ATE405669T1 - Remodellierung von glycoproteinen unter verwendung von endoglycanasen - Google Patents

Remodellierung von glycoproteinen unter verwendung von endoglycanasen

Info

Publication number
ATE405669T1
ATE405669T1 AT02786845T AT02786845T ATE405669T1 AT E405669 T1 ATE405669 T1 AT E405669T1 AT 02786845 T AT02786845 T AT 02786845T AT 02786845 T AT02786845 T AT 02786845T AT E405669 T1 ATE405669 T1 AT E405669T1
Authority
AT
Austria
Prior art keywords
glycoproteins
endoglycanases
remodeling
provides methods
recombinantly produced
Prior art date
Application number
AT02786845T
Other languages
English (en)
Inventor
Shawn Defrees
Karl Johnson
Original Assignee
Neose Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neose Technologies Inc filed Critical Neose Technologies Inc
Application granted granted Critical
Publication of ATE405669T1 publication Critical patent/ATE405669T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT02786845T 2001-11-28 2002-11-27 Remodellierung von glycoproteinen unter verwendung von endoglycanasen ATE405669T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33430101P 2001-11-28 2001-11-28

Publications (1)

Publication Number Publication Date
ATE405669T1 true ATE405669T1 (de) 2008-09-15

Family

ID=23306575

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02786845T ATE405669T1 (de) 2001-11-28 2002-11-27 Remodellierung von glycoproteinen unter verwendung von endoglycanasen

Country Status (7)

Country Link
EP (1) EP1461445B1 (de)
JP (1) JP2005535280A (de)
AT (1) ATE405669T1 (de)
AU (1) AU2002351199A1 (de)
CA (1) CA2468295C (de)
DE (1) DE60228492D1 (de)
WO (1) WO2003046150A2 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
AU2004221824B2 (en) 2003-03-14 2009-08-27 Ratiopharm Gmbh Branched water-soluble polymers and their conjugates
CA2522345A1 (en) 2003-04-09 2004-11-18 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
US7932364B2 (en) 2003-05-09 2011-04-26 Novo Nordisk A/S Compositions and methods for the preparation of human growth hormone glycosylation mutants
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US7956032B2 (en) 2003-12-03 2011-06-07 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
NZ548123A (en) 2004-01-08 2010-05-28 Novo Nordisk As O-linked glycosylation of peptides
CA2565414A1 (en) 2004-05-04 2005-11-24 Novo Nordisk Health Care Ag O-linked glycoforms of polypeptides and method to manufacture them
WO2006010143A2 (en) 2004-07-13 2006-01-26 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
WO2006031811A2 (en) 2004-09-10 2006-03-23 Neose Technologies, Inc. Glycopegylated interferon alpha
EP1797192A1 (de) * 2004-09-29 2007-06-20 Novo Nordisk Health Care AG Modifizierte proteine
EP1814573B1 (de) 2004-10-29 2016-03-09 ratiopharm GmbH Remodellierung und glykopegylierung von fibroblasten-wachstumsfaktor (fgf)
CA2593682C (en) 2005-01-10 2016-03-22 Neose Technologies, Inc. Glycopegylated granulocyte colony stimulating factor
US8148112B2 (en) * 2005-02-16 2012-04-03 National University Corporation Hokkaido University Sugar chain containing 4-position halogenated galactose and application thereof
US9187546B2 (en) 2005-04-08 2015-11-17 Novo Nordisk A/S Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
WO2006127910A2 (en) 2005-05-25 2006-11-30 Neose Technologies, Inc. Glycopegylated erythropoietin formulations
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
US20070249014A1 (en) 2006-02-10 2007-10-25 Invitrogen Corporation Labeling and detection of post translationally modified proteins
CN101516388B (zh) 2006-07-21 2012-10-31 诺和诺德公司 通过o-联糖基化序列的肽的糖基化
US8969532B2 (en) 2006-10-03 2015-03-03 Novo Nordisk A/S Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
DK2101821T3 (da) 2006-12-15 2014-10-06 Baxter Healthcare Sa Faktor VIIA-(poly)sialinsyre-konjugat med forlænget halveringstid in vivo
EP2144923B1 (de) 2007-04-03 2013-02-13 BioGeneriX AG Behandlungsverfahren mit glycopegyliertem g-csf
WO2008154639A2 (en) 2007-06-12 2008-12-18 Neose Technologies, Inc. Improved process for the production of nucleotide sugars
US8207112B2 (en) 2007-08-29 2012-06-26 Biogenerix Ag Liquid formulation of G-CSF conjugate
US20130189239A1 (en) 2008-02-27 2013-07-25 Novo Nordisk A/S Conjugated Factor VIII Molecules
CA2733362C (en) 2008-08-08 2016-10-18 Universiteit Gent Cells producing glycoproteins having altered glycosylation patterns and methods and use thereof
EP3608330B1 (de) * 2008-12-16 2022-11-09 Genzyme Corporation Synthetische zwischenprodukte zur verwendung zur herstellung von oligosaccharid-protein-konjugate
KR101793195B1 (ko) 2009-03-27 2017-11-02 아카데미아 시니카 바이러스에 대한 면역을 위한 방법 및 조성물
US8642737B2 (en) 2010-07-26 2014-02-04 Baxter International Inc. Nucleophilic catalysts for oxime linkage
RU2744370C2 (ru) 2009-07-27 2021-03-05 Баксалта Инкорпорейтед Конъюгаты белков свертывания крови
BR112012001814A8 (pt) 2009-07-27 2018-02-06 Baxalta GmbH Conjugados de proteína de coagulação sanguínea
US8809501B2 (en) 2009-07-27 2014-08-19 Baxter International Inc. Nucleophilic catalysts for oxime linkage
EP3081233B1 (de) 2009-07-27 2020-12-23 Baxalta GmbH Glycopolysialylierung von proteinen ausser blutgerinnungsproteinen
TWI537385B (zh) 2010-11-04 2016-06-11 中央研究院 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法
ES2800983T3 (es) 2010-12-22 2021-01-07 Baxalta GmbH Materiales y métodos para conjugar un derivado de ácido graso soluble en agua con una proteína
US10851174B2 (en) 2011-03-03 2020-12-01 University Of Maryland, Baltimore Core fucosylated glycopeptides and glycoproteins: chemoenzymatic synthesis and uses thereof
JP6282232B2 (ja) 2012-02-10 2018-02-21 ユニバーシティー オブ メリーランド，ボルティモア 抗体及びそのＦｃフラグメントの酵素化学的糖鎖改変
DK3320105T3 (da) 2015-07-09 2021-06-07 Vib Vzw Celler, der producerer glycoproteiner med ændrede o- og o-glycosyleringsmønstre, samt tilhørende fremgangsmåder og anvendelse
WO2019043457A2 (en) 2017-09-04 2019-03-07 89Bio Ltd. CONJUGATES OF MUTANT PEPTIDE FGF-21 AND USES THEREOF

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63502716A (ja) 1986-03-07 1988-10-13 マサチューセッツ・インステチュート・オブ・テクノロジー 糖タンパク安定性の強化方法
US5728554A (en) 1995-04-11 1998-03-17 Cytel Corporation Enzymatic synthesis of glycosidic linkages
US6030815A (en) 1995-04-11 2000-02-29 Neose Technologies, Inc. Enzymatic synthesis of oligosaccharides
US5922577A (en) 1995-04-11 1999-07-13 Cytel Corporation Enzymatic synthesis of glycosidic linkages
US5876980A (en) 1995-04-11 1999-03-02 Cytel Corporation Enzymatic synthesis of oligosaccharides
AU736993B2 (en) 1997-01-16 2001-08-09 Novo Nordisk A/S Practical in vitro sialylation of recombinant glycoproteins
NZ522320A (en) * 2000-05-12 2007-03-30 Neose Technologies Inc In vitro modification of glycosylation patterns of recombinant glycopeptides

Also Published As

Publication number Publication date
DE60228492D1 (de) 2008-10-02
CA2468295A1 (en) 2003-06-05
CA2468295C (en) 2010-08-03
WO2003046150A3 (en) 2003-11-27
WO2003046150A2 (en) 2003-06-05
AU2002351199A1 (en) 2003-06-10
EP1461445B1 (de) 2008-08-20
JP2005535280A (ja) 2005-11-24
EP1461445A2 (de) 2004-09-29
EP1461445A4 (de) 2005-08-17

Similar Documents

Publication Publication Date Title
DE60228492D1 (de) Remodellierung von glycoproteinen unter verwendung von endoglycanasen
DK1015622T3 (da) Praktisk sialylering in vitro af rekombinante glycoproteiner
MXPA02011016A (es) Glicopeptidos recombinantes de glucolisacion in vitro.
DE69635948D1 (de) Methoden zur modifikation von kohlenhydratanteilen
IL149459A0 (en) Recombinant gelatins
ATE556540T1 (de) Adaptive filterung in abhängigkeit von der blockkantenstärke
ATE392430T1 (de) Verfahren zur herstellung von dipeptiden
BRPI0510295A (pt) preparação de uma glicoproteìna, e, método para produzir a mesma
DE60124730D1 (de) Neue methoden unter verwendung von cholinesteraseinhibitoren
BR0206429A (pt) Composição alvejante para a lavagem de roupa, método de branqueamento de um substrato, e, ligando
WO2003104540A3 (en) Non-woven fabric
DE60336956D1 (de) Laserstrahlmaschine
DE60316726D1 (de) Verfahren zur herstellung eines pressfilzes und pressfilz in form einer geschlossenen schleife
DE69915310D1 (de) Methoden zur behandlung der salzabhängigen hypertonie
DK1078063T3 (da) BASB029-polynukleotider og -polypeptider fra Neisseria meningitidis
ATE354802T1 (de) Methoden zum screening knochenmorphogenetishemimetika
ATE506351T1 (de) Verfahren zur herstellung von 10,11-dihydro-10- oxo-5h-dibenzoäb,füazepin-5-carboxamid
ATE554426T1 (de) Verfahren zur ermöglichung der übertragung von im wesentlichen gleichen energiemengen
ATE358172T1 (de) Verfahren zur herstellung von olefinen.
DE69913951D1 (de) Verfahren zur hydrophobierung von gips unter verwendung von mindestens eines alkylhydogenpolysiloxans und mindestens eines hydrokolloides
ATE374757T1 (de) Verfahren zur herstellung von (1,4,5)- oxadiazepinderivaten
ATE323677T1 (de) Verfahren zur herstellung von 4-amino-2,5- bisheterocyclylchinazolinen
ATE259256T1 (de) Düse zur verdünnung von phosphorwasserstoff
ATE470442T1 (de) Verwendung von gamma-tocotrienol als diuretika
DE50211365D1 (de) Substituierte 1-phenethylpiperidinverbindungen, die unter anderem als analgetika verwendung finden

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties