SE516272C2 - Metoder och kit för analytdetektion mha proximitets-probning - Google Patents

Metoder och kit för analytdetektion mha proximitets-probning

Info

Publication number
SE516272C2
SE516272C2 SE0000538A SE0000538A SE516272C2 SE 516272 C2 SE516272 C2 SE 516272C2 SE 0000538 A SE0000538 A SE 0000538A SE 0000538 A SE0000538 A SE 0000538A SE 516272 C2 SE516272 C2 SE 516272C2
Authority
SE
Sweden
Prior art keywords
analyte
binding
proximity
nucleic acid
ligation
Prior art date
Application number
SE0000538A
Other languages
English (en)
Swedish (sv)
Other versions
SE0000538D0 (sv
SE0000538L (sv
Inventor
Ulf Landegren
Simon Fredriksson
Original Assignee
Ulf Landegren
Simon Fredriksson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ulf Landegren, Simon Fredriksson filed Critical Ulf Landegren
Priority to SE0000538A priority Critical patent/SE516272C2/sv
Publication of SE0000538D0 publication Critical patent/SE0000538D0/xx
Priority to DE60134957T priority patent/DE60134957D1/de
Priority to EP01906476A priority patent/EP1255861B1/de
Priority to AT01906476T priority patent/ATE402269T1/de
Priority to CA002400384A priority patent/CA2400384A1/en
Priority to PCT/SE2001/000341 priority patent/WO2001061037A1/en
Priority to AU34300/01A priority patent/AU783644B2/en
Priority to JP2001559873A priority patent/JP4804691B2/ja
Publication of SE0000538L publication Critical patent/SE0000538L/xx
Publication of SE516272C2 publication Critical patent/SE516272C2/sv

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
SE0000538A 2000-02-18 2000-02-18 Metoder och kit för analytdetektion mha proximitets-probning SE516272C2 (sv)

Priority Applications (8)

Application Number Priority Date Filing Date Title
SE0000538A SE516272C2 (sv) 2000-02-18 2000-02-18 Metoder och kit för analytdetektion mha proximitets-probning
DE60134957T DE60134957D1 (de) 2000-02-18 2001-02-16 Methoden und testsätze für annäherungstest
EP01906476A EP1255861B1 (de) 2000-02-18 2001-02-16 Methoden und testsätze für annäherungstest
AT01906476T ATE402269T1 (de) 2000-02-18 2001-02-16 Methoden und testsätze für annäherungstest
CA002400384A CA2400384A1 (en) 2000-02-18 2001-02-16 Methods and kits for proximity probing
PCT/SE2001/000341 WO2001061037A1 (en) 2000-02-18 2001-02-16 Methods and kits for proximity probing
AU34300/01A AU783644B2 (en) 2000-02-18 2001-02-16 Methods and kits for proximity probing
JP2001559873A JP4804691B2 (ja) 2000-02-18 2001-02-16 近接プロービング方法およびキット

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0000538A SE516272C2 (sv) 2000-02-18 2000-02-18 Metoder och kit för analytdetektion mha proximitets-probning

Publications (3)

Publication Number Publication Date
SE0000538D0 SE0000538D0 (sv) 2000-02-18
SE0000538L SE0000538L (sv) 2001-08-19
SE516272C2 true SE516272C2 (sv) 2001-12-10

Family

ID=20278505

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0000538A SE516272C2 (sv) 2000-02-18 2000-02-18 Metoder och kit för analytdetektion mha proximitets-probning

Country Status (8)

Country Link
EP (1) EP1255861B1 (de)
JP (1) JP4804691B2 (de)
AT (1) ATE402269T1 (de)
AU (1) AU783644B2 (de)
CA (1) CA2400384A1 (de)
DE (1) DE60134957D1 (de)
SE (1) SE516272C2 (de)
WO (1) WO2001061037A1 (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US20070166741A1 (en) 1998-12-14 2007-07-19 Somalogic, Incorporated Multiplexed analyses of test samples
WO2002088733A1 (fr) * 2001-04-23 2002-11-07 Eiken Kagaku Kabushiki Kaisha Methode d'analyse faisant intervenir une interaction intermoleculaire par rapporteur (marqueur)
EP1427821B1 (de) * 2001-08-20 2007-06-20 Regenesis Bioremediation Products Biosensor für kleinmolekulare analyten
EP1436419A1 (de) * 2001-10-03 2004-07-14 ISEAO Technologies Limited Methoden zum nachweis von zielmolekülen und molekularen interaktionen
GB0212544D0 (en) * 2002-05-30 2002-07-10 Microsens Biophage Ltd Methods for detection of target molecules and molecular interactions
WO2003044231A1 (en) * 2001-11-23 2003-05-30 Simon Fredriksson Method and kit for proximity probing with multivalent proximity probes
US7553619B2 (en) 2002-02-08 2009-06-30 Qiagen Gmbh Detection method using dissociated rolling circle amplification
US9487823B2 (en) 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
US7595160B2 (en) 2004-01-13 2009-09-29 U.S. Genomics, Inc. Analyte detection using barcoded polymers
WO2005067692A2 (en) * 2004-01-13 2005-07-28 U.S. Genomics, Inc. Detection and quantification of analytes in solution using polymers
CA2552858A1 (en) * 2004-01-23 2005-08-04 Lingvitae As Improving polynucleotide ligation reactions
WO2005123963A2 (en) * 2004-06-14 2005-12-29 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for use in analyte detection using proximity probes
CN103146808A (zh) * 2004-11-03 2013-06-12 意力速分子诊断股份有限公司 均相分析物检测
EP1904648A4 (de) * 2005-07-06 2010-03-10 Uppsala Uni Projekt Ab Verfahren zur lokalisierung von mit nukleinsäure assoziierten molekülen und modifikationen
EP1762627A1 (de) 2005-09-09 2007-03-14 Qiagen GmbH Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion
EP1945813A4 (de) * 2005-10-11 2010-04-21 Stratagene California Binäre signalnachweistests
EP1957664A1 (de) * 2005-11-14 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Verfahren zum nachweis von mikroorganismen
EP2613147B1 (de) * 2006-01-17 2015-03-11 Somalogic, Inc. Multiplex-Analysen von Testproben
GB0605584D0 (en) * 2006-03-20 2006-04-26 Olink Ab Method for analyte detection using proximity probes
WO2007117444A2 (en) * 2006-03-31 2007-10-18 Yinghe Hu Protein detection by aptamers
EP2484781B1 (de) * 2006-08-01 2017-08-23 Applied Biosystems, LLC Nachweis von Analyten und Nukleinsäuren
US8778846B2 (en) * 2006-12-04 2014-07-15 General Electric Company Composition, device and associated method
US8975026B2 (en) 2007-01-16 2015-03-10 Somalogic, Inc. Method for generating aptamers with improved off-rates
US7947447B2 (en) 2007-01-16 2011-05-24 Somalogic, Inc. Method for generating aptamers with improved off-rates
US20110136099A1 (en) 2007-01-16 2011-06-09 Somalogic, Inc. Multiplexed Analyses of Test Samples
GB0918712D0 (en) * 2009-10-26 2009-12-09 Axis Shield Diagnostics Ltd An assay
GB201004292D0 (en) 2010-03-15 2010-04-28 Olink Ab Assay for localised detection of analytes
US20120004132A1 (en) * 2010-07-02 2012-01-05 Affymetrix, Inc. Detection of Nucleic Acids and Proteins
GB201011971D0 (en) * 2010-07-15 2010-09-01 Olink Ab Methods and product
WO2012049316A1 (en) 2010-10-15 2012-04-19 Olink Ab Dynamic range methods
EP2633081B1 (de) * 2010-10-29 2017-01-11 Olink Bioscience AB Näherungsligationstechnologie für western-blot-anwendungen
EP2466310A1 (de) 2010-12-17 2012-06-20 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Mittel und Verfahren für den Nachweis von mehrstrangigen Brüchen
EP3733867A1 (de) 2011-01-17 2020-11-04 Life Technologies Corporation Enzymatische ligation von nukleinsäuren
ES2632768T3 (es) * 2011-01-17 2017-09-15 Life Technologies Corporation Flujo de trabajo para la detección de ligandos empleando ácidos nucleicos
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
US11560585B2 (en) 2011-01-31 2023-01-24 Roche Sequencing Solutions, Inc. Methods of identifying multiple epitopes in cells
JP6069224B2 (ja) 2011-01-31 2017-02-01 アプライズ バイオ， インコーポレイテッド 細胞において複数のエピトープを同定する方法
GB201107863D0 (en) 2011-05-11 2011-06-22 Olink Ab Method and product
US10597701B2 (en) 2011-05-11 2020-03-24 Navinci Diagnostics Ab Unfolding proximity probes and methods for the use thereof
GB201108678D0 (en) 2011-05-24 2011-07-06 Olink Ab Multiplexed proximity ligation assay
US9029086B2 (en) * 2012-01-26 2015-05-12 Masood Kamali Moghaddam Detection of single and multimodal analytes
GB201201547D0 (en) 2012-01-30 2012-03-14 Olink Ab Method and product
EP2920320B1 (de) 2012-11-14 2016-12-28 Olink Bioscience AB Rca-reportersonden und deren verwendung zur detektion von nukleinsäuremolekülen
EP2920324B1 (de) 2012-11-14 2017-12-27 Olink Bioscience AB Lokalisiertes rca-basiertes verstärkungsverfahren
GB201320145D0 (en) 2013-11-14 2014-01-01 Olink Ab Localised RCA-based amplification method using a padlock-probe
GB201321123D0 (en) 2013-11-29 2014-01-15 Linea Ab Q Amplification of circular molecules
GB201401885D0 (en) 2014-02-04 2014-03-19 Olink Ab Proximity assay with detection based on hybridisation chain reaction (HCR)
JP2017537645A (ja) * 2014-12-19 2017-12-21 アプライズ バイオ， インコーポレイテッド 細胞の選択された部分集団中の複数エピトープを識別するための方法
EP3265587A4 (de) * 2015-03-02 2018-08-08 The Regents of the University of California Homogener entropiegesteuerter biomolekulartest (heba)
WO2016168711A1 (en) * 2015-04-17 2016-10-20 The Regents Of The University Of California Methods for detecting agglutination and compositions for use in practicing the same
WO2017070309A1 (en) * 2015-10-20 2017-04-27 Quateris Llc Multiplex dna immuno-sandwich assay (mdisa)
GB201518655D0 (en) * 2015-10-21 2015-12-02 Olink Ab Method for generating proximity probes
EP3420110B1 (de) 2016-02-26 2021-09-22 The Board of Trustees of the Leland Stanford Junior University Multiplexierte einzelmolekül-rna-visualisierung mit einem zwei-sonden-proximitätsligationssystem
JP2019521680A (ja) * 2016-06-17 2019-08-08 プロクシミティー バイオサイエンシズ，エルエルシー アプタマーペアを選択する方法
GB201614023D0 (en) 2016-08-16 2016-09-28 Olink Bioscience Ab Double-stranded circle probes
NZ743812A (en) * 2016-10-21 2019-12-20 Zelda Therapeutics Operations Pty Ltd Prognostic method and kits useful in said method
GB201621514D0 (en) 2016-12-16 2017-02-01 Q-Linea Ab Padlock probe detection method
US12359253B2 (en) 2018-04-09 2025-07-15 The Board Of Trustees Of The Leland Stanford Junior University Method of in situ gene sequencing
CN111139285A (zh) * 2018-11-02 2020-05-12 深圳华大生命科学研究院 一种高通量检测多个待测样本中不同目的蛋白含量的方法及其专用试剂盒
WO2021034971A1 (en) * 2019-08-19 2021-02-25 Brickbio, Inc. Methods and compositions for analyte detection and quantification
EP4069731A4 (de) 2019-12-03 2024-05-29 Alamar Biosciences, Inc. Nukleinsäure-gekoppelter immun-sandwich-assay (nulisa)
GB201919029D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
GB201919032D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
AU2021241898A1 (en) 2020-03-27 2022-10-13 Olink Proteomics Ab Method for detecting analytes of varying abundance
GB202004472D0 (en) 2020-03-27 2020-05-13 Olink Proteomics Ab Method for detecting analytes of varying abundance
GB202004469D0 (en) 2020-03-27 2020-05-13 Olink Proteomics Ab Controls for proximity detection assays
JP2023545038A (ja) * 2020-10-06 2023-10-26 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 中和標的のシグナルオン検出のための方法、組成物、キット、およびシステム
GB202017873D0 (en) 2020-11-12 2020-12-30 Olso Unversitetssykehus Hf Method of determining DLBCL prognosis
GB202018503D0 (en) 2020-11-25 2021-01-06 Olink Proteomics Ab Analyte detection method employing concatamers
JP2024500447A (ja) * 2020-12-16 2024-01-09 コグネクスト ダイアグノスティックス エルエルシー アルツハイマー病及び他の神経障害の診断方法
CN113945720B (zh) * 2021-09-26 2024-08-16 瑞博奥(广州)生物科技股份有限公司 基于核酸适配体探针的pdgf-bb识别方法及检测pdgf-bb的试剂盒
WO2023122345A1 (en) * 2021-12-23 2023-06-29 California Institute Of Technology Suppression of non-specific signals by exonucleases in fish experiment
GB202213930D0 (en) 2022-09-23 2022-11-09 Xu Bo Padlock blocking oligonucleotide
EP4615996A1 (de) 2022-11-11 2025-09-17 Olink Proteomics AB Bibliothek von proximitätssonden und verwendungsverfahren
EP4382534A1 (de) 2022-12-06 2024-06-12 Biomérieux Synthetisches peptid zur verwendung in einem immunmolekulartest
KR20260034627A (ko) 2023-07-11 2026-03-11 오링크 프로테오믹스 에이비 건조 시약
WO2025012226A1 (en) 2023-07-12 2025-01-16 Olink Proteomics Ab Method, components and software for detecting a systematic error in a protein detection system
WO2025031642A1 (en) 2023-08-07 2025-02-13 Olink Proteomics Ab A method for determining run errors for an analysis-method for quantifying a plurality of analytes in a plurality of biological samples
CN119757755B (zh) * 2024-11-01 2025-08-29 上海伯杰医疗科技股份有限公司 一种环状连接超敏免疫检测方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4883750A (en) * 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
AU622426B2 (en) * 1987-12-11 1992-04-09 Abbott Laboratories Assay using template-dependent nucleic acid probe reorganization
EP0666927B1 (de) * 1991-09-13 1997-05-07 Cytocell Limited Verfahren zur Bestimmung von einer Nukleinsäuresequenz
US5846709A (en) * 1993-06-15 1998-12-08 Imclone Systems Incorporated Chemical process for amplifying and detecting nucleic acid sequences
SE504798C2 (sv) * 1995-06-16 1997-04-28 Ulf Landegren Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten
WO2001023894A1 (de) * 1999-09-28 2001-04-05 Evotec Oai Ag Quantitative analyse und typisierung subzellulärer partikel

Also Published As

Publication number Publication date
CA2400384A1 (en) 2001-08-23
SE0000538D0 (sv) 2000-02-18
JP4804691B2 (ja) 2011-11-02
JP2003524419A (ja) 2003-08-19
SE0000538L (sv) 2001-08-19
ATE402269T1 (de) 2008-08-15
WO2001061037A1 (en) 2001-08-23
AU783644B2 (en) 2005-11-17
AU3430001A (en) 2001-08-27
EP1255861B1 (de) 2008-07-23
EP1255861A1 (de) 2002-11-13
DE60134957D1 (de) 2008-09-04

Similar Documents

Publication Publication Date Title
JP4804691B2 (ja) 近接プロービング方法およびキット
US7306904B2 (en) Methods and kits for proximity probing
US11293053B2 (en) Bifunctional oligonucleotide probe for universal real time multianalyte detection
JP3738910B2 (ja) 特定の核酸配列を検出するためのハイブリダイゼーション−ライゲーション分析
CN115698318B (zh) 用于邻近检测测定的对照
US20200399689A1 (en) Methods of detecting nucleic acid sequences with high specificity
JP2005521409A (ja) 単一プライマー等温核酸増幅−増強型被分析物検出および定量
JP2003535599A (ja) 核酸の捕捉部とその使用
JP7815132B2 (ja) 存在量が異なる分析物を検出するための方法
JP2023550568A (ja) コンカテマーを用いた分析物検出方法
JP2022145606A (ja) 核酸の正確な並行定量のための高感度な方法
CN107002066A (zh) 复合式多步核酸扩增
US20070166709A1 (en) Immuno-pcr method
WO2022208171A1 (en) Methods for analyte detection
WO2024117954A1 (en) In vitro detection method and device
Göransson Readout Strategies for Biomolecular Analyses
Razdan et al. Diagnosis of Medically Important Viruses: A Molecular Approach
JP2019180308A (ja) ニッキングエンザイムを利用した測定方法
JP2005110664A (ja) 核酸シグナルの増幅による標的ｄｎａの存在を検出する方法、及び免疫学的配位子の検出又は定量する方法

Legal Events

Date Code Title Description
NUG Patent has lapsed