ATE402146T1 - Industrielles verfahren zur herstellung isobutylmethyl-1,4-dihydro-2,6-dimethyl-4-(2- nitrobenzol) - Google Patents
Industrielles verfahren zur herstellung isobutylmethyl-1,4-dihydro-2,6-dimethyl-4-(2- nitrobenzol)Info
- Publication number
- ATE402146T1 ATE402146T1 AT03761517T AT03761517T ATE402146T1 AT E402146 T1 ATE402146 T1 AT E402146T1 AT 03761517 T AT03761517 T AT 03761517T AT 03761517 T AT03761517 T AT 03761517T AT E402146 T1 ATE402146 T1 AT E402146T1
- Authority
- AT
- Austria
- Prior art keywords
- dihydro
- dimethyl
- isobutylmethyl
- nitrobenzene
- producing
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- ZYVYEJXMYBUCMN-UHFFFAOYSA-N 1-methoxy-2-methylpropane Chemical group COCC(C)C ZYVYEJXMYBUCMN-UHFFFAOYSA-N 0.000 abstract 1
- MGPMEYRPZPIHIL-UHFFFAOYSA-N 2-methylpropyl 2-[(2-nitrophenyl)methylidene]-3-oxobutanoate Chemical compound CC(C)COC(=O)C(C(C)=O)=CC1=CC=CC=C1[N+]([O-])=O MGPMEYRPZPIHIL-UHFFFAOYSA-N 0.000 abstract 1
- XKORCTIIRYKLLG-ARJAWSKDSA-N methyl (z)-3-aminobut-2-enoate Chemical compound COC(=O)\C=C(\C)N XKORCTIIRYKLLG-ARJAWSKDSA-N 0.000 abstract 1
- VKQFCGNPDRICFG-UHFFFAOYSA-N methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1C1=CC=CC=C1[N+]([O-])=O VKQFCGNPDRICFG-UHFFFAOYSA-N 0.000 abstract 1
- 229960000227 nisoldipine Drugs 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002MI001445A ITMI20021445A1 (it) | 2002-07-01 | 2002-07-01 | Processo di sintesi industriale del isobutil metil 1,4-diidro-2,6-dimetil-4-(2-nitrofenil)piridin-3,5-dicarbossilato (nisoldipina) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE402146T1 true ATE402146T1 (de) | 2008-08-15 |
Family
ID=11450118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03761517T ATE402146T1 (de) | 2002-07-01 | 2003-06-26 | Industrielles verfahren zur herstellung isobutylmethyl-1,4-dihydro-2,6-dimethyl-4-(2- nitrobenzol) |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7060838B2 (de) |
| EP (1) | EP1532110B1 (de) |
| JP (1) | JP2006512287A (de) |
| AT (1) | ATE402146T1 (de) |
| AU (1) | AU2003246594A1 (de) |
| DE (1) | DE60322396D1 (de) |
| ES (1) | ES2311112T3 (de) |
| IT (1) | ITMI20021445A1 (de) |
| PT (1) | PT1532110E (de) |
| WO (1) | WO2004002958A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7490255B2 (en) | 2006-06-30 | 2009-02-10 | Intel Corporation | Power efficient flow control model for USB asynchronous transfers |
| CN108752263B (zh) * | 2018-06-08 | 2021-10-26 | 迪嘉药业集团有限公司 | 一种高纯度硝苯地平结晶的制备方法 |
| CN116425635A (zh) * | 2020-03-24 | 2023-07-14 | 合肥立方制药股份有限公司 | 一种使用组合催化剂合成硝苯地平中间体的方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4154839A (en) * | 1975-11-05 | 1979-05-15 | Bayer Aktiengesellschaft | 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine |
| US4600778A (en) | 1983-04-05 | 1986-07-15 | Bayer Aktiengesellschaft | Process for the preparation of 1,4-dihydropyridinedicarboxylic esters |
-
2002
- 2002-07-01 IT IT2002MI001445A patent/ITMI20021445A1/it unknown
-
2003
- 2003-06-26 EP EP03761517A patent/EP1532110B1/de not_active Expired - Lifetime
- 2003-06-26 AT AT03761517T patent/ATE402146T1/de not_active IP Right Cessation
- 2003-06-26 US US10/520,066 patent/US7060838B2/en not_active Expired - Fee Related
- 2003-06-26 WO PCT/EP2003/006755 patent/WO2004002958A1/en not_active Ceased
- 2003-06-26 PT PT03761517T patent/PT1532110E/pt unknown
- 2003-06-26 DE DE60322396T patent/DE60322396D1/de not_active Expired - Lifetime
- 2003-06-26 JP JP2004516691A patent/JP2006512287A/ja active Pending
- 2003-06-26 AU AU2003246594A patent/AU2003246594A1/en not_active Abandoned
- 2003-06-26 ES ES03761517T patent/ES2311112T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20050240022A1 (en) | 2005-10-27 |
| AU2003246594A1 (en) | 2004-01-19 |
| EP1532110B1 (de) | 2008-07-23 |
| EP1532110A1 (de) | 2005-05-25 |
| ITMI20021445A1 (it) | 2004-01-02 |
| ES2311112T3 (es) | 2009-02-01 |
| US7060838B2 (en) | 2006-06-13 |
| JP2006512287A (ja) | 2006-04-13 |
| ITMI20021445A0 (it) | 2002-07-01 |
| WO2004002958A1 (en) | 2004-01-08 |
| DE60322396D1 (de) | 2008-09-04 |
| PT1532110E (pt) | 2008-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE348814T1 (de) | Verfahren zur herstellung von chinolinderivaten | |
| DE60220646D1 (de) | Verfahren zur herstellung von verbindungsprofilen | |
| EP1427445A4 (de) | Verfahren zur reifung von plasmacytoiden dendritischen zellen unter verwendung von die immunantwort modifizierenden molekülen | |
| DE60203569D1 (de) | Verfahren zur Herstellung von Methanol | |
| DK1223474T3 (da) | Fremgangsmåde til fremstilling af estervoks | |
| ATE497013T1 (de) | Verfahren zur herstellung von glutaminsäurederivaten | |
| CY1108471T1 (el) | Μεθοδος για την παραγωγη εστερων σκοπινης | |
| DE60336867D1 (de) | Verfahren zur Herstellung von 3-Halo-4,5-Dihydro-1H-Pyrazolen | |
| DE50106029D1 (de) | Verfahren zur Herstellung von Polycarbonat | |
| DE602004019329D1 (de) | Verfahren zur herstellung substituierter nikotinsäureester | |
| DE50301594D1 (de) | Verfahren zur Herstellung von Emulsionspolymeren mit hoher Reinheit | |
| DE50105968D1 (de) | VERFAHREN ZUR HERSTELLUNG VON AlKYLVERBRÜCKTEN LIGANDSYSTEMEN UND ÜBERGANGSMETALLVERBINDUNGEN | |
| ATE197150T1 (de) | Verfahren zur herstellung von dihydroxypyrimidin- derivaten | |
| ATE402146T1 (de) | Industrielles verfahren zur herstellung isobutylmethyl-1,4-dihydro-2,6-dimethyl-4-(2- nitrobenzol) | |
| DE60300144D1 (de) | Verfahren zur Herstellung von Al-Sinterlegierung | |
| ATE410485T1 (de) | Härtbare farbige zusammensetzung, farbfilter und verfahren zu deren herstellung | |
| ATE503747T1 (de) | Verfahren zur herstellung von 6,7-bis(2- methoxyethoxy)-chinazolin-4-on | |
| ATE363469T1 (de) | Verfahren zur herstellung von 1,4-dihydropyridin- intermediate und deren derivate | |
| AU2003205563A1 (en) | Method for producing acrylic acid | |
| ATE546432T1 (de) | Verfahren zur herstellung von 2- aminomethylpyridin-derivate | |
| ATE226190T1 (de) | Verfahren zur herstellung von 13-cis-retinsäure | |
| ATE356116T1 (de) | Neues verfahren zur herstellung von 2- aminomethylpyridinderivaten | |
| DE50105621D1 (de) | 1h-pyrazol-derivate, verfahren zu ihrer herstellung und deren verwendung zur hemmung und steuerung der nitrifikation | |
| DE69714858D1 (de) | Verfahren zur herstellung von cyanozimtsäure-amiden | |
| DE60323991D1 (de) | Verfahren zur herstellung von aldehydverbindungen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |