ATE419258T1 - Carbacyclisches phosphatidsäurederivat - Google Patents
Carbacyclisches phosphatidsäurederivatInfo
- Publication number
- ATE419258T1 ATE419258T1 AT03733345T AT03733345T ATE419258T1 AT E419258 T1 ATE419258 T1 AT E419258T1 AT 03733345 T AT03733345 T AT 03733345T AT 03733345 T AT03733345 T AT 03733345T AT E419258 T1 ATE419258 T1 AT E419258T1
- Authority
- AT
- Austria
- Prior art keywords
- linear
- carbon atoms
- group containing
- acid derivative
- phosphatidic acid
- Prior art date
Links
- PUPWWTUVIZOPTB-KTKRTIGZSA-N (2-hydroxy-2-oxo-1,2$l^{5}-oxaphospholan-4-yl)methyl (z)-octadec-9-enoate Chemical class CCCCCCCC\C=C/CCCCCCCC(=O)OCC1COP(O)(=O)C1 PUPWWTUVIZOPTB-KTKRTIGZSA-N 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 230000004709 cell invasion Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyamides (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Chemical And Physical Treatments For Wood And The Like (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002169743A JP4162927B2 (ja) | 2002-06-11 | 2002-06-11 | カルバ環状ホスファチジン酸誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE419258T1 true ATE419258T1 (de) | 2009-01-15 |
Family
ID=29727741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03733345T ATE419258T1 (de) | 2002-06-11 | 2003-06-10 | Carbacyclisches phosphatidsäurederivat |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7550449B2 (de) |
| EP (1) | EP1535926B1 (de) |
| JP (1) | JP4162927B2 (de) |
| AT (1) | ATE419258T1 (de) |
| DE (1) | DE60325609D1 (de) |
| WO (1) | WO2003104246A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4815063B2 (ja) * | 2001-04-13 | 2011-11-16 | きみ子 室伏 | 環状ホスファチジン酸を含むグリア細胞の増殖、分化及び／又は生存の促進のための薬剤 |
| WO2008081580A1 (ja) | 2006-12-28 | 2008-07-10 | Ochanomizu University | 環状ホスファチジン酸誘導体を含む鎮痛剤 |
| EP2767541A1 (de) * | 2008-03-03 | 2014-08-20 | Rxbio, Inc. | LPA-Rezeptoragonisten und -antagonisten |
| SG11201402226PA (en) | 2011-11-11 | 2014-10-30 | Sansho Co | Therapeutic agent for arthrosis |
| JP6074411B2 (ja) * | 2012-04-27 | 2017-02-01 | Ｓａｎｓｈｏ株式会社 | 育毛剤 |
| WO2014115885A1 (ja) | 2013-01-28 | 2014-07-31 | 国立大学法人お茶の水女子大学 | 脱髄疾患治療薬 |
| ES2884041T3 (es) | 2014-08-12 | 2021-12-10 | Otsuka Chemical Co Ltd | Cristal de sal sódica de ácido fosfónico cíclico y método para fabricar el mismo |
| TWI868287B (zh) * | 2019-12-23 | 2025-01-01 | 日商大塚化學股份有限公司 | carba-環狀磷脂酸化合物 |
| CN116710105A (zh) | 2020-11-26 | 2023-09-05 | 山椒株式会社 | 肺纤维化治疗剂 |
| EP4691472A1 (de) | 2023-04-06 | 2026-02-11 | Homo Contribuens Research and Development Institute | Verbesserung/therapeutisches arzneimittel gegen demenz, insbesondere demenz vom alzheimer-typ |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5238965A (en) * | 1991-05-31 | 1993-08-24 | The Procter & Gamble Company | Methods of using lysophosphatidic acids for regulating skin wrinkles |
| JP3195833B2 (ja) | 1991-09-30 | 2001-08-06 | きみ子 室伏 | 新規生理活性物質及びその製造法 |
| JPH06228169A (ja) | 1993-02-05 | 1994-08-16 | Sagami Chem Res Center | １−ｏ−アシルグリセロール２，３−ホスフェートの製造法 |
| JPH07149772A (ja) | 1993-11-26 | 1995-06-13 | Sagami Chem Res Center | タンパク質リン酸化酵素ｃの活性促進剤 |
| JPH07258278A (ja) | 1994-03-18 | 1995-10-09 | Sagami Chem Res Center | １−Ｏ−アシルグリセロール−２，３−ホスフェート誘導体を有効成分とするＤＮＡポリメラーゼαの阻害剤 |
| JPH0925235A (ja) | 1995-07-13 | 1997-01-28 | Sagami Chem Res Center | １−ｏ−アシルグリセロール−２，３−ホスフェート誘導体を有効成分とするがん転移抑制剤 |
| DE19542305A1 (de) * | 1995-11-14 | 1997-05-15 | Hoechst Schering Agrevo Gmbh | Triazolylmethyl-cyclophosphanoxide, ihre Verwendung als Herbizide oder Pflanzenwachstumsregulatoren und Verfahren zu ihrer Herstellung |
| EP1069895A4 (de) | 1998-03-18 | 2002-07-31 | Lxr Biotechnology Inc | Zusammenstellungen die lysophosphatidylsäure enthalten welche apoptosis hemmen und deren verwendungen |
| US6150345A (en) | 1998-08-10 | 2000-11-21 | Regents Of The University Of California | Methods for promoting survival of myelin producing cells |
| IL129178A0 (en) | 1999-03-25 | 2000-02-17 | Yeda Res & Dev | Induction of nerve generation |
| IL129179A0 (en) | 1999-03-25 | 2000-02-17 | Yeda Res & Dev | Cyclic glycerophosphates and analogs thereof |
| JP4815063B2 (ja) * | 2001-04-13 | 2011-11-16 | きみ子 室伏 | 環状ホスファチジン酸を含むグリア細胞の増殖、分化及び／又は生存の促進のための薬剤 |
| JP4836345B2 (ja) * | 2001-04-13 | 2011-12-14 | きみ子 室伏 | 環状ホスファチジン酸誘導体を含む神経細胞の生存促進剤 |
| US20040214799A1 (en) * | 2001-05-21 | 2004-10-28 | Mutsuko Mukai | Cancerous metastasis inhibitors containing carbacyclic phosphatidic acid derivatives |
-
2002
- 2002-06-11 JP JP2002169743A patent/JP4162927B2/ja not_active Expired - Lifetime
-
2003
- 2003-06-10 EP EP03733345A patent/EP1535926B1/de not_active Expired - Lifetime
- 2003-06-10 DE DE60325609T patent/DE60325609D1/de not_active Expired - Lifetime
- 2003-06-10 AT AT03733345T patent/ATE419258T1/de not_active IP Right Cessation
- 2003-06-10 US US10/516,315 patent/US7550449B2/en not_active Expired - Lifetime
- 2003-06-10 WO PCT/JP2003/007335 patent/WO2003104246A1/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE60325609D1 (en) | 2009-02-12 |
| WO2003104246A1 (ja) | 2003-12-18 |
| JP2004010582A (ja) | 2004-01-15 |
| US20060122155A1 (en) | 2006-06-08 |
| EP1535926B1 (de) | 2008-12-31 |
| JP4162927B2 (ja) | 2008-10-08 |
| HK1078586A1 (en) | 2006-03-17 |
| EP1535926A1 (de) | 2005-06-01 |
| EP1535926A4 (de) | 2008-03-12 |
| US7550449B2 (en) | 2009-06-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |