ATE389631T1 - Verfahren zur herstellung von fexofenadinen - Google Patents
Verfahren zur herstellung von fexofenadinenInfo
- Publication number
- ATE389631T1 ATE389631T1 AT01947748T AT01947748T ATE389631T1 AT E389631 T1 ATE389631 T1 AT E389631T1 AT 01947748 T AT01947748 T AT 01947748T AT 01947748 T AT01947748 T AT 01947748T AT E389631 T1 ATE389631 T1 AT E389631T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- compound
- formula
- alkyl
- hereinbefore defined
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 7
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229950008193 azacyclonol Drugs 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- ZMISODWVFHHWNR-UHFFFAOYSA-N diphenyl(4-piperidinyl)methanol Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(O)C1CCNCC1 ZMISODWVFHHWNR-UHFFFAOYSA-N 0.000 abstract 1
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 abstract 1
- 229960003592 fexofenadine Drugs 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 229910052763 palladium Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940100890 silver compound Drugs 0.000 abstract 1
- 150000003379 silver compounds Chemical class 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/313—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of doubly bound oxygen containing functional groups, e.g. carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Catalysts (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0018691.6A GB0018691D0 (en) | 2000-07-28 | 2000-07-28 | Process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE389631T1 true ATE389631T1 (de) | 2008-04-15 |
Family
ID=9896639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01947748T ATE389631T1 (de) | 2000-07-28 | 2001-07-19 | Verfahren zur herstellung von fexofenadinen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7176318B2 (de) |
| EP (1) | EP1307423B1 (de) |
| AT (1) | ATE389631T1 (de) |
| AU (1) | AU2001269388A1 (de) |
| DE (1) | DE60133288T2 (de) |
| ES (1) | ES2302737T3 (de) |
| GB (1) | GB0018691D0 (de) |
| PT (1) | PT1307423E (de) |
| WO (1) | WO2002010115A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20040015734A (ko) * | 2001-06-18 | 2004-02-19 | 닥터 레디스 레보러터리즈 리미티드 | 4-[4-[4-(히드록실디페닐메틸)-1-피페리디닐]-1-히드록시부틸]-α,α-디메틸벤젠 아세트산 및 그 염산염의 신규 결정형태 |
| US7700779B2 (en) | 2001-06-18 | 2010-04-20 | Dr. Reddy's Laboratories Limited | Crystalline forms of fexofenadine and its hydrochloride |
| EP1616861A3 (de) * | 2004-06-15 | 2006-02-08 | Dipharma S.p.A. | Verfahren zur Herstellung von Keto-Verbindungen |
| US7498345B2 (en) * | 2004-09-17 | 2009-03-03 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
| US7498443B2 (en) | 2004-09-17 | 2009-03-03 | Albany Molecular Research, Inc. | Process for production of carebastine |
| EP2240464A4 (de) | 2008-02-12 | 2011-09-14 | Yuhan Corp | Verfahren zur herstellung von 2-methyl-2´-phenylpropionsäure-derivaten und neuartigen zwischenprodukten |
| CN102070512B (zh) * | 2009-11-21 | 2014-11-19 | 浙江华海药业股份有限公司 | 一种高纯度非索非那定及其中间体的合成路线与制备方法 |
| CN102070490B (zh) * | 2009-11-21 | 2014-07-30 | 浙江华海药业股份有限公司 | 一种非索非那定中间体2-(4-(4-羟基丁酰基)苯基)-2-甲基丙氰的制备方法 |
| US20130237709A1 (en) * | 2012-03-02 | 2013-09-12 | Chemelectiva S.R.L. | Intermediates useful for the synthesis of fexofenadine, processes for their preparation and for the preparation of fexofenadine |
| ITMI20120589A1 (it) * | 2012-04-12 | 2013-10-13 | Chemelectiva S R L | Intermedi utili per la sintesi di fexofenadina, processo per la loro preparazione e per la preparazione di fexofenadina |
| US10336698B2 (en) | 2015-01-22 | 2019-07-02 | Sanofi-Aventis Deutschland Gmbh | Process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile |
| PT3365327T (pt) * | 2015-10-22 | 2020-02-06 | Sanofi Aventis Deutschland | Processo para a preparação de fexofenadina e de intermediários usados no mesmo |
| CN107782804B (zh) * | 2016-08-25 | 2020-11-13 | 人福普克药业（武汉）有限公司 | 检测盐酸非索非那定样品中有关物质的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5499135A (en) * | 1990-12-24 | 1996-03-12 | Alcatel N.V. | Optical amplifier |
| DK1026147T3 (da) * | 1993-06-24 | 2004-03-22 | Albany Molecular Res Inc | Forbindelser, der er anvendelige som mellemprodukter i fremstillingen af piperidinderivater |
| HU226037B1 (en) * | 1993-06-25 | 2008-03-28 | Aventis Inc | Process for producing antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives and novel intermediates |
| IT1271417B (it) * | 1993-10-15 | 1997-05-28 | Erregierre Ind Chim | Composti ad attivita' antiistaminica procedimento per la loro preperazione e composizioni farmaceutiche che li contengono. |
| JPH08237203A (ja) * | 1995-02-23 | 1996-09-13 | Fujitsu Ltd | 光フィルタアレイ、光送信機及び光送信システム |
| US6101200A (en) * | 1997-12-24 | 2000-08-08 | Nortel Networks Corporation | Laser module allowing simultaneous wavelength and power control |
| US6134253A (en) * | 1998-02-19 | 2000-10-17 | Jds Uniphase Corporation | Method and apparatus for monitoring and control of laser emission wavelength |
| FR2776302B1 (fr) * | 1998-03-19 | 2002-04-12 | Hoechst Marion Roussel Inc | Nouveau procede de preparation de la fexofenadine |
| JP3197869B2 (ja) * | 1998-03-31 | 2001-08-13 | アンリツ株式会社 | 波長可変レーザ光源装置 |
| US6018536A (en) * | 1998-11-20 | 2000-01-25 | Sarnoff Corporation | Multiple-wavelength mode-locked laser |
-
2000
- 2000-07-28 GB GBGB0018691.6A patent/GB0018691D0/en not_active Ceased
-
2001
- 2001-07-19 AU AU2001269388A patent/AU2001269388A1/en not_active Abandoned
- 2001-07-19 WO PCT/IB2001/001294 patent/WO2002010115A1/en not_active Ceased
- 2001-07-19 DE DE60133288T patent/DE60133288T2/de not_active Expired - Fee Related
- 2001-07-19 AT AT01947748T patent/ATE389631T1/de not_active IP Right Cessation
- 2001-07-19 ES ES01947748T patent/ES2302737T3/es not_active Expired - Lifetime
- 2001-07-19 PT PT01947748T patent/PT1307423E/pt unknown
- 2001-07-19 US US10/333,974 patent/US7176318B2/en not_active Expired - Fee Related
- 2001-07-19 EP EP01947748A patent/EP1307423B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002010115A1 (en) | 2002-02-07 |
| EP1307423A1 (de) | 2003-05-07 |
| EP1307423B1 (de) | 2008-03-19 |
| DE60133288T2 (de) | 2009-04-16 |
| ES2302737T3 (es) | 2008-08-01 |
| PT1307423E (pt) | 2008-06-09 |
| GB0018691D0 (en) | 2000-09-20 |
| US20030166682A1 (en) | 2003-09-04 |
| AU2001269388A1 (en) | 2002-02-13 |
| DE60133288D1 (de) | 2008-04-30 |
| US7176318B2 (en) | 2007-02-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1307423 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |