ATE411385T1 - Apo-2 ligand - Google Patents

Apo-2 ligand

Info

Publication number
ATE411385T1
ATE411385T1 AT99903166T AT99903166T ATE411385T1 AT E411385 T1 ATE411385 T1 AT E411385T1 AT 99903166 T AT99903166 T AT 99903166T AT 99903166 T AT99903166 T AT 99903166T AT E411385 T1 ATE411385 T1 AT E411385T1
Authority
AT
Austria
Prior art keywords
ligand
apo
antibodies
believed
nucleic acid
Prior art date
Application number
AT99903166T
Other languages
English (en)
Inventor
Avi Ashkenazi
Robert Kelley
Mark O'connel
Robert Pitti
Ralph Schwall
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE411385T1 publication Critical patent/ATE411385T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT99903166T 1998-01-15 1999-01-15 Apo-2 ligand ATE411385T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US788698A 1998-01-15 1998-01-15
US6053398A 1998-04-15 1998-04-15

Publications (1)

Publication Number Publication Date
ATE411385T1 true ATE411385T1 (de) 2008-10-15

Family

ID=26677483

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99903166T ATE411385T1 (de) 1998-01-15 1999-01-15 Apo-2 ligand

Country Status (12)

Country Link
US (1) US6740739B1 (de)
EP (2) EP2017341A3 (de)
JP (2) JP2002508962A (de)
AT (1) ATE411385T1 (de)
AU (1) AU2325199A (de)
CA (1) CA2318029C (de)
CY (1) CY1108681T1 (de)
DE (1) DE69939732D1 (de)
DK (1) DK1045906T3 (de)
ES (1) ES2316182T3 (de)
PT (1) PT1045906E (de)
WO (1) WO1999036535A1 (de)

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US7741285B2 (en) 2001-11-13 2010-06-22 Genentech, Inc. APO-2 ligand/trail formulations
EP1450847B1 (de) 2001-11-13 2010-09-29 Genentech, Inc. Zusammensetzungen basierend auf APO2-Ligand/ TRAIL und ihre Verwendung
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EP2500032A1 (de) * 2002-06-24 2012-09-19 Genentech, Inc. APO-2-Liganden-/Trailvarianten und Verwendungen dafür
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AU2012200601B2 (en) * 2004-08-06 2012-10-11 Genentech, Inc. Assays and methods using biomarkers
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US8029783B2 (en) 2005-02-02 2011-10-04 Genentech, Inc. DR5 antibodies and articles of manufacture containing same
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US9289468B2 (en) 2011-09-16 2016-03-22 Beijing Sunbio Biotech Co. Ltd. Fusion protein comprising circularly permuted form of trail/Apo2L, coding gene and use thereof
EP2684896A1 (de) 2012-07-09 2014-01-15 International-Drug-Development-Biotech Antikörper gegen die DR5-Familie, bispezifische oder multivalente Antikörper gegen die DR5-Familie und Verfahren zu deren Verwendung
WO2014159562A1 (en) 2013-03-14 2014-10-02 Bristol-Myers Squibb Company Combination of dr5 agonist and anti-pd-1 antagonist and methods of use
US9914761B2 (en) 2014-07-10 2018-03-13 Washington University Oligomers for TNF superfamily inhibition
CN109476737A (zh) 2015-12-01 2019-03-15 根马布有限公司 抗dr5抗体及其使用方法
US11299530B2 (en) 2017-01-05 2022-04-12 Kahr Medical Ltd. SIRP alpha-CD70 fusion protein and methods of use thereof
RU2769769C2 (ru) 2017-01-05 2022-04-05 Кахр Медикал Лтд. СЛИТЫЙ БЕЛОК SIRPα-4-1BBL И СПОСОБЫ ЕГО ПРИМЕНЕНИЯ
US11566060B2 (en) 2017-01-05 2023-01-31 Kahr Medical Ltd. PD1-CD70 fusion protein and methods of use thereof
CN110536693B (zh) 2017-01-05 2023-12-22 卡尔医学有限公司 Pd1-41bbl融合蛋白及使用其的方法
KR102945860B1 (ko) 2018-07-11 2026-03-31 카 메디컬 리미티드 SIRPalpha-4-1BBL 변이체 융합 단백질 및 이의 사용 방법
EP3820887A4 (de) 2018-07-11 2022-04-20 KAHR Medical Ltd. Pd1-4-1bbl-fusionsproteinvariante und ihre verwendunge

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Also Published As

Publication number Publication date
PT1045906E (pt) 2009-01-27
ES2316182T3 (es) 2009-04-01
WO1999036535A9 (en) 2000-03-02
AU2325199A (en) 1999-08-02
CA2318029A1 (en) 1999-07-22
EP1045906B1 (de) 2008-10-15
JP2002508962A (ja) 2002-03-26
EP2017341A2 (de) 2009-01-21
HK1032603A1 (en) 2001-07-27
DE69939732D1 (de) 2008-11-27
CY1108681T1 (el) 2014-04-09
CA2318029C (en) 2009-05-19
JP2010246560A (ja) 2010-11-04
WO1999036535A1 (en) 1999-07-22
EP2017341A3 (de) 2009-04-08
US6740739B1 (en) 2004-05-25
EP1045906A1 (de) 2000-10-25
DK1045906T3 (da) 2009-02-16

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