ATE408451T1 - Mikroarray enthaltend gel mit fixierter biosubstanz sowie seine herstellung und verwendung - Google Patents
Mikroarray enthaltend gel mit fixierter biosubstanz sowie seine herstellung und verwendungInfo
- Publication number
- ATE408451T1 ATE408451T1 AT03745212T AT03745212T ATE408451T1 AT E408451 T1 ATE408451 T1 AT E408451T1 AT 03745212 T AT03745212 T AT 03745212T AT 03745212 T AT03745212 T AT 03745212T AT E408451 T1 ATE408451 T1 AT E408451T1
- Authority
- AT
- Austria
- Prior art keywords
- gel
- fixed
- dimethylacrylamide
- filled
- tube bodies
- Prior art date
Links
- 238000002493 microarray Methods 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 abstract 4
- 239000000126 substance Substances 0.000 abstract 4
- 229940088644 n,n-dimethylacrylamide Drugs 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000012491 analyte Substances 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000003431 cross linking reagent Substances 0.000 abstract 1
- 238000005520 cutting process Methods 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N37/00—Details not covered by any other group of this subclass
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
- B01J2219/00317—Microwell devices, i.e. having large numbers of wells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00513—Essentially linear supports
- B01J2219/0052—Essentially linear supports in the shape of elongated tubes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00513—Essentially linear supports
- B01J2219/00524—Essentially linear supports in the shape of fiber bundles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00572—Chemical means
- B01J2219/00576—Chemical means fluorophore
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
- B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
- B01J2219/00644—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being present in discrete locations, e.g. gel pads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00673—Slice arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Sustainable Development (AREA)
- Food Science & Technology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Colloid Chemistry (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002101675 | 2002-04-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE408451T1 true ATE408451T1 (de) | 2008-10-15 |
Family
ID=28672124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03745212T ATE408451T1 (de) | 2002-04-03 | 2003-04-03 | Mikroarray enthaltend gel mit fixierter biosubstanz sowie seine herstellung und verwendung |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20060084060A1 (de) |
| EP (1) | EP1491888B1 (de) |
| JP (1) | JP3654894B2 (de) |
| KR (1) | KR100989196B1 (de) |
| CN (1) | CN100334450C (de) |
| AT (1) | ATE408451T1 (de) |
| AU (1) | AU2003236359A1 (de) |
| CA (1) | CA2481323C (de) |
| DE (1) | DE60323615D1 (de) |
| IL (1) | IL164366A0 (de) |
| WO (1) | WO2003083475A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7122378B1 (en) * | 1999-03-05 | 2006-10-17 | Mitsubishi Rayon Co., Ltd. | Carriers having biological substance |
| CN100334229C (zh) * | 2005-06-17 | 2007-08-29 | 东南大学 | 基于凝胶固定核酸的dna微阵列芯片制备方法 |
| CN101351260B (zh) * | 2005-11-01 | 2011-12-21 | 西北大学 | 用于微通道分离的基质和动态聚合物体系和组合物 |
| US12179014B2 (en) | 2005-11-18 | 2024-12-31 | Zoll Respicardia, Inc. | Transvenous phrenic nerve stimulation system |
| EP2371416B1 (de) | 2005-11-18 | 2018-08-22 | Respicardia, Inc. | System zur Modulation des Zwerchfellsnervs zur Vermeidung von Schlafapnoe |
| US8909341B2 (en) | 2007-01-22 | 2014-12-09 | Respicardia, Inc. | Device and method for the treatment of breathing disorders and cardiac disorders |
| US9987488B1 (en) | 2007-06-27 | 2018-06-05 | Respicardia, Inc. | Detecting and treating disordered breathing |
| JP2009156767A (ja) * | 2007-12-27 | 2009-07-16 | National Institute Of Advanced Industrial & Technology | タンパク質アレイ基板 |
| US8233987B2 (en) | 2009-09-10 | 2012-07-31 | Respicardia, Inc. | Respiratory rectification |
| SG192251A1 (en) * | 2011-02-10 | 2013-09-30 | Mitsubishi Rayon Co | Method for detecting nucleic acid |
| JP5790113B2 (ja) * | 2011-04-18 | 2015-10-07 | 三菱レイヨン株式会社 | 生体関連物質の検出方法 |
| CN104054372A (zh) * | 2011-11-04 | 2014-09-17 | 诺基亚通信公司 | Anr建立解决方案 |
| WO2013080941A1 (ja) * | 2011-12-01 | 2013-06-06 | 三菱レイヨン株式会社 | 核酸増幅用基材及び核酸増幅方法 |
| CN104603168B (zh) | 2012-09-14 | 2016-07-06 | 富士胶片株式会社 | 固化性组合物及图像形成方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4414374A (en) * | 1980-03-24 | 1983-11-08 | The Firestone Tire & Rubber Company | Butadiene-styrene-N,N-dialkylacrylamine terpolymers |
| WO1987006594A1 (en) * | 1986-04-30 | 1987-11-05 | Southwest Foundation For Biomedical Research | Polyamide resin and method for preparation of reagents for immunodiagnostic use |
| WO1993014133A1 (en) * | 1992-01-15 | 1993-07-22 | Allergan, Inc. | Hydrogel compositions and structures made from same |
| EP0862741B1 (de) * | 1995-10-23 | 2001-04-25 | Novartis AG | Optisches sensorsystem zur ionenstärkeunabhängigen ph-messung |
| AU9806298A (en) * | 1997-10-16 | 1999-05-03 | Larry S. Millstein | Method for producing arrays and devices relating thereto |
| US6087102A (en) * | 1998-01-07 | 2000-07-11 | Clontech Laboratories, Inc. | Polymeric arrays and methods for their use in binding assays |
| JP2000270879A (ja) * | 1999-03-26 | 2000-10-03 | Mitsubishi Rayon Co Ltd | 核酸固定化ゲル保持繊維並びに該繊維配列体及びその薄片 |
| JP2000270878A (ja) * | 1999-03-26 | 2000-10-03 | Mitsubishi Rayon Co Ltd | 核酸固定化ゲル保持中空繊維並びに該中空繊維配列体及びその薄片 |
| US7122378B1 (en) * | 1999-03-05 | 2006-10-17 | Mitsubishi Rayon Co., Ltd. | Carriers having biological substance |
| JP2000270877A (ja) * | 1999-03-26 | 2000-10-03 | Mitsubishi Rayon Co Ltd | 核酸固定化ゲル保持多孔質繊維並びに該多孔質繊維配列体及びその薄片 |
| JP2001248072A (ja) * | 2000-03-02 | 2001-09-14 | Mitsubishi Rayon Co Ltd | 中空繊維内壁部の処理方法及びゲル充填方法 |
| US6506594B1 (en) * | 1999-03-19 | 2003-01-14 | Cornell Res Foundation Inc | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| US6451191B1 (en) * | 1999-11-18 | 2002-09-17 | 3M Innovative Properties Company | Film based addressable programmable electronic matrix articles and methods of manufacturing and using the same |
| MXPA03006228A (es) * | 2001-01-12 | 2004-12-06 | Amersham Plc | Haluros de perfluoro sulfonilo y especies relacionadas como modificadores de soporte de polimero. |
| JP4022149B2 (ja) * | 2001-02-08 | 2007-12-12 | 三菱レイヨン株式会社 | ビニル化核酸の製造方法 |
| US6794458B2 (en) | 2001-05-18 | 2004-09-21 | 3M Innovative Properties Company | Azlactone-functional hydrophilic coatings and hydrogels |
| WO2003012423A1 (en) * | 2001-07-31 | 2003-02-13 | Mitsubishi Rayon Co., Ltd. | Hollow fiber having inner wall into which comb polymer is introduced, hollow fiber impregnated with gel, and fiber array thin section |
| JP2003083967A (ja) * | 2001-09-11 | 2003-03-19 | Mitsubishi Rayon Co Ltd | 生体関連物質固定化ゲル及び該ゲルが保持された生体関連物質固定化ゲルチップ |
-
2003
- 2003-04-03 AT AT03745212T patent/ATE408451T1/de not_active IP Right Cessation
- 2003-04-03 DE DE60323615T patent/DE60323615D1/de not_active Expired - Lifetime
- 2003-04-03 KR KR1020047015783A patent/KR100989196B1/ko not_active Expired - Fee Related
- 2003-04-03 CA CA2481323A patent/CA2481323C/en not_active Expired - Fee Related
- 2003-04-03 IL IL16436603A patent/IL164366A0/xx unknown
- 2003-04-03 WO PCT/JP2003/004274 patent/WO2003083475A1/ja not_active Ceased
- 2003-04-03 AU AU2003236359A patent/AU2003236359A1/en not_active Abandoned
- 2003-04-03 JP JP2003580857A patent/JP3654894B2/ja not_active Expired - Fee Related
- 2003-04-03 CN CNB03810119XA patent/CN100334450C/zh not_active Expired - Fee Related
- 2003-04-03 US US10/508,946 patent/US20060084060A1/en not_active Abandoned
- 2003-04-03 EP EP03745212A patent/EP1491888B1/de not_active Expired - Lifetime
-
2008
- 2008-01-15 US US12/014,251 patent/US20090023601A1/en not_active Abandoned
-
2011
- 2011-05-02 US US13/098,613 patent/US8802369B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1491888A1 (de) | 2004-12-29 |
| CA2481323C (en) | 2013-12-24 |
| US20090023601A1 (en) | 2009-01-22 |
| IL164366A0 (en) | 2005-12-18 |
| WO2003083475A1 (en) | 2003-10-09 |
| CN100334450C (zh) | 2007-08-29 |
| DE60323615D1 (de) | 2008-10-30 |
| JP3654894B2 (ja) | 2005-06-02 |
| KR20050008671A (ko) | 2005-01-21 |
| EP1491888B1 (de) | 2008-09-17 |
| US8802369B2 (en) | 2014-08-12 |
| US20060084060A1 (en) | 2006-04-20 |
| KR100989196B1 (ko) | 2010-10-20 |
| EP1491888A4 (de) | 2006-05-03 |
| JPWO2003083475A1 (ja) | 2005-08-04 |
| CN1650164A (zh) | 2005-08-03 |
| US20120010088A1 (en) | 2012-01-12 |
| AU2003236359A1 (en) | 2003-10-13 |
| CA2481323A1 (en) | 2003-10-09 |
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