DE69920455D1 - Bis-indolederivate und ihre verwendung als entzündungshemmende mittel - Google Patents

Bis-indolederivate und ihre verwendung als entzündungshemmende mittel

Info

Publication number
DE69920455D1
DE69920455D1 DE69920455T DE69920455T DE69920455D1 DE 69920455 D1 DE69920455 D1 DE 69920455D1 DE 69920455 T DE69920455 T DE 69920455T DE 69920455 T DE69920455 T DE 69920455T DE 69920455 D1 DE69920455 D1 DE 69920455D1
Authority
DE
Germany
Prior art keywords
bis
compounds
indolederivate
inflammatory agent
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69920455T
Other languages
English (en)
Other versions
DE69920455T2 (de
Inventor
E Wright
Ralph Mattern
S Jacobs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
University of California Berkeley
Harbor Branch Oceanographic Institute Foundation Inc
Original Assignee
University of California
Harbor Branch Oceanographic Institution Inc
University of California Berkeley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California, Harbor Branch Oceanographic Institution Inc, University of California Berkeley filed Critical University of California
Application granted granted Critical
Publication of DE69920455D1 publication Critical patent/DE69920455D1/de
Publication of DE69920455T2 publication Critical patent/DE69920455T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69920455T 1998-07-08 1999-07-08 Bis-indolederivate und ihre verwendung als entzündungshemmende mittel Expired - Fee Related DE69920455T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9199198P 1998-07-08 1998-07-08
US91991P 1998-07-08
PCT/US1999/015376 WO2000002857A1 (en) 1998-07-08 1999-07-08 Bis-indole derivatives and their use as antiinflammatory agents

Publications (2)

Publication Number Publication Date
DE69920455D1 true DE69920455D1 (de) 2004-10-28
DE69920455T2 DE69920455T2 (de) 2005-01-20

Family

ID=22230663

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69920455T Expired - Fee Related DE69920455T2 (de) 1998-07-08 1999-07-08 Bis-indolederivate und ihre verwendung als entzündungshemmende mittel

Country Status (8)

Country Link
US (2) US6323233B1 (de)
EP (1) EP1093455B1 (de)
JP (1) JP2002520315A (de)
AT (1) ATE277010T1 (de)
CA (1) CA2335254A1 (de)
DE (1) DE69920455T2 (de)
ES (1) ES2229736T3 (de)
WO (1) WO2000002857A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6589975B2 (en) 1998-07-08 2003-07-08 The Regents Of The University Of California Synthetic compounds for treatment of inflammation
JP2002520315A (ja) * 1998-07-08 2002-07-09 ハーバー ブランチ オーシャノグラフィック インスティテューション インク． ビスインドール誘導体および抗炎症剤としてのそれらの使用
WO2003022274A2 (en) 2001-09-13 2003-03-20 Synta Pharmaceuticals Corp. 2-aroylimidazole compounds for treating cancer
US6800655B2 (en) * 2002-08-20 2004-10-05 Sri International Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
US7074938B2 (en) * 2002-11-19 2006-07-11 The Regents Of The University Of California Method for the synthesis of soritin compounds
US7232771B2 (en) * 2003-11-04 2007-06-19 Regents Of The University Of Minnesota Method and apparatus for depositing charge and/or nanoparticles
US7592269B2 (en) * 2003-11-04 2009-09-22 Regents Of The University Of Minnesota Method and apparatus for depositing charge and/or nanoparticles
US7989486B2 (en) 2004-12-30 2011-08-02 Bioresponse, L.L.C. Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associated conditions
JP2008545663A (ja) * 2005-05-27 2008-12-18 クイーンズ ユニバーシティ アット キングストン タンパク質フォールディング障害の治療
UA95788C2 (en) 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
WO2008057253A2 (en) 2006-10-27 2008-05-15 Bioresponse, L.L.C. Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
WO2008091581A1 (en) 2007-01-22 2008-07-31 The University Of Minnesota Nanoparticles with grafted organic molecules
WO2016164770A1 (en) 2015-04-10 2016-10-13 Bioresponse, L.L.C. Self-emulsifying formulations of dim-related indoles
CN108822116A (zh) * 2018-06-04 2018-11-16 南京中医药大学 具有抗肿瘤活性的吲哚生物碱及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1403617A (fr) 1962-04-02 1965-06-25 Rhone Poulenc Sa Nouveaux dérivés de l'indole et leur préparation
US4866084A (en) * 1987-07-17 1989-09-12 Harbor Branch Oceanographic Institution, Inc. Topsentin compounds effective against viruses and certain tumors
CA2015996C (en) 1989-05-05 2001-08-28 Hartmut Osswald Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals
US4970226A (en) 1989-10-03 1990-11-13 Harbor Branch Oceanographic Institution, Inc. Bis-indole imidazole compounds which are useful antitumor and antimicrobial agents
CA2046801C (en) * 1990-08-07 2002-02-26 Peter D. Davis Substituted pyrroles
US5290777A (en) 1993-02-24 1994-03-01 Regents Of The Univ. Of California Use for topsentin compounds and pharmaceutical compositions containing same
JP2001503414A (ja) 1996-10-31 2001-03-13 ハーバー ブランチ オーシャノグラフィック インスティテューション インク． 抗神経性炎症化合物および組成物ならびにその使用法
EP0887348A1 (de) 1997-06-25 1998-12-30 Boehringer Mannheim Italia S.p.A. Bis-Indolderivative mit antimetastatischer Wirkung, Verfahren für deren Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
JP2002520315A (ja) * 1998-07-08 2002-07-09 ハーバー ブランチ オーシャノグラフィック インスティテューション インク． ビスインドール誘導体および抗炎症剤としてのそれらの使用

Also Published As

Publication number Publication date
US20010056112A1 (en) 2001-12-27
WO2000002857A1 (en) 2000-01-20
DE69920455T2 (de) 2005-01-20
EP1093455A1 (de) 2001-04-25
ATE277010T1 (de) 2004-10-15
EP1093455B1 (de) 2004-09-22
WO2000002857A9 (en) 2000-07-20
ES2229736T3 (es) 2005-04-16
US6444697B2 (en) 2002-09-03
US6323233B1 (en) 2001-11-27
CA2335254A1 (en) 2000-01-20
JP2002520315A (ja) 2002-07-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee