ATE398636T1 - Polyamin-polymere - Google Patents

Polyamin-polymere

Info

Publication number
ATE398636T1
ATE398636T1 AT04810309T AT04810309T ATE398636T1 AT E398636 T1 ATE398636 T1 AT E398636T1 AT 04810309 T AT04810309 T AT 04810309T AT 04810309 T AT04810309 T AT 04810309T AT E398636 T1 ATE398636 T1 AT E398636T1
Authority
AT
Austria
Prior art keywords
anion
binding polymers
cases
binding
polymers
Prior art date
Application number
AT04810309T
Other languages
English (en)
Inventor
Han Chang
Dominique Charmot
Samir Zard
Original Assignee
Ilypsa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/701,385 external-priority patent/US7385012B2/en
Priority claimed from US10/806,495 external-priority patent/US7335795B2/en
Application filed by Ilypsa Inc filed Critical Ilypsa Inc
Application granted granted Critical
Publication of ATE398636T1 publication Critical patent/ATE398636T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F26/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F26/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F26/06—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C08G73/0213—Preparatory process
    • C08G73/022—Preparatory process from polyamines and epihalohydrins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
    • C08L39/02—Homopolymers or copolymers of vinylamine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Steroid Compounds (AREA)
AT04810309T 2003-11-03 2004-11-03 Polyamin-polymere ATE398636T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/701,385 US7385012B2 (en) 2003-11-03 2003-11-03 Polyamine polymers
US10/806,495 US7335795B2 (en) 2004-03-22 2004-03-22 Crosslinked amine polymers
US10/965,044 US7459502B2 (en) 2003-11-03 2004-10-13 Pharmaceutical compositions comprising crosslinked polyamine polymers

Publications (1)

Publication Number Publication Date
ATE398636T1 true ATE398636T1 (de) 2008-07-15

Family

ID=34557428

Family Applications (5)

Application Number Title Priority Date Filing Date
AT04810309T ATE398636T1 (de) 2003-11-03 2004-11-03 Polyamin-polymere
AT07109664T ATE414730T1 (de) 2003-11-03 2004-11-03 Anionenbindende polymere und ihre verwendung
AT07108283T ATE546482T1 (de) 2003-11-03 2004-11-03 Anionenbindende polymere und ihre verwendung
AT04810316T ATE364057T1 (de) 2003-11-03 2004-11-03 Anionenbindende polymere und ihre verwendungen
AT08164715T ATE445662T1 (de) 2003-11-03 2004-11-03 Anionbindende polymere sowie deren verwendung

Family Applications After (4)

Application Number Title Priority Date Filing Date
AT07109664T ATE414730T1 (de) 2003-11-03 2004-11-03 Anionenbindende polymere und ihre verwendung
AT07108283T ATE546482T1 (de) 2003-11-03 2004-11-03 Anionenbindende polymere und ihre verwendung
AT04810316T ATE364057T1 (de) 2003-11-03 2004-11-03 Anionenbindende polymere und ihre verwendungen
AT08164715T ATE445662T1 (de) 2003-11-03 2004-11-03 Anionbindende polymere sowie deren verwendung

Country Status (17)

Country Link
US (1) US7459502B2 (de)
EP (5) EP1687349B1 (de)
JP (3) JP3996944B2 (de)
KR (1) KR101052581B1 (de)
AT (5) ATE398636T1 (de)
AU (1) AU2004285609B2 (de)
BR (1) BRPI0416172A (de)
CA (1) CA2542730C (de)
CY (3) CY1107728T1 (de)
DE (5) DE602004023661D1 (de)
DK (3) DK1854826T3 (de)
ES (4) ES2287806T3 (de)
GB (1) GB2426248B (de)
PL (3) PL1854826T3 (de)
PT (3) PT1854826E (de)
SI (3) SI1854826T1 (de)
WO (2) WO2005041902A2 (de)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
US20040161474A1 (en) * 2002-05-24 2004-08-19 Moerck Rudi E. Rare earth metal compounds methods of making, and methods of using the same
US20060083791A1 (en) 2002-05-24 2006-04-20 Moerck Rudi E Rare earth metal compounds methods of making, and methods of using the same
DK2792363T3 (da) * 2003-08-26 2016-09-26 Shire Biopharmaceuticals Holdings Ireland Ltd Farmaceutisk formulering, der omfatter lanthanforbindelser
US7381428B2 (en) 2003-08-26 2008-06-03 Shire International Licensing B.V. Stabilized lanthanum carbonate compositions
US7385012B2 (en) 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
US7767768B2 (en) * 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7449605B2 (en) * 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
US7459502B2 (en) * 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
US7608674B2 (en) * 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7335795B2 (en) * 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US20060134225A1 (en) * 2004-10-15 2006-06-22 Moerck Rudi E Phosphate binder with reduced pill burden
US7985418B2 (en) 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
US20060177415A1 (en) * 2004-11-01 2006-08-10 Burke Steven K Once a day formulation for phosphate binders
ITME20040015A1 (it) 2004-12-07 2005-03-07 Vincenzo Savica Chewing gum, caramelle gommose, pastiglie, compresse a lento rilascio di chelanti fosfato e/o fosforo salivare e capsule a lento rilascio di chelanti fosfato e/o fosforo a livello gastroenterico.
WO2007022466A2 (en) * 2005-08-17 2007-02-22 Altairnano, Inc. Hyperphosphatemia in domestic animals: compositions and methods of treatment
WO2007022445A2 (en) * 2005-08-17 2007-02-22 Altairnano, Inc. Treatment of chronic renal failure and other conditions in domestic animals: compositions and methods
JP2009507019A (ja) 2005-09-02 2009-02-19 ジェンザイム・コーポレーション リン酸塩を除去する方法およびそれに使用される重合体
US8114393B2 (en) * 2005-09-14 2012-02-14 Wisconsin Alumni Research Foundation Methods and compositions for phosphate binding
EP1924256A1 (de) 2005-09-14 2008-05-28 Wisconsin Alumni Research Foundation Zusammensetzung mit einem dendrimer und deren verwendung zur phosphatbindung
CN103027896B (zh) * 2005-09-15 2016-01-20 基酶有限公司 胺聚合物的小袋制剂
AU2012205214B2 (en) * 2005-09-15 2015-05-21 Genzyme Corporation Formulation for Amine Polymers
CN101321519A (zh) * 2005-09-30 2008-12-10 伊立普萨公司 制备含有交联壳的核-壳型复合物的方法及其得到的核-壳型复合物
JP2009510126A (ja) * 2005-09-30 2009-03-12 レリプサ, インコーポレイテッド 哺乳類の胃腸管からカリウムイオンを選択的に除去するための方法および組成物
DK1973529T3 (da) * 2006-01-05 2011-09-12 Veloxis Pharmaceuticals As Fyldbar tablet, som er i stand til at falde hen
US20070177866A1 (en) * 2006-01-31 2007-08-02 Yoshizo Fujimoto Camera extension arm
WO2007094779A1 (en) * 2006-02-14 2007-08-23 Teva Pharmaceutical Industries Ltd. Pharmaceutical formulations of aliphatic amine polymers and methods for their manufacture
CN100398112C (zh) * 2006-03-24 2008-07-02 辽宁诺康生物制药有限责任公司 一种治疗血磷酸盐过多症的药物及其制备方法
JP2009536246A (ja) * 2006-05-05 2009-10-08 ゲンズイメ コーポレーション ホスフェート捕捉剤としてのアミン縮合重合体
US20100124542A1 (en) * 2006-07-18 2010-05-20 Genzyme Corporation Amine dendrimers
US7964182B2 (en) * 2006-09-01 2011-06-21 USV, Ltd Pharmaceutical compositions comprising phosphate-binding polymer
EP2441779A1 (de) * 2006-09-01 2012-04-18 USV Limited Verfahren zur Herstellung von Sevelamerhydrochlorid und Formulierung daraus
BRPI0717545A2 (pt) 2006-09-29 2013-10-22 Gezyme Corp Composição farmacêutica, método para tratar uma doença, polímero de amida, rede de polímero, e, método para preparar um polímero de amida
JP2010513271A (ja) * 2006-12-14 2010-04-30 ゲンズイメ コーポレーション アミド−アミンポリマー組成物
US20100129309A1 (en) * 2007-02-23 2010-05-27 Dhal Pradeep K Amine polymer compositions
US20100196305A1 (en) * 2007-03-08 2010-08-05 Dhal Pradeep K Sulfone polymer compositions
EP2152277A1 (de) * 2007-04-27 2010-02-17 Genzyme Corporation Amido-amin-dendrimer-zusammensetzungen
JPWO2009008480A1 (ja) * 2007-07-11 2010-09-09 東レ株式会社 架橋ポリアリルアミン又はその酸付加塩、及びその医薬用途
EP2016947A1 (de) * 2007-07-17 2009-01-21 Chemo Ibérica, S.A. Neuartiges Verfahren zur Herstellung vernetzter Poly(allylamin-)Polymere in einem einzigen Schritt
WO2009023544A2 (en) * 2007-08-10 2009-02-19 Ilypsa, Inc. Dosage unit anion-exchange polymer pharmaceutical compositions
WO2009034540A1 (en) * 2007-09-11 2009-03-19 Ranbaxy Laboratories Limited Pharmaceutical composition of sevelamer
JP5332520B2 (ja) * 2007-11-07 2013-11-06 アステラス製薬株式会社 医薬用錠剤
WO2009097127A1 (en) * 2008-01-31 2009-08-06 Genzyme Corporation Pharmaceutical compositions
WO2009154747A1 (en) * 2008-06-20 2009-12-23 Genzyme Corporation Pharmaceutical compositions
US20110081413A1 (en) * 2009-01-22 2011-04-07 Ashok Omray Pharmaceutical Compositions Comprising Phosphate-Binding Polymer
IT1394299B1 (it) * 2009-05-12 2012-06-06 Chimico Internaz Spa Lab Procedimento per la preparazione di sevelamer
ES2549513T3 (es) 2010-02-24 2015-10-28 Relypsa, Inc. Polivinilamina, polialilamina y polietilenimina reticuladas para uso como secuestradores de ácidos biliares
BR112012021448A2 (pt) * 2010-02-24 2016-05-31 Relypsa Inc polímero de amina, método para tratar doença, método de remoção de sais biliares de um indivíduo animal, método para melhorar o controle glicêmico em um indivíduo, e, processo para preparar o polímero de amina.
RU2017106587A (ru) * 2010-02-24 2019-01-21 Релипса, Инк. Аминосодержащие полимеры для применения в качестве секвестрантов желчных кислот
AU2011252983C1 (en) 2010-05-12 2015-02-19 Unicycive Therapeutics, Inc. Lanthanum carbonate hydroxide, lanthanum oxycarbonate and methods of their manufacture and use
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9302922B2 (en) 2012-01-30 2016-04-05 California Institute Of Technology Filtration membranes and related compositions, methods and systems
US10369529B2 (en) 2012-01-30 2019-08-06 California Institute Of Technology Mixed matrix membranes with embedded polymeric particles and networks and related compositions, methods, and systems
EP2557074A1 (de) 2011-08-11 2013-02-13 Astellas Pharma Inc. Verfahren zur Herstellung von N,N,N',N'-tetrakis(3-aminpropyl)-1,4-butanediamin
WO2014015121A1 (en) 2012-07-19 2014-01-23 Georgia-Pacific Chemicals Llc High efficiency wet strength resins from new cross-linkers
CA2906501A1 (en) * 2013-03-15 2014-09-25 Genzyme Corporation Sequestrants of advanced glycation end product (age) precursors
KR102633597B1 (ko) 2013-06-05 2024-02-06 트리시다, 인크. 경구 투여를 위한 양성자-결합 중합체
US10435528B2 (en) 2013-09-17 2019-10-08 Aquanano Llc High-capacity anion exchange materials
JP5843986B2 (ja) * 2014-03-25 2016-01-13 アステラス製薬株式会社 粒状医薬組成物
WO2016043808A1 (en) 2014-09-17 2016-03-24 Aquanano Llc High-capacity anion exchange material
IL322207A (en) * 2014-12-10 2025-09-01 Tricida Inc Proton-binding polymers for oral administration
BR112017021396A2 (pt) 2015-04-06 2018-07-03 3M Innovative Properties Company composição em gel, filme e método para aplicação de uma composição em gel
MX2017015378A (es) * 2015-05-29 2018-03-15 Ecolab Usa Inc Resinas de resistencia a la humedad de alta eficiencia de nuevos reticuladores.
IL262660B2 (en) * 2016-05-06 2024-04-01 Tricida Inc Compositions for and method of treating acid-base disorders
JP6792640B2 (ja) 2016-12-28 2020-11-25 富士フイルム株式会社 窒素原子含有ポリマー又はその塩の乳化液、その製造方法、及び粒子の製造方法
CN107141408A (zh) * 2017-06-12 2017-09-08 厦门建霖健康家居股份有限公司 一种抗菌聚合物及其制备方法
US10934380B1 (en) 2017-09-25 2021-03-02 Tricida, Inc. Crosslinked poly(allylamine) polymer pharmaceutical compositions
JP7018451B2 (ja) 2017-10-16 2022-02-10 富士フイルム株式会社 高リン血症治療剤および粒子
EP3698799B1 (de) * 2017-10-16 2022-01-26 FUJIFILM Corporation Mittel zur behandlung von hyperphosphatämie
IL319146A (en) 2017-11-03 2025-04-01 Tricida Inc Compositions for and method of treating acid-base disorders
JP2021093979A (ja) * 2019-12-18 2021-06-24 太陽化学株式会社 難水溶性物質含有組成物
CN111521705B (zh) * 2020-05-05 2021-04-20 大连润生康泰医学检验实验室有限公司 一种血清中胆汁酸的富集方法
WO2023064357A1 (en) * 2021-10-13 2023-04-20 Tricida, Inc. Pharmaceutical compositions for the treatment of lithiasis disorders
CN115260355A (zh) * 2022-05-16 2022-11-01 江苏中天药业有限公司 一种阴离子交换树脂、其制备方法、该树脂与药物的复合物和其掩味制剂

