ATE403437T1 - Lfa-1 antagonisten und tnf-alpha antagonisten zur behandlung von rheumatoiden arthritis - Google Patents

Lfa-1 antagonisten und tnf-alpha antagonisten zur behandlung von rheumatoiden arthritis

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Publication number
ATE403437T1
ATE403437T1 AT00986377T AT00986377T ATE403437T1 AT E403437 T1 ATE403437 T1 AT E403437T1 AT 00986377 T AT00986377 T AT 00986377T AT 00986377 T AT00986377 T AT 00986377T AT E403437 T1 ATE403437 T1 AT E403437T1
Authority
AT
Austria
Prior art keywords
antagonists
lfa
tnf
alpha
treatment
Prior art date
Application number
AT00986377T
Other languages
English (en)
Inventor
Wyne Lee
Daniel Tumas
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE403437T1 publication Critical patent/ATE403437T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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AT00986377T 1999-12-14 2000-12-14 Lfa-1 antagonisten und tnf-alpha antagonisten zur behandlung von rheumatoiden arthritis ATE403437T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17069699P 1999-12-14 1999-12-14

Publications (1)

Publication Number Publication Date
ATE403437T1 true ATE403437T1 (de) 2008-08-15

Family

ID=22620900

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00986377T ATE403437T1 (de) 1999-12-14 2000-12-14 Lfa-1 antagonisten und tnf-alpha antagonisten zur behandlung von rheumatoiden arthritis

Country Status (15)

Country Link
US (3) US20010031260A1 (de)
EP (1) EP1237575B1 (de)
JP (1) JP2003517022A (de)
KR (1) KR100567292B1 (de)
CN (1) CN1409639A (de)
AT (1) ATE403437T1 (de)
AU (1) AU768324B2 (de)
CA (1) CA2394862C (de)
DE (1) DE60039783D1 (de)
DK (1) DK1237575T3 (de)
ES (1) ES2311483T3 (de)
IL (1) IL149890A0 (de)
NZ (1) NZ519222A (de)
PT (1) PT1237575E (de)
WO (1) WO2001043773A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6867203B2 (en) 1998-12-29 2005-03-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
CA2417432C (en) 2000-09-01 2010-11-02 The Center For Blood Research, Inc. Modified polypeptides stabilized in a desired conformation and methods for producing same
AU2002306651B2 (en) * 2001-03-02 2007-12-13 Medimmune, Llc Methods of preventing or treating inflammatory or autoimmune disorders by administering integrin alphav Beta3 antagonists
GB0111497D0 (en) * 2001-05-11 2001-07-04 Medical Res Council Therapeutic methods
SI1478394T1 (sl) 2002-02-27 2008-12-31 Immunex Corp STABILIZIRAN TNFR-Fc SESTAVEK Z ARGININOM
EP1946776B1 (de) * 2002-02-27 2017-01-18 Immunex Corporation Stabilisierte tnfr-fc-verbindung mit arginin
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
BR0314603A (pt) * 2002-09-20 2005-07-26 Alcon Inc Uso de inibidores da sìntese de citoquina para o tratamento de distúrbios de olhos secos
ATE472556T1 (de) 2002-12-02 2010-07-15 Amgen Fremont Inc Gegen den tumor nekrose faktor gerichtete antikörper und deren verwendungen
WO2005039502A2 (en) * 2003-10-24 2005-05-06 Azopax Therapeutics Llc Macromer-melt formulations
JP5105578B2 (ja) 2003-11-05 2012-12-26 サーコード バイオサイエンス インコーポレイテッド 細胞接着のモジュレーター
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
US7871988B1 (en) * 2005-01-04 2011-01-18 Gp Medical, Inc. Nanoparticles for protein drug delivery
KR101465456B1 (ko) 2005-05-16 2014-11-27 애브비 바이오테크놀로지 리미티드 미란성 다발관절염의 치료를 위한 ｔｎｆ 억제제의 용도
US8168655B2 (en) * 2005-05-17 2012-05-01 Sarcode Bioscience Inc. Compositions and methods for treatment of eye disorders
WO2006138181A2 (en) 2005-06-14 2006-12-28 Amgen Inc. Self-buffering protein formulations
AU2006326870A1 (en) * 2005-12-22 2007-06-28 Apollo Life Sciences Transdermal delivery of pharmaceutical agents
US9605064B2 (en) 2006-04-10 2017-03-28 Abbvie Biotechnology Ltd Methods and compositions for treatment of skin disorders
EP2666472A3 (de) 2006-04-10 2014-04-02 Abbott Biotechnology Ltd Anwendungen und Zusammensetzungen zur Behandlung von Psoriasis-Arthritis
US8999337B2 (en) 2007-06-11 2015-04-07 Abbvie Biotechnology Ltd. Methods for treating juvenile idiopathic arthritis by inhibition of TNFα
MX2010004281A (es) 2007-10-19 2010-09-10 Sarcode Corp Composiciones y metodos para el tratamiento de la retinopatia diabetica.
EP2265124A4 (de) * 2008-04-15 2011-12-28 Sarcode Bioscience Inc Aerosolisierte lfa-1-antagonisten zur verwendung bei der lokalen behandlung von immunerkrankungen
ES2763703T3 (es) * 2008-04-15 2020-05-29 Sarcode Bioscience Inc Antagonistas de LFA-1 tópicos utilizados en el tratamiento localizado de trastornos inmunes
WO2009139817A2 (en) 2008-04-15 2009-11-19 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
WO2011063127A1 (en) 2009-11-18 2011-05-26 University Of Medicine And Dentistry Of New Jersey Targeting tumor cells with chemotherapeutic agents conjugated to matriptase antibodies
PL2461700T3 (pl) * 2009-08-06 2016-11-30 Środek konserwujący do wody i pożywienia
US8378105B2 (en) * 2009-10-21 2013-02-19 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
US9849192B2 (en) 2009-11-18 2017-12-26 Rutgers, The State University Of New Jersey Targeting tumor cells with chemotherapeutic agents conjugated to matriptase antibodies
LT2611310T (lt) * 2010-08-27 2017-10-10 Anitox Corporation Antimikrobinė kompozicija
MX2014004618A (es) 2011-10-20 2014-05-27 Anitox Corp Formulaciones antimicrobianas con acido pelargonico.
ES2859788T3 (es) 2011-11-30 2021-10-04 Anitox Corp Mezcla antimicrobiana de aldehídos, ácidos orgánicos y ésteres de ácidos orgánicos
SI3715345T1 (sl) 2012-07-25 2024-07-31 Bausch + Lomb Ireland Limited Priprava zaviralca lfa-1
WO2014046631A1 (en) 2012-09-19 2014-03-27 Tezcaner Aysen CONTROLED DRUG DELIVERY SYSTEMS FOR ANTI-TNF-α
US9549993B2 (en) 2012-10-02 2017-01-24 Rutgers, The State University Of New Jersey Specific delivery of toxins conjugated with antibodies to activate matripase
WO2016149139A1 (en) * 2015-03-13 2016-09-22 Samsung Bioepis Co., Ltd. Anti-tnf-alpha polypeptide composition and use thereof
RU2613056C1 (ru) * 2016-03-14 2017-03-15 Государственное бюджетное образовательное учреждение высшего профессионального образования "Южно-Уральский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО ЮУГМУ Минздрава России) Способ прогнозирования развития увеита у детей с ювенильным идиопатическим артритом
JP7145374B2 (ja) 2016-03-18 2022-10-03 ラトガース ザ ステイト ユニバーシティー オブ ニュージャージー インビボでの切断可能連結部分によって抗マトリプターゼ抗体にコンジュゲートされた化学療法剤を用いる腫瘍細胞の標的化
ES3064802T3 (en) 2016-10-21 2026-04-29 Amgen Inc Pharmaceutical formulations and methods of making the same

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672347A (en) * 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
IL83878A (en) * 1987-09-13 1995-07-31 Yeda Res & Dev Soluble protein corresponding to tnf inhibitory protein its preparation and pharmaceutical compositions containing it
US5336603A (en) * 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
US5225538A (en) * 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US5690933A (en) * 1989-05-31 1997-11-25 Glaxo Wellcome Inc. Monoclonal antibodies for inducing tolerance
US5605690A (en) * 1989-09-05 1997-02-25 Immunex Corporation Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
US5945397A (en) * 1989-09-05 1999-08-31 Immunex Corporation Purified p75 (type II) tumor necrosis factor receptor polypeptides
NZ235148A (en) * 1989-09-05 1991-12-23 Immunex Corp Tumour necrosis factor receptor protein and dna sequences
US5994510A (en) * 1990-12-21 1999-11-30 Celltech Therapeutics Limited Recombinant antibodies specific for TNFα
US5656272A (en) * 1991-03-18 1997-08-12 New York University Medical Center Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies
US5919452A (en) * 1991-03-18 1999-07-06 New York University Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies
US5698195A (en) * 1991-03-18 1997-12-16 New York University Medical Center Methods of treating rheumatoid arthritis using chimeric anti-TNF antibodies
GB9115364D0 (en) * 1991-07-16 1991-08-28 Wellcome Found Antibody
AU687755B2 (en) * 1992-08-21 1998-03-05 Genentech Inc. Method for treating an LFA-1-mediated disorder
WO1995009652A1 (en) * 1993-10-06 1995-04-13 The Kennedy Institute For Rheumatology Treatment of autoimmune and inflammatory disorders
ZA938208B (en) * 1992-11-03 1995-01-03 Gene Shears Pty Ltd TNF-alpha ribozymes and degradation resistant mRNA derivatives linked to TNF-alpha ribozymes
EP0614984B2 (de) * 1993-03-05 2010-11-03 Bayer HealthCare LLC Humane monoklonale anti-TNF alpha Antikörper
US5594106A (en) * 1993-08-23 1997-01-14 Immunex Corporation Inhibitors of TNF-α secretion
JPH10130240A (ja) * 1996-10-30 1998-05-19 Dai Ichi Seiyaku Co Ltd Ｉｃａｍ−１産生阻害剤
PT936923E (pt) * 1996-11-15 2004-04-30 Kennedy Inst Of Rheumatology Supressao de tnfalfa e il-12 em terapia
US6037454A (en) * 1996-11-27 2000-03-14 Genentech, Inc. Humanized anti-CD11a antibodies
DK0941344T3 (da) * 1996-11-27 2004-09-27 Genentech Inc Humaniserede anti-CD11a-antistoffer
DK0942740T3 (da) * 1996-12-06 2003-12-15 Amgen Inc Kombinationsterapi under anvendelse af et TFN-bindende protein til behandling af TFN-medierede sygdomme

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EP1237575A1 (de) 2002-09-11
PT1237575E (pt) 2008-11-17
US20050214291A1 (en) 2005-09-29
DE60039783D1 (de) 2008-09-18
CA2394862A1 (en) 2001-06-21
KR100567292B1 (ko) 2006-04-04
US20080031875A1 (en) 2008-02-07
US20010031260A1 (en) 2001-10-18
EP1237575B1 (de) 2008-08-06
AU5439701A (en) 2001-06-25
DK1237575T3 (da) 2008-12-08
JP2003517022A (ja) 2003-05-20
KR20020068372A (ko) 2002-08-27
NZ519222A (en) 2004-04-30
CA2394862C (en) 2011-10-11
CN1409639A (zh) 2003-04-09
AU768324B2 (en) 2003-12-11
ES2311483T3 (es) 2009-02-16
IL149890A0 (en) 2002-11-10
WO2001043773A1 (en) 2001-06-21

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