ATE414703T1 - Isoxazolderivate als inverse gaba a alpha5 agonisten - Google Patents
Isoxazolderivate als inverse gaba a alpha5 agonistenInfo
- Publication number
- ATE414703T1 ATE414703T1 AT06793294T AT06793294T ATE414703T1 AT E414703 T1 ATE414703 T1 AT E414703T1 AT 06793294 T AT06793294 T AT 06793294T AT 06793294 T AT06793294 T AT 06793294T AT E414703 T1 ATE414703 T1 AT E414703T1
- Authority
- AT
- Austria
- Prior art keywords
- alpha5
- agonists
- gaba
- isoxazole derivatives
- isoxazole
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title 1
- 238000003874 inverse correlation nuclear magnetic resonance spectroscopy Methods 0.000 title 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical class C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 239000002475 cognitive enhancer Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05108599 | 2005-09-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE414703T1 true ATE414703T1 (de) | 2008-12-15 |
Family
ID=37682513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06793294T ATE414703T1 (de) | 2005-09-19 | 2006-09-07 | Isoxazolderivate als inverse gaba a alpha5 agonisten |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7538132B2 (de) |
| EP (1) | EP1931661B1 (de) |
| JP (1) | JP2009508905A (de) |
| KR (1) | KR100976675B1 (de) |
| CN (1) | CN101263139A (de) |
| AT (1) | ATE414703T1 (de) |
| AU (1) | AU2006298867A1 (de) |
| BR (1) | BRPI0616184A2 (de) |
| CA (1) | CA2623043A1 (de) |
| DE (1) | DE602006003777D1 (de) |
| ES (1) | ES2314943T3 (de) |
| IL (1) | IL189762A0 (de) |
| WO (1) | WO2007039389A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010005753A (es) * | 2007-12-04 | 2010-06-15 | Hoffmann La Roche | Derivados de isoxazolo-pirazina. |
| US7943619B2 (en) * | 2007-12-04 | 2011-05-17 | Hoffmann-La Roche Inc. | Isoxazolo-pyridazine derivatives |
| US7902201B2 (en) | 2007-12-04 | 2011-03-08 | Hoffmann-La Roche Inc. | Isoxazolo-pyrazine derivatives |
| JP5301557B2 (ja) | 2007-12-04 | 2013-09-25 | エフ．ホフマン−ラ ロシュ アーゲー | イソオキサゾロ−ピリジン誘導体 |
| TW201033201A (en) * | 2009-02-19 | 2010-09-16 | Hoffmann La Roche | Isoxazole-isoxazole and isoxazole-isothiazole derivatives |
| US8389550B2 (en) | 2009-02-25 | 2013-03-05 | Hoffmann-La Roche Inc. | Isoxazoles / O-pyridines with ethyl and ethenyl linker |
| US8222246B2 (en) | 2009-04-02 | 2012-07-17 | Hoffmann-La Roche Inc. | Substituted isoxazoles |
| US20100280019A1 (en) * | 2009-04-30 | 2010-11-04 | Roland Jakob-Roetne | Isoxazoles |
| AU2010245072B2 (en) * | 2009-05-05 | 2013-11-28 | Merck Sharp & Dohme Corp. | p38 kinase inhibiting agents |
| BRPI1011729A2 (pt) | 2009-05-05 | 2016-03-15 | Hoffmann La Roche | derivados de isoxazol-tiazol como um receptor inverso gaba a agonista para uso no tratamento de distúrbios cognitivos |
| EP2427455B1 (de) * | 2009-05-05 | 2020-01-15 | F.Hoffmann-La Roche Ag | Isoxazol-pyrazole derivate |
| SG175867A1 (en) * | 2009-05-05 | 2011-12-29 | Hoffmann La Roche | Isoxazole-pyridine derivatives |
| AU2010244545A1 (en) | 2009-05-05 | 2011-10-13 | F. Hoffmann-La Roche Ag | Isoxazole-pyridazine derivatives |
| AU2010244555A1 (en) | 2009-05-07 | 2011-11-03 | F. Hoffmann-La Roche Ag | Isoxazole-pyridine derivatives as GABA modulators |
| US8604062B2 (en) | 2011-10-20 | 2013-12-10 | Hoffman-La Roche Inc. | Process for the preparation of isoxazolyl-methoxy nicotinic acids |
| US8785435B2 (en) | 2011-10-20 | 2014-07-22 | Hoffmann-La Roche Inc. | Solid forms |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| WO2014001279A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| AU2013283488A1 (en) | 2012-06-26 | 2015-01-15 | Saniona Aps | A phenyl triazole derivative and its use for modulating the GABAA receptor complex |
| WO2014001280A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| US9206160B2 (en) | 2012-06-26 | 2015-12-08 | Saniona Aps | Phenyl triazole derivative and its use for modulating the GABAA receptor complex |
| WO2014001278A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| BR102019014802A2 (pt) | 2018-07-20 | 2020-02-04 | Boehringer Ingelheim Int | difluorometil-fenil triazóis |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5484944A (en) | 1993-10-27 | 1996-01-16 | Neurogen Corporation | Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands |
| AU2001290940A1 (en) * | 2000-09-15 | 2002-03-26 | Vertex Pharmaceuticals Incorporated | Isoxazoles and their use as inhibitors of erk |
| EP1691803A1 (de) | 2003-12-05 | 2006-08-23 | Warner-Lambert Company LLC | N-alkyl-pyrrole als hmg-coa-reductase-hemmer |
| SE0401653D0 (sv) * | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | New compounds |
-
2006
- 2006-09-07 JP JP2008531661A patent/JP2009508905A/ja active Pending
- 2006-09-07 DE DE602006003777T patent/DE602006003777D1/de active Active
- 2006-09-07 AU AU2006298867A patent/AU2006298867A1/en not_active Abandoned
- 2006-09-07 BR BRPI0616184-7A patent/BRPI0616184A2/pt not_active IP Right Cessation
- 2006-09-07 ES ES06793294T patent/ES2314943T3/es active Active
- 2006-09-07 AT AT06793294T patent/ATE414703T1/de active
- 2006-09-07 WO PCT/EP2006/066094 patent/WO2007039389A1/en not_active Ceased
- 2006-09-07 CN CNA2006800335278A patent/CN101263139A/zh active Pending
- 2006-09-07 KR KR1020087006583A patent/KR100976675B1/ko not_active Expired - Fee Related
- 2006-09-07 EP EP06793294A patent/EP1931661B1/de not_active Not-in-force
- 2006-09-07 CA CA002623043A patent/CA2623043A1/en not_active Abandoned
- 2006-09-13 US US11/520,394 patent/US7538132B2/en not_active Expired - Fee Related
-
2008
- 2008-02-25 IL IL189762A patent/IL189762A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL189762A0 (en) | 2008-08-07 |
| KR100976675B1 (ko) | 2010-08-18 |
| ES2314943T3 (es) | 2009-03-16 |
| CA2623043A1 (en) | 2007-04-12 |
| EP1931661B1 (de) | 2008-11-19 |
| EP1931661A1 (de) | 2008-06-18 |
| AU2006298867A1 (en) | 2007-04-12 |
| BRPI0616184A2 (pt) | 2011-06-07 |
| JP2009508905A (ja) | 2009-03-05 |
| WO2007039389A1 (en) | 2007-04-12 |
| DE602006003777D1 (de) | 2009-01-02 |
| CN101263139A (zh) | 2008-09-10 |
| US20070066668A1 (en) | 2007-03-22 |
| US7538132B2 (en) | 2009-05-26 |
| KR20080043361A (ko) | 2008-05-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL189762A0 (en) | Isoxazolo derivatives as gaba a alpha5 inverse agonists | |
| ATE438632T1 (de) | Aryl-4-ethinylisoxazolderivate | |
| IL190867A0 (en) | 3-aryl-isoxazole-4-carbonyl-benzofuran derivatives | |
| MX2010005717A (es) | Derivados de isoxazolo-piridina. | |
| HUS2100028I1 (hu) | ERBB I. típusú receptor tirozinkináz-gátló N4-fenil-kinazolin-4-amin származékok és rokon vegyületeik a hiperproliferatív betegségek kezelésére | |
| NO20082719L (no) | Aryl-isoksazol-4-yl-oksadiazolderivater | |
| NO20071967L (no) | Imidazo-benzodiazepinderivater | |
| IL186777A0 (en) | (3,4-dihydro-quinazolin-2-yl) - (2-aryloxy-ethyl) - amines having an activity on the 5 - ht receptor | |
| MX2011011477A (es) | Derivados de isoxazol-piridazina. | |
| MX2010002938A (es) | Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer. | |
| MX2010005753A (es) | Derivados de isoxazolo-pirazina. | |
| WO2007062999A3 (en) | 1,5-substituted indol-2-yl amide derivatives | |
| NO20082747L (no) | Arylisoksazol-4-yl-imidazolderivater | |
| MX2009014001A (es) | Derivados de isoxazol-imidazol. | |
| ATE486058T1 (de) | Prolinamidderivate als nk3-antagonisten | |
| MX2011011490A (es) | Derivados de isoxazol-tiazol como agonistas inversos del receptor de acido gamma-aminobutirico a (gaba a), para usarse en el tratamiento de trastornos cognitivos. | |
| ATE370147T1 (de) | Thiazolopyrimidinderivate und deren verwendung als antagonisten des cx3cr1 rezeptors | |
| ATE477255T1 (de) | Imidazobenzdiazepinderivate | |
| TW200631953A (en) | Tetracyclic imidazo-benzodiazepines | |
| ATE466007T1 (de) | 5-substituierte indol-2-carbonsäureamidderivate | |
| IL184439A0 (en) | 2,5-disubstituted phenyl methanone derivatives as glycine transporter 1 | |
| ATE549316T1 (de) | Piperidinderivate als nk3-rezeptorantagonisten | |
| DE602008005014D1 (de) | Prolinamidtetrazolderivate als nk3-rezeptorantagonisten | |
| TH80293A (th) | เตตระไซคลิก อิมมิดาโซ-เบนโซไดอะซีพิน | |
| TH177807A (th) | อนุพันธ์ไอซอกซาโซโล-ไพริดีน |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1931661 Country of ref document: EP |