ATE414071T1 - Verbessertes verfahren zur herstellung von 4- hydroxypyran-2-onderivaten - Google Patents

Verbessertes verfahren zur herstellung von 4- hydroxypyran-2-onderivaten

Info

Publication number: ATE414071T1
Authority: AT; Austria
Prior art keywords: formula; hydrogen; derivatives; alkali; methyl
Prior art date: 2004-03-30

Application number

AT04770635T

Other languages

English (en)

Inventor

Milind Moreshwar Gharpure

Swapnil Panditrao Sonawane

Srihari Shivaji Mane

Rajendra Dagesing Mahale

Original Assignee

Lupin Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-03-30

Filing date

2004-03-30

Publication date

2008-11-15

2004-03-30 Application filed by Lupin Ltd filed Critical Lupin Ltd

2008-11-15 Application granted granted Critical

2008-11-15 Publication of ATE414071T1 publication Critical patent/ATE414071T1/de

Links

VNZOLPIHDIJPBZ-UHFFFAOYSA-N 4-hydroxypyran-2-one Chemical class OC=1C=COC(=O)C=1 VNZOLPIHDIJPBZ-UHFFFAOYSA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
239000012535 impurity Substances 0.000 abstract 3
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
239000003513 alkali Substances 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
229910052783 alkali metal Chemical group 0.000 abstract 1
150000001340 alkali metals Chemical group 0.000 abstract 1
150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
230000008025 crystallization Effects 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
-1 hydrogen salts Chemical class 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
150000002576 ketones Chemical class 0.000 abstract 1
238000006386 neutralization reaction Methods 0.000 abstract 1
150000007530 organic bases Chemical class 0.000 abstract 1
235000011007 phosphoric acid Nutrition 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1
239000011877 solvent mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polyesters Or Polycarbonates (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT04770635T 2004-03-30 2004-03-30 Verbessertes verfahren zur herstellung von 4- hydroxypyran-2-onderivaten ATE414071T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/IN2004/000075 WO2005095374A1 (en)	2004-03-30	2004-03-30	An improved method for manufacture of 4-hydroxy pyran-2-one derivatives

Publications (1)

Publication Number	Publication Date
ATE414071T1 true ATE414071T1 (de)	2008-11-15

Family

ID=34958565

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04770635T ATE414071T1 (de)	2004-03-30	2004-03-30	Verbessertes verfahren zur herstellung von 4- hydroxypyran-2-onderivaten

Country Status (7)

Country	Link
US (1)	US7777056B2 (de)
EP (1)	EP1732912B1 (de)
AT (1)	ATE414071T1 (de)
AU (1)	AU2004317826A1 (de)
BR (1)	BRPI0418644A (de)
DE (1)	DE602004017784D1 (de)
WO (1)	WO2005095374A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7678928B2 (en)	2005-02-04	2010-03-16	Lupin Limited	Process for manufacture of simvastatin
JP2009114121A (ja) *	2007-11-06	2009-05-28	Kaneka Corp	シンバスタチンの製造方法
CN116253675B (zh) *	2023-05-10	2023-07-25	山东信谊制药有限公司	一种n-取代-2-哌啶酮的合成方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4231938A (en) *	1979-06-15	1980-11-04	Merck & Co., Inc.	Hypocholesteremic fermentation products and process of preparation
US4444784A (en) *	1980-08-05	1984-04-24	Merck & Co., Inc.	Antihypercholesterolemic compounds
DK149080C (da) *	1980-06-06	1986-07-28	Sankyo Co	Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
US4739073A (en) *	1983-11-04	1988-04-19	Sandoz Pharmaceuticals Corp.	Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
DE3713178A1 (de) *	1987-04-17	1988-11-03	Bayer Ag	Verfahren zur herstellung eines verbundsystems aus einem gummielastischen material und einer polyurethanschaumstoff-schicht
US4820850A (en) *	1987-07-10	1989-04-11	Merck & Co., Inc.	Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US4916239A (en) *	1988-07-19	1990-04-10	Merck & Co., Inc.	Process for the lactonization of mevinic acids and analogs thereof
FI94339C (fi) *	1989-07-21	1995-08-25	Warner Lambert Co	Menetelmä farmaseuttisesti käyttökelpoisen /R-(R,R)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
SI9300303A (en) *	1993-06-08	1994-12-31	Krka Tovarna Zdravil	Process for isolation of hypolipemic effective substance
EA000954B1 (ru)	1995-12-06	2000-08-28	Балканфарма - Разград Ад	Способ получения ловастатина
EP0877089A1 (de)	1997-05-07	1998-11-11	Gist-Brocades B.V.	Verfahren zur Herstellung eines Inhibitors der Hmg-Coa Reduktase
IN186880B (de) *	1997-10-28	2001-12-01	Ranbaxy Lab Ltd
IN186879B (de) *	1997-10-28	2001-12-01	Ranbaxy Lab Ltd
WO2001030773A2 (en) *	1999-10-27	2001-05-03	Merck & Co., Inc.	Lactonization process
IN191580B (de)	1999-12-17	2003-12-06	Ranbaxy Lab Ltd
IN192861B (de)	2000-06-30	2004-05-22	Ranbaxy Lab Ltd
NL1017548C2 (nl) *	2001-03-09	2002-09-10	Synthon Bv	Een lactonisatie proces.
EP1294706A1 (de)	2001-05-18	2003-03-26	Aurobindo Pharma Limited	Prozess zur herstellung von simvastatin durch lactonisierung
EP1387835A1 (de)	2001-05-18	2004-02-11	Aurobindo Pharma Limited	Verfahren zur laktonierung um hochreines simvastatin herzustellen
KR100407758B1 (ko) *	2001-08-27	2003-12-01	씨제이 주식회사	스타틴의 제조에 있어서 락톤화 방법
US6472542B1 (en) *	2001-11-29	2002-10-29	Fermic S.A. De C.V.	Method for alkylating the alpha carbon of the 2-methylbutyrate secondary chain of lovastatin
KR100423892B1 (ko)	2001-12-03	2004-03-22	씨제이 주식회사	스타틴의 제조에 있어서 새로운 락톤화 방법

2004
- 2004-03-30 BR BRPI0418644-3A patent/BRPI0418644A/pt not_active IP Right Cessation
- 2004-03-30 WO PCT/IN2004/000075 patent/WO2005095374A1/en not_active Ceased
- 2004-03-30 DE DE602004017784T patent/DE602004017784D1/de not_active Expired - Fee Related
- 2004-03-30 AT AT04770635T patent/ATE414071T1/de not_active IP Right Cessation
- 2004-03-30 US US11/547,533 patent/US7777056B2/en not_active Expired - Fee Related
- 2004-03-30 EP EP04770635A patent/EP1732912B1/de not_active Expired - Lifetime
- 2004-03-30 AU AU2004317826A patent/AU2004317826A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20080269508A1 (en)	2008-10-30
WO2005095374A1 (en)	2005-10-13
US7777056B2 (en)	2010-08-17
EP1732912B1 (de)	2008-11-12
BRPI0418644A (pt)	2007-05-29
AU2004317826A1 (en)	2005-10-13
EP1732912A1 (de)	2006-12-20
DE602004017784D1 (de)	2008-12-24

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Legal Events

Date	Code	Title	Description
2009-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties