ATE404579T1 - Verfahren zur herstellung von 4-(17alpha-methyl- substituierten)3-oxoestra-4,9-dien-11beta- yl)benzaldehyd-(1e oder 1z)-oximen - Google Patents

Verfahren zur herstellung von 4-(17alpha-methyl- substituierten)3-oxoestra-4,9-dien-11beta- yl)benzaldehyd-(1e oder 1z)-oximen

Info

Publication number: ATE404579T1
Authority: AT; Austria
Prior art keywords: sub; oxoestra; 11beta; 17alpha; oximes
Prior art date: 2000-11-10

Application number

AT01993607T

Other languages

English (en)

Inventor

Gerd Schubert

Sven Ring

Bernd Erhart

Gerd Mueller

Original Assignee

Bayer Schering Pharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-10

Filing date

2001-11-09

Publication date

2008-08-15

2001-11-09 Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag

2008-08-15 Application granted granted Critical

2008-08-15 Publication of ATE404579T1 publication Critical patent/ATE404579T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 title 2
QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0085—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT01993607T 2000-11-10 2001-11-09 Verfahren zur herstellung von 4-(17alpha-methyl- substituierten)3-oxoestra-4,9-dien-11beta- yl)benzaldehyd-(1e oder 1z)-oximen ATE404579T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10056675A DE10056675A1 (de)	2000-11-10	2000-11-10	Verfahren zur Herstellung von 4-(17alpha-Methylsubstituierten 3-Oxoestra-4,9-dien-11ß-yl)-benzaldehyd-(1E oder 1Z)-oximen

Publications (1)

Publication Number	Publication Date
ATE404579T1 true ATE404579T1 (de)	2008-08-15

Family

ID=7663440

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01993607T ATE404579T1 (de)	2000-11-10	2001-11-09	Verfahren zur herstellung von 4-(17alpha-methyl- substituierten)3-oxoestra-4,9-dien-11beta- yl)benzaldehyd-(1e oder 1z)-oximen

Country Status (9)

Country	Link
US (1)	US7268241B2 (de)
EP (1)	EP1339733B1 (de)
JP (1)	JP4331478B2 (de)
AT (1)	ATE404579T1 (de)
AU (1)	AU2002216910A1 (de)
DE (2)	DE10056675A1 (de)
ES (1)	ES2311559T3 (de)
NO (1)	NO325338B1 (de)
WO (1)	WO2002038581A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20090054387A1 (en) *	2006-04-18	2009-02-26	Detlef Grawe	Method for preparing 4-[17beta-methoxy-17alpha-methoxymethyl-3-oxestra-4,9-dien-11beta-yl]benzaldehyde (E)-oxime (asoprisnil)
DE102006018888A1 (de) *	2006-04-18	2007-10-25	Bayer Schering Pharma Ag	Verfahren zur Herstellung von 4-[17beta-Methoxy-17alpha-methoxymethyl-3-oxoestra-4,9-dien-11beta-yl]benzaldehyd-(E)-oxims (Asoprisnil)
CN119490551B (zh) *	2024-11-15	2025-10-31	湖北葛店人福药业有限责任公司	一种地屈孕酮的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE289539C (de) *
DD289539A5 (de) *	1989-10-12	1991-05-02	Zi F. Mikrobiologie U. Experimentelle Therapie,De	Verfahren zur herstellung von 11 beta-(4-acetylphenyl)-17alpha-alkoxy-methyl-estra-4,9-dien-3-onen
DE4332283A1 (de)	1993-09-20	1995-04-13	Jenapharm Gmbh	Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

2000
- 2000-11-10 DE DE10056675A patent/DE10056675A1/de not_active Ceased
2001
- 2001-11-09 AU AU2002216910A patent/AU2002216910A1/en not_active Abandoned
- 2001-11-09 WO PCT/DE2001/004217 patent/WO2002038581A2/de not_active Ceased
- 2001-11-09 JP JP2002541113A patent/JP4331478B2/ja not_active Expired - Fee Related
- 2001-11-09 AT AT01993607T patent/ATE404579T1/de not_active IP Right Cessation
- 2001-11-09 ES ES01993607T patent/ES2311559T3/es not_active Expired - Lifetime
- 2001-11-09 DE DE50114228T patent/DE50114228D1/de not_active Expired - Lifetime
- 2001-11-09 US US10/416,234 patent/US7268241B2/en not_active Expired - Lifetime
- 2001-11-09 EP EP01993607A patent/EP1339733B1/de not_active Expired - Lifetime
2003
- 2003-05-09 NO NO20032079A patent/NO325338B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU2002216910A1 (en)	2002-05-21
JP4331478B2 (ja)	2009-09-16
EP1339733A2 (de)	2003-09-03
DE50114228D1 (de)	2008-09-25
EP1339733B1 (de)	2008-08-13
ES2311559T3 (es)	2009-02-16
WO2002038581A2 (de)	2002-05-16
NO20032079L (no)	2003-05-09
DE10056675A1 (de)	2002-05-16
US20040063172A1 (en)	2004-04-01
US7268241B2 (en)	2007-09-11
NO20032079D0 (no)	2003-05-09
WO2002038581A3 (de)	2002-09-12
JP2004513178A (ja)	2004-04-30
NO325338B1 (no)	2008-03-31

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Legal Events

Date	Code	Title	Description
2010-02-15	REN	Ceased due to non-payment of the annual fee