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US814789A (en) 1904-12-21 1906-03-13 Edward D Mackintosh Drawing and plotting device.
US3308020A (en) * 1961-09-22 1967-03-07 Merck & Co Inc Compositions and method for binding bile acids in vivo including hypocholesteremics
US3499960A (en) * 1965-01-25 1970-03-10 Merck & Co Inc Palatable coated particles of an anion exchange resin
US3692895A (en) * 1970-09-08 1972-09-19 Norman A Nelson Method of reducing hypercholesteremia in humans employing a copolymer of polyethylenepolyamine and a bifunctional substance, such as epichlorohydria
US3974272A (en) * 1972-09-01 1976-08-10 Merck & Co., Inc. Palatable cholestyramine coacervate compositions
US4027009A (en) * 1973-06-11 1977-05-31 Merck & Co., Inc. Compositions and methods for depressing blood serum cholesterol
US3930810A (en) * 1974-07-31 1976-01-06 Universal Oil Products Company Additives for petroleum distillates
US4015939A (en) * 1976-05-12 1977-04-05 Bio-Rad Laboratories, Inc. Competitive binding thyroid assay with improved bound-free separation step
US4135880A (en) * 1977-08-19 1979-01-23 Bio-Rad Laboratories, Inc. Folate assay with ion exchange resin bound-free separation
US4362711A (en) 1980-07-11 1982-12-07 Evreka Inc. Blood cholesterol level reducing agent and method
US4410688A (en) * 1981-04-29 1983-10-18 Allied Corporation Macromolecular highly branched homogeneous compound
US4568737A (en) * 1983-01-07 1986-02-04 The Dow Chemical Company Dense star polymers and dendrimers
US4631337A (en) * 1983-01-07 1986-12-23 The Dow Chemical Company Hydrolytically-stable dense star polyamine
US4558120A (en) * 1983-01-07 1985-12-10 The Dow Chemical Company Dense star polymer
US4507466A (en) * 1983-01-07 1985-03-26 The Dow Chemical Corporation Dense star polymers having core, core branches, terminal groups
US4737550A (en) * 1983-01-07 1988-04-12 The Dow Chemical Company Bridged dense star polymers
JPS6090243A (ja) * 1983-10-25 1985-05-21 Nitto Boseki Co Ltd 小球状モノアリルアミン橋かけ重合体の製造方法
US4587329A (en) * 1984-08-17 1986-05-06 The Dow Chemical Company Dense star polymers having two dimensional molecular diameter
US4599400A (en) * 1984-12-18 1986-07-08 The Dow Chemical Company Star/comb-branched polyamide
US4747881A (en) * 1985-02-05 1988-05-31 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4734200A (en) * 1986-04-04 1988-03-29 Advanced Separation Technologies Incorporated Process for removal of fluoride and phosphorus-type contaminants from acidic wastewater
IT1190349B (it) * 1986-06-16 1988-02-16 Prodotti Formenti Srl Composizioni farmaceutiche ad attivita' sequestrante degli acidi biliari contenenti colestiramina quale principio attivo,e procedimento per prepararle
US5338532A (en) * 1986-08-18 1994-08-16 The Dow Chemical Company Starburst conjugates
US5807582A (en) * 1988-08-26 1998-09-15 Pharmacia & Upjohn Company Fine-beaded colestipol hydrochloride and pharmaceutically elegant dosage forms made therefrom
GB8829088D0 (en) 1988-12-13 1989-01-25 Smith Kline French Lab Compounds
US5091175A (en) * 1990-05-14 1992-02-25 Erbamont Inc. Pharmaceutical composition containing bile acid sequestrant enclosed in a size-exclusion membrane
FR2680791B1 (fr) * 1991-08-30 1994-09-09 Bp Chemicals Snc Procede de fabrication d'un polymere reticule et utilisation du polymere.
US5530092A (en) * 1992-01-13 1996-06-25 Dsm N.V. Dendritic macromolecule and the preparation thereof
BR9303946A (pt) 1992-01-13 1994-08-02 Dsm Nv Macromolécula dendrítica e preparação da mesma
BE1007260A3 (nl) 1993-07-08 1995-05-02 Dsm Nv Werkwijze voor het bereiden van een dendritisch macromolekuul.
US5380522A (en) * 1992-08-11 1995-01-10 Day; Charles E. Method for treatment of irritable bowel syndrome
US5556619A (en) 1992-08-20 1996-09-17 The Du Pont Merck Pharmaceutical Company Crosslinked polymeric ammonium salts
US5451397A (en) * 1992-12-21 1995-09-19 Rohm And Haas Company Bile acid sequestrant
EP0684958B1 (de) 1993-02-17 1998-06-10 Btg International Limited 1 guanidino gruppen enthaltende polymere zur verwendung in der therapie
US5487888A (en) * 1993-05-20 1996-01-30 Geltex, Inc. Iron-binding polymers for oral administration
WO1994027619A1 (en) 1993-05-20 1994-12-08 Geltex Pharmaceuticals, Inc. Process for adjusting ion concentration in a patient and compositions therefor
US5618530A (en) * 1994-06-10 1997-04-08 Geltex Pharmaceuticals, Inc. Hydrophobic amine polymer sequestrant and method of cholesterol depletion
US6129910A (en) * 1993-06-02 2000-10-10 Geltex Pharmaceuticals, Inc. Water-insoluble noncrosslinked bile acid sequestrants
US5607669A (en) * 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
CA2129079C (en) * 1993-08-03 2006-01-17 Tatsuo Nomura Orally administrable cholesterol lowering agent
US5496545A (en) * 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5667775A (en) * 1993-08-11 1997-09-16 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5414068A (en) 1994-01-24 1995-05-09 Rohm And Haas Company Crosslinked anion exchange particles and method for producing the particles
ES2118554T3 (es) 1994-01-28 1998-09-16 Dsm Nv Macromolecula dendritica y procedimiento para su preparacion.
BE1008134A3 (nl) 1994-03-16 1996-01-23 Dsm Nv Bereiding van stervormig vertakte polymeren.
TW474813B (en) * 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
GB9503061D0 (en) * 1995-02-16 1995-04-05 British Tech Group Polymeric compounds
US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
NL1001973C2 (nl) * 1995-12-21 1997-06-24 Stork Friesland Bv Semipermeabel composietmembraan.
NL1001977C2 (nl) 1995-12-22 1997-06-24 Dsm Nv Werkwijze voor de bereiding van een macromolekuul.
EP0793960B1 (de) * 1996-03-05 2001-08-01 Mitsubishi Chemical Corporation Verwendung von Anionenaustauscherharzen zur Herstellung eines Arzneimittels zur Behandlung der Hyperphosphatemie
JP3885130B2 (ja) 1996-06-11 2007-02-21 株式会社大塚製薬工場 グアニジノ化合物低下剤並びに水分及びカリウムイオン吸着剤
US6034129A (en) * 1996-06-24 2000-03-07 Geltex Pharmaceuticals, Inc. Ionic polymers as anti-infective agents
AU3649697A (en) 1996-06-27 1998-01-14 G.D. Searle & Co. Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications
CN1230118A (zh) * 1996-07-19 1999-09-29 日研化学株式会社 高磷血症治疗剂
WO1998017707A1 (en) * 1996-10-23 1998-04-30 The Dow Chemical Company Water-soluble polymers for the reduction of dietary phosphate or oxalate absorption
JPH10130154A (ja) 1996-10-29 1998-05-19 Otsuka Pharmaceut Factory Inc 腎疾患患者用延命率改善薬
AU2446497A (en) 1997-03-25 1998-10-20 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers combined with a calcium supplement for oral administration
TW592727B (en) 1997-04-04 2004-06-21 Chugai Pharmaceutical Co Ltd Phosphate-binding polymer preparations
JP2003183168A (ja) * 1997-04-04 2003-07-03 Chugai Pharmaceut Co Ltd リン酸結合性ポリマー含有製剤
US6423754B1 (en) * 1997-06-18 2002-07-23 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with polyallylamine polymers
CN1210390C (zh) 1997-09-15 2005-07-13 普罗格特-甘布尔公司 含有基于直链胺的聚合物以改善被洗涤织物的外观和完整效果的洗衣洗涤剂组合物
US6007803A (en) * 1997-09-19 1999-12-28 Geltex Pharmaceuticals, Inc. Ionic polymers as toxin binding agents
US20040170600A1 (en) * 1997-10-22 2004-09-02 Jaime Simon Water-soluble polymers for the reduction of dietary phosphate or oxalate absorption
US6566407B2 (en) * 1997-11-05 2003-05-20 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
US5985938A (en) * 1997-11-05 1999-11-16 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
US6726905B1 (en) * 1997-11-05 2004-04-27 Genzyme Corporation Poly (diallylamines)-based phosphate binders
JP2001526212A (ja) * 1997-12-19 2001-12-18 スミスクライン・ビーチャム・コーポレイション 咀嚼分散性錠剤の製造法
WO1999040990A1 (en) 1998-02-17 1999-08-19 University Of Maryland Anion binding polymers and the use thereof
US6333051B1 (en) * 1998-09-03 2001-12-25 Supratek Pharma, Inc. Nanogel networks and biological agent compositions thereof
TW568788B (en) 1998-10-12 2004-01-01 Chugai Pharmaceutical Co Ltd Polymer combining with phosphoric acid and preparation containing the same
JP3363143B2 (ja) * 1998-10-12 2003-01-08 中外製薬株式会社 リン酸結合性ポリマー粒子
US6361768B1 (en) * 1998-12-29 2002-03-26 Pmd Holdings Corp. Hydrophilic ampholytic polymer
