano Methods of Screening for Modified Antibodies With Agonistic Activities
JP5057967B2 (ja) 2005-03-31 2012-10-24 中外製薬株式会社 ｓｃ（Ｆｖ）２構造異性体
US20090022687A1 (en) * 2005-05-18 2009-01-22 Chugai Seiyaku Kabushiki Kaisha Novel Pharmaceuticals That Use Anti-HLA Antibodies
KR101367544B1 (ko) 2005-06-10 2014-02-26 추가이 세이야쿠 가부시키가이샤 메글루민을 함유하는 단백질 제제의 안정화제, 및 그의이용
CA2611726C (en) 2005-06-10 2017-07-11 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical compositions containing sc(fv)2
WO2007033221A2 (en) * 2005-09-13 2007-03-22 The General Hospital Corporation Methods and compositions for inhibition of immune responses
US20100150927A1 (en) * 2006-07-13 2010-06-17 Chugai Seiyaku Kabushiki Kaisha Cell death inducer
CL2008000719A1 (es) * 2007-03-12 2008-09-05 Univ Tokushima Chugai Seiyaku Agente terapeutico para cancer resistente a agentes quimioterapeuticos que comprende un anticuerpo que reconoce hla de clase i como ingrediente activo; composicion farmaceutica que comprende dicho anticuerpo; y metodo para tratar cancer resistente a
ES2582340T3 (es) 2008-01-15 2016-09-12 The Board Of Trustees Of The Leland Stanford Junior University Métodos para manipular fagocitosis mediada por CD47
EP3043181B1 (de) 2008-01-15 2020-04-08 The Board of Trustees of the Leland Stanford Junior University Marker für stammzellen von akuter myeloischer leukämie
AU2009279676C1 (en) 2008-08-07 2015-08-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Radioprotectants targeting thrombospondin-1 and CD47
KR102100388B1 (ko) * 2012-02-06 2020-04-13 인히브릭스, 인크. Cd47 항체 및 그 사용 방법
US9221908B2 (en) 2012-12-12 2015-12-29 Vasculox, Inc. Therapeutic CD47 antibodies
BR112015013431A2 (pt) 2012-12-12 2017-11-14 Vasculox Inc anticorpos monoclonais ou respectivos fragmentos ligantes de antígenos, composição farmacêutica, e usos de anticorpo monoclonal ou respectivo fragmento ligante de antígenos
RU2748401C2 (ru) 2015-09-18 2021-05-25 Арч Онколоджи, Инк. Терапевтические антитела к CD47
CN109789092A (zh) 2016-07-13 2019-05-21 哈佛学院院长等 抗原呈递细胞模拟支架及其制备和使用方法
EP3529276A4 (de) 2016-10-21 2020-06-17 Arch Oncology, Inc. Therapeutische cd47-antikörper
SG11202004864TA (en) 2017-12-01 2020-06-29 Seattle Genetics Inc Cd47 antibodies and uses thereof for treating cancer
CN110066336B (zh) * 2019-05-12 2021-11-09 杭州科兴生物科技有限公司 抗cd47单克隆抗体、片段及其医药用途
AU2022378579A1 (en) 2021-10-28 2024-05-02 Lyell Immunopharma, Inc. Methods of generating cells
WO2024077174A1 (en) 2022-10-05 2024-04-11 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
WO2025217398A1 (en) 2024-04-10 2025-10-16 Lyell Immunopharma, Inc. Methods for culturing cells with improved culture medium
WO2026006604A1 (en) 2024-06-26 2026-01-02 Lyell Immunopharma, Inc. Feeder cell replacement

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2156149T3 (es) * 1992-12-04 2001-06-16 Medical Res Council Proteinas de union multivalente y multiespecificas, su fabricacion y su uso.
CZ294359B6 (cs) * 1993-09-03 2004-12-15 Chugai Seiyaku Kabushiki Kaisha Monoklonální protilátka způsobující apoptózu buněk kostní dřeně, její fragment, hybridom ji produkující a farmaceutický prostředek, který ji obsahuje
US6719972B1 (en) * 1994-06-03 2004-04-13 Repligen Corporation Methods of inhibiting T cell proliferation or IL-2 accumulation with CTLA4- specific antibodies
US5885574A (en) * 1994-07-26 1999-03-23 Amgen Inc. Antibodies which activate an erythropoietin receptor
US5783186A (en) * 1995-12-05 1998-07-21 Amgen Inc. Antibody-induced apoptosis
AU2232597A (en) * 1996-03-06 1997-09-22 Chugai Seiyaku Kabushiki Kaisha Method of screening apoptosis inducing substances
US7531643B2 (en) * 1997-09-11 2009-05-12 Chugai Seiyaku Kabushiki Kaisha Monoclonal antibody inducing apoptosis
US7696325B2 (en) * 1999-03-10 2010-04-13 Chugai Seiyaku Kabushiki Kaisha Polypeptide inducing apoptosis

Also Published As

Publication number Publication date
EP1035132A1 (de) 2000-09-13
RU2212413C2 (ru) 2003-09-20
CN1198845C (zh) 2005-04-27
NO20001238L (no) 2000-05-11
US20030157100A1 (en) 2003-08-21
AU9002898A (en) 1999-03-29
KR20040106585A (ko) 2004-12-17
EP1035132A4 (de) 2005-02-09
PL339265A1 (en) 2000-12-04
KR20010023866A (ko) 2001-03-26
AU740225B2 (en) 2001-11-01
SK3232000A3 (en) 2000-09-12
EP1035132B1 (de) 2008-05-14
WO1999012973A1 (en) 1999-03-18
CA2303072A1 (en) 1999-03-18
CN1276798A (zh) 2000-12-13
HUP0003513A3 (en) 2004-05-28
HUP0003513A2 (hu) 2001-02-28
DE69839492D1 (de) 2008-06-26
NO20001238D0 (no) 2000-03-09

Similar Documents

Publication Publication Date Title
ATE395362T1 (de) Monoklonale antikörper zur apoptosis-induzierung
ATE318147T1 (de) Spezifische monoklonale antikörperfür die extrazelluläre domäne von protasta-spezifischem membranantigen
EP1565489A4 (de) Neues raag10-zelloberflächenziel und dieses ziel erkennende antikörperfamilie
DE60226641D1 (de) Antikörperkategorisierung auf der grundlage von bindungseigenschaften
DE69813158D1 (de) Assays zur Bestimmung von Proteinfragmenten in biologischen Medien
PT733069E (pt) Antigenios ctla-8 de primata purificados e reagentes relacionados
ATE123652T1 (de) Antigene.
PL313260A1 (en) Monoclonal antibodies having properties making them able to cause apoptosis
CU22615A1 (es) Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos
DK1064303T3 (da) Monoklonale antistoffer, der er specifikke for det prostataspecifikke membranantigens ekstracellulære domæne
DK1167389T3 (da) Antistoffer mod SEMP1-proteinet, fremgangsmåde til fremstilling heraf samt anvendelse deraf
DE69932812D1 (de) Epitope in der viralen hüllproteine und spezifische antikörper gegen diese epitope: verwendung für die detektion von hcv viralantigene im empfängergewebe
ATE202116T1 (de) Antikörperklassenspezifisches entstörungsreagenz
DE50009240D1 (de) Verwendung von Antikörpern zur Vakzinierung gegen Krebs
NO973875D0 (no) Fremgangsmåte for simulering av en immunrespons
DE69504959D1 (de) Humanisierte monoklonale antikörper gegen humanes interleukin - 4
ATE206621T1 (de) Il-8 antagonisten zur behandlung von asthma
ATE265533T1 (de) Saeugetierchemokine
DE69823660D1 (de) Methode zur identifizierung von tumorantigenen mit autoantikörpern in serum
ES2061324T3 (es) Complejo aglutinante como reactivo de identificacion de grupo sanguineo.
PT744027E (pt) Utilizacao de metodos para identificar oligopeptidos de sinal hidrofilicos
DE69132144D1 (de) Menschliche phospholipase aktivierender proteinteil
ES2092606T3 (es) Anticuerpos monoclonales para polimeros sulfonados.
DE69533904D1 (de) Chemische Modifikation von Antikörpern und Antigenen
DE69716728D1 (de) Zytofluorometrisches verfahren zur bestimmung von antikörper gegen tumorantigene im serum

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties