ATE411997T1 - Multicyclische verbindungen und deren verwendung als inhibitoren der parp, vegfr2 und mlk3 enzyme - Google Patents

Multicyclische verbindungen und deren verwendung als inhibitoren der parp, vegfr2 und mlk3 enzyme

Info

Publication number: ATE411997T1
Authority: AT; Austria
Prior art keywords: vegfr2; parp; inhibitors; mlk3; enzymes
Prior art date: 2000-05-09

Application number

AT05076862T

Other languages

English (en)

Inventor

Mark A Ator

Ron Bihovsky

Sankar Chatterjee

Derek Dunn

Robert L Hudkins

Original Assignee

Cephalon Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-09

Filing date

2001-05-09

Publication date

2008-11-15

2001-05-09 Application filed by Cephalon Inc filed Critical Cephalon Inc

2008-11-15 Application granted granted Critical

2008-11-15 Publication of ATE411997T1 publication Critical patent/ATE411997T1/de

Links

101001005602 Homo sapiens Mitogen-activated protein kinase kinase kinase 11 Proteins 0.000 title abstract 2
101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 title abstract 2
102100025207 Mitogen-activated protein kinase kinase kinase 11 Human genes 0.000 title abstract 2
229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 title abstract 2
102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title 1
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
206010061218 Inflammation Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
101710179684 Poly [ADP-ribose] polymerase Proteins 0.000 abstract 1
102100023712 Poly [ADP-ribose] polymerase 1 Human genes 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
208000028867 ischemia Diseases 0.000 abstract 1
230000004770 neurodegeneration Effects 0.000 abstract 1
208000015122 neurodegenerative disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Hematology (AREA)
Psychology (AREA)
Cardiology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Hospice & Palliative Care (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Enzymes And Modification Thereof (AREA)

AT05076862T 2000-05-09 2001-05-09 Multicyclische verbindungen und deren verwendung als inhibitoren der parp, vegfr2 und mlk3 enzyme ATE411997T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US20294700P	2000-05-09	2000-05-09
US09/850,858 US7122679B2 (en)	2000-05-09	2001-05-08	Multicyclic compounds and the use thereof

Publications (1)

Publication Number	Publication Date
ATE411997T1 true ATE411997T1 (de)	2008-11-15

Family

ID=26898160

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AT01935215T ATE315039T1 (de)	2000-05-09	2001-05-09	Multizyklische verbindungen und ihre verwendung als inhibitoren der parp, vegfr2 und mlk3 enzyme
AT08075834T ATE482215T1 (de)	2000-05-09	2001-05-09	Multicyclische verbindungen und deren verwendung als inhibitoren der parp, vegfr2 und mlk3 enzyme
AT05076862T ATE411997T1 (de)	2000-05-09	2001-05-09	Multicyclische verbindungen und deren verwendung als inhibitoren der parp, vegfr2 und mlk3 enzyme

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
AT01935215T ATE315039T1 (de)	2000-05-09	2001-05-09	Multizyklische verbindungen und ihre verwendung als inhibitoren der parp, vegfr2 und mlk3 enzyme
AT08075834T ATE482215T1 (de)	2000-05-09	2001-05-09	Multicyclische verbindungen und deren verwendung als inhibitoren der parp, vegfr2 und mlk3 enzyme

Country Status (27)

Country	Link
US (1)	US7122679B2 (de)
EP (3)	EP2050750B1 (de)
JP (1)	JP5156150B2 (de)
KR (1)	KR100832602B1 (de)
CN (2)	CN100554268C (de)
AT (3)	ATE315039T1 (de)
AU (1)	AU6132701A (de)
BG (1)	BG66036B1 (de)
BR (1)	BR0110993A (de)
CA (1)	CA2409758A1 (de)
CY (1)	CY1108722T1 (de)
CZ (2)	CZ304911B6 (de)
DE (3)	DE60143140D1 (de)
DK (1)	DK1754707T3 (de)
EA (1)	EA007868B1 (de)
ES (2)	ES2256238T3 (de)
HU (1)	HU229448B1 (de)
IL (1)	IL152663A0 (de)
MX (1)	MXPA02010977A (de)
NO (1)	NO324256B1 (de)
NZ (1)	NZ522539A (de)
PL (1)	PL226805B1 (de)
PT (1)	PT1754707E (de)
SK (1)	SK287591B6 (de)
UA (1)	UA73773C2 (de)
WO (1)	WO2001085686A2 (de)
ZA (1)	ZA200209065B (de)

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KR20240156074A (ko)	2023-04-21	2024-10-29	(주)엠디바이오팜	Hpk1 및 mlk3 저해제 및 이를 함유하는 항암용 조성물
CN121398822A (zh)	2023-06-21	2026-01-23	四方生物科学有限公司	用于在治疗hr功能正常的癌症的方法中的用途的包含脱氧胞苷衍生物和parp抑制剂的组合
KR20250041906A (ko)	2023-09-19	2025-03-26	(주)엠디바이오팜	Hpk1 및 mlk3 저해 활성을 갖는 신규한 화합물 및 이를 함유하는 항암용 조성물

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Publication number	Publication date
WO2001085686A2 (en)	2001-11-15
SK287591B6 (sk)	2011-03-04
CZ304911B6 (cs)	2015-01-21
KR100832602B1 (ko)	2008-05-27
BR0110993A (pt)	2003-06-24
HK1051369A1 (en)	2003-08-01
PL363167A1 (en)	2004-11-15
EP1754707B1 (de)	2008-10-22
NO324256B1 (no)	2007-09-17
UA73773C2 (uk)	2005-09-15
DE60143140D1 (de)	2010-11-04
WO2001085686A3 (en)	2002-05-30
CA2409758A1 (en)	2001-11-15
NZ522539A (en)	2004-05-28
US7122679B2 (en)	2006-10-17
HUP0302385A3 (en)	2007-03-28
DK1754707T3 (da)	2008-12-15
EP2050750A3 (de)	2009-07-08
EA200201183A1 (ru)	2003-06-26
ES2256238T3 (es)	2006-07-16
EP2050750B1 (de)	2010-09-22
ES2315789T3 (es)	2009-04-01
HK1129381A1 (en)	2009-11-27
HU229448B1 (en)	2013-12-30
IL152663A0 (en)	2003-06-24
DE60116485D1 (de)	2006-03-30
CZ305350B6 (cs)	2015-08-12
ATE315039T1 (de)	2006-02-15
CN100554268C (zh)	2009-10-28
CN1440409A (zh)	2003-09-03
CN101560213B (zh)	2011-01-19
MXPA02010977A (es)	2003-07-14
HK1097841A1 (en)	2007-07-06
BG107355A (bg)	2003-07-31
BG66036B1 (bg)	2010-11-30
AU6132701A (en)	2001-11-20
EP1754707A2 (de)	2007-02-21
PT1754707E (pt)	2008-12-12
SK15802002A3 (sk)	2003-05-02
EP1294725A2 (de)	2003-03-26
CN101560213A (zh)	2009-10-21
EP1294725B1 (de)	2006-01-04
HUP0302385A2 (hu)	2003-12-29
DE60116485T2 (de)	2006-11-09
PL226805B1 (pl)	2017-09-29
EA007868B1 (ru)	2007-02-27
ZA200209065B (en)	2004-02-09
EP1754707A3 (de)	2007-02-28
CZ20023679A3 (cs)	2003-10-15
US20020028815A1 (en)	2002-03-07
DE60136305D1 (de)	2008-12-04
JP5156150B2 (ja)	2013-03-06
KR20030007603A (ko)	2003-01-23
NO20025376D0 (no)	2002-11-08
EP2050750A2 (de)	2009-04-22
CY1108722T1 (el)	2014-04-09
ATE482215T1 (de)	2010-10-15
NO20025376L (no)	2003-01-08
JP2004501097A (ja)	2004-01-15

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