ATE421336T1 - Medizinische zusammensetzungen mit cholesterin erniedrigender wirkung - Google Patents
Medizinische zusammensetzungen mit cholesterin erniedrigender wirkungInfo
- Publication number
- ATE421336T1 ATE421336T1 AT98933883T AT98933883T ATE421336T1 AT E421336 T1 ATE421336 T1 AT E421336T1 AT 98933883 T AT98933883 T AT 98933883T AT 98933883 T AT98933883 T AT 98933883T AT E421336 T1 ATE421336 T1 AT E421336T1
- Authority
- AT
- Austria
- Prior art keywords
- effect
- ppar
- cholesterol
- delta
- activating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19823297 | 1997-07-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE421336T1 true ATE421336T1 (de) | 2009-02-15 |
Family
ID=16387713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98933883T ATE421336T1 (de) | 1997-07-24 | 1998-07-22 | Medizinische zusammensetzungen mit cholesterin erniedrigender wirkung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6300364B1 (de) |
| EP (1) | EP1023907B1 (de) |
| JP (1) | JP4427825B2 (de) |
| AT (1) | ATE421336T1 (de) |
| AU (1) | AU8355998A (de) |
| CA (1) | CA2295930C (de) |
| DE (1) | DE69840510D1 (de) |
| ES (1) | ES2320181T3 (de) |
| WO (1) | WO1999004815A1 (de) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY123337A (en) | 1998-05-11 | 2006-05-31 | Takeda Chemical Industries Ltd | Oxyiminoalkanoic acid derivatives. |
| GB9914977D0 (en) * | 1999-06-25 | 1999-08-25 | Glaxo Group Ltd | Chemical compounds |
| GB9917405D0 (en) * | 1999-07-23 | 1999-09-22 | Univ Dundee | Methods of treatment and drug screening methods |
| TWI262185B (en) | 1999-10-01 | 2006-09-21 | Eisai Co Ltd | Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives |
| EP1304121A4 (de) * | 1999-11-10 | 2004-06-23 | Takeda Chemical Industries Ltd | Inhibitoren der koerpergewichtszunahme |
| EP1310494B1 (de) | 2000-08-11 | 2012-01-25 | Nippon Chemiphar Co., Ltd. | Ppar-delta aktivatoren |
| GB0024362D0 (en) * | 2000-10-05 | 2000-11-22 | Glaxo Group Ltd | Medicaments |
| GB0024361D0 (en) | 2000-10-05 | 2000-11-22 | Glaxo Group Ltd | Medicaments |
| US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| PT1355644E (pt) | 2001-01-26 | 2006-11-30 | Schering Corp | Utilização de compostos azetidinona substituídos para o tratamento de sitosterolemia |
| EP1911462A3 (de) | 2001-01-26 | 2011-11-30 | Schering Corporation | Zusammensetzungen enthaltend einen Sterolabsorptionshemmer |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| RS20100015A (sr) | 2001-01-26 | 2010-12-31 | Schering Corporation | Kombinacija aktivatora receptora aktiviranog peroksizom- proliferatorom (ppar) fenofibrata sa inhibitorom apsorpcije sterola ezetimibom za vaskularne indikacije |
| EP1357914A2 (de) * | 2001-02-02 | 2003-11-05 | SmithKline Beecham Corporation | Verfahren zur behandlung von ppar vermittelten krankheiten |
| US7253178B2 (en) | 2001-03-28 | 2007-08-07 | Eisai Co., Ltd. | Carboxylic acids |
| JP4549021B2 (ja) | 2001-03-30 | 2010-09-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ベンゼン化合物およびその塩 |
| TWI311133B (en) | 2001-04-20 | 2009-06-21 | Eisai R&D Man Co Ltd | Carboxylic acid derivativeand the salt thereof |
| ATE480236T1 (de) * | 2001-04-25 | 2010-09-15 | Takeda Pharmaceutical | Verwendung des abc-expressionspromotors pioglitazon zur behandlung von arteriosklerose obliterans |
| US7687664B2 (en) | 2001-06-04 | 2010-03-30 | Eisai R&D Management Co., Ltd. | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it |
| JP2004537525A (ja) * | 2001-06-11 | 2004-12-16 | メルク エンド カムパニー インコーポレーテッド | PPARδアゴニストの投与による炎症性疾患の治療法 |
| JP3888998B2 (ja) * | 2001-07-17 | 2007-03-07 | 帝人株式会社 | PPARδ活性化作用を測定することを特徴とする物質の選択方法及び薬剤 |
| JP4870464B2 (ja) * | 2001-07-17 | 2012-02-08 | 帝人株式会社 | PPARδ活性化作用を測定することを特徴とする物質の選択方法及び薬剤 |
| AU2002323776B2 (en) * | 2001-08-10 | 2008-07-31 | Nippon Chemiphar Co., Ltd. | Activator for peroxisome proliferator-responsive receptor Delta |
| EP1452521A4 (de) | 2001-08-17 | 2007-03-14 | Eisai R&D Man Co Ltd | Cyclische verbindung und ppar-agonist |
| US6869975B2 (en) | 2001-09-14 | 2005-03-22 | Tularik Inc. | Linked biaryl compounds |
| EP1429756B1 (de) | 2001-09-21 | 2006-11-22 | Schering Corporation | Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| JP4276074B2 (ja) * | 2001-10-12 | 2009-06-10 | 日本ケミファ株式会社 | ペルオキシソーム増殖剤応答性受容体δの活性化剤 |
| PL375700A1 (en) | 2002-09-05 | 2005-12-12 | Novo Nordisk A/S | Novel vinyl carboxylic acid derivatives and their therapeutical use |
| US7129268B2 (en) | 2002-10-28 | 2006-10-31 | Novo Nordisk A/S | Peroxisome proliferator activated receptor-active arylene acetic acid derivatives |
| MXPA05004402A (es) | 2002-10-28 | 2005-07-26 | Novo Nordisk As | Compuestos novedosos y su uso como moduladores de receptores activados por proliferador de peroxisoma. |
| ATE469882T1 (de) | 2002-10-28 | 2010-06-15 | High Point Pharmaceuticals Llc | Neue verbindungen, die sich f r die behandlung von durch ppar vermittelten krankheiten eignen |
| US20050080115A1 (en) | 2002-10-28 | 2005-04-14 | Lone Jeppesen | Novel compounds, their preparation and use |
| JP2006508188A (ja) | 2002-11-06 | 2006-03-09 | シェーリング コーポレイション | 脱髄の処置のためのコレステロール吸収インヒビター |
| DE602004016123D1 (de) | 2003-03-07 | 2008-10-09 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
| CN1756755A (zh) | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
| CN1756756A (zh) | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
| US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| WO2004093910A1 (ja) * | 2003-04-22 | 2004-11-04 | Astellas Pharma Inc. | PPARδアゴニストによる脳神経変性疾患治療剤 |
| EP2100877B1 (de) | 2003-09-19 | 2012-01-25 | Janssen Pharmaceutica N.V. | 4-((Phenoxyalkyl)thio)-phenoxyessigsäuren und Analoga |
| EP1745014B1 (de) | 2004-05-05 | 2011-07-06 | High Point Pharmaceuticals, LLC | Neue verbindungen, deren herstellung und verwendung |
| JP2007536343A (ja) | 2004-05-05 | 2007-12-13 | ノボ ノルディスク アクティーゼルスカブ | Pparアゴニストとしてのフェノキシ酢酸誘導体 |
| AU2005247473A1 (en) | 2004-05-25 | 2005-12-08 | Metabolex, Inc. | Substituted triazoles as modulators of PPAR and methods of their preparation |
| US8111617B2 (en) * | 2004-08-13 | 2012-02-07 | Broadcom Corporation | Multiple independent pathway communications |
| MY147518A (en) | 2004-09-15 | 2012-12-31 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| MY145712A (en) * | 2004-09-15 | 2012-03-30 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| JP2008538351A (ja) | 2005-03-21 | 2008-10-23 | メタボレックス インコーポレーティッド | 癌を含むPPARγ反応性疾患の処置または予防における浮腫を回避するための方法 |
| US7943669B2 (en) | 2005-06-30 | 2011-05-17 | High Point Pharmaceuticals, Llc | Phenoxy acetic acids as PPAR delta activators |
| US8097610B2 (en) * | 2005-08-26 | 2012-01-17 | Shionogi & Co., Ltd. | Derivative having PPAR agonistic activity |
| JO3006B1 (ar) | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
| EA201101084A1 (ru) | 2005-12-22 | 2012-04-30 | ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Феноксиуксусные кислоты в качестве активаторов ppar дельта |
| JP2009529512A (ja) | 2006-03-09 | 2009-08-20 | ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー | 新規な化合物、それらの製造法、及び使用法 |
| UY30288A1 (es) | 2006-04-18 | 2007-08-31 | Janssen Pharmaceutica Nv | Derivados del ácido benzoazepin-oxi-acético como agonistas de ppar-delta usados para aumentar hdl-c. reducir ldl-c y reducir colesterol |
| ZA200809148B (en) * | 2006-04-18 | 2010-01-27 | Nippon Chemiphar Co | Activating agent for peroxisome proliferator activated receptor delta |
| CA2663115C (en) | 2006-09-08 | 2015-04-28 | Rhode Island Hospital | Treatment, prevention, and reversal of alcohol-induced liver disease |
| KR20090066289A (ko) | 2006-09-08 | 2009-06-23 | 로드아일랜드하스피틀 | 알코올 유발성 뇌 질환의 치료, 예방 및 역행 |
| EP2155769B1 (de) | 2007-05-04 | 2012-06-27 | Katholieke Universiteit Leuven KU Leuven Research & Development | Schutz gegen gewebedegeneration |
| JP5474769B2 (ja) * | 2008-04-15 | 2014-04-16 | 日本ケミファ株式会社 | ペルオキシソーム増殖剤活性化受容体の活性化剤 |
| CN102724978A (zh) * | 2009-08-14 | 2012-10-10 | 塞伦尼斯治疗公司 | 用于治疗或预防炎症或能量代谢/产生相关疾病的PPARδ配体的用途 |
| US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
| ES2811087T3 (es) | 2013-09-09 | 2021-03-10 | Vtv Therapeutics Llc | Uso de agonistas de PPAR-delta para tratar la atrofia muscular |
| WO2023147309A1 (en) | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Use of ppar-delta agonists in the treatment of disease |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA858493B (en) | 1984-11-12 | 1986-07-30 | Yamanouchi Pharma Co Ltd | Heterocyclic compounds and process of producing them |
| JPS61268657A (ja) | 1985-05-23 | 1986-11-28 | Takeda Chem Ind Ltd | フエニル酢酸誘導体およびその製造法 |
| JPH0788426B2 (ja) | 1986-07-30 | 1995-09-27 | 住友ベークライト株式会社 | 耐熱性樹脂の製造方法 |
| JPH02215717A (ja) | 1989-02-14 | 1990-08-28 | Yamanouchi Pharmaceut Co Ltd | 血清脂質低下剤 |
| CZ281130B6 (cs) | 1993-06-18 | 1996-06-12 | Galena, A.S. | Deriváty 4-alkyloxy-3-propyl-2-hydroxyacetofenonu |
| AU2952695A (en) | 1994-07-01 | 1996-01-25 | Salk Institute For Biological Studies, The | Mammalian peroxisome proliferator-activated receptors and uses thereof |
| GB2292885A (en) | 1994-09-08 | 1996-03-13 | Merck & Co Inc | Method of treating hyperlipidemia |
| WO1997010813A1 (en) | 1995-09-18 | 1997-03-27 | Ligand Pharmaceuticals Incorporated | Ppar gamma antagonists for treating obesity |
| DK0859608T3 (da) | 1995-09-18 | 2004-06-14 | Ligand Pharm Inc | Behandling af NIDDM med RXR-agonister |
| EP1011651B1 (de) | 1996-02-02 | 2005-04-27 | Merck & Co., Inc. | Verfahren zur behandlung von diabetes und verwandter krankheitszustände. |
| US6090839A (en) * | 1996-12-23 | 2000-07-18 | Merck & Co., Inc. | Antidiabetic agents |
-
1998
- 1998-07-22 ES ES98933883T patent/ES2320181T3/es not_active Expired - Lifetime
- 1998-07-22 US US09/463,334 patent/US6300364B1/en not_active Expired - Lifetime
- 1998-07-22 EP EP98933883A patent/EP1023907B1/de not_active Revoked
- 1998-07-22 AT AT98933883T patent/ATE421336T1/de not_active IP Right Cessation
- 1998-07-22 WO PCT/JP1998/003266 patent/WO1999004815A1/ja not_active Ceased
- 1998-07-22 DE DE69840510T patent/DE69840510D1/de not_active Expired - Lifetime
- 1998-07-22 AU AU83559/98A patent/AU8355998A/en not_active Abandoned
- 1998-07-22 CA CA2295930A patent/CA2295930C/en not_active Expired - Fee Related
- 1998-07-22 JP JP50965799A patent/JP4427825B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1023907A4 (de) | 2001-02-21 |
| EP1023907A1 (de) | 2000-08-02 |
| CA2295930A1 (en) | 1999-02-04 |
| US6300364B1 (en) | 2001-10-09 |
| CA2295930C (en) | 2010-12-14 |
| WO1999004815A1 (fr) | 1999-02-04 |
| AU8355998A (en) | 1999-02-16 |
| DE69840510D1 (de) | 2009-03-12 |
| ES2320181T3 (es) | 2009-05-19 |
| JP4427825B2 (ja) | 2010-03-10 |
| EP1023907B1 (de) | 2009-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |