ATE402607T1 - Delta-4-desaturase-gene und ihre verwendung - Google Patents
Delta-4-desaturase-gene und ihre verwendungInfo
- Publication number
- ATE402607T1 ATE402607T1 AT02731579T AT02731579T ATE402607T1 AT E402607 T1 ATE402607 T1 AT E402607T1 AT 02731579 T AT02731579 T AT 02731579T AT 02731579 T AT02731579 T AT 02731579T AT E402607 T1 ATE402607 T1 AT E402607T1
- Authority
- AT
- Austria
- Prior art keywords
- acid
- desaturase
- delta
- delta4
- conversion
- Prior art date
Links
- 101000912235 Rebecca salina Acyl-lipid (7-3)-desaturase Proteins 0.000 title abstract 3
- 101000877236 Siganus canaliculatus Acyl-CoA Delta-4 desaturase Proteins 0.000 title abstract 3
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 abstract 2
- TWSWSIQAPQLDBP-CGRWFSSPSA-N (7e,10e,13e,16e)-docosa-7,10,13,16-tetraenoic acid Chemical compound CCCCC\C=C\C\C=C\C\C=C\C\C=C\CCCCCC(O)=O TWSWSIQAPQLDBP-CGRWFSSPSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 235000021292 Docosatetraenoic acid Nutrition 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- TWSWSIQAPQLDBP-UHFFFAOYSA-N adrenic acid Natural products CCCCCC=CCC=CCC=CCC=CCCCCCC(O)=O TWSWSIQAPQLDBP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 229940090949 docosahexaenoic acid Drugs 0.000 abstract 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000016709 nutrition Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
- A23L7/10—Cereal-derived products
- A23L7/117—Flakes or other shapes of ready-to-eat type; Semi-finished or partly-finished products therefor
- A23L7/126—Snacks or the like obtained by binding, shaping or compacting together cereal grains or cereal pieces, e.g. cereal bars
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L9/00—Puddings; Cream substitutes; Preparation or treatment thereof
- A23L9/10—Puddings; Dry powder puddings
- A23L9/12—Ready-to-eat liquid or semi-liquid desserts, e.g. puddings, not to be mixed with liquids, e.g. water, milk
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6434—Docosahexenoic acids [DHA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Polymers & Plastics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Animal Husbandry (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Cosmetics (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/849,199 US20030082754A1 (en) | 2001-05-04 | 2001-05-04 | Delta4 - desaturase genes and uses thereof |
| US10/120,637 US7045683B2 (en) | 2001-05-04 | 2002-04-11 | Δ4-desaturase genes and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE402607T1 true ATE402607T1 (de) | 2008-08-15 |
Family
ID=26818584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02731579T ATE402607T1 (de) | 2001-05-04 | 2002-05-02 | Delta-4-desaturase-gene und ihre verwendung |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US7045683B2 (de) |
| EP (1) | EP1401259B1 (de) |
| JP (1) | JP4173010B2 (de) |
| AT (1) | ATE402607T1 (de) |
| AU (1) | AU2002303551B2 (de) |
| CA (1) | CA2446439C (de) |
| DE (1) | DE60227951D1 (de) |
| ES (1) | ES2310204T3 (de) |
