ATE397017T1 - Verfahren zur herstellung von insulinvorläufern und von analogen von insulinvorläufern - Google Patents

Verfahren zur herstellung von insulinvorläufern und von analogen von insulinvorläufern

Info

Publication number: ATE397017T1
Authority: AT; Austria
Prior art keywords: insulin precursors; precursors; insulin; analogues; precursor analogs
Prior art date: 1999-12-29

Application number

AT00981169T

Other languages

English (en)

Inventor

Thomas Kjeldsen

Svend Ludvigsen

Niels Kaarsholm

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-29

Filing date

2000-12-04

Publication date

2008-06-15

2000-12-04 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2008-06-15 Application granted granted Critical

2008-06-15 Publication of ATE397017T1 publication Critical patent/ATE397017T1/de

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 11
239000002243 precursor Substances 0.000 title abstract 8
102000004877 Insulin Human genes 0.000 title abstract 5
108090001061 Insulin Proteins 0.000 title abstract 5
229940125396 insulin Drugs 0.000 title abstract 5
238000004519 manufacturing process Methods 0.000 title 1
102000040430 polynucleotide Human genes 0.000 abstract 2
108091033319 polynucleotide Proteins 0.000 abstract 2
239000002157 polynucleotide Substances 0.000 abstract 2
VOUAQYXWVJDEQY-QENPJCQMSA-N 33017-11-7 Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 VOUAQYXWVJDEQY-QENPJCQMSA-N 0.000 abstract 1
108010075254 C-Peptide Proteins 0.000 abstract 1
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
239000013598 vector Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Toxicology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT00981169T 1999-12-29 2000-12-04 Verfahren zur herstellung von insulinvorläufern und von analogen von insulinvorläufern ATE397017T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DKPA199901868		1999-12-29
DKPA200000440		2000-03-17

Publications (1)

Publication Number	Publication Date
ATE397017T1 true ATE397017T1 (de)	2008-06-15

Family

ID=26066172

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00981169T ATE397017T1 (de)	1999-12-29	2000-12-04	Verfahren zur herstellung von insulinvorläufern und von analogen von insulinvorläufern

Country Status (13)

Country	Link
EP (1)	EP1246845B1 (de)
JP (1)	JP4773023B2 (de)
KR (1)	KR20030004317A (de)
CN (1)	CN100432104C (de)
AT (1)	ATE397017T1 (de)
AU (1)	AU1850601A (de)
BR (1)	BR0016867A (de)
CA (1)	CA2392840C (de)
DE (1)	DE60039074D1 (de)
ES (1)	ES2307544T3 (de)
HU (1)	HUP0203475A3 (de)
RU (1)	RU2283846C2 (de)
WO (1)	WO2001049742A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7105314B2 (en)	2001-04-02	2006-09-12	Novo Nordisk A/S	Method for making human insulin precursors
EP1377608B1 (de) *	2001-04-02	2009-09-16	Novo Nordisk A/S	Insulinvorstufen und verfahren zu deren herstellung
CA2464616C (en)	2001-11-19	2012-07-24	Are Bogsnes	Process for preparing insulin compounds
WO2004085472A1 (en) *	2003-03-27	2004-10-07	Novo Nordisk A/S	Method for making human insulin precursors and human insulin
ES2369895T3 (es) *	2003-12-03	2011-12-07	Novo Nordisk A/S	Insulina monocatenaria.
CN100460508C (zh) *	2004-11-03	2009-02-11	马延高	人胰岛素基因在甲醇酵母中的分泌表达方法
US8575096B2 (en)	2007-08-13	2013-11-05	Novo Nordisk A/S	Rapid acting insulin analogues
AU2008288413B2 (en)	2007-08-15	2013-09-26	Novo Nordisk A/S	Insulin analogues with an acyl and aklylene glycol moiety
WO2009022006A1 (en)	2007-08-15	2009-02-19	Novo Nordisk A/S	Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids
EP2262539B1 (de)	2008-04-01	2015-07-15	Novo Nordisk A/S	Insulin-albumin-konzentrate
EP2585484A1 (de)	2010-06-23	2013-05-01	Novo Nordisk A/S	Zusätzliche disulfidbindungen enthaltende insulinanaloga
EP2585483A1 (de)	2010-06-23	2013-05-01	Novo Nordisk A/S	Humane insulinanaloga mit zusätzlichen disulfid-bindungen
CA2802510A1 (en)	2010-06-23	2011-12-29	Novo Nordisk A/S	Insulin derivatives containing additional disulfide bonds
EP2720711A1 (de)	2011-06-15	2014-04-23	Novo Nordisk A/S	Mehrfach substituierte insuline
CN104788556A (zh) *	2011-12-15	2015-07-22	上海恒瑞医药有限公司	人胰岛素类似物及其酰化衍生物
US20160115216A1 (en) *	2013-06-07	2016-04-28	Novo Nordisk A/S	Method for Making Mature Insulin Polypeptides
CN105087724B (zh) *	2014-05-04	2019-12-03	重庆派金生物科技有限公司	酵母重组表达门冬胰岛素的制备方法
CN107417787B (zh) *	2016-05-23	2020-11-17	江苏恒瑞医药股份有限公司	一种人松弛素2类似物的制备方法
CN107446039B (zh) *	2016-05-31	2021-11-12	江苏恒瑞医药股份有限公司	一种人胰岛素类似物前体及其制备方法
CN106699872B (zh) *	2016-12-27	2019-12-24	江南大学	一种提高胰岛素前体产量的方法
CA3071686A1 (en)	2017-08-17	2019-02-21	Novo Nordisk A/S	Novel acylated insulin analogues and uses thereof
CN108148114B (zh) *	2017-12-08	2020-05-15	珠海冀百康生物科技有限公司	一种提高重组小分子蛋白表达量的串联前导肽及方法
CN108929370B (zh) *	2018-07-15	2021-06-25	渤海大学	三种具有ace抑制活性的鸡蛋源活性肽
EP3852873A1 (de)	2018-09-19	2021-07-28	Ziylo Ltd	Glucose-empfindliche insuline und verwendungen davon
CN113773392B (zh) *	2020-06-09	2023-04-07	宁波鲲鹏生物科技有限公司	一种甘精胰岛素的制备方法
WO2022090448A1 (en)	2020-10-30	2022-05-05	Novo Nordisk A/S	Novel acylating reagents
WO2023144240A1 (en)	2022-01-26	2023-08-03	Novo Nordisk Research Centre Oxford Limited	Glucose sensitive insulin derivatives and uses thereof
WO2025099208A1 (en)	2023-11-10	2025-05-15	Intervet International B.V.	Recombinant insulin precursor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK58285D0 (da) *	1984-05-30	1985-02-08	Novo Industri As	Peptider samt fremstilling og anvendelse deraf
WO1995016708A1 (en) *	1993-12-17	1995-06-22	Novo Nordisk A/S	Proinsulin-like compounds
KR0150565B1 (ko) *	1995-02-15	1998-08-17	김정재	유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법

2000
- 2000-12-04 RU RU2002120512/13A patent/RU2283846C2/ru not_active IP Right Cessation
- 2000-12-04 JP JP2001550282A patent/JP4773023B2/ja not_active Expired - Fee Related
- 2000-12-04 HU HU0203475A patent/HUP0203475A3/hu unknown
- 2000-12-04 AU AU18506/01A patent/AU1850601A/en not_active Abandoned
- 2000-12-04 CN CNB008179603A patent/CN100432104C/zh not_active Expired - Lifetime
- 2000-12-04 WO PCT/DK2000/000665 patent/WO2001049742A1/en not_active Ceased
- 2000-12-04 BR BR0016867-0A patent/BR0016867A/pt not_active Application Discontinuation
- 2000-12-04 KR KR1020027008588A patent/KR20030004317A/ko not_active Withdrawn
- 2000-12-04 CA CA2392840A patent/CA2392840C/en not_active Expired - Fee Related
- 2000-12-04 ES ES00981169T patent/ES2307544T3/es not_active Expired - Lifetime
- 2000-12-04 DE DE60039074T patent/DE60039074D1/de not_active Expired - Lifetime
- 2000-12-04 AT AT00981169T patent/ATE397017T1/de not_active IP Right Cessation
- 2000-12-04 EP EP00981169A patent/EP1246845B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP2003518945A (ja)	2003-06-17
CA2392840A1 (en)	2001-07-12
CN1414974A (zh)	2003-04-30
EP1246845A1 (de)	2002-10-09
HUP0203475A3 (en)	2005-11-28
HUP0203475A2 (hu)	2003-02-28
DE60039074D1 (de)	2008-07-10
JP4773023B2 (ja)	2011-09-14
RU2002120512A (ru)	2004-01-27
WO2001049742A1 (en)	2001-07-12
RU2283846C2 (ru)	2006-09-20
PL355871A1 (en)	2004-05-31
KR20030004317A (ko)	2003-01-14
AU1850601A (en)	2001-07-16
CA2392840C (en)	2012-07-17
ES2307544T3 (es)	2008-12-01
BR0016867A (pt)	2002-10-08
EP1246845B1 (de)	2008-05-28
CN100432104C (zh)	2008-11-12

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Legal Events

Date	Code	Title	Description
2008-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties