ATE410696T1 - Identizifierung von antiprionwirkstoffen mittels screening mit hohem durchsatz auf sift-basis - Google Patents

Identizifierung von antiprionwirkstoffen mittels screening mit hohem durchsatz auf sift-basis

Info

Publication number
ATE410696T1
ATE410696T1 AT05759896T AT05759896T ATE410696T1 AT E410696 T1 ATE410696 T1 AT E410696T1 AT 05759896 T AT05759896 T AT 05759896T AT 05759896 T AT05759896 T AT 05759896T AT E410696 T1 ATE410696 T1 AT E410696T1
Authority
AT
Austria
Prior art keywords
protein
aggregation
compound
antiprion
sift
Prior art date
Application number
AT05759896T
Other languages
English (en)
Inventor
Uwe Bertsch
Armin Giese
Hans Kretzschmar
Paul Tavan
Thomas Hirschberger
Jan Bieschke
Petra Weber
Konstanze Winklhofer
Joerg Tatzelt
F Hartl
Gerda Wuensch
Tobias Hoegen
Original Assignee
Univ Muenchen L Maximilians
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Muenchen L Maximilians filed Critical Univ Muenchen L Maximilians
Application granted granted Critical
Publication of ATE410696T1 publication Critical patent/ATE410696T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
AT05759896T 2004-05-24 2005-05-24 Identizifierung von antiprionwirkstoffen mittels screening mit hohem durchsatz auf sift-basis ATE410696T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04012254 2004-05-24

Publications (1)

Publication Number Publication Date
ATE410696T1 true ATE410696T1 (de) 2008-10-15

Family

ID=35451505

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05759896T ATE410696T1 (de) 2004-05-24 2005-05-24 Identizifierung von antiprionwirkstoffen mittels screening mit hohem durchsatz auf sift-basis

Country Status (5)

Country Link
US (1) US20100029773A1 (de)
EP (1) EP1751553B1 (de)
AT (1) ATE410696T1 (de)
DE (1) DE602005010241D1 (de)
WO (1) WO2005116640A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1865326B1 (de) 2006-06-08 2011-09-07 FU Berlin Assay zur Diagnose von Alzheimer basierend auf der Bestimmung des Verhältnisses von Sekretase-Aß-Spaltprodukten
US9006283B2 (en) 2007-07-12 2015-04-14 Acumen Pharmaceuticals, Inc. Methods of modifying amyloid β oligomers using non-peptidic compounds
EP2194975A2 (de) * 2007-07-12 2010-06-16 Acumen Pharmaceuticals, Inc. Verfahren zur unterdrückung der bildung von amyloid-b-diffundierbaren liganden mit acylhydrazid-verbindungen
EP2173340B1 (de) * 2007-07-12 2013-07-10 Acumen Pharmaceuticals, Inc. Verfahren zur verbesserung der kognitiven funktion mit nicht-peptidischen verbindungen
RU2461377C2 (ru) * 2007-07-12 2012-09-20 Эйкьюмен Фамэсьютиклз, Инк. Способ улучшения когнитивной функции (варианты)
US8962677B2 (en) 2007-07-12 2015-02-24 Acumen Pharmaceuticals, Inc. Methods of restoring cognitive ability using non-peptidic compounds
WO2009008890A1 (en) * 2007-07-12 2009-01-15 Acumen Pharmaceuticals, Inc. METHODS OF MODIFYING AMYLOID β OLIGOMERS USING NON-PEPTIDIC COMPOUNDS
US9217024B2 (en) 2007-12-18 2015-12-22 Acumen Pharmaceuticals, Inc. ADDL receptor polypeptides, polynucleotides and host cells for recombinant production
KR101366372B1 (ko) 2012-01-30 2014-02-25 부산대학교 산학협력단 피부미백, 항산화 및 ｐｐａｒ 활성을 갖는 신규 화합물 및 이의 의학적 용도
GB201303507D0 (en) * 2013-02-27 2013-04-10 Hollfelder Florian Assays
US20210338694A1 (en) * 2020-05-04 2021-11-04 Yi Zheng Sos1 allosteric site targeting
US12172948B2 (en) * 2020-11-12 2024-12-24 Oregon State University Molecular probe for selective detection of copper (II) ions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6613942B1 (en) * 1997-07-01 2003-09-02 Novo Nordisk A/S Glucagon antagonists/inverse agonists
WO2001025192A1 (en) * 1999-10-06 2001-04-12 Melacure Therapeutics Ab Guanidine derivatives and their use in the production of a medicament for blocking xanthine oxidase/dehydrogenase
KR20060088885A (ko) * 2003-09-25 2006-08-07 아카디아 파마슈티칼스 인코포레이티드 뉴로펩티드 ｆｆ 리셉터 2의 작용제를 이용한 신경병증성통증 치료 방법

Also Published As

Publication number Publication date
WO2005116640A3 (en) 2006-03-09
DE602005010241D1 (de) 2008-11-20
EP1751553B1 (de) 2008-10-08
WO2005116640A2 (en) 2005-12-08
EP1751553A2 (de) 2007-02-14
US20100029773A1 (en) 2010-02-04

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