| WO (1) | WO2002090493A2 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6566583B1 (en) * | 1997-06-04 | 2003-05-20 | Daniel Facciotti | Schizochytrium PKS genes |
| GB0316629D0 (en) * | 2003-07-16 | 2003-08-20 | Univ York | Transgenic cell |
| US20040172682A1 (en) * | 2003-02-12 | 2004-09-02 | Kinney Anthony J. | Production of very long chain polyunsaturated fatty acids in oilseed plants |
| MXPA05010571A (es) * | 2003-04-08 | 2005-11-23 | Basf Plant Science Gmbh | Delta-4-desaturasas a partir de euglena gracilis, que expresan plantas y aceites que comprenden pufa |
| US7238482B2 (en) | 2003-05-07 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US7125672B2 (en) | 2003-05-07 | 2006-10-24 | E. I. Du Pont De Nemours And Company | Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts |
| ES2713548T3 (es) | 2003-08-01 | 2019-05-22 | Basf Plant Science Gmbh | Procedimiento para la producción de ácidos grasos poliinsaturados en organismos transgénicos |
| AU2004290051A1 (en) | 2003-11-12 | 2005-05-26 | E.I. Dupont De Nemours And Company | Delta-15 desaturases suitable for altering levels of polyunsaturated fatty acids in oilseed plants and oleaginous yeast |
| WO2005083053A2 (de) | 2004-02-27 | 2005-09-09 | Basf Plant Science Gmbh | Verfahren zur herstellung von ungesättigten omega-3-fettsäuren in transgenen organismen |
| EP2623584B1 (de) | 2004-02-27 | 2019-04-10 | BASF Plant Science GmbH | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen Pflanzen |
| CA3056110C (en) * | 2004-04-22 | 2020-07-14 | Surinder Pal Singh | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| DK1756280T3 (en) | 2004-04-22 | 2015-02-02 | Commw Scient Ind Res Org | SYNTHESIS OF CHAIN, polyunsaturated fatty acids BY RECOMBINANT CELLS |
| CA2568689A1 (en) | 2004-06-04 | 2005-12-15 | Fluxome Sciences A/S | Metabolically engineered cells for the production of polyunsaturated fatty acids |
| US7550286B2 (en) | 2004-11-04 | 2009-06-23 | E. I. Du Pont De Nemours And Company | Docosahexaenoic acid producing strains of Yarrowia lipolytica |
| ES2626018T3 (es) | 2005-06-07 | 2017-07-21 | Dsm Nutritional Products Ag | Microorganismos eucariotas para la producción de lípidos y antioxidantes |
| CN101268190A (zh) * | 2005-07-20 | 2008-09-17 | 阿维斯塔金格兰技术有限公司 | 来自破囊壶菌属(Thraustochytrid)的△6去饱和酶及其用途 |
| AR059376A1 (es) | 2006-02-21 | 2008-03-26 | Basf Plant Science Gmbh | Procedimiento para la produccion de acidos grasos poliinsaturados |
| US7678560B2 (en) | 2006-05-17 | 2010-03-16 | E.I. Du Pont De Nemours And Company | Δ 5 desaturase and its use in making polyunsaturated fatty acids |
| US7695950B2 (en) | 2006-05-17 | 2010-04-13 | E. I. Du Pont De Nemours And Company | Δ5 desaturase and its use in making polyunsaturated fatty acids |
| CN101981201A (zh) * | 2006-08-01 | 2011-02-23 | 加拿大海洋营养食品有限公司 | 产油微生物及改良这些微生物的方法 |
| CN101578363A (zh) | 2006-08-29 | 2009-11-11 | 联邦科学技术研究组织 | 脂肪酸的合成 |
| US8389808B2 (en) | 2007-02-12 | 2013-03-05 | E.I. Du Pont De Nemours And Company | Production of arachidonic acid in oilseed plants |
| ES2559312T3 (es) * | 2007-04-03 | 2016-02-11 | E. I. Du Pont De Nemours And Company | Multienzimas y su uso en la fabricación de ácidos grasos poliinsaturados |
| US8119784B2 (en) * | 2008-04-02 | 2012-02-21 | E. I. Du Pont De Nemours And Company | Delta-4 desaturase and its use in making polyunsaturated fatty acids |
| NO2358882T3 (de) | 2008-11-18 | 2017-12-23 | ||
| US9493520B2 (en) * | 2009-07-17 | 2016-11-15 | Basf Plant Science Company Gmbh | Fatty acid desaturases and elongases and uses thereof |
| EP2585600B1 (de) * | 2010-06-24 | 2016-02-03 | Dow AgroSciences LLC | Verringerung des gehalts an gesättigten fettsäuren von pflanzensamen |
| US20120252888A1 (en) | 2011-03-29 | 2012-10-04 | Palupa Medical Ltd. | Compositions and Methods for Treating Neurologic Disorders |
| BR112014025265A2 (pt) | 2012-04-12 | 2017-07-11 | Rothamsted Res Ltd | produção de ácidos graxos poli-insaturados ômega-3 de cadeia longa |
| PL2861059T3 (pl) | 2012-06-15 | 2017-10-31 | Commw Scient Ind Res Org | Wytwarzanie długołańcuchowych wielonienasyconych kwasów tłuszczowych w komórkach roślinnych |
| GB201217524D0 (en) | 2012-10-01 | 2012-11-14 | Rothamsted Res Ltd | Recombinant organisms |
| DK2970926T3 (en) | 2013-03-13 | 2018-04-16 | Dsm Nutritional Products Ag | GENMANIPULATION OF MICROorganisms |
| NZ721036A (en) | 2013-12-18 | 2023-07-28 | Grains Res & Dev Corp | Lipid comprising long chain polyunsaturated fatty acids |
| PH12016502586B1 (en) | 2014-06-27 | 2023-07-19 | Commw Scient Ind Res Org | Lipid comprising docosapentaenoic acid |
| DE102014223256A1 (de) * | 2014-11-14 | 2016-05-19 | Robert Bosch Gmbh | Vorrichtung zur Öffnungssensierung einer Verpackung sowie Verfahren zur Herstellung der Vorrichtung |
| US10264732B2 (en) * | 2016-09-27 | 2019-04-23 | L.P. Brown Company, Inc. | Harvested bale wrapping material sheets |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8507058D0 (en) | 1985-03-19 | 1985-04-24 | Efamol Ltd | Pharmaceutical & dietary compositions |
| GB8524275D0 (en) | 1985-10-02 | 1985-11-06 | Efamol Ltd | Pharmaceutical & dietary compositions |
| GB8524276D0 (en) | 1985-10-02 | 1985-11-06 | Efamol Ltd | Pharmaceutical & dietary compositions |
| US5340742A (en) | 1988-09-07 | 1994-08-23 | Omegatech Inc. | Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids |
| US5985348A (en) | 1995-06-07 | 1999-11-16 | Omegatech, Inc. | Milk products having high concentrations of omega-3 highly unsaturated fatty acids |
| US5116871A (en) | 1988-09-13 | 1992-05-26 | Efamol Holdings Plc | Fatty acid therapy and compositions for the treatment of myalgic encephalomyelitis |
| US5196198A (en) | 1989-06-02 | 1993-03-23 | Abbott Laboratories | Parenteral nutrition product |
| WO1991018985A1 (en) | 1990-05-25 | 1991-12-12 | E.I. Du Pont De Nemours And Company | Nucleotide sequence of soybean stearoyl-acp desaturase gene |
| PH31293A (en) | 1991-10-10 | 1998-07-06 | Rhone Poulenc Agrochimie | Production of y-linolenic acid by a delta6-desaturage. |
| CA2124673C (en) | 1991-12-04 | 2008-08-05 | John Browse | Fatty acid desaturase genes from plants |
| DK0668919T3 (da) | 1992-11-17 | 2003-09-15 | Du Pont | Gener for mikorsomale delta-12-fedtsyredesaturaser og beslægtede enzymer fra planter |
| JPH078215A (ja) | 1993-04-30 | 1995-01-13 | Kawasaki Steel Corp | ドコサヘキサエン酸含有海洋性微細藻類食品素材およびその製造方法 |
| WO1995024494A1 (en) | 1994-03-09 | 1995-09-14 | Abbott Laboratories | Humanized milk |
| US5654402A (en) | 1994-10-26 | 1997-08-05 | Michigan State University | Methods and compositions relating to plant Δ6 palmitoyl-acyl carrier protein desaturase |
| DE19629433A1 (de) | 1996-07-22 | 1998-01-29 | Hoechst Ag | Omega-3-fettsäurenenthaltende Zubereitung aus Mikroorganismen als Prophylaktikum bzw. Therapeutikum gegen parasitäre Erkrankungen beim Tier |
| NZ337459A (en) * | 1997-04-11 | 2000-07-28 | Abbott Lab | Nucleic acid construct in plants and dietary supplement |
| US6677145B2 (en) | 1998-09-02 | 2004-01-13 | Abbott Laboratories | Elongase genes and uses thereof |
| US6403349B1 (en) | 1998-09-02 | 2002-06-11 | Abbott Laboratories | Elongase gene and uses thereof |
| KR19990046733A (ko) | 1999-04-20 | 1999-07-05 | 류성구 | 미생물슈도모나스에의한도코사핵사노인산(ｄｈａ)의제조방법 |
| WO2001004636A1 (en) * | 1999-07-12 | 2001-01-18 | Ohio University | Mammalian cells expressing desaturases and elongases |
| CN101845446B (zh) | 2000-09-28 | 2016-01-20 | 生物源食物及科学公司 | 脂肪酸去饱和酶家族成员fad4、fad5、fad5-2和fad6及它们的应用 |
| WO2002081668A2 (en) * | 2001-01-25 | 2002-10-17 | Abbott Laboratories | Desaturase genes and uses thereof |
-
2002
- 2002-04-11 US US10/120,637 patent/US7045683B2/en not_active Expired - Fee Related
- 2002-05-02 WO PCT/US2002/013589 patent/WO2002090493A2/en not_active Ceased
- 2002-05-02 DE DE60227951T patent/DE60227951D1/de not_active Expired - Lifetime
- 2002-05-02 CA CA2446439A patent/CA2446439C/en not_active Expired - Fee Related
- 2002-05-02 AU AU2002303551A patent/AU2002303551B2/en not_active Ceased
- 2002-05-02 AT AT02731579T patent/ATE402607T1/de not_active IP Right Cessation
- 2002-05-02 ES ES02731579T patent/ES2310204T3/es not_active Expired - Lifetime
- 2002-05-02 JP JP2002587556A patent/JP4173010B2/ja not_active Expired - Fee Related
- 2002-05-02 EP EP02731579A patent/EP1401259B1/de not_active Revoked
-
2004
- 2004-08-06 US US10/913,271 patent/US7220897B2/en not_active Expired - Fee Related
- 2004-08-06 US US10/913,226 patent/US7208297B2/en not_active Expired - Fee Related
- 2004-08-06 US US10/913,779 patent/US7205134B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2310204T3 (es) | 2009-01-01 |
| CA2446439A1 (en) | 2002-11-14 |
| US20050005329A1 (en) | 2005-01-06 |
| US20050003442A1 (en) | 2005-01-06 |
| EP1401259A2 (de) | 2004-03-31 |
| US7205134B2 (en) | 2007-04-17 |
| US20030134400A1 (en) | 2003-07-17 |
| JP4173010B2 (ja) | 2008-10-29 |
| US7220897B2 (en) | 2007-05-22 |
| JP2005525780A (ja) | 2005-09-02 |
| US7045683B2 (en) | 2006-05-16 |
| CA2446439C (en) | 2012-06-05 |
| EP1401259A4 (de) | 2005-06-22 |
| DE60227951D1 (de) | 2008-09-11 |
| AU2002303551B2 (en) | 2007-06-14 |
| US20050005328A1 (en) | 2005-01-06 |
| AU2002303551B8 (en) | 2002-11-18 |
| US7208297B2 (en) | 2007-04-24 |
| EP1401259B1 (de) | 2008-07-30 |
| WO2002090493A2 (en) | 2002-11-14 |
| WO2002090493A3 (en) | 2003-10-16 |
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