ATE396982T1 - Phenylfuranverbindungen als modulatoren des vitamin-d-rezeptors - Google Patents

Phenylfuranverbindungen als modulatoren des vitamin-d-rezeptors

Info

Publication number: ATE396982T1
Authority: AT; Austria
Prior art keywords: vitamin; compounds; receptor; phenylfuran; modulators
Prior art date: 2003-11-20

Application number

AT04810027T

Other languages

English (en)

Inventor

Robert Gajewski

Charles Jones

Jianliang Lu

Tianwei Ma

Sunil Nagpal

Ying Yee

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-11-20

Filing date

2004-11-16

Publication date

2008-06-15

2004-11-16 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2008-06-15 Application granted granted Critical

2008-06-15 Publication of ATE396982T1 publication Critical patent/ATE396982T1/de

Links

102000009310 vitamin D receptors Human genes 0.000 title abstract 3
108050000156 vitamin D receptors Proteins 0.000 title abstract 3
150000005353 phenylfurans Chemical class 0.000 title abstract 2
GMRQFYUYWCNGIN-UHFFFAOYSA-N 1,25-Dihydroxy-vitamin D3' Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CC(O)C1=C GMRQFYUYWCNGIN-UHFFFAOYSA-N 0.000 abstract 1
208000020084 Bone disease Diseases 0.000 abstract 1
201000004681 Psoriasis Diseases 0.000 abstract 1
235000020964 calcitriol Nutrition 0.000 abstract 1
239000011612 calcitriol Substances 0.000 abstract 1
GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000000121 hypercalcemic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Immunology (AREA)
Endocrinology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Transplantation (AREA)
Hospice & Palliative Care (AREA)
Oncology (AREA)
Emergency Medicine (AREA)
Toxicology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Liquid Crystal Substances (AREA)
Pyrane Compounds (AREA)

AT04810027T 2003-11-20 2004-11-16 Phenylfuranverbindungen als modulatoren des vitamin-d-rezeptors ATE396982T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US52401503P	2003-11-20	2003-11-20

Publications (1)

Publication Number	Publication Date
ATE396982T1 true ATE396982T1 (de)	2008-06-15

Family

ID=34632855

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04810027T ATE396982T1 (de)	2003-11-20	2004-11-16	Phenylfuranverbindungen als modulatoren des vitamin-d-rezeptors

Country Status (8)

Country	Link
US (1)	US7468449B2 (de)
EP (1)	EP1692123B1 (de)
JP (1)	JP4750713B2 (de)
AT (1)	ATE396982T1 (de)
CA (1)	CA2546729A1 (de)
DE (1)	DE602004014188D1 (de)
ES (1)	ES2307069T3 (de)
WO (1)	WO2005051936A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1511740T3 (da) *	2002-05-29	2009-08-24	Lilly Co Eli	Vitamin-D-receptor-modulatorer af phenyl-thiophen-typen
ES2319984T3 (es)	2002-11-22	2009-05-18	Eli Lilly And Company	Moduladores del receptor de vitamina d.
CA2546729A1 (en)	2003-11-20	2005-06-09	Eli Lilly And Company	Phenyl-furan compounds as vitamin d receptor modulators
WO2005051898A2 (en)	2003-11-20	2005-06-09	Eli Lilly And Company	Vitamin d receptor modulators
CA2544501A1 (en)	2003-11-20	2005-06-09	Eli Lilly And Company	Vitamin d receptor modulators
WO2005051938A1 (en) *	2003-11-20	2005-06-09	Eli Lilly And Company	Vitamin d receptor modulators
JP4717006B2 (ja) *	2003-11-20	2011-07-06	イーライリリーアンドカンパニー	ビタミンｄ受容体モジュレータ
KR100931777B1 (ko) *	2004-12-21	2009-12-14	일라이 릴리 앤드 캄파니	비타민 ｄ 수용체 조절제
BRPI0519494A2 (pt) *	2004-12-21	2009-02-03	Lilly Co Eli	composto, derivado de prà-droga do composto, derivado de sal do composto, formulaÇço,e, uso de um composto
US9370527B2 (en)	2012-12-28	2016-06-21	The Regents Of The University Of Michigan	Amelioration of intestinal fibrosis and treatment of Crohn's disease
CN103193695B (zh) *	2013-04-22	2015-08-05	中国药科大学	3-苯基-3-吡咯基戊烷类衍生物及其医药用途
EP3371159B1 (de)	2015-11-06	2021-10-27	Regents of the University of Minnesota	Verfahren zur herstellung aromatenhaltiger verbindungen
CN108602791B (zh)	2015-11-06	2023-07-14	明尼苏达大学评议会	芳族表面活性剂
CN106908559B (zh) *	2015-12-23	2020-08-11	重庆华邦胜凯制药有限公司	卡泊三醇中间体l及相关杂质的分离与测定方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4282246A (en) *	1980-03-07	1981-08-04	Pfizer Inc.	Antidiabetic furancarboxylic and thiphenecarboxylic acids
US6218430B1 (en) *	1998-08-24	2001-04-17	Ligand Pharmaceuticals Incorporated	Vitamin D3 mimics
DK1511740T3 (da) *	2002-05-29	2009-08-24	Lilly Co Eli	Vitamin-D-receptor-modulatorer af phenyl-thiophen-typen
DE10229456A1 (de) *	2002-07-01	2004-02-05	Wank, Rudolf, Prof. Dr.med.	Verwendung von Dopamin-Rezeptor-Agonisten zur Behandlung von Hautgeschwülsten und Warzen
WO2004063348A2 (en)	2003-01-10	2004-07-29	Eli Lilly And Company	Vesicant treatment with phenyl-thiophene type vitamin d receptor modulators
EP1587906A2 (de)	2003-01-10	2005-10-26	Eli Lilly And Company	Vesikansbehandlung mit vitamin-d-rezeptormodulatoren des phenyl-phenyl-typs
WO2005051898A2 (en)	2003-11-20	2005-06-09	Eli Lilly And Company	Vitamin d receptor modulators
CA2546729A1 (en)	2003-11-20	2005-06-09	Eli Lilly And Company	Phenyl-furan compounds as vitamin d receptor modulators
CA2544501A1 (en)	2003-11-20	2005-06-09	Eli Lilly And Company	Vitamin d receptor modulators
WO2005051938A1 (en) *	2003-11-20	2005-06-09	Eli Lilly And Company	Vitamin d receptor modulators
JP4717006B2 (ja)	2003-11-20	2011-07-06	イーライリリーアンドカンパニー	ビタミンｄ受容体モジュレータ

2004
- 2004-11-16 CA CA002546729A patent/CA2546729A1/en not_active Abandoned
- 2004-11-16 WO PCT/US2004/035527 patent/WO2005051936A1/en not_active Ceased
- 2004-11-16 AT AT04810027T patent/ATE396982T1/de not_active IP Right Cessation
- 2004-11-16 JP JP2006541190A patent/JP4750713B2/ja not_active Expired - Fee Related
- 2004-11-16 ES ES04810027T patent/ES2307069T3/es not_active Expired - Lifetime
- 2004-11-16 DE DE602004014188T patent/DE602004014188D1/de not_active Expired - Lifetime
- 2004-11-16 US US10/578,991 patent/US7468449B2/en not_active Expired - Fee Related
- 2004-11-16 EP EP04810027A patent/EP1692123B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US20070105951A1 (en)	2007-05-10
EP1692123A1 (de)	2006-08-23
DE602004014188D1 (de)	2008-07-10
JP2007512326A (ja)	2007-05-17
JP4750713B2 (ja)	2011-08-17
WO2005051936A1 (en)	2005-06-09
US7468449B2 (en)	2008-12-23
CA2546729A1 (en)	2005-06-09
ES2307069T3 (es)	2008-11-16
EP1692123B1 (de)	2008-05-28

Legal Events

Date	Code	Title	Description
2008-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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ATE455749T1 (de)	2010-02-15	Verbindungen mit verbrückten ringen als pharmazeutische mittel
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DE602005027322D1 (de)	2011-05-19	Verwendung von antikörpern gegen tweak zur behandlung von schlaganfall
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AU2002251873A1 (en)	2002-08-19	Methods and compositions for modulating gluconeogenesis using pgc-1