US6362266B1 (en) * 1999-09-03 2002-03-26 The Dow Chemical Company Process for reducing cohesiveness of polyallylamine polymer gels during drying
US6180754B1 (en) * 1999-09-03 2001-01-30 The Dow Chemical Company Process for producing cross-linked polyallylamine polymer
KR100794427B1 (ko) 1999-10-19 2008-01-16 젠자임 코포레이션 직접 압축형 중합체 정제 코어
US6733780B1 (en) * 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
US20020054903A1 (en) * 1999-10-19 2002-05-09 Joseph Tyler Direct compression polymer tablet core
FI109353B (fi) 1999-11-17 2002-07-15 Neste Chemicals Oy Maleimidimodifioidut poly(propyleeni-imiini)dendrimeerit ja menetelmä niiden valmistamiseksi
DE10011481A1 (de) * 2000-03-09 2001-10-18 Fresenius Hemocare Gmbh Adsorbens zum Absenken der Konzentration von Fibrinogen und/oder Fibrin, Verwendung des Adsorbens zur Herstellung eines Adsorbers und Adsorber mit dem Adsorbens
US20040059065A1 (en) * 2000-03-09 2004-03-25 Takeshi Goto Crosslinked anion-exchange resin or salt thereof
WO2001066607A1 (en) * 2000-03-09 2001-09-13 Hisamitsu Pharmaceutical Co., Inc. Crosslinked anion-exchange resin or salt thereof and phosphorus adsorbent comprising the same
AU2001241095A1 (en) * 2000-03-13 2001-09-24 Hisamitsu Pharmaceutical Co. Inc. Preventives and/or remedies for hyperphosphatemia
US6471968B1 (en) * 2000-05-12 2002-10-29 Regents Of The University Of Michigan Multifunctional nanodevice platform
MY133977A (en) * 2000-06-16 2007-11-30 Nippon Catalytic Chem Ind Crosslinked polymers containing tertiary amine and/or quaternary ammonium salt structures, processes for making and uses thereof
WO2002032974A2 (en) 2000-10-18 2002-04-25 Fujisawa Pharmaceutical Co., Ltd. Polymer and its use for the treatment and/or prevention of hyperphosphoremia
DE10056840A1 (de) 2000-11-16 2002-05-23 Basf Ag Verfahren zur Hydrierung von Nitrilen an Raney-Katalysatoren
US6908609B2 (en) * 2000-11-20 2005-06-21 Dow Global Technologies Inc. In vivo use of water absorbent polymers
WO2002066543A1 (en) * 2001-02-16 2002-08-29 Genzyme Corporation Method of drying a material having a cohesive phase
EP1373368B1 (de) 2001-03-27 2013-02-27 Firmenich SA Verbindungen zur gesteuerten freisetzung von wirkstoffen
WO2002085379A1 (en) * 2001-04-18 2002-10-31 Geltex Pharmaceuticals, Inc. Method for improving vascular access in patients with vascular shunts
WO2002085380A1 (en) * 2001-04-18 2002-10-31 Geltex Pharmaceuticals, Inc. Method for treating gout and reducing serum uric acid
CA2444347A1 (en) * 2001-04-18 2002-10-31 Genzyme Corporation Method for treating gout and binding uric acid
WO2002085383A1 (en) * 2001-04-18 2002-10-31 Genzyme Corporation Method for reducing copper levels and treating copper toxicosis
WO2002085377A1 (en) * 2001-04-18 2002-10-31 Genzyme Corporation Method for lowering serum glucose
EP1379259A1 (de) * 2001-04-18 2004-01-14 Genzyme Corporation Verfahren zur behandlung von syndrom x mit aliphatischen polyaminen
US6600011B2 (en) * 2001-10-09 2003-07-29 Genzyme Corporation Process for purification and drying of polymer hydrogels
JP3931639B2 (ja) 2001-11-19 2007-06-20 セイコーエプソン株式会社 インクジェットプリンタに使用するための水性インク組成物
US7220406B2 (en) * 2002-10-22 2007-05-22 Genzyme Corporation Method for promoting bone formation
DE10305807A1 (de) 2003-02-12 2004-08-26 Basf Ag Polymethylenamine und Verfahren zu deren Herstellung
US7459502B2 (en) * 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
US7335795B2 (en) * 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7385012B2 (en) * 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
US7449605B2 (en) * 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
US7608674B2 (en) * 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
CA2551528A1 (en) 2003-12-31 2005-07-21 Genzyme Corporation Enteric coated aliphatic amine polymer bile acid sequestrants
US20050276781A1 (en) * 2004-06-09 2005-12-15 Ross Edward A Molecularly imprinted phosphate binders for therapeutic use
ES2342947T3 (es) 2004-10-13 2010-07-19 Ilypsa, Inc. Polimeros de amina reticulados.
GB0422877D0 (en) 2004-10-14 2004-11-17 Univ Glasgow Bioactive polymers

Also Published As

Publication number Publication date
WO2005041900A3 (en) 2006-06-08
PT2009042E (pt) 2009-10-23
EP1682606A4 (de) 2006-12-20
WO2005041902A2 (en) 2005-05-12
SI2009042T1 (sl) 2009-12-31
JP5074838B2 (ja) 2012-11-14
EP1682606A2 (de) 2006-07-26
WO2005041900A2 (en) 2005-05-12
SI1854826T1 (sl) 2009-06-30
ATE364057T1 (de) 2007-06-15
DK1854826T3 (da) 2009-01-12
JP4902864B2 (ja) 2012-03-21
EP1834976A1 (de) 2007-09-19
ES2287806T3 (es) 2007-12-16
CA2542730C (en) 2012-07-10
ATE445662T1 (de) 2009-10-15
EP2009042B1 (de) 2009-10-14
EP2009042A1 (de) 2008-12-31
EP1834976B1 (de) 2012-02-22
JP2007262421A (ja) 2007-10-11
US20050131138A1 (en) 2005-06-16
DE602004017918D1 (de) 2009-01-02
ES2330693T3 (es) 2009-12-14
GB0610607D0 (en) 2006-07-05
SI1682606T1 (sl) 2007-10-31
BRPI0416172A (pt) 2007-01-16
CY1110475T1 (el) 2015-04-29
ES2308294T3 (es) 2008-12-01
EP1687349B1 (de) 2008-06-18
EP1687349A4 (de) 2006-12-27
CY1110562T1 (el) 2015-04-29
KR101052581B1 (ko) 2011-07-29
EP1854826B1 (de) 2008-11-19
DE602004014527D1 (de) 2008-07-31
EP1854826A1 (de) 2007-11-14
CA2542730A1 (en) 2005-05-12
PT1854826E (pt) 2008-12-15
DE602004006892D1 (de) 2007-07-19
DK2009042T3 (da) 2009-11-30
PL1682606T3 (pl) 2007-10-31
PT1682606E (pt) 2007-09-05
DK1682606T3 (da) 2007-10-01
DE602004006892T2 (de) 2008-02-07
ATE414730T1 (de) 2008-12-15
GB2426248B (en) 2008-08-13
PL2009042T3 (pl) 2010-05-31
AU2004285609A1 (en) 2005-05-12
JP2007510783A (ja) 2007-04-26
JP2007146180A (ja) 2007-06-14
GB2426248A (en) 2006-11-22
KR20070026338A (ko) 2007-03-08
EP1687349A2 (de) 2006-08-09
ATE546482T1 (de) 2012-03-15
WO2005041902A3 (en) 2006-05-18
JP3996944B2 (ja) 2007-10-24
CY1107728T1 (el) 2013-04-18
AU2004285609B2 (en) 2009-04-23
EP1682606B1 (de) 2007-06-06
DE112004002099T5 (de) 2007-01-04
US7459502B2 (en) 2008-12-02
PL1854826T3 (pl) 2009-06-30
DE602004023661D1 (de) 2009-11-26
HK1101697A1 (zh) 2007-10-26
ES2318823T3 (es) 2009-05-01

Similar Documents

Publication Publication Date Title
DE602004014527D1 (de) Polyamin-polymere
Guilherme et al. Superabsorbent hydrogel based on modified polysaccharide for removal of Pb2+ and Cu2+ from water with excellent performance
DE60322111D1 (de) Verfahren zur herstellung von hydrogelen aus thiosulfonat-zusammensetzungen und ihre verwendungen
DE602006009991D1 (de) Methoden zur Herstellung von Oberflächen die unspezifisches Binden von Proteinen und Zellen verhindern.
ATE239049T1 (de) Pulverförmige, vernetzte, absorbierende polymere, verfahren zu ihrer herstellung und ihre verwendung
WO2005030820A3 (de) Hydrogel
AU2008222967A8 (en) Cross-linking of antioxidant-containing polymers
ATE239759T1 (de) Verfahren zur herstellung stabilisierter, feindisperser und niedrigviskoser polymerpolyole mit hohen gehalt an styrol oder styrol- copolymerisaten
Ekici et al. Development of polyampholyte hydrogels based on laponite for electrically stimulated drug release
ATE461960T1 (de) Verfahren zur herstellung von polymermaleimiden
BRPI0508227A (pt) géis poliméricos interligados e uso de tais géis poliméricos na recuperação de hidrocarboneto
Baş et al. Removal of cobalt ions from aqueous solutions by using poly (N, N‐dimethylaminopropyl methacrylamide/itaconic acid) hydrogels
BRPI0820909A2 (pt) Processo para tratamento de um tecido
BR0007284A (pt) Método para medir a concentração de um polìmero anionicamente carregado em uma solução aquosa, e, solução reagente
CY1110805T1 (el) Μεθοδος εξετασης ουσιων πανω σε βιομητρες
Dehli et al. Gelatin-based foamed and non-foamed hydrogels for sorption and controlled release of metoprolol
Karadağ et al. Investigation of sorption/swelling characteristics of chemically crosslinked AAm/SMA hydrogels as biopotential sorbent
Hegger et al. Charge matters: modulating secondary interactions in hyaluronan hydrogels
ATE472568T1 (de) Wasserabsorbierende vernetzte polymere

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties