ATE410431T1 - Verfahren zur herstellung von rapamycin-42-estern und fk-506-32-estern mit dicarbonsäure, vorstufen für rapamycinkonjugate und antikörper - Google Patents

Verfahren zur herstellung von rapamycin-42-estern und fk-506-32-estern mit dicarbonsäure, vorstufen für rapamycinkonjugate und antikörper

Info

Publication number: ATE410431T1
Authority: AT; Austria
Prior art keywords: esters; rapamycin; precursors; antibodies; conjugates
Prior art date: 2004-04-14

Application number

AT05735488T

Other languages

English (en)

Inventor

Jianxin Gu

Ping Cai

Mark Ruppen

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-04-14

Filing date

2005-04-12

Publication date

2008-10-15

2005-04-12 Application filed by Wyeth Corp filed Critical Wyeth Corp

2008-10-15 Application granted granted Critical

2008-10-15 Publication of ATE410431T1 publication Critical patent/ATE410431T1/de

Links

ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title abstract 3
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title abstract 3
229960002930 sirolimus Drugs 0.000 title abstract 3
150000002148 esters Chemical class 0.000 title abstract 2
ZFTFAPZRGNKQPU-UHFFFAOYSA-N dicarbonic acid Chemical compound OC(=O)OC(O)=O ZFTFAPZRGNKQPU-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
239000002243 precursor Substances 0.000 title 1
238000000034 method Methods 0.000 abstract 2
102000004882 Lipase Human genes 0.000 abstract 1
108090001060 Lipase Proteins 0.000 abstract 1
239000004367 Lipase Substances 0.000 abstract 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
150000008064 anhydrides Chemical class 0.000 abstract 1
230000001588 bifunctional effect Effects 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
150000001991 dicarboxylic acids Chemical class 0.000 abstract 1
235000019421 lipase Nutrition 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Wood Science & Technology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

AT05735488T 2004-04-14 2005-04-12 Verfahren zur herstellung von rapamycin-42-estern und fk-506-32-estern mit dicarbonsäure, vorstufen für rapamycinkonjugate und antikörper ATE410431T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US56196604P	2004-04-14	2004-04-14

Publications (1)

Publication Number	Publication Date
ATE410431T1 true ATE410431T1 (de)	2008-10-15

Family

ID=34965703

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05735488T ATE410431T1 (de)	2004-04-14	2005-04-12	Verfahren zur herstellung von rapamycin-42-estern und fk-506-32-estern mit dicarbonsäure, vorstufen für rapamycinkonjugate und antikörper

Country Status (14)

Country	Link
US (2)	US7445916B2 (de)
EP (1)	EP1735321B1 (de)
JP (1)	JP2007532655A (de)
CN (1)	CN1942478A (de)
AT (1)	ATE410431T1 (de)
AU (1)	AU2005238432A1 (de)
BR (1)	BRPI0509810A (de)
CA (1)	CA2562962A1 (de)
DE (1)	DE602005010228D1 (de)
DK (1)	DK1735321T3 (de)
ES (1)	ES2313328T3 (de)
MX (1)	MXPA06011882A (de)
PL (1)	PL1735321T3 (de)
WO (1)	WO2005105812A1 (de)

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US9283211B1 (en)	2009-11-11	2016-03-15	Rapamycin Holdings, Llc	Oral rapamycin preparation and use for stomatitis
PT2885007T (pt)	2012-08-16	2018-12-10	Pfizer	Processos e composições de glicoconjugação
US20160030401A1 (en)	2013-03-13	2016-02-04	The Board Of Regents Of The University Of Texas System	Use of mtor inhibitors for prevention of intestinal polyp growth and cancer
US9700544B2 (en)	2013-12-31	2017-07-11	Neal K Vail	Oral rapamycin nanoparticle preparations
EP3848065B1 (de)	2017-05-15	2023-07-26	C. R. Bard, Inc.	Medizinische vorrichtung mit wirkstofffreisetzender beschichtung und zwischenschicht
JP7262581B2 (ja)	2018-11-14	2023-04-21	ルトニックス，インコーポレーテッド	改質されたデバイス表面に薬物溶出コーティングを有する医療用デバイス
CN113939324A (zh)	2019-04-08	2022-01-14	巴德外周血管股份有限公司	在经改性装置表面上具有药物洗脱涂层的医疗装置
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2005
- 2005-04-12 PL PL05735488T patent/PL1735321T3/pl unknown
- 2005-04-12 AU AU2005238432A patent/AU2005238432A1/en not_active Withdrawn
- 2005-04-12 WO PCT/US2005/012268 patent/WO2005105812A1/en not_active Ceased
- 2005-04-12 ES ES05735488T patent/ES2313328T3/es not_active Expired - Lifetime
- 2005-04-12 MX MXPA06011882A patent/MXPA06011882A/es active IP Right Grant
- 2005-04-12 JP JP2007508443A patent/JP2007532655A/ja not_active Withdrawn
- 2005-04-12 EP EP05735488A patent/EP1735321B1/de not_active Expired - Lifetime
- 2005-04-12 DE DE602005010228T patent/DE602005010228D1/de not_active Expired - Fee Related
- 2005-04-12 CN CNA200580011299XA patent/CN1942478A/zh not_active Withdrawn
- 2005-04-12 AT AT05735488T patent/ATE410431T1/de not_active IP Right Cessation
- 2005-04-12 US US11/104,349 patent/US7445916B2/en not_active Expired - Lifetime
- 2005-04-12 BR BRPI0509810-6A patent/BRPI0509810A/pt not_active IP Right Cessation
- 2005-04-12 DK DK05735488T patent/DK1735321T3/da active
- 2005-04-12 CA CA002562962A patent/CA2562962A1/en not_active Abandoned
2008
- 2008-09-29 US US12/240,230 patent/US7625726B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK1735321T3 (da)	2009-01-12
EP1735321A1 (de)	2006-12-27
ES2313328T3 (es)	2009-03-01
AU2005238432A1 (en)	2005-11-10
CA2562962A1 (en)	2005-11-10
US20050234087A1 (en)	2005-10-20
MXPA06011882A (es)	2006-12-14
BRPI0509810A (pt)	2007-09-18
PL1735321T3 (pl)	2009-04-30
DE602005010228D1 (de)	2008-11-20
CN1942478A (zh)	2007-04-04
JP2007532655A (ja)	2007-11-15
US7625726B2 (en)	2009-12-01
US20090029426A1 (en)	2009-01-29
WO2005105812A1 (en)	2005-11-10
EP1735321B1 (de)	2008-10-08
US7445916B2 (en)	2008-11-04

Legal Events

Date	Code	Title	Description
2009-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE602005010228D1 (de)	2008-11-20	Verfahren zur herstellung von rapamycin-42-estern und fk-506-32-estern mit dicarbonsäure, vorstufen für rapamycinkonjugate und antikörper
EP2345432A3 (de)	2012-07-25	Verfahren zur Herstellung von Estern von Polyalkoholen
ATE129694T1 (de)	1995-11-15	Verfahren zur katalytischen veresterung.
WO2003082795A3 (en)	2003-12-24	METHODS OF MANUFACTURING DERIVATIVES OF β-HYDROXYCARBOXYLIC ACIDS
WO2006078809A3 (en)	2007-07-12	Method for the preparation of maytansinoid esters
DE502005007836D1 (de)	2009-09-17	Verfahren zur Herstellung von alicyclischen Carbonsäuren oder deren Derivaten
DE60143084D1 (de)	2010-10-28	Verfahren zur herstellung von glyceriden mittels lipasen
ATE511547T1 (de)	2011-06-15	Verfahren zur herstellung von beta-lactam- verbindungen
ATE401360T1 (de)	2008-08-15	Poly(etherester)polyole und verfahren zu ihrer herstellung
WO2008111941A3 (en)	2008-11-20	Process and system for butanol production
DE602005018836D1 (de)	2010-02-25	Weichmacher für phenolschaumstoff und verfahren zur herstellung von phenolschaumstoff
BRPI0704791A2 (pt)	2009-07-28	processo de sìntese de ésteres com lipases imobilizadas no substrato sólido fermentado
DE602005013981D1 (de)	2009-05-28	Pulverförmige lipasezusammensetzung und verfahren zur herstellung von verestertem produkt unter verwendung davon
DE50313568D1 (de)	2011-05-05	Verfahren zur herstellung von linearen bzw. verzweigten fettsäureestern durch heterogen katalysierte reaktive rektifikation mit vorreaktor
ATE402920T1 (de)	2008-08-15	Verfahren zur herstellung aromatischer thiophenylketone
DE502005010825D1 (de)	2011-02-24	Verfahren zur lösungsmittelfreien Herstellung von Ethercarbonsäuren mit niedrigem Restsalzgehalt
ATE434595T1 (de)	2009-07-15	Verfahren zur herstellung von essigsäure
ATE406811T1 (de)	2008-09-15	Verfahren zur herstellung von brühe- oder würzewürfeln
DE60332894D1 (de)	2010-07-22	Verfahren zur Herstellung eines immobilisierten Enzyms
ATE238303T1 (de)	2003-05-15	Verfahren zur herstellung von 2-phenyl-imidazo(1, 2-a)pyridine-3-acetamiden
ATE435299T1 (de)	2009-07-15	Verfahren zur enzymatischen herstellung enantiomerenangereicherter beta-aminosäuren
TW200609211A (en)	2006-03-16	Esterification catalyst and process therewith
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