ATE427360T1 - Endomannosidasen zur modifzierung der glykoproteine in eukaryoten - Google Patents
Endomannosidasen zur modifzierung der glykoproteine in eukaryotenInfo
- Publication number
- ATE427360T1 ATE427360T1 AT04713369T AT04713369T ATE427360T1 AT E427360 T1 ATE427360 T1 AT E427360T1 AT 04713369 T AT04713369 T AT 04713369T AT 04713369 T AT04713369 T AT 04713369T AT E427360 T1 ATE427360 T1 AT E427360T1
- Authority
- AT
- Austria
- Prior art keywords
- eukaryotes
- endomannosidases
- modifying
- methods
- glycoproteins
- Prior art date
Links
- 102000003886 Glycoproteins Human genes 0.000 title abstract 3
- 108090000288 Glycoproteins Proteins 0.000 title abstract 3
- 241000206602 Eukaryota Species 0.000 title abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 230000013595 glycosylation Effects 0.000 abstract 2
- 238000006206 glycosylation reaction Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 241000233866 Fungi Species 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2477—Hemicellulases not provided in a preceding group
- C12N9/2488—Mannanases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/0113—Glycoprotein endo-alpha-1,2-mannosidase (3.2.1.130)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/371,877 US7449308B2 (en) | 2000-06-28 | 2003-02-20 | Combinatorial DNA library for producing modified N-glycans in lower eukaryotes |
| US10/695,243 US7332299B2 (en) | 2003-02-20 | 2003-10-27 | Endomannosidases in the modification of glycoproteins in eukaryotes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE427360T1 true ATE427360T1 (de) | 2009-04-15 |
Family
ID=32911944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04713369T ATE427360T1 (de) | 2003-02-20 | 2004-02-20 | Endomannosidasen zur modifzierung der glykoproteine in eukaryoten |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7332299B2 (de) |
| EP (1) | EP1597379B3 (de) |
| JP (2) | JP4787737B2 (de) |
| AT (1) | ATE427360T1 (de) |
| AU (1) | AU2004213860B2 (de) |
| CA (1) | CA2516527A1 (de) |
| DE (1) | DE602004020321D1 (de) |
| WO (1) | WO2004074497A2 (de) |
Families Citing this family (46)
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| ATE440959T1 (de) * | 2000-06-28 | 2009-09-15 | Glycofi Inc | Verfahren für die herstellung modifizierter glykoproteine |
| US7863020B2 (en) * | 2000-06-28 | 2011-01-04 | Glycofi, Inc. | Production of sialylated N-glycans in lower eukaryotes |
| US20060029604A1 (en) * | 2000-06-28 | 2006-02-09 | Gerngross Tillman U | Immunoglobulins comprising predominantly a GlcNAc2Man3GlcNAc2 glycoform |
| US7449308B2 (en) | 2000-06-28 | 2008-11-11 | Glycofi, Inc. | Combinatorial DNA library for producing modified N-glycans in lower eukaryotes |
| US20060024304A1 (en) * | 2000-06-28 | 2006-02-02 | Gerngross Tillman U | Immunoglobulins comprising predominantly a Man5GlcNAc2 glycoform |
| US20060034828A1 (en) * | 2000-06-28 | 2006-02-16 | Gerngross Tillman U | Immunoglobulins comprising predominantly a GlcNAcMAN5GLCNAC2 glycoform |
| US8697394B2 (en) * | 2000-06-28 | 2014-04-15 | Glycofi, Inc. | Production of modified glycoproteins having multiple antennary structures |
| TWI324181B (en) | 2001-04-16 | 2010-05-01 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
| US20060024292A1 (en) * | 2001-12-27 | 2006-02-02 | Gerngross Tillman U | Immunoglobulins comprising predominantly a Gal2GlcNAc2Man3GlcNAc2 glycoform |
| US20060034829A1 (en) * | 2001-12-27 | 2006-02-16 | Gerngross Tillman U | Immunoglobulins comprising predominantly a MAN3GLCNAC2 glycoform |
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| EP1937305A4 (de) * | 2005-09-09 | 2008-10-08 | Glycofi Inc | Immunglobulin, das vorwiegend eine man7glcnac2, man8glcnac2 glycoform enthält |
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| BRPI0711898A2 (pt) * | 2006-05-19 | 2011-12-27 | Glycofi Inc | composiÇço de proteÍna da eritropoietina substancialmente homogÊnea, composiÇço farmacÊutica, e, mÉtodos de aumentar hematàcrito em um mamÍfero, e de produzir uma composiÇço de eritropoietina |
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| CA2679732A1 (en) * | 2007-03-07 | 2008-09-18 | Glycofi, Inc. | Production of glycoproteins with modified fucosylation |
| AU2009279062B2 (en) * | 2008-08-08 | 2014-01-16 | Universiteit Gent | Cells producing glycoproteins having altered glycosylation patterns and methods and use thereof |
| EP2401378B1 (de) | 2009-02-25 | 2013-08-14 | Merck Sharp & Dohme Corp. | Stoffwechselmanipulation eines galaktoseassimilationswegs bei der glycoengineerten hefe pichia pastoris |
| TWI504749B (zh) | 2009-03-16 | 2015-10-21 | Dsm Ip Assets Bv | 於網黏菌門微生物中生產蛋白質之技術 |
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| IN2012DN06277A (de) | 2009-12-28 | 2015-09-25 | Dsm Ip Assets Bv | |
| EP2519636B8 (de) * | 2009-12-28 | 2017-08-09 | DSM IP Assets B.V. | Herstellung eines hämagglutinin-neuraminidase-proteins in mikroalgen |
| ES2651313T3 (es) * | 2009-12-28 | 2018-01-25 | Dsm Ip Assets B.V. | Traustoquítridos recombinantes que crecen en xilosa, y composiciones, métodos de preparación y usos de los mismos |
| KR101930961B1 (ko) | 2010-02-24 | 2018-12-19 | 머크 샤프 앤드 돔 코포레이션 | 피키아 파스토리스에서 생산된 치료 당단백질 상의 n-글리코실화 부위 점유를 증가시키는 방법 |
| KR20140091017A (ko) * | 2011-10-28 | 2014-07-18 | 머크 샤프 앤드 돔 코포레이션 | Alg3 발현이 결핍된 피키아 파스토리스 균주에서 n-글리칸 점유율을 증가시키고 하이브리드 n-글리칸의 생산을 감소시키는 방법 |
| DK2852610T3 (en) | 2012-05-23 | 2018-09-03 | Glykos Finland Oy | PRODUCTION OF FUCOSYLED GLYCOPROTEIN |
| EP2911681A1 (de) | 2012-10-26 | 2015-09-02 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Lyve-1-antagonisten zur vorbeugung oder behandlung eines pathologischen leidens in zusammenhang mit lymphangiogenese |
| WO2014090948A1 (en) | 2012-12-13 | 2014-06-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Serpin spn4a and biologically active derivatives thereof for use in the treatment of cancer |
| AU2013373679A1 (en) | 2013-01-16 | 2015-08-13 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | A soluble fibroblast growth factor receptor 3 (FGR3) polypeptide for use in the prevention or treatment of skeletal growth retardation disorders |
| WO2015044379A1 (en) | 2013-09-27 | 2015-04-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A dyrk1a polypeptide for use in preventing or treating metabolic disorders |
| AU2015293949B2 (en) | 2014-07-21 | 2019-07-25 | Teknologian Tutkimuskeskus Vtt Oy | Production of glycoproteins with mammalian-like N-glycans in filamentous fungi |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US20260041734A1 (en) | 2022-07-21 | 2026-02-12 | Technische Universität Dresden | M-csf for use in the prophylaxis and/or treatment of viral infections in states of immunosuppression |
| EP4309666A1 (de) | 2022-07-21 | 2024-01-24 | Technische Universität Dresden | M-csf zur verwendung bei der prophylaxe und/oder behandlung viraler infektionen bei immunsuppressionszuständen |
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-
2003
- 2003-10-27 US US10/695,243 patent/US7332299B2/en not_active Expired - Lifetime
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- 2004-02-20 WO PCT/US2004/005131 patent/WO2004074497A2/en not_active Ceased
- 2004-02-20 JP JP2006503759A patent/JP4787737B2/ja not_active Expired - Fee Related
- 2004-02-20 CA CA002516527A patent/CA2516527A1/en not_active Abandoned
- 2004-02-20 AT AT04713369T patent/ATE427360T1/de not_active IP Right Cessation
- 2004-02-20 EP EP04713369.9A patent/EP1597379B3/de not_active Expired - Lifetime
- 2004-02-20 DE DE602004020321T patent/DE602004020321D1/de not_active Expired - Lifetime
- 2004-02-20 AU AU2004213860A patent/AU2004213860B2/en not_active Ceased
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- 2008-01-16 US US12/009,105 patent/US20090130709A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| EP1597379B2 (de) | 2016-08-03 |
| CA2516527A1 (en) | 2004-09-02 |
| AU2004213860B2 (en) | 2009-04-02 |
| WO2004074497A3 (en) | 2004-12-02 |
| EP1597379B3 (de) | 2021-06-23 |
| JP5280399B2 (ja) | 2013-09-04 |
| DE602004020321D1 (de) | 2009-05-14 |
| EP1597379A2 (de) | 2005-11-23 |
| US20040171826A1 (en) | 2004-09-02 |
| US20090130709A1 (en) | 2009-05-21 |
| WO2004074497A2 (en) | 2004-09-02 |
| JP2010187693A (ja) | 2010-09-02 |
| US8986949B2 (en) | 2015-03-24 |
| AU2004213860A1 (en) | 2004-09-02 |
| US7332299B2 (en) | 2008-02-19 |
| JP4787737B2 (ja) | 2011-10-05 |
| JP2006518598A (ja) | 2006-08-17 |
| EP1597379B1 (de) | 2009-04-01 |
| US20120064568A1 (en) | 2012-03-15 |
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