ATE411078T1 - Acylsulfonamid-verbindungen als inhibitoren der rna-abhängigen rna-polymerase - Google Patents
Acylsulfonamid-verbindungen als inhibitoren der rna-abhängigen rna-polymeraseInfo
- Publication number
- ATE411078T1 ATE411078T1 AT04703128T AT04703128T ATE411078T1 AT E411078 T1 ATE411078 T1 AT E411078T1 AT 04703128 T AT04703128 T AT 04703128T AT 04703128 T AT04703128 T AT 04703128T AT E411078 T1 ATE411078 T1 AT E411078T1
- Authority
- AT
- Austria
- Prior art keywords
- rna
- inhibitors
- dependent
- rna polymerase
- acylsulfonamide compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 108060004795 Methyltransferase Proteins 0.000 title 1
- 108700008776 hepatitis C virus NS-5 Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44167403P | 2003-01-22 | 2003-01-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE411078T1 true ATE411078T1 (de) | 2008-10-15 |
Family
ID=32771957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04703128T ATE411078T1 (de) | 2003-01-22 | 2004-01-19 | Acylsulfonamid-verbindungen als inhibitoren der rna-abhängigen rna-polymerase |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7098231B2 (de) |
| EP (1) | EP1587585B1 (de) |
| JP (1) | JP4460570B2 (de) |
| AT (1) | ATE411078T1 (de) |
| CA (1) | CA2511301C (de) |
| DE (1) | DE602004017126D1 (de) |
| ES (1) | ES2315633T3 (de) |
| WO (1) | WO2004064925A1 (de) |
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| MY148123A (en) | 2003-09-05 | 2013-02-28 | Vertex Pharma | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
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| DK2161273T3 (en) * | 2003-12-22 | 2015-07-20 | Leuven K U Res & Dev | Imidazo [4,5-C] pyridine compounds and methods for antiviral therapy |
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-
2004
- 2004-01-12 US US10/755,544 patent/US7098231B2/en not_active Expired - Lifetime
- 2004-01-19 DE DE602004017126T patent/DE602004017126D1/de not_active Expired - Lifetime
- 2004-01-19 JP JP2006500428A patent/JP4460570B2/ja not_active Expired - Fee Related
- 2004-01-19 WO PCT/CA2004/000017 patent/WO2004064925A1/en not_active Ceased
- 2004-01-19 EP EP04703128A patent/EP1587585B1/de not_active Expired - Lifetime
- 2004-01-19 ES ES04703128T patent/ES2315633T3/es not_active Expired - Lifetime
- 2004-01-19 AT AT04703128T patent/ATE411078T1/de active
- 2004-01-19 CA CA2511301A patent/CA2511301C/en not_active Expired - Fee Related
-
2006
- 2006-04-17 US US11/405,144 patent/US7323470B2/en not_active Expired - Lifetime
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2007
- 2007-11-30 US US11/948,239 patent/US7838537B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004064925A1 (en) | 2004-08-05 |
| US7323470B2 (en) | 2008-01-29 |
| US7098231B2 (en) | 2006-08-29 |
| ES2315633T3 (es) | 2009-04-01 |
| EP1587585B1 (de) | 2008-10-15 |
| JP2006515364A (ja) | 2006-05-25 |
| EP1587585A1 (de) | 2005-10-26 |
| DE602004017126D1 (de) | 2008-11-27 |
| CA2511301C (en) | 2011-01-18 |
| US20060189672A1 (en) | 2006-08-24 |
| US20040186125A1 (en) | 2004-09-23 |
| JP4460570B2 (ja) | 2010-05-12 |
| US7838537B2 (en) | 2010-11-23 |
| US20080119490A1 (en) | 2008-05-22 |
| CA2511301A1 (en) | 2004-08-05 |
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