SE0000538L - Metoder och kit för analytdetektion mha proximitets-probning - Google Patents

Metoder och kit för analytdetektion mha proximitets-probning

Info

Publication number
SE0000538L
SE0000538L SE0000538A SE0000538A SE0000538L SE 0000538 L SE0000538 L SE 0000538L SE 0000538 A SE0000538 A SE 0000538A SE 0000538 A SE0000538 A SE 0000538A SE 0000538 L SE0000538 L SE 0000538L
Authority
SE
Sweden
Prior art keywords
proximity
kits
methods
nucleic acid
analyte detection
Prior art date
Application number
SE0000538A
Other languages
English (en)
Other versions
SE0000538D0 (sv
SE516272C2 (sv
Inventor
Ulf Landegren
Simon Fredriksson
Original Assignee
Ulf Landegren
Simon Fredriksson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ulf Landegren, Simon Fredriksson filed Critical Ulf Landegren
Priority to SE0000538A priority Critical patent/SE516272C2/sv
Publication of SE0000538D0 publication Critical patent/SE0000538D0/sv
Priority to DE60134957T priority patent/DE60134957D1/de
Priority to EP01906476A priority patent/EP1255861B1/en
Priority to AT01906476T priority patent/ATE402269T1/de
Priority to CA002400384A priority patent/CA2400384A1/en
Priority to PCT/SE2001/000341 priority patent/WO2001061037A1/en
Priority to AU34300/01A priority patent/AU783644B2/en
Priority to JP2001559873A priority patent/JP4804691B2/ja
Publication of SE0000538L publication Critical patent/SE0000538L/sv
Publication of SE516272C2 publication Critical patent/SE516272C2/sv

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
SE0000538A 2000-02-18 2000-02-18 Metoder och kit för analytdetektion mha proximitets-probning SE516272C2 (sv)

Priority Applications (8)

Application Number Priority Date Filing Date Title
SE0000538A SE516272C2 (sv) 2000-02-18 2000-02-18 Metoder och kit för analytdetektion mha proximitets-probning
DE60134957T DE60134957D1 (de) 2000-02-18 2001-02-16 Methoden und testsätze für annäherungstest
EP01906476A EP1255861B1 (en) 2000-02-18 2001-02-16 Methods and kits for proximity probing
AT01906476T ATE402269T1 (de) 2000-02-18 2001-02-16 Methoden und testsätze für annäherungstest
CA002400384A CA2400384A1 (en) 2000-02-18 2001-02-16 Methods and kits for proximity probing
PCT/SE2001/000341 WO2001061037A1 (en) 2000-02-18 2001-02-16 Methods and kits for proximity probing
AU34300/01A AU783644B2 (en) 2000-02-18 2001-02-16 Methods and kits for proximity probing
JP2001559873A JP4804691B2 (ja) 2000-02-18 2001-02-16 近接プロービング方法およびキット

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0000538A SE516272C2 (sv) 2000-02-18 2000-02-18 Metoder och kit för analytdetektion mha proximitets-probning

Publications (3)

Publication Number Publication Date
SE0000538D0 SE0000538D0 (sv) 2000-02-18
SE0000538L true SE0000538L (sv) 2001-08-19
SE516272C2 SE516272C2 (sv) 2001-12-10

Family

ID=20278505

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0000538A SE516272C2 (sv) 2000-02-18 2000-02-18 Metoder och kit för analytdetektion mha proximitets-probning

Country Status (8)

Country Link
EP (1) EP1255861B1 (sv)
JP (1) JP4804691B2 (sv)
AT (1) ATE402269T1 (sv)
AU (1) AU783644B2 (sv)
CA (1) CA2400384A1 (sv)
DE (1) DE60134957D1 (sv)
SE (1) SE516272C2 (sv)
WO (1) WO2001061037A1 (sv)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US20070166741A1 (en) 1998-12-14 2007-07-19 Somalogic, Incorporated Multiplexed analyses of test samples
WO2002088733A1 (fr) * 2001-04-23 2002-11-07 Eiken Kagaku Kabushiki Kaisha Methode d'analyse faisant intervenir une interaction intermoleculaire par rapporteur (marqueur)
EP1427821B1 (en) * 2001-08-20 2007-06-20 Regenesis Bioremediation Products Biosensor for small molecule analytes
EP1436419A1 (en) * 2001-10-03 2004-07-14 ISEAO Technologies Limited Methods for detection of target molecules and molecular interactions
GB0212544D0 (en) * 2002-05-30 2002-07-10 Microsens Biophage Ltd Methods for detection of target molecules and molecular interactions
WO2003044231A1 (en) * 2001-11-23 2003-05-30 Simon Fredriksson Method and kit for proximity probing with multivalent proximity probes
US7553619B2 (en) 2002-02-08 2009-06-30 Qiagen Gmbh Detection method using dissociated rolling circle amplification
US9487823B2 (en) 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
US7595160B2 (en) 2004-01-13 2009-09-29 U.S. Genomics, Inc. Analyte detection using barcoded polymers
WO2005067692A2 (en) * 2004-01-13 2005-07-28 U.S. Genomics, Inc. Detection and quantification of analytes in solution using polymers
CA2552858A1 (en) * 2004-01-23 2005-08-04 Lingvitae As Improving polynucleotide ligation reactions
WO2005123963A2 (en) * 2004-06-14 2005-12-29 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for use in analyte detection using proximity probes
CN103146808A (zh) * 2004-11-03 2013-06-12 意力速分子诊断股份有限公司 均相分析物检测
EP1904648A4 (en) * 2005-07-06 2010-03-10 Uppsala Uni Projekt Ab PROCESS FOR LOCALIZING NUCLEIC ACID ASSOCIATED MOLECULES AND MODIFICATIONS
EP1762627A1 (de) 2005-09-09 2007-03-14 Qiagen GmbH Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion
EP1945813A4 (en) * 2005-10-11 2010-04-21 Stratagene California BINARY SIGNAL CHECK TESTING
EP1957664A1 (en) * 2005-11-14 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Method for detecting microorganisms
EP2613147B1 (en) * 2006-01-17 2015-03-11 Somalogic, Inc. Detection methods using aptamers
GB0605584D0 (en) * 2006-03-20 2006-04-26 Olink Ab Method for analyte detection using proximity probes
WO2007117444A2 (en) * 2006-03-31 2007-10-18 Yinghe Hu Protein detection by aptamers
EP2484781B1 (en) * 2006-08-01 2017-08-23 Applied Biosystems, LLC Detection of analytes and nucleic acids
US8778846B2 (en) * 2006-12-04 2014-07-15 General Electric Company Composition, device and associated method
US8975026B2 (en) 2007-01-16 2015-03-10 Somalogic, Inc. Method for generating aptamers with improved off-rates
US7947447B2 (en) 2007-01-16 2011-05-24 Somalogic, Inc. Method for generating aptamers with improved off-rates
US20110136099A1 (en) 2007-01-16 2011-06-09 Somalogic, Inc. Multiplexed Analyses of Test Samples
GB0918712D0 (en) * 2009-10-26 2009-12-09 Axis Shield Diagnostics Ltd An assay
GB201004292D0 (en) 2010-03-15 2010-04-28 Olink Ab Assay for localised detection of analytes
US20120004132A1 (en) * 2010-07-02 2012-01-05 Affymetrix, Inc. Detection of Nucleic Acids and Proteins
GB201011971D0 (en) * 2010-07-15 2010-09-01 Olink Ab Methods and product
WO2012049316A1 (en) 2010-10-15 2012-04-19 Olink Ab Dynamic range methods
EP2633081B1 (en) * 2010-10-29 2017-01-11 Olink Bioscience AB Proximity ligation technology for western blot applications
EP2466310A1 (en) 2010-12-17 2012-06-20 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Means and methods for detecting double-strand breaks
EP3733867A1 (en) 2011-01-17 2020-11-04 Life Technologies Corporation Enzymatic ligation of nucleic acids
ES2632768T3 (es) * 2011-01-17 2017-09-15 Life Technologies Corporation Flujo de trabajo para la detección de ligandos empleando ácidos nucleicos
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
US11560585B2 (en) 2011-01-31 2023-01-24 Roche Sequencing Solutions, Inc. Methods of identifying multiple epitopes in cells
JP6069224B2 (ja) 2011-01-31 2017-02-01 アプライズ バイオ， インコーポレイテッド 細胞において複数のエピトープを同定する方法
GB201107863D0 (en) 2011-05-11 2011-06-22 Olink Ab Method and product
US10597701B2 (en) 2011-05-11 2020-03-24 Navinci Diagnostics Ab Unfolding proximity probes and methods for the use thereof
GB201108678D0 (en) 2011-05-24 2011-07-06 Olink Ab Multiplexed proximity ligation assay
US9029086B2 (en) * 2012-01-26 2015-05-12 Masood Kamali Moghaddam Detection of single and multimodal analytes
GB201201547D0 (en) 2012-01-30 2012-03-14 Olink Ab Method and product
EP2920320B1 (en) 2012-11-14 2016-12-28 Olink Bioscience AB Rca reporter probes and their use in detecting nucleic acid molecules
EP2920324B1 (en) 2012-11-14 2017-12-27 Olink Bioscience AB Localised rca-based amplification method
GB201320145D0 (en) 2013-11-14 2014-01-01 Olink Ab Localised RCA-based amplification method using a padlock-probe
GB201321123D0 (en) 2013-11-29 2014-01-15 Linea Ab Q Amplification of circular molecules
GB201401885D0 (en) 2014-02-04 2014-03-19 Olink Ab Proximity assay with detection based on hybridisation chain reaction (HCR)
JP2017537645A (ja) * 2014-12-19 2017-12-21 アプライズ バイオ， インコーポレイテッド 細胞の選択された部分集団中の複数エピトープを識別するための方法
EP3265587A4 (en) * 2015-03-02 2018-08-08 The Regents of the University of California Homogenous entropy-driven biomolecular assay (heba)
WO2016168711A1 (en) * 2015-04-17 2016-10-20 The Regents Of The University Of California Methods for detecting agglutination and compositions for use in practicing the same
WO2017070309A1 (en) * 2015-10-20 2017-04-27 Quateris Llc Multiplex dna immuno-sandwich assay (mdisa)
GB201518655D0 (en) * 2015-10-21 2015-12-02 Olink Ab Method for generating proximity probes
EP3420110B1 (en) 2016-02-26 2021-09-22 The Board of Trustees of the Leland Stanford Junior University Multiplexed single molecule rna visualization with a two-probe proximity ligation system
JP2019521680A (ja) * 2016-06-17 2019-08-08 プロクシミティー バイオサイエンシズ，エルエルシー アプタマーペアを選択する方法
GB201614023D0 (en) 2016-08-16 2016-09-28 Olink Bioscience Ab Double-stranded circle probes
NZ743812A (en) * 2016-10-21 2019-12-20 Zelda Therapeutics Operations Pty Ltd Prognostic method and kits useful in said method
GB201621514D0 (en) 2016-12-16 2017-02-01 Q-Linea Ab Padlock probe detection method
US12359253B2 (en) 2018-04-09 2025-07-15 The Board Of Trustees Of The Leland Stanford Junior University Method of in situ gene sequencing
CN111139285A (zh) * 2018-11-02 2020-05-12 深圳华大生命科学研究院 一种高通量检测多个待测样本中不同目的蛋白含量的方法及其专用试剂盒
WO2021034971A1 (en) * 2019-08-19 2021-02-25 Brickbio, Inc. Methods and compositions for analyte detection and quantification
EP4069731A4 (en) 2019-12-03 2024-05-29 Alamar Biosciences, Inc. Nucleic acid linked immune-sandwich assay (nulisa)
GB201919029D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
GB201919032D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
AU2021241898A1 (en) 2020-03-27 2022-10-13 Olink Proteomics Ab Method for detecting analytes of varying abundance
GB202004472D0 (en) 2020-03-27 2020-05-13 Olink Proteomics Ab Method for detecting analytes of varying abundance
GB202004469D0 (en) 2020-03-27 2020-05-13 Olink Proteomics Ab Controls for proximity detection assays
JP2023545038A (ja) * 2020-10-06 2023-10-26 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 中和標的のシグナルオン検出のための方法、組成物、キット、およびシステム
GB202017873D0 (en) 2020-11-12 2020-12-30 Olso Unversitetssykehus Hf Method of determining DLBCL prognosis
GB202018503D0 (en) 2020-11-25 2021-01-06 Olink Proteomics Ab Analyte detection method employing concatamers
JP2024500447A (ja) * 2020-12-16 2024-01-09 コグネクスト ダイアグノスティックス エルエルシー アルツハイマー病及び他の神経障害の診断方法
CN113945720B (zh) * 2021-09-26 2024-08-16 瑞博奥(广州)生物科技股份有限公司 基于核酸适配体探针的pdgf-bb识别方法及检测pdgf-bb的试剂盒
WO2023122345A1 (en) * 2021-12-23 2023-06-29 California Institute Of Technology Suppression of non-specific signals by exonucleases in fish experiment
GB202213930D0 (en) 2022-09-23 2022-11-09 Xu Bo Padlock blocking oligonucleotide
EP4615996A1 (en) 2022-11-11 2025-09-17 Olink Proteomics AB Library of proximity probes and method of use
EP4382534A1 (en) 2022-12-06 2024-06-12 Biomérieux Synthetic peptide for use in an immunomolecular assay
KR20260034627A (ko) 2023-07-11 2026-03-11 오링크 프로테오믹스 에이비 건조 시약
WO2025012226A1 (en) 2023-07-12 2025-01-16 Olink Proteomics Ab Method, components and software for detecting a systematic error in a protein detection system
WO2025031642A1 (en) 2023-08-07 2025-02-13 Olink Proteomics Ab A method for determining run errors for an analysis-method for quantifying a plurality of analytes in a plurality of biological samples
CN119757755B (zh) * 2024-11-01 2025-08-29 上海伯杰医疗科技股份有限公司 一种环状连接超敏免疫检测方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4883750A (en) * 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
AU622426B2 (en) * 1987-12-11 1992-04-09 Abbott Laboratories Assay using template-dependent nucleic acid probe reorganization
EP0666927B1 (en) * 1991-09-13 1997-05-07 Cytocell Limited Method of detecting a nucleic acid sequence
US5846709A (en) * 1993-06-15 1998-12-08 Imclone Systems Incorporated Chemical process for amplifying and detecting nucleic acid sequences
SE504798C2 (sv) * 1995-06-16 1997-04-28 Ulf Landegren Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten
WO2001023894A1 (de) * 1999-09-28 2001-04-05 Evotec Oai Ag Quantitative analyse und typisierung subzellulärer partikel

Also Published As

Publication number Publication date
CA2400384A1 (en) 2001-08-23
SE0000538D0 (sv) 2000-02-18
JP4804691B2 (ja) 2011-11-02
JP2003524419A (ja) 2003-08-19
ATE402269T1 (de) 2008-08-15
SE516272C2 (sv) 2001-12-10
WO2001061037A1 (en) 2001-08-23
AU783644B2 (en) 2005-11-17
AU3430001A (en) 2001-08-27
EP1255861B1 (en) 2008-07-23
EP1255861A1 (en) 2002-11-13
DE60134957D1 (de) 2008-09-04

Similar Documents

Publication Publication Date Title
SE0000538D0 (sv) Methods and kits for proximity probing
DK2082226T3 (da) Sekventiel analyse af biologiske prøver
ATE515693T1 (de) Nachweis einer zielsubstanz in einer probe
ATE524736T1 (de) Sequenzielle analyse biologischer proben mit bleichung von intermediären fluoreszenzsignalen
DK2082238T3 (da) Sekventiel analyse af biologiske prøver med intermediær fluorescensdetektorblegning
DE60023539D1 (de) Immunologischer nachweis von rna:dna hybriden auf mikroarrays
RU2003100531A (ru) Композиции, содержащие краситель на основе производного мочевины, для выявления аналита, и способы их использования
CY1107490T1 (el) Μεθοδος για την ταυτοποιηση δειγματος σε θηλαστικα καθως και κιτ για την εκτελεση αυτης της μεθοδου
KR970707299A (ko) 다중 특이적 핵산 서열의 동시 검출 및 정량을 위한 조성물 및 방법(Compositions and Methods for the Simultaneous Detection and Quantification of Multiple Specific Nucleic Acid Sequences)
DK1639130T3 (da) Prober, biblioteker og kits til analyse af blandinger af nukleinsyrer og metoder til opbygning af disse
IL80922A (en) Method and kit for heterogeneous specific binding assay using water dispersible aggregating support material
BRPI0610092B8 (pt) métodos para a detecção de um analito e de um ácido nucleico em uma amostra, e de sintetização de uma molécula de ácido nucleico ou de análogo de ácido nucleico, kit reagente, uso do mesmo, molécula de ácido nucleico ou de análogo de ácido nucleico e produto associado
AU2003260457A1 (en) A method and kit for the quantitative and/or qualitative detection of components in a sample
Obubuafo et al. Poly (methyl methacrylate) microchip affinity capillary gel electrophoresis of aptamer–protein complexes for the analysis of thrombin in plasma
CA2385830A1 (en) Probe for protein-protein interaction analysis, and method of using it for analysis of protein-protein interaction
BRPI0416270A (pt) método para detectar um analito em uma amostra, e, método e kit para detectar um anticorpo especìfico de uma amostra
FR2853077B1 (fr) Procedes immunochromatographiques en phase solide
DE60113811D1 (de) NACHWEIS DER BINDUNG VON Ladungsträgern mittels PH- ODER POTENTiaL-SENSITIVEr SONDEN
DK1360491T3 (da) Biokemisk fremgangsmåde og apparat til detektion af proteinegenskaber
CA2419046A1 (en) Method for detecting or measuring hbv
WO2001084161A3 (en) Process for the measurement of non-transferrin bound iron
DK1057021T3 (da) Fremgangsmåde til måling af totalanalyt
DE69632826D1 (de) Nukleinsaeure erkennung von hepatitis gb virus
ATE500505T1 (de) Enzymhemmungsimmunverfahren
ATE322687T1 (de) Nachweis von prostatakrebs durch bestimmen des verhältnisses von psa zu igf-1

Legal Events

Date Code Title Description
NUG Patent has lapsed