ATE421516T1 - Als modulatoren des glucocorticoidrezeptors geeignete nichtsteroidale verbindungen - Google Patents

Als modulatoren des glucocorticoidrezeptors geeignete nichtsteroidale verbindungen

Info

Publication number: ATE421516T1
Authority: AT; Austria
Prior art keywords: modulators; glucocorticoid receptor; compounds suitable; nonsteroid; nonsteroid compounds
Prior art date: 2005-08-29

Application number

AT06764340T

Other languages

English (en)

Inventor

Ralf Plate

Christiaan Jans

Original Assignee

Organon Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-08-29

Filing date

2006-08-25

Publication date

2009-02-15

2006-08-25 Application filed by Organon Nv filed Critical Organon Nv

2009-02-15 Application granted granted Critical

2009-02-15 Publication of ATE421516T1 publication Critical patent/ATE421516T1/de

Links

102000003676 Glucocorticoid Receptors Human genes 0.000 title 1
108090000079 Glucocorticoid Receptors Proteins 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Neurology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Transplantation (AREA)
Gastroenterology & Hepatology (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Otolaryngology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT06764340T 2005-08-29 2006-08-25 Als modulatoren des glucocorticoidrezeptors geeignete nichtsteroidale verbindungen ATE421516T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP05107896		2005-08-29

Publications (1)

Publication Number	Publication Date
ATE421516T1 true ATE421516T1 (de)	2009-02-15

Family

ID=35466054

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06764340T ATE421516T1 (de)	2005-08-29	2006-08-25	Als modulatoren des glucocorticoidrezeptors geeignete nichtsteroidale verbindungen

Country Status (30)

Country	Link
US (1)	US8575152B2 (de)
EP (1)	EP1924580B1 (de)
JP (1)	JP5191383B2 (de)
KR (1)	KR20080040024A (de)
CN (1)	CN101304999B (de)
AR (1)	AR058027A1 (de)
AT (1)	ATE421516T1 (de)
AU (1)	AU2006286524B2 (de)
BR (1)	BRPI0615412A2 (de)
CA (1)	CA2621229A1 (de)
CY (1)	CY1109041T1 (de)
DE (1)	DE602006005006D1 (de)
DK (1)	DK1924580T3 (de)
EC (1)	ECSP088289A (de)
ES (1)	ES2320273T3 (de)
HR (1)	HRP20090116T3 (de)
IL (1)	IL189463A (de)
MY (1)	MY145591A (de)
NO (1)	NO20080940L (de)
NZ (1)	NZ566005A (de)
PE (1)	PE20070331A1 (de)
PL (1)	PL1924580T3 (de)
PT (1)	PT1924580E (de)
RS (1)	RS50763B (de)
RU (1)	RU2420528C2 (de)
SI (1)	SI1924580T1 (de)
TW (1)	TWI375676B (de)
UA (1)	UA92024C2 (de)
WO (1)	WO2007025938A1 (de)
ZA (1)	ZA200801599B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN103130717B (zh) *	2011-11-29	2015-04-01	上海博康精细化工有限公司	二苯并氮卓酮的制备方法
WO2025255469A1 (en) *	2024-06-06	2025-12-11	Psammiad Therapeutics, Inc.	Compounds and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3657250A (en) *	1970-02-10	1972-04-18	Ayerst Mckenna & Harrison	Benzocycloheptaisoquinoline derivatives
IL36085A (en) *	1970-02-10	1974-09-10	Ayerst Mckenna & Harrison	Octahydrobenzo(6,7)cyclohepta(1,2,3-d,a)pyrido(or pyrrolo)-(2,1-a)isoquinolines and decahydrobenzo-(6,7)cyclohepta-(1,2,3-d,e)azepino(2,1-a)isoquinolines and their preparation
NL7305811A (de) *	1973-04-26	1974-10-29
US4016161A (en) *	1974-04-24	1977-04-05	Akzona Incorporated	Amino-substituted 1,2,3,4,10,146-hexahydro-pyridino[1,2-a]dibenzo[c,f]azepines
EP1043325B1 (de) *	1994-12-22	2004-06-16	Ligand Pharmaceuticals Incorporated	Steroidrezeptor-Modulator Verbindungen und Methoden
IL146057A (en) *	2000-10-27	2007-09-20	Pfizer Prod Inc	A process for the preparation of modulators of a non-steroidal glucocorticoid receptor
TWI297685B (en) *	2002-04-04	2008-06-11	Organon Nv	Non-steroidal progesterone receptor modulators
EP1534273A4 (de)	2002-07-18	2007-08-22	Bristol Myers Squibb Co	Modulatoren des glucocorticoid-rezeptors und verfahren

2006
- 2006-08-09 TW TW095129231A patent/TWI375676B/zh not_active IP Right Cessation
- 2006-08-25 NZ NZ566005A patent/NZ566005A/en not_active IP Right Cessation
- 2006-08-25 DK DK06764340T patent/DK1924580T3/da active
- 2006-08-25 RU RU2008112206/04A patent/RU2420528C2/ru not_active IP Right Cessation
- 2006-08-25 RS RSP-2009/0132A patent/RS50763B/sr unknown
- 2006-08-25 PL PL06764340T patent/PL1924580T3/pl unknown
- 2006-08-25 PE PE2006001032A patent/PE20070331A1/es not_active Application Discontinuation
- 2006-08-25 EP EP06764340A patent/EP1924580B1/de active Active
- 2006-08-25 WO PCT/EP2006/065696 patent/WO2007025938A1/en not_active Ceased
- 2006-08-25 US US12/065,241 patent/US8575152B2/en not_active Expired - Fee Related
- 2006-08-25 DE DE602006005006T patent/DE602006005006D1/de active Active
- 2006-08-25 UA UAA200802209A patent/UA92024C2/ru unknown
- 2006-08-25 CN CN200680036676XA patent/CN101304999B/zh not_active Expired - Fee Related
- 2006-08-25 AR ARP060103702A patent/AR058027A1/es not_active Application Discontinuation
- 2006-08-25 PT PT06764340T patent/PT1924580E/pt unknown
- 2006-08-25 HR HR20090116T patent/HRP20090116T3/xx unknown
- 2006-08-25 AT AT06764340T patent/ATE421516T1/de active
- 2006-08-25 MY MYPI20080356A patent/MY145591A/en unknown
- 2006-08-25 JP JP2008528488A patent/JP5191383B2/ja not_active Expired - Fee Related
- 2006-08-25 AU AU2006286524A patent/AU2006286524B2/en not_active Ceased
- 2006-08-25 ES ES06764340T patent/ES2320273T3/es active Active
- 2006-08-25 BR BRPI0615412-3A patent/BRPI0615412A2/pt not_active IP Right Cessation
- 2006-08-25 SI SI200630234T patent/SI1924580T1/sl unknown
- 2006-08-25 KR KR1020087007048A patent/KR20080040024A/ko not_active Abandoned
- 2006-08-25 CA CA002621229A patent/CA2621229A1/en not_active Abandoned
2008
- 2008-02-12 IL IL189463A patent/IL189463A/en not_active IP Right Cessation
- 2008-02-18 ZA ZA200801599A patent/ZA200801599B/xx unknown
- 2008-02-25 NO NO20080940A patent/NO20080940L/no not_active Application Discontinuation
- 2008-03-17 EC EC2008008289A patent/ECSP088289A/es unknown
2009
- 2009-04-14 CY CY20091100438T patent/CY1109041T1/el unknown

Also Published As

Publication number	Publication date
UA92024C2 (ru)	2010-09-27
RU2008112206A (ru)	2009-10-10
NZ566005A (en)	2010-01-29
PL1924580T3 (pl)	2009-07-31
CN101304999A (zh)	2008-11-12
RU2420528C2 (ru)	2011-06-10
AU2006286524B2 (en)	2011-06-16
EP1924580B1 (de)	2009-01-21
DK1924580T3 (da)	2009-05-11
BRPI0615412A2 (pt)	2012-12-04
CA2621229A1 (en)	2007-03-08
ECSP088289A (es)	2008-04-28
KR20080040024A (ko)	2008-05-07
US8575152B2 (en)	2013-11-05
CN101304999B (zh)	2011-11-16
ES2320273T3 (es)	2009-05-20
TWI375676B (en)	2012-11-01
AU2006286524A1 (en)	2007-03-08
AR058027A1 (es)	2008-01-23
PE20070331A1 (es)	2007-04-16
NO20080940L (no)	2008-05-05
WO2007025938A1 (en)	2007-03-08
RS50763B (sr)	2010-08-31
DE602006005006D1 (de)	2009-03-12
JP2009506093A (ja)	2009-02-12
IL189463A0 (en)	2008-06-05
US20080188459A1 (en)	2008-08-07
HRP20090116T3 (en)	2009-04-30
SI1924580T1 (sl)	2009-06-30
PT1924580E (pt)	2009-04-01
TW200745105A (en)	2007-12-16
MY145591A (en)	2012-02-29
IL189463A (en)	2011-07-31
CY1109041T1 (el)	2014-07-02
EP1924580A1 (de)	2008-05-28
JP5191383B2 (ja)	2013-05-08
ZA200801599B (en)	2009-01-28

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2009-09-15

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