ATE402269T1 - Methoden und testsätze für annäherungstest - Google Patents

Methoden und testsätze für annäherungstest

Info

Publication number
ATE402269T1
ATE402269T1 AT01906476T AT01906476T ATE402269T1 AT E402269 T1 ATE402269 T1 AT E402269T1 AT 01906476 T AT01906476 T AT 01906476T AT 01906476 T AT01906476 T AT 01906476T AT E402269 T1 ATE402269 T1 AT E402269T1
Authority
AT
Austria
Prior art keywords
proximity
test
methods
nucleic acid
sets
Prior art date
Application number
AT01906476T
Other languages
English (en)
Inventor
Ab Olink
Original Assignee
Ab Olink
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ab Olink filed Critical Ab Olink
Application granted granted Critical
Publication of ATE402269T1 publication Critical patent/ATE402269T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT01906476T 2000-02-18 2001-02-16 Methoden und testsätze für annäherungstest ATE402269T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0000538A SE516272C2 (sv) 2000-02-18 2000-02-18 Metoder och kit för analytdetektion mha proximitets-probning

Publications (1)

Publication Number Publication Date
ATE402269T1 true ATE402269T1 (de) 2008-08-15

Family

ID=20278505

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01906476T ATE402269T1 (de) 2000-02-18 2001-02-16 Methoden und testsätze für annäherungstest

Country Status (8)

Country Link
EP (1) EP1255861B1 (de)
JP (1) JP4804691B2 (de)
AT (1) ATE402269T1 (de)
AU (1) AU783644B2 (de)
CA (1) CA2400384A1 (de)
DE (1) DE60134957D1 (de)
SE (1) SE516272C2 (de)
WO (1) WO2001061037A1 (de)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US20070166741A1 (en) 1998-12-14 2007-07-19 Somalogic, Incorporated Multiplexed analyses of test samples
EP1382965B1 (de) * 2001-04-23 2005-11-30 Eiken Kagaku Kabushiki Kaisha Analyseverfahren mit intermolekularer wechselwirkung eines reporters (markers)
ATE365211T1 (de) * 2001-08-20 2007-07-15 Regenesis Bioremediation Produ Biosensor für kleinmolekulare analyten
GB0212544D0 (en) * 2002-05-30 2002-07-10 Microsens Biophage Ltd Methods for detection of target molecules and molecular interactions
JP2005504308A (ja) * 2001-10-03 2005-02-10 イセアオ テクノロジーズ リミテッド 標的分子および分子間相互作用の検出法
US8013134B2 (en) 2001-11-23 2011-09-06 Olink Ab Kit for proximity probing with multivalent proximity probes
US7553619B2 (en) 2002-02-08 2009-06-30 Qiagen Gmbh Detection method using dissociated rolling circle amplification
US9487823B2 (en) 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
US7977048B2 (en) 2004-01-13 2011-07-12 Pathogenetix, Inc. Detection and quantification of analytes in solution using polymers
US7595160B2 (en) 2004-01-13 2009-09-29 U.S. Genomics, Inc. Analyte detection using barcoded polymers
US20080261204A1 (en) * 2004-01-23 2008-10-23 Lingvitae As Polynucleotide Ligation Reactions
WO2005123963A2 (en) 2004-06-14 2005-12-29 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for use in analyte detection using proximity probes
CN101137758B (zh) † 2004-11-03 2012-10-10 意力速分子诊断股份有限公司 均相分析物检测
JP2009500033A (ja) * 2005-07-06 2009-01-08 フォルスカルパテント・アイ・ウプサラ・エービー 核酸付随分子及び修飾の局在化方法
EP1762627A1 (de) 2005-09-09 2007-03-14 Qiagen GmbH Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion
EP1945813A4 (de) * 2005-10-11 2010-04-21 Stratagene California Binäre signalnachweistests
WO2007054515A1 (en) * 2005-11-14 2007-05-18 Boehringer Ingelheim Vetmedica Gmbh Method for detecting microorganisms
HUE025489T2 (en) * 2006-01-17 2016-04-28 Somalogic Inc Multiplexed analysis of test samples
GB0605584D0 (en) * 2006-03-20 2006-04-26 Olink Ab Method for analyte detection using proximity probes
WO2007117444A2 (en) * 2006-03-31 2007-10-18 Yinghe Hu Protein detection by aptamers
EP2049688B1 (de) * 2006-08-01 2018-01-24 Applied Biosystems, LLC Nachweis von analyten und nukleinsäuren
US8778846B2 (en) * 2006-12-04 2014-07-15 General Electric Company Composition, device and associated method
US8975026B2 (en) 2007-01-16 2015-03-10 Somalogic, Inc. Method for generating aptamers with improved off-rates
US7947447B2 (en) 2007-01-16 2011-05-24 Somalogic, Inc. Method for generating aptamers with improved off-rates
US20110136099A1 (en) 2007-01-16 2011-06-09 Somalogic, Inc. Multiplexed Analyses of Test Samples
GB0918712D0 (en) * 2009-10-26 2009-12-09 Axis Shield Diagnostics Ltd An assay
GB201004292D0 (en) 2010-03-15 2010-04-28 Olink Ab Assay for localised detection of analytes
US20120004132A1 (en) * 2010-07-02 2012-01-05 Affymetrix, Inc. Detection of Nucleic Acids and Proteins
GB201011971D0 (en) * 2010-07-15 2010-09-01 Olink Ab Methods and product
WO2012049316A1 (en) 2010-10-15 2012-04-19 Olink Ab Dynamic range methods
EP2633081B1 (de) * 2010-10-29 2017-01-11 Olink Bioscience AB Näherungsligationstechnologie für western-blot-anwendungen
WO2012099832A2 (en) 2011-01-17 2012-07-26 Life Technologies Corporation Enzymatic ligation of nucleic acids
EP2466310A1 (de) 2010-12-17 2012-06-20 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Mittel und Verfahren für den Nachweis von mehrstrangigen Brüchen
US20120196294A1 (en) 2011-01-17 2012-08-02 Life Technologies Corporation Workflow for detection of ligands using nucleic acids
CN103703143B (zh) 2011-01-31 2016-12-14 爱普瑞斯生物公司 鉴定细胞中的多个表位的方法
US11560585B2 (en) 2011-01-31 2023-01-24 Roche Sequencing Solutions, Inc. Methods of identifying multiple epitopes in cells
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
GB201107863D0 (en) 2011-05-11 2011-06-22 Olink Ab Method and product
US10597701B2 (en) 2011-05-11 2020-03-24 Navinci Diagnostics Ab Unfolding proximity probes and methods for the use thereof
GB201108678D0 (en) 2011-05-24 2011-07-06 Olink Ab Multiplexed proximity ligation assay
US9029086B2 (en) * 2012-01-26 2015-05-12 Masood Kamali Moghaddam Detection of single and multimodal analytes
GB201201547D0 (en) 2012-01-30 2012-03-14 Olink Ab Method and product
US10174366B2 (en) 2012-11-14 2019-01-08 Olink Bioscience Ab Localised RCA-based amplification method
US20160369321A1 (en) 2012-11-14 2016-12-22 Olink Ab RCA Reporter Probes and Their Use in Detecting Nucleic Acid Molecules
GB201320145D0 (en) 2013-11-14 2014-01-01 Olink Ab Localised RCA-based amplification method using a padlock-probe
GB201321123D0 (en) 2013-11-29 2014-01-15 Linea Ab Q Amplification of circular molecules
GB201401885D0 (en) 2014-02-04 2014-03-19 Olink Ab Proximity assay with detection based on hybridisation chain reaction (HCR)
US20180320241A1 (en) * 2014-12-19 2018-11-08 Roche Sequencing Solutions, Inc. Methods for identifying multiple epitopes in selected sub-populations of cells
US20180179576A1 (en) * 2015-03-02 2018-06-28 The Regents Of The University Of California Homogeneous entropy-driven biomolecular assay (heba)
AU2016249392A1 (en) * 2015-04-17 2017-11-16 The Regents Of The University Of California Methods for detecting agglutination and compositions for use in practicing the same
WO2017070309A1 (en) * 2015-10-20 2017-04-27 Quateris Llc Multiplex dna immuno-sandwich assay (mdisa)
GB201518655D0 (en) * 2015-10-21 2015-12-02 Olink Ab Method for generating proximity probes
EP4015647B1 (de) 2016-02-26 2023-08-30 The Board of Trustees of the Leland Stanford Junior University Multiplexierte einzelmolekül-rna-visualisierung mit einem zwei-sonden-proximitätsligationssystem
WO2017218881A1 (en) * 2016-06-17 2017-12-21 Proximity Biosciences, Llc Method for aptamer pair selection
GB201614023D0 (en) 2016-08-16 2016-09-28 Olink Bioscience Ab Double-stranded circle probes
HRP20200476T1 (hr) * 2016-10-21 2020-06-26 Zelda Therapeutics Operations Pty Ltd Prognostički postupak i pribor koristan za navedeni postupak
GB201621514D0 (en) 2016-12-16 2017-02-01 Q-Linea Ab Padlock probe detection method
CN112243463B (zh) 2018-04-09 2024-12-13 小利兰·斯坦福大学托管委员会 原位基因测序方法
CN111139285A (zh) * 2018-11-02 2020-05-12 深圳华大生命科学研究院 一种高通量检测多个待测样本中不同目的蛋白含量的方法及其专用试剂盒
WO2021034971A1 (en) * 2019-08-19 2021-02-25 Brickbio, Inc. Methods and compositions for analyte detection and quantification
JP7727628B2 (ja) 2019-12-03 2025-08-21 アラマー バイオサイエンシーズ， インク． 核酸結合免疫サンドイッチアッセイ（ｎｕｌｉｓａ）
GB201919029D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
GB201919032D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
WO2021191442A1 (en) 2020-03-27 2021-09-30 Olink Proteomics Ab Method for detecting analytes of varying abundance
GB202004472D0 (en) 2020-03-27 2020-05-13 Olink Proteomics Ab Method for detecting analytes of varying abundance
GB202004469D0 (en) 2020-03-27 2020-05-13 Olink Proteomics Ab Controls for proximity detection assays
JP2023545038A (ja) * 2020-10-06 2023-10-26 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 中和標的のシグナルオン検出のための方法、組成物、キット、およびシステム
GB202017873D0 (en) 2020-11-12 2020-12-30 Olso Unversitetssykehus Hf Method of determining DLBCL prognosis
GB202018503D0 (en) 2020-11-25 2021-01-06 Olink Proteomics Ab Analyte detection method employing concatamers
WO2022133107A1 (en) * 2020-12-16 2022-06-23 Cognext Diagnostics LLC Methods for diagnosing alzheimer's disease and other neurological disorders
EP4738279A3 (de) 2021-02-19 2026-05-13 The Broad Institute Inc. Multiskalare räumliche transkriptomikanalyse
EP4334471A1 (de) 2021-05-07 2024-03-13 The Broad Institute Inc. Räumlich-zeitlich aufgelöste transkriptomik bei subzellulärer auflösung
US12704508B2 (en) 2021-06-02 2026-08-11 Alamar Biosciences, Inc. Nucleic acid linked immune-sandwich assay (NULISA)
CN113945720B (zh) * 2021-09-26 2024-08-16 瑞博奥(广州)生物科技股份有限公司 基于核酸适配体探针的pdgf-bb识别方法及检测pdgf-bb的试剂盒
WO2023122345A1 (en) * 2021-12-23 2023-06-29 California Institute Of Technology Suppression of non-specific signals by exonucleases in fish experiment
GB202213930D0 (en) 2022-09-23 2022-11-09 Xu Bo Padlock blocking oligonucleotide
EP4615996A1 (de) 2022-11-11 2025-09-17 Olink Proteomics AB Bibliothek von proximitätssonden und verwendungsverfahren
EP4382534A1 (de) 2022-12-06 2024-06-12 Biomérieux Synthetisches peptid zur verwendung in einem immunmolekulartest
EP4743220A1 (de) 2023-07-11 2026-05-20 Olink Proteomics AB Getrocknete reagenzien
EP4744052A1 (de) 2023-07-12 2026-05-20 Olink Proteomics AB Verfahren, komponenten und software zur erkennung eines systematischen fehlers in einem proteindetektionssystem
WO2025031642A1 (en) 2023-08-07 2025-02-13 Olink Proteomics Ab A method for determining run errors for an analysis-method for quantifying a plurality of analytes in a plurality of biological samples
CN119757755B (zh) * 2024-11-01 2025-08-29 上海伯杰医疗科技股份有限公司 一种环状连接超敏免疫检测方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4883750A (en) * 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
CA1323293C (en) * 1987-12-11 1993-10-19 Keith C. Backman Assay using template-dependent nucleic acid probe reorganization
CA2118913C (en) * 1991-09-13 2008-08-19 Donald Leonard Nicholas Cardy Nucleic acids extension assay
US5846709A (en) * 1993-06-15 1998-12-08 Imclone Systems Incorporated Chemical process for amplifying and detecting nucleic acid sequences
SE504798C2 (sv) * 1995-06-16 1997-04-28 Ulf Landegren Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten
EP1216417A1 (de) * 1999-09-28 2002-06-26 Evotec OAI AG Quantitative analyse und typisierung subzellulärer partikel

Also Published As

Publication number Publication date
JP4804691B2 (ja) 2011-11-02
AU3430001A (en) 2001-08-27
WO2001061037A1 (en) 2001-08-23
JP2003524419A (ja) 2003-08-19
EP1255861A1 (de) 2002-11-13
EP1255861B1 (de) 2008-07-23
DE60134957D1 (de) 2008-09-04
SE0000538L (sv) 2001-08-19
CA2400384A1 (en) 2001-08-23
SE516272C2 (sv) 2001-12-10
SE0000538D0 (sv) 2000-02-18
AU783644B2 (en) 2005-11-17

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