ATE423391T1 - Retentatchromatographievorrichtung und proteinchipmatrizen mit anwendungen in biologie und medizin - Google Patents

Retentatchromatographievorrichtung und proteinchipmatrizen mit anwendungen in biologie und medizin

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Publication number
ATE423391T1
ATE423391T1 AT03025393T AT03025393T ATE423391T1 AT E423391 T1 ATE423391 T1 AT E423391T1 AT 03025393 T AT03025393 T AT 03025393T AT 03025393 T AT03025393 T AT 03025393T AT E423391 T1 ATE423391 T1 AT E423391T1
Authority
AT
Austria
Prior art keywords
biology
medicine
applications
retentate chromatography
protein chip
Prior art date
Application number
AT03025393T
Other languages
English (en)
Inventor
William T Hutchens
Tai-Tung Yip
Original Assignee
Bio Rad Laboratories
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Publication date
Application filed by Bio Rad Laboratories filed Critical Bio Rad Laboratories
Application granted granted Critical
Publication of ATE423391T1 publication Critical patent/ATE423391T1/de

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    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
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    • H01J49/02—Details
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Families Citing this family (482)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020037517A1 (en) * 1993-05-28 2002-03-28 Hutchens T. William Methods for sequencing biopolymers
WO1994028418A1 (en) * 1993-05-28 1994-12-08 Baylor College Of Medicine Method and apparatus for desorption and ionization of analytes
WO1997000969A1 (de) * 1995-06-20 1997-01-09 Johannes Schumacher Verfahren und vorrichtung zur bestimmung der aktivität von enzymen in flüssigkeiten, beziehungsweise der konzentration und/oder aktivität von inhibitoren in flüssigkeiten
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US7622294B2 (en) * 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
ATE311443T1 (de) * 1997-09-03 2005-12-15 Biovation Ltd Methoden zur durchforstung (screenen) von proteinen
CA2318175A1 (en) 1998-02-04 1999-08-12 Invitrogen Corporation Microarrays and uses therefor
US20030138973A1 (en) * 1998-07-14 2003-07-24 Peter Wagner Microdevices for screening biomolecules
US6780582B1 (en) * 1998-07-14 2004-08-24 Zyomyx, Inc. Arrays of protein-capture agents and methods of use thereof
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US20020119579A1 (en) * 1998-07-14 2002-08-29 Peter Wagner Arrays devices and methods of use thereof
US20040242521A1 (en) * 1999-10-25 2004-12-02 Board Of Regents, The University Of Texas System Thio-siRNA aptamers
US6867289B1 (en) * 1998-10-26 2005-03-15 Board Of Regents, The University Of Texas Systems Thio-modified aptamer synthetic methods and compositions
US20060172925A1 (en) * 1998-10-26 2006-08-03 Board Of Regents, The University Of Texas System Thio-siRNA aptamers
EP1169641B1 (de) * 1999-04-15 2007-10-17 The University Of Virginia Patent Foundation Proteomabbau
KR100713786B1 (ko) 1999-04-27 2007-05-07 바이오 래드 래버러토리스 인코오포레이티드 기체상 이온 분광계용 탐침
US6555813B1 (en) 1999-04-29 2003-04-29 Ciphergen Biosystems, Inc. Probes with hydrophobic coatings for gas phase ion spectrometers
JP4543187B2 (ja) * 1999-06-18 2010-09-15 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 薬物候補物に関連する薬物動態パラメータ推定のための薬物候補物のアッセイのための方法および装置
US20090233806A1 (en) * 1999-07-06 2009-09-17 Carr Francis J Protein isolation and analysis
WO2001007162A1 (en) * 1999-07-26 2001-02-01 Harvard Apparatus, Inc. Surface coated housing for sample preparation
US7179638B2 (en) 1999-07-30 2007-02-20 Large Scale Biology Corporation Microarrays and their manufacture by slicing
US6713309B1 (en) 1999-07-30 2004-03-30 Large Scale Proteomics Corporation Microarrays and their manufacture
US7138254B2 (en) 1999-08-02 2006-11-21 Ge Healthcare (Sv) Corp. Methods and apparatus for performing submicroliter reactions with nucleic acids or proteins
AU7103500A (en) * 1999-09-01 2001-03-26 Medalys Corporation High throughput chemical profiling
WO2001016284A1 (en) * 1999-09-01 2001-03-08 Medalys Corporation Automated test agent profiling system
US6869572B1 (en) * 1999-09-13 2005-03-22 Millipore Corporation High density cast-in-place sample preparation card
US6783929B1 (en) * 1999-11-02 2004-08-31 Chiron Corporation Biological sample component purification and differential display
US6936424B1 (en) 1999-11-16 2005-08-30 Matritech, Inc. Materials and methods for detection and treatment of breast cancer
US6620625B2 (en) * 2000-01-06 2003-09-16 Caliper Technologies Corp. Ultra high throughput sampling and analysis systems and methods
DE10000629C5 (de) * 2000-01-10 2010-06-02 november Aktiengesellschaft, Gesellschaft für Molekulare Medizin Verfahren zur Identifizierung einer auf einen festen Körper aufgebrachten Markierung
US20030087265A1 (en) * 2000-01-21 2003-05-08 Edward Sauter Specific microarrays for breast cancer screening
WO2001059460A2 (en) * 2000-02-08 2001-08-16 The Regents Of The University Of Michigan Mapping of differential display of proteins
US6720157B2 (en) 2000-02-23 2004-04-13 Zyomyx, Inc. Chips having elevated sample surfaces
US6815215B2 (en) * 2000-02-28 2004-11-09 Hitachi, Ltd. Method of recovering a plurality of nucleic acids by an identical stationary phase and an apparatus thereof
US6569383B1 (en) * 2000-03-11 2003-05-27 Intrinsic Bioprobes, Inc. Bioactive chip mass spectrometry
US7351540B1 (en) * 2000-03-17 2008-04-01 Merck Patent Gmbh Protein isolation and analysis
CA2301451A1 (en) * 2000-03-20 2001-09-21 Thang T. Pham Method for analysis of analytes by mass spectrometry
US8399383B2 (en) 2000-05-04 2013-03-19 Yale University Protein chips for high throughput screening of protein activity
JP2003536073A (ja) * 2000-06-05 2003-12-02 カイロン コーポレイション プロテオミクス分析を実施するためのマイクロアレイ
US7153682B2 (en) * 2000-06-05 2006-12-26 Chiron Corporation Microarrays on mirrored substrates for performing proteomic analyses
US7148058B2 (en) 2000-06-05 2006-12-12 Chiron Corporation Protein microarrays on mirrored surfaces for performing proteomic analyses
ATE406627T1 (de) 2000-06-19 2008-09-15 Correlogic Systems Inc Heuristisches klassifikationsverfahren
AU2001280581A1 (en) * 2000-07-18 2002-01-30 Correlogic Systems, Inc. A process for discriminating between biological states based on hidden patterns from biological data
US6379550B1 (en) * 2000-07-24 2002-04-30 Health Research, Inc. Method for detecting PSA and its molecular forms using thiophilic gel
EP1178317B1 (de) 2000-07-24 2004-11-10 Health Research, Inc. Verfahren zur Detektion von Prostata-spezifischem Membran-Antigen in Serum
US6610499B1 (en) * 2000-08-31 2003-08-26 The Regents Of The University Of California Capillary array and related methods
US20050158702A1 (en) * 2000-09-05 2005-07-21 Stuelpnagel John R. Cellular arrays comprising encoded cells
EP1331996A2 (de) * 2000-09-18 2003-08-06 Harvard College Verfahren und vorrichtung zur gradientenerzeugung
CA2320549A1 (en) * 2000-09-25 2002-03-25 Eastern Virginia Medical College Biomarkers of transitional cell carcinoma of the bladder
CA2425434A1 (en) * 2000-10-11 2002-04-18 Tina Morris Methods for characterizing molecular interactions using affinity capture tandem mass spectrometry
DE10054055A1 (de) 2000-10-31 2002-05-23 Nmi Univ Tuebingen Verfahren zur Analyse von Proteinen
JP3375941B2 (ja) 2000-11-24 2003-02-10 科学技術振興事業団 高効率抗体スクリーニング法
US6585646B2 (en) * 2000-11-29 2003-07-01 Hermetic Diagnostics, Inc. Screening test and procedure using skin patches
EP1343914A2 (de) * 2000-12-11 2003-09-17 HK Pharmaceuticals, Inc. Multiplex-proteinexpression und aktivitätsbestimmung
IL156446A0 (en) * 2000-12-14 2004-01-04 Paul Stroobant Differential phage capture proteomics
US20020115056A1 (en) * 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
US20020119490A1 (en) * 2000-12-26 2002-08-29 Aebersold Ruedi H. Methods for rapid and quantitative proteome analysis
US7691645B2 (en) * 2001-01-09 2010-04-06 Agilent Technologies, Inc. Immunosubtraction method
US20030129666A1 (en) * 2001-01-09 2003-07-10 Mitsubishi Pharma Corporation Novel proteome analysis method and devices therefor
WO2004031759A1 (ja) * 2002-10-04 2004-04-15 Protosera Inc. 質量分析用プレート、その調製方法およびその用途
US6969757B2 (en) * 2001-01-26 2005-11-29 Syngenta Participations Ag Differential labeling for quantitative analysis of complex protein mixtures
US7166436B2 (en) 2001-01-26 2007-01-23 Syngenta Participations, Ag Differential labeling for quantitative analysis of complex protein mixtures
US20020169562A1 (en) * 2001-01-29 2002-11-14 Gregory Stephanopoulos Defining biological states and related genes, proteins and patterns
US7332286B2 (en) * 2001-02-02 2008-02-19 University Of Pennsylvania Peptide or protein microassay method and apparatus
JP3640387B2 (ja) * 2001-02-27 2005-04-20 独立行政法人理化学研究所 レーザーアブレーションを用いた高分子の分析方法およびそのシステム
WO2002073180A1 (en) * 2001-03-08 2002-09-19 Ruo-Pan Huang An antibody-based protein array system
US20030228639A1 (en) * 2001-03-19 2003-12-11 Wright George L Prostate cancer markers
WO2002074979A2 (en) * 2001-03-20 2002-09-26 Ortho-Clinical Diagnostics, Inc. Expression profiles and methods of use
EP1565747B1 (de) * 2001-03-29 2013-11-27 Cellect Technologies Corp. Verfahren and System zum Sortieren und Trennen von Teilchen
US20030219734A1 (en) * 2001-04-13 2003-11-27 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
US7524635B2 (en) * 2003-04-17 2009-04-28 Biosite Incorporated Methods and compositions for measuring natriuretic peptides and uses thereof
WO2002084252A2 (en) * 2001-04-17 2002-10-24 Xenoport, Inc. Epitope-captured antibody display
US20020155587A1 (en) 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
US20020160421A1 (en) * 2001-04-30 2002-10-31 George Jackowski Method for monitoring and validating stress induction of disease state
US20050182242A1 (en) * 2001-05-11 2005-08-18 Michael Snyder Global analysis of protein activities using proteome chips
JP4194370B2 (ja) 2001-05-25 2008-12-10 ウォーターズ・インヴェストメンツ・リミテッド Maldi質量分析用脱塩プレート
US20050130222A1 (en) * 2001-05-25 2005-06-16 Lee Peter J.J. Sample concentration maldi plates for maldi mass spectrometry
US7723123B1 (en) * 2001-06-05 2010-05-25 Caliper Life Sciences, Inc. Western blot by incorporating an affinity purification zone
US20020197729A1 (en) * 2001-06-21 2002-12-26 Fuji Photo Film Co., Ltd. Biochemical analysis unit and method for manufacturing the same
AU2002316372A1 (en) 2001-06-22 2003-01-08 Symyx Technologies, Inc. Inverse chromatography methods and apparatus for evaluation of interactions between modifying agents and receptors
JP4500540B2 (ja) * 2001-06-29 2010-07-14 ヴェリ‐キュー,インコーポレイテッド 化学的に合成された核酸の純度を決定し、かつ化学的に合成された核酸を精製するための方法および組成物
US7297553B2 (en) 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
US6800449B1 (en) * 2001-07-13 2004-10-05 Syngenta Participations Ag High throughput functional proteomics
WO2003006676A2 (en) 2001-07-13 2003-01-23 Nanosphere, Inc. Method for immobilizing molecules onto surfaces
US7517496B2 (en) * 2001-07-17 2009-04-14 Bio-Rad Laboratories, Inc. Latex based adsorbent chip
JP4264002B2 (ja) * 2001-07-17 2009-05-13 バイオ−ラド ラボラトリーズ インコーポレイテッド ラテックスベース吸着チップ
AU2002355732B2 (en) * 2001-08-01 2006-11-09 Merck Sharp & Dohme Corp. Benzimidazo[4,5-f]isoquinolinone derivatives
GB0120131D0 (en) * 2001-08-17 2001-10-10 Micromass Ltd Maldi target plate
WO2004072616A2 (en) * 2003-02-10 2004-08-26 Waters Investments Limited A sample preparation plate for mass spectrometry
WO2003019193A1 (en) * 2001-08-30 2003-03-06 Ciphergen Biosystems, Inc. Method of diagnosing nephrotic syndrome
ATE346952T1 (de) * 2001-09-03 2006-12-15 Kyowa Hakko Kogyo Kk Verfahren zur bestimmung eines zielproteins eines arzneistoffs
US20040171026A1 (en) * 2001-09-05 2004-09-02 Hochstrasser Denis Francois Diagnostic method for transmissible spongiform encephalopathies
GB2379737A (en) * 2001-09-05 2003-03-19 Univ Geneve Diagnostic method for spongiform encephalopathy disease
US20030068655A1 (en) * 2001-09-12 2003-04-10 Protiveris, Inc. Microcantilever apparatus and methods for detection of enzymes
US20040043436A1 (en) * 2001-09-21 2004-03-04 Antonia Vlahou Biomarkers of transitional cell carcinoma of the bladder
US6756586B2 (en) 2001-10-15 2004-06-29 Vanderbilt University Methods and apparatus for analyzing biological samples by mass spectrometry
US20050064446A1 (en) * 2001-11-01 2005-03-24 Minerva Biotechnologies Corporation Detection of binding species with colloidal and non-colloidal structures
US7842498B2 (en) 2001-11-08 2010-11-30 Bio-Rad Laboratories, Inc. Hydrophobic surface chip
WO2003062444A2 (en) * 2001-11-13 2003-07-31 Emory University Array systems and methods
US20030091976A1 (en) * 2001-11-14 2003-05-15 Ciphergen Biosystems, Inc. Methods for monitoring polypeptide production and purification using surface enhanced laser desorption/ionization mass spectrometry
US20030162190A1 (en) * 2001-11-15 2003-08-28 Gorenstein David G. Phosphoromonothioate and phosphorodithioate oligonucleotide aptamer chip for functional proteomics
DE60232013D1 (de) * 2001-11-20 2009-05-28 Exact Sciences Corp Automatische probenvorbereitungsverfahren und -vorrichtungen
US7132244B2 (en) * 2001-11-21 2006-11-07 Syn X Pharma, Inc. Betaine/GABA transport protein biopolymer marker indicative of insulin resistance
US7179605B2 (en) * 2001-11-23 2007-02-20 Nanogen Inc. Fibronectin precursor biopolymer markers indicative of alzheimer's disease
US6946653B2 (en) 2001-11-27 2005-09-20 Ciphergen Biosystems, Inc. Methods and apparatus for improved laser desorption ionization tandem mass spectrometry
SE0202398D0 (sv) * 2001-12-11 2002-08-13 Thomas Laurell Target plate and use thereof for improved analysis
WO2003049602A2 (en) * 2001-12-11 2003-06-19 University Of Medicine And Dentistry Of New Jersey Diagnostic methods for protein profiling
US20030150812A1 (en) * 2001-12-19 2003-08-14 Irving Wainer Novel parallel throughput system
US20030116501A1 (en) * 2001-12-21 2003-06-26 Council Of Scientific And Industrial Research Process for preparing immobilized nano-sized metal particles
WO2003065043A2 (en) * 2002-01-29 2003-08-07 King's College London An Institute Incorporated By Royal Charter Of Strand Identification and relative quantification of proteins
US7094579B2 (en) * 2002-02-13 2006-08-22 Xoma Technology Ltd. Eukaryotic signal sequences for prokaryotic expression
GB0203768D0 (en) * 2002-02-18 2002-04-03 Univ Geneve Diagnostic method for stroke
US20050153360A1 (en) * 2002-02-18 2005-07-14 Hochstrasser Denis F. Diagnostic method for stroke
EP1485461A4 (de) * 2002-02-21 2005-06-22 Eastern Virginia Med School Protein-biomarker, die prostatakrebs von nichtmalignen zellen unterscheiden
US7504364B2 (en) * 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
ATE421088T1 (de) * 2002-03-11 2009-01-15 Caprotec Bioanalytics Gmbh Verbindungen und verfahren für die analyse des proteoms
US20030228709A1 (en) * 2002-03-25 2003-12-11 Kozlowski Roland Zbignieiw Arrays
US6803566B2 (en) 2002-04-16 2004-10-12 Ut-Battelle, Llc Sampling probe for microarray read out using electrospray mass spectrometry
ES2271565T3 (es) * 2002-05-03 2007-04-16 Dsm Ip Assets B.V. Proceso para el monitoreo de la eliminacion de contaminantes durante el proceso de purificacion de un producto farmaceutico producido por una celula hospedera.
AU2003237185A1 (en) * 2002-05-07 2003-11-11 The Research Foundation Of State University Of New York A method to rapidly prepare and screen formulations and compositions containing same
US7460960B2 (en) * 2002-05-10 2008-12-02 Epitome Biosystems, Inc. Proteome epitope tags and methods of use thereof in protein modification analysis
US7618788B2 (en) * 2002-05-10 2009-11-17 Millipore Corporation Proteome epitope tags and methods of use thereof in protein modification analysis
US20040052412A1 (en) * 2002-05-10 2004-03-18 Large Scale Biology Corporation Satellite image enhancement and feature identification using information theory radial-basis bio-marker filter
US7138230B2 (en) 2002-12-06 2006-11-21 Renovar, Inc. Systems and methods for characterizing kidney diseases
WO2003097867A1 (en) * 2002-05-17 2003-11-27 Ciphergen Biosystems, Inc. Detection of kinase substrates and products using ion mass spectrometry
US20040033613A1 (en) * 2002-05-30 2004-02-19 Zwick Michael G. Saliva-based protein profiling
CA2487895A1 (en) * 2002-05-31 2003-12-11 Ciphergen Biosystems, Inc. Defensins: use as antiviral agents
DK1511843T3 (da) * 2002-06-07 2006-07-24 Sophion Bioscience As Screeningsmetoder
WO2004001377A2 (en) * 2002-06-20 2003-12-31 Paul Stroobant Improved methods for performing differential capture proteomics
JP4380535B2 (ja) 2002-06-28 2009-12-09 キヤノン株式会社 プローブ担体および該プローブ担体の分析方法
US20040137491A1 (en) * 2002-06-28 2004-07-15 Tadashi Okamoto Method of analyzing probe carrier using time-of-flight secondary ion mass spectrometry
CN1672040A (zh) * 2002-06-28 2005-09-21 佳能株式会社 使用飞行时间型二次离子质量分析法的探针载体的分析方法
DE10329928A1 (de) * 2002-07-12 2004-02-05 Benq Corp., Kweishan Verfahren zur Aufbereitung von Biochips und Biochip
DE60326864D1 (de) * 2002-07-24 2009-05-07 Bio Rad Laboratories Proteininteraktionsdifferenzabbildung
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
FR2842826B1 (fr) * 2002-07-25 2006-01-20 Centre Nat Rech Scient Procede de fabrication de puces biologiques
TW200407543A (en) * 2002-07-29 2004-05-16 Correlogic Systems Inc Quality assurance/quality control for high throughput bioassay process
US7655474B2 (en) * 2002-07-29 2010-02-02 The United States Of America As Represented By The Secretary Of The Navy Trioxyethylene gold nanoclusters functionalized with a single DNA
AU2003257109A1 (en) * 2002-08-05 2004-02-23 Invitrogen Corporation Compositions and methods for molecular biology
US20040153249A1 (en) * 2002-08-06 2004-08-05 The Johns Hopkins University System, software and methods for biomarker identification
NZ562192A (en) * 2002-08-06 2009-07-31 Ciphergen Biosystems Inc Use of biomarkers for detecting ovarian cancer
GB2391867A (en) * 2002-08-13 2004-02-18 Smartbead Technologies Ltd Analysis system using coded supports
WO2004016586A2 (en) * 2002-08-16 2004-02-26 Board Of Regents The University Of Texas System Compositions and methods related to flavivirus envelope protein domain iii antigens
US20050233473A1 (en) * 2002-08-16 2005-10-20 Zyomyx, Inc. Methods and reagents for surface functionalization
US20060292701A1 (en) * 2002-09-13 2006-12-28 Ciphergen Biosystems Inc. Photocrosslinked hydrogel blend surface coatings
US7045366B2 (en) * 2003-09-12 2006-05-16 Ciphergen Biosystems, Inc. Photocrosslinked hydrogel blend surface coatings
US7144743B2 (en) 2002-09-13 2006-12-05 Pall Corporation Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays
US20050037381A1 (en) * 2002-09-16 2005-02-17 Receptors Llc Artificial receptors, building blocks, and methods
US20050037429A1 (en) * 2003-03-28 2005-02-17 Receptors Llc Artificial receptors including reversibly immobilized building blocks and methods
US20050136483A1 (en) * 2003-09-03 2005-06-23 Receptors Llc Nanodevices employing combinatorial artificial receptors
WO2005003326A2 (en) * 2003-03-28 2005-01-13 Receptors Llc. Artificial receptors including reversibly immobilized building blocks and methods
US20040137481A1 (en) * 2002-09-16 2004-07-15 Receptors Llc Artificial receptor building blocks, components, and kits
US20060051802A1 (en) * 2002-09-16 2006-03-09 Receptors Llc Artificial receptors, building blocks, and methods
US20050170385A1 (en) * 2002-09-16 2005-08-04 Receptors Llc Artificial receptors including gradients
ATE517340T1 (de) * 2002-10-15 2011-08-15 Abmetrix Inc Sätze gegen kurze epitope gerichteter digitaler antikörper sowie diese verwendende verfahren
CA2749227A1 (en) * 2002-10-16 2005-01-13 Board Of Regents Of The University Of Texas System Bead bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries
EP2211181A1 (de) 2002-10-30 2010-07-28 Proteome Sciences Plc Methoden um übertragbare Spongiforme Enzephalopathien zu diagnostizieren
US7122384B2 (en) * 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
US20030153013A1 (en) * 2002-11-07 2003-08-14 Ruo-Pan Huang Antibody-based protein array system
MXPA05005071A (es) 2002-11-12 2005-07-22 Becton Dickinson Co Diagnostico de la sepsis o sirs usando perfiles de biomarcadores.
EP1573054A4 (de) * 2002-11-12 2005-12-28 Becton Dickinson Co Sepsis- oder sirs-diagnose mittels biomarkerprofilen
BR0316232A (pt) 2002-11-12 2005-10-04 Becton Dickinson Co Métodos para determinar o estado de sepsia, para prognosticar o começo de sepsia e para diagnosticar a sìndrome de resposta inflamatória sistêmica em um indivìduo
WO2004043238A2 (en) * 2002-11-14 2004-05-27 Ciphergen Biosystems, Inc. Biomarkers for intra-amniotic inflammation
US7846748B2 (en) * 2002-12-02 2010-12-07 The University Of North Carolina At Chapel Hill Methods of quantitation and identification of peptides and proteins
DE10258674A1 (de) * 2002-12-13 2004-06-24 Sunyx Surface Nanotechnologies Gmbh Verfahren zur Herstellung eines Probenträgers für die MALDI-Massenspektrometrie
AU2003294377A1 (en) 2002-12-18 2004-07-29 Ciphergen Biosystems, Inc. Serum biomarkers in lung cancer
US7422865B2 (en) * 2003-01-13 2008-09-09 Agilent Technologies, Inc. Method of identifying peptides in a proteomic sample
DE602004030212D1 (de) 2003-01-16 2011-01-05 Caprotec Bioanalytics Gmbh Verfahren zur identifizierung von auf arzneimittel nicht-zielgerichteten proteinen
US6909981B2 (en) * 2003-01-27 2005-06-21 Ciphergen Biosystems, Inc. Data management system and method for processing signals from sample spots
US7046357B2 (en) * 2003-01-30 2006-05-16 Ciphergen Biosystems, Inc. Apparatus for microfluidic processing and reading of biochip arrays
WO2004073492A2 (en) * 2003-02-14 2004-09-02 Massachusetts Eye And Ear Infirmary Chlamydia pneumoniae associated chronic intraocular disorders and treatment thereof
DE10311384A1 (de) * 2003-03-11 2004-09-30 Universität Potsdam Nachweisverfahren für pflanzliche Moleküle
GB0305656D0 (en) * 2003-03-12 2003-04-16 Bioinvent Int Ab Screening assay
US7919332B2 (en) * 2003-03-14 2011-04-05 Kitakyushu Foundation For The Advancement Of Industry Science And Technology Biological molecule-immobilized chip and its use
KR101322019B1 (ko) * 2003-03-25 2013-10-29 인스트랙션 게엠베하 적어도 2가 결합으로서 기재를 흡착제에 선택적으로 결합시키는 방법
CA2521034A1 (en) * 2003-04-02 2004-10-21 Merck & Co., Inc. Mass spectrometry data analysis techniques
US6977370B1 (en) 2003-04-07 2005-12-20 Ciphergen Biosystems, Inc. Off-resonance mid-IR laser desorption ionization
WO2004094460A2 (en) 2003-04-17 2004-11-04 Ciphergen Biosystems, Inc. Polypeptides related to natriuretic peptides and methods of their identification and use
EP1616180A4 (de) * 2003-04-22 2006-07-19 Ciphergen Biosystems Inc Analyseverfahren für wirtszellproteine
WO2004097368A2 (en) * 2003-04-28 2004-11-11 Ciphergen Biosystems, Inc. Improved immunoassays
US20040219589A1 (en) * 2003-04-29 2004-11-04 Taehoon Lee Ligand profiling and identification
WO2005039381A2 (en) * 2003-05-05 2005-05-06 Drug Risk Solutions, L.L.C. Compositions and processes for analysis of pharmacologic agents in biological samples
US7425700B2 (en) 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
US20040236603A1 (en) * 2003-05-22 2004-11-25 Biospect, Inc. System of analyzing complex mixtures of biological and other fluids to identify biological state information
CA2526690C (en) 2003-05-23 2014-01-14 Board Of Regents The University Of Texas System Structure based and combinatorially selected oligonucleoside phosphorothioate and phosphorodithioate aptamer targeting ap-1 transcription factors
EP1635693A2 (de) * 2003-05-23 2006-03-22 Board Of Regents, The University Of Texas System Screening mit hohem durchsatz von aptamer-bibliotheken für die spezifische bindung an proteine auf viren und anderen erregern
US20040241742A1 (en) * 2003-05-30 2004-12-02 Peck Bill J. Ligand array processing methods that include a low surface tension fluid deposition step and compositions for practicing the same
US20040241668A1 (en) * 2003-05-30 2004-12-02 Amorese Douglas A. Ligand array assays that include a low surface tension fluid wash step and compositions for practicing the same
US20040241880A1 (en) * 2003-05-30 2004-12-02 Leproust Eric M. Ligand array assays having reduced fluorescent dye degradation and compositions for practicing the same
US20040248323A1 (en) 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
US20050100967A1 (en) * 2003-07-11 2005-05-12 Science & Technology Corporation @ Unm Detection of endometrial pathology
US20050032113A1 (en) * 2003-07-17 2005-02-10 Mitsubishi Pharma Corporation Membrane protein library for proteome analysis and method for preparing same
EP1648909A4 (de) * 2003-07-24 2008-11-12 Univ Texas Thioaptamere, die die entdeckung von physiologischen pfaden und neue therapeutische strategien ermöglichen
US20050026304A1 (en) * 2003-07-30 2005-02-03 Laurakay Bruhn Microarray based affinity purification and analysis device coupled with secondary analysis technologies
EP1649281A4 (de) * 2003-08-01 2007-11-07 Correlogic Systems Inc Mehrere hochauflösende proteomische serummerkmale zum nachweis von eierstockkrebs
US20050037424A1 (en) * 2003-08-13 2005-02-17 Schembri Carol T. Selectable length linear microarrays
JP2007502837A (ja) * 2003-08-18 2007-02-15 テシス バイオサイエンス, インコーポレイテッド 小型エピトープ抗体を使用するサンプルの複雑さを低減するための方法
WO2005019875A2 (en) * 2003-08-22 2005-03-03 Stratos Biosystems, Llc Electrowetting sample presentation device
US20080070791A1 (en) * 2003-09-09 2008-03-20 Zephyr Proteomix Ltd. Libraries Of Chimeric Cellulose Binding Proteins And Methods Of Use Thereof
JP2007524844A (ja) * 2003-09-22 2007-08-30 ベクトン・ディキンソン・アンド・カンパニー デンドリマー内部標準を使用する質量分析による生体分子検体の定量化
WO2005047851A2 (en) * 2003-10-15 2005-05-26 The Trustees Of Columbia University In The City Of New York Device for measuring nanometer level pattern-dependent binding reactions
US20050084866A1 (en) * 2003-10-15 2005-04-21 Caren Michael P. Methods and apparatus for sample mixing
US20050084867A1 (en) * 2003-10-15 2005-04-21 Caren Michael P. Hybridization and scanning apparatus
US8137548B2 (en) * 2003-10-17 2012-03-20 Zirchrom Separations, Inc. Chelator-modified inorganic oxide particles
US20050112650A1 (en) * 2003-10-20 2005-05-26 Ciphergen Biosystems, Inc. Reactive polyurethane-based polymers
US7858071B2 (en) 2003-10-23 2010-12-28 University of Pittsburgh—of the Commonwealth System of Higher Education Biomarkers for amyotrophic lateral sclerosis
WO2005040163A1 (en) * 2003-10-28 2005-05-06 Dr. Reddy's Laboratories Ltd Heterocyclic compounds that block the effects of advanced glycation end products (age)
WO2005047904A2 (en) * 2003-11-06 2005-05-26 Sru Biosystems, Inc. High-density amine-functionalized surface
EP2369348A1 (de) 2003-11-07 2011-09-28 Ciphergen Biosystems, Inc. Biomarker für Morbus Alzheimer
US20050112588A1 (en) * 2003-11-25 2005-05-26 Caren Michael P. Methods and apparatus for analyzing arrays
US20050158745A1 (en) * 2003-11-25 2005-07-21 Ye Jack Z. Methods and compositions for detection of nasopharyngeal carcinoma
WO2005055812A2 (en) 2003-12-05 2005-06-23 Ciphergen Biosystems, Inc. Serum biomarkers for chagas disease
JP2007514173A (ja) * 2003-12-15 2007-05-31 ユニバーシティ オブ ペンシルベニア Maldi質量分析に向けたターゲットプレート上で反応を行うための方法および装置
WO2005061532A1 (es) * 2003-12-23 2005-07-07 Berthet Francois Xavier Composiciones y procedimientos para detectar infección patógena
DE102004062281A1 (de) * 2003-12-29 2005-07-28 Siemens Ag Verfahren und Spotting-Lösung zum Herstellen von Microarrays
US7183544B2 (en) * 2003-12-31 2007-02-27 Ciphergen Biosystems Inc. Bi-functional polymer chip
US20050181398A1 (en) * 2004-01-16 2005-08-18 Fung Eric T. Specific detection of host response protein clusters
JP4801598B2 (ja) * 2004-01-20 2011-10-26 ポール・コーポレーション 生理的イオン強度でタンパク質を吸着させるためのクロマトグラフィー材料
US20050178959A1 (en) * 2004-02-18 2005-08-18 Viorica Lopez-Avila Methods and compositions for assessing a sample by maldi mass spectrometry
US20050181513A1 (en) * 2004-02-18 2005-08-18 Viorica Lopez-Avila Methods and compositions for assessing a sample by MAILDI mass spectrometry
US7138642B2 (en) * 2004-02-23 2006-11-21 Gemio Technologies, Inc. Ion source with controlled superposition of electrostatic and gas flow fields
US8003934B2 (en) * 2004-02-23 2011-08-23 Andreas Hieke Methods and apparatus for ion sources, ion control and ion measurement for macromolecules
US20050202485A1 (en) * 2004-03-03 2005-09-15 Ye Jack Z. Method and compositions for detection of liver cancer
US20050233400A1 (en) * 2004-03-03 2005-10-20 Weiner Carl P Proteomic method for predicting success of rescue cerclage
EP1580559B1 (de) * 2004-03-23 2013-12-25 Bio-Rad Laboratories, Inc. Methoden zur Verringerung der Varianz der Analytkonzentrationen von komplexen Probenmischungen
US20060275923A1 (en) * 2004-03-23 2006-12-07 Hammond David J Methods for reducing the range in concentrations of analyte species in a sample
US20090206245A1 (en) * 2004-03-31 2009-08-20 Shionogi Co., Ltd Mass analysis method using fine metal particles
GB0408351D0 (en) * 2004-04-15 2004-05-19 Plasso Technology Ltd Reversible binding surface
AU2005238446B2 (en) 2004-04-15 2009-07-30 Banyan Biomarkers Inc. Neural proteins as biomarkers for nervous system injury and other neural disorders
US20050239134A1 (en) * 2004-04-21 2005-10-27 Board Of Regents, The University Of Texas System Combinatorial selection of phosphorothioate single-stranded DNA aptamers for TGF-beta-1 protein
WO2005103281A2 (en) 2004-04-26 2005-11-03 Children's Medical Center Corporation Platelet biomarkers for the detection of disease
US20050244973A1 (en) * 2004-04-29 2005-11-03 Predicant Biosciences, Inc. Biological patterns for diagnosis and treatment of cancer
US7749716B2 (en) * 2004-05-18 2010-07-06 Vermilllion, Inc. Methods of detecting a fragment of neurosecretory protein VGF for diagnosing alzheimer's disease
US20060003204A1 (en) * 2004-07-01 2006-01-05 Callahan Christopher W Controlling fuel cell fuel purge in response to recycle fuel blower operating conditions
EP2261672B1 (de) 2004-07-14 2014-09-03 The Regents of The University of California Biomarker für den frühzeitigen Nachweis von Ovarialkarzinom
US20060024722A1 (en) 2004-07-30 2006-02-02 Mark Fischer-Colbrie Samples for detection of oncofetal fibronectin and uses thereof
WO2006029234A1 (en) * 2004-09-03 2006-03-16 Receptors Llc Combinatorial artificial receptors including tether building blocks
WO2006029383A2 (en) * 2004-09-11 2006-03-16 Receptors Llc Combinatorial artificial receptors including peptide building blocks
US20060068434A1 (en) * 2004-09-21 2006-03-30 Jay Stoerker Methods and compositions for detecting cancer using components of the U2 spliceosomal particle
WO2006047417A2 (en) 2004-10-21 2006-05-04 University Of Florida Research Foundation, Inc. Detection of cannabinoid receptor biomarkers and uses thereof
WO2006071469A2 (en) 2004-12-02 2006-07-06 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Modulation of the neuroendocrine system as a therapy for amyotrophic lateral sclerosis
US7332296B2 (en) * 2004-12-02 2008-02-19 Wright State University Screening assay for enzymes involved in pathophysiology using SELDI-TOF mass spectrometry
CA2590188A1 (en) 2004-12-08 2006-06-15 Lyotropic Therapeutics, Inc. Compositions for binding to assay substrata and methods of using
US20060128031A1 (en) * 2004-12-15 2006-06-15 Robotti Karla M Addressable recovery of bound analytes from an evanescent wave sensor
WO2006074360A2 (en) 2005-01-06 2006-07-13 Eastern Virginia Medical School Apolipoprotein a-ii isoform as a biomarker for prostate cancer
US20060157647A1 (en) * 2005-01-18 2006-07-20 Becton, Dickinson And Company Multidimensional liquid chromatography/spectrometry
US7841247B2 (en) * 2005-01-25 2010-11-30 Oscillogy Llc Temperature controller for small fluid samples with different heat capacities
AU2006207954A1 (en) 2005-01-28 2006-08-03 Childrens Medical Center Corporation Methods for diagnosis and prognosis of epithelial cancers
US7358485B2 (en) * 2005-02-08 2008-04-15 Perkinelmer Las, Inc. Zirconia toughened alumina composition and use in ion and electron optical systems
WO2007053170A2 (en) * 2005-02-09 2007-05-10 Correlogic Systems, Inc. Identification of bacteria and spores
US20060183863A1 (en) * 2005-02-14 2006-08-17 Ciphergen Biosystems, Inc. Zwitterionic polymers
US20060234265A1 (en) * 2005-03-21 2006-10-19 Jim Richey Microarrays having multi-functional, compartmentalized analysis areas and methods of use
EP1869230B1 (de) * 2005-03-23 2017-08-30 Bio-Rad Laboratories, Inc. Verfahren zur reinigung von proteinen
EP1871726A2 (de) 2005-03-23 2008-01-02 Bio-Rad Laboratories, Inc. Diverse zu kleinen teilchen mit paramagnetischen eigenschaften gebundene chemische archive
US20090247421A1 (en) * 2005-03-23 2009-10-01 Egisto Boschetti Diverse chemical libraries bound to small particles with paramagnetic properties
US7645584B2 (en) * 2005-04-01 2010-01-12 University Of Florida Research Foundation, Inc. Biomarkers of liver injury
US8048638B2 (en) * 2005-04-01 2011-11-01 University Of Florida Research Foundation, Inc. Biomarkers of liver injury
KR20080006617A (ko) 2005-04-15 2008-01-16 백톤 디킨슨 앤드 컴퍼니 패혈증의 진단
US20070087387A1 (en) * 2005-04-21 2007-04-19 Prasad Devarajan Method for the Early Detection of Renal Disease Using Proteomics
JP4577083B2 (ja) * 2005-04-28 2010-11-10 味の素株式会社 クローン病の診断方法
US7622273B2 (en) * 2005-05-11 2009-11-24 Gibbs Bernard F Method for chemical and enzymatic treatment of posttranslationally modified proteins bound to a protein chip
US20070003954A1 (en) * 2005-05-12 2007-01-04 The Board Of Regents Of The University Of Texas System Protein and antibody profiling using small molecule microarrays
WO2006124628A2 (en) * 2005-05-12 2006-11-23 Correlogic Systems, Inc. A model for classifying a biological sample in relation to breast cancer based on mass spectral data
WO2006125094A2 (en) * 2005-05-18 2006-11-23 Board Of Regents, The University Of Texas System Combinatorial selection of phosphorothioate aptamers for rnases
ATE511643T1 (de) * 2005-06-16 2011-06-15 Vermillion Inc Fragment des neurosekretorischen proteins vgf als biomarker für morbus alzheimer
GB0512401D0 (en) * 2005-06-17 2005-07-27 Randox Lab Ltd Method
AU2005333725A1 (en) 2005-06-17 2007-01-04 North Carolina A & T State University A device including a proteinaceous factor, a recombinant proteinaceous factor, and a nucleotide sequence encoding the proteinaceous factor
WO2007002069A2 (en) * 2005-06-21 2007-01-04 Anthony Goncalves Serum biomarkers for breast cancer
AU2006261904B2 (en) 2005-06-24 2012-05-31 Aspira Women’s Health Inc. Biomarkers for ovarian cancer: beta-2 microglobulin
US7514267B1 (en) * 2005-08-19 2009-04-07 Stcunm Detection systems utilizing supported lipid bilayers
US20070048786A1 (en) * 2005-09-01 2007-03-01 Arnon Chait Systems and methods for fractionation of protein mixtures
WO2007033253A1 (en) * 2005-09-14 2007-03-22 Symyx Technologies, Inc. High throughput chemical speciation
US7972802B2 (en) * 2005-10-31 2011-07-05 University Of Washington Lipoprotein-associated markers for cardiovascular disease
WO2007059430A2 (en) 2005-11-10 2007-05-24 Bristol-Myers Squibb Pharma Company Moesin, caveolin 1 and yes associated protein 1 as predictive markers of response to dasatinib in breast cancers
WO2007061981A2 (en) * 2005-11-21 2007-05-31 Lumera Corporation Surface plasmon resonance spectrometer with an actuator-driven angle scanning mechanism
US7463358B2 (en) 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
US20090215086A1 (en) * 2005-12-12 2009-08-27 Momar Ndao Biomarkers for Babesia
JP2009524829A (ja) * 2006-01-27 2009-07-02 イースタン バージニア メディカル スクール ヒトivf由来胚のプロテオームフィンガープリンティング:発生能のバイオマーカーの同定法
AU2007217861A1 (en) 2006-02-17 2007-08-30 Children's Medical Center Corporation Free NGAL as a biomarker for cancer
DE102006009083B4 (de) * 2006-02-28 2018-05-30 Bruker Daltonik Gmbh Massenspektrometrische Bestimmung der Aktivität von Blutenzymen
WO2007120999A2 (en) * 2006-03-06 2007-10-25 Bio-Rad Laboratories, Inc. Chelating monomers and polymers
EP1996942A1 (de) * 2006-03-10 2008-12-03 Tethys Bioscience, Inc. Multiplex-protein-fraktionierung
EP1996949A4 (de) 2006-03-11 2010-01-20 Univ Leland Stanford Junior Beta-2 mikroglobulin als biomarker für periphere arterienerkrankung
US7855057B2 (en) * 2006-03-23 2010-12-21 Millipore Corporation Protein splice variant/isoform discrimination and quantitative measurements thereof
EP2013800A2 (de) * 2006-03-29 2009-01-14 Cangen Biotechnologies, Inc. Filtriervorrichtung und -verfahren zur besseren erkennung von spitzen
KR100754399B1 (ko) * 2006-04-05 2007-08-31 삼성전자주식회사 단일 챔버를 이용한 세포 파괴 및 핵산의 정제 방법 및장치
CA2649859A1 (en) 2006-04-21 2008-05-08 Wyeth Differential expression profiling analysis of cell culture phenotypes and the uses thereof
US8084734B2 (en) * 2006-05-26 2011-12-27 The George Washington University Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays
WO2007139989A2 (en) 2006-05-26 2007-12-06 Brandeis University Tissue sample preparation, and maldi ms imaging thereof
US20080193772A1 (en) * 2006-07-07 2008-08-14 Bio-Rad Laboratories, Inc Mass spectrometry probes having hydrophobic coatiings
CA2657576C (en) 2006-07-14 2023-10-31 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
US7879799B2 (en) * 2006-08-10 2011-02-01 Institute For Systems Biology Methods for characterizing glycoproteins and generating antibodies for same
WO2008030122A1 (en) 2006-09-07 2008-03-13 University Of Otago Biomarkers
CN101646943A (zh) * 2006-10-31 2010-02-10 Sru生物系统公司 阻断官能化表面上的非特异性蛋白结合的方法
AU2007341981A1 (en) * 2006-12-29 2008-07-10 The Salk Institute For Biological Studies Methods for enhancing exercise performance
GB0700475D0 (en) * 2007-01-10 2007-02-21 Cole Polytechnique Federale De Ionization device
CN101715443A (zh) 2007-03-14 2010-05-26 诺普神经科学股份有限公司 手性纯化的取代的苯并噻唑二胺的合成
US8221984B2 (en) 2007-03-27 2012-07-17 Vermillion, Inc. Biomarkers for ovarian cancer
US20100113746A1 (en) * 2007-04-23 2010-05-06 Arvind Mallinath Lali Process for purification of immunoglobulins using a pseudobioaffinity adsorbent
US20110091377A1 (en) 2007-05-11 2011-04-21 The Johns Hopkins University Biomarkers for melanoma
EP2160478B1 (de) * 2007-06-06 2014-08-27 Siemens Healthcare Diagnostics Inc. Prognostische diagnose von nierenerkrankungen
WO2008157299A2 (en) * 2007-06-15 2008-12-24 Wyeth Differential expression profiling analysis of cell culture phenotypes and uses thereof
EP3127549B1 (de) 2007-06-22 2019-12-18 Children's Medical Center Corporation Verfahren und verwendung von einem fragment von saposin a
CN101855553B (zh) 2007-06-29 2014-06-11 韩国安国药品株式会社 卵巢癌的预测标记
WO2009021190A2 (en) * 2007-08-08 2009-02-12 Renovar, Inc. Systems and methods for characterizing lupus erythematosus
JP2009047956A (ja) * 2007-08-21 2009-03-05 Sony Corp 撮像装置
US20090060786A1 (en) * 2007-08-29 2009-03-05 Gibum Kim Microfluidic apparatus for wide area microarrays
WO2009058331A2 (en) 2007-10-29 2009-05-07 Vermilllion, Inc. Biomarkers for the detection of early stage ovarian cancer
CA2707182C (en) 2007-11-30 2017-12-12 Siemens Healthcare Diagnostics Inc. Adiponectin receptor fragments and methods of use
US8004669B1 (en) 2007-12-18 2011-08-23 Plexera Llc SPR apparatus with a high performance fluid delivery system
WO2009086215A2 (en) * 2007-12-21 2009-07-09 Wyeth Pathway analysis of cell culture phenotypes and uses thereof
US8569006B2 (en) 2008-02-29 2013-10-29 Imec Cell-enzyme based biosensors
JP5574990B2 (ja) 2008-03-10 2014-08-20 リニーゲン、インコーポレイテッド Copdバイオマーカーシグネチャー
JP2011516038A (ja) 2008-03-12 2011-05-26 オタゴ イノベーション リミテッド バイオマーカー
ES2666725T3 (es) * 2008-03-12 2018-05-07 Otago Innovation Limited Biomarcadores
WO2009118343A1 (en) * 2008-03-27 2009-10-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for determining the occurrence of a liver disease in a subject
US8669113B2 (en) 2008-04-03 2014-03-11 Becton, Dickinson And Company Advanced detection of sepsis
JP5646457B2 (ja) 2008-04-29 2014-12-24 アッヴィ・インコーポレイテッド 二重可変ドメイン免疫グロブリン及びその使用
US8673644B2 (en) 2008-05-13 2014-03-18 Battelle Memorial Institute Serum markers for type II diabetes mellitus
US7999221B2 (en) * 2008-06-02 2011-08-16 Bio-Rad Laboratories, Inc. Mass spectrometric detection of material transferred to a surface
EP3002299A1 (de) 2008-06-03 2016-04-06 AbbVie Inc. Dual-variable- domain-immunglobuline und ihre verwendungen
US20110210074A1 (en) * 2008-06-26 2011-09-01 Winchester James F Removal of myoglobin from blood and/or physiological fluids
US8241861B1 (en) 2008-07-08 2012-08-14 Insilicos, Llc Methods and compositions for diagnosis or prognosis of cardiovascular disease
US12601749B2 (en) 2008-08-11 2026-04-14 Banyan Biomarkers, Inc. Biomarker detection process and assay of neurological condition
AU2009282117B2 (en) 2008-08-11 2016-05-12 Banyan Biomarkers, Inc. Biomarker detection process and assay of neurological condition
US20110138935A1 (en) * 2008-08-12 2011-06-16 Wako Pure Chemical Industries, Ltd. Polymer for filler for preprocessing column
US20110190356A1 (en) 2008-08-19 2011-08-04 Knopp Neurosciences Inc. Compositions and Methods of Using (R)- Pramipexole
EP2687609B1 (de) 2008-11-10 2017-01-04 The United States of America, as represented by The Secretary, Department of Health and Human Services Behandlung von soliden Tumoren
CN102203610A (zh) * 2008-12-01 2011-09-28 利兰·斯坦福青年大学托管委员会 用于检测补体结合性抗体的方法和组合物
US8349325B2 (en) 2008-12-23 2013-01-08 Abbott Laboratories Soluble FMS-like tyrosine kinase-1 (sFLT-1) antibody and related composition, kit, methods of using, and materials and method for making
CA3013992A1 (en) 2008-12-30 2010-07-08 Children's Medical Center Corporation Method of predicting acute appendicitis
AU2009333489A1 (en) 2008-12-30 2010-07-08 Centocor Ortho Biotech Inc. Serum markers predicting clinical response to anti-TNF antibodies in patients with ankylosing spondylitis
DE102009004371A1 (de) * 2009-01-08 2010-07-15 Papst Licensing Gmbh & Co. Kg Vorrichtung und Verfahren zum Messen der Aktivität von Enzymen nach Inhibitorentzug
WO2010079253A2 (es) 2009-01-09 2010-07-15 Proyecto De Biomedicina Cima, S.L. Biomarcadores para el diagnóstico de fibrosis
US8110796B2 (en) 2009-01-17 2012-02-07 The George Washington University Nanophotonic production, modulation and switching of ions by silicon microcolumn arrays
WO2010087985A2 (en) 2009-01-28 2010-08-05 Yale University Novel markers for detection of complications resulting from in utero encounters
WO2010089138A1 (en) 2009-02-09 2010-08-12 Caprotec Bioanalytics Gmbh Devices, systems and methods for separating magnetic particles
WO2010093872A2 (en) 2009-02-13 2010-08-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Molecular-based method of cancer diagnosis and prognosis
US20100227776A1 (en) * 2009-03-05 2010-09-09 The Ohio State University Rapid Genotyping of SNPs
TW201613969A (en) * 2009-03-05 2016-04-16 Abbvie Inc IL-17 binding proteins
US9490113B2 (en) * 2009-04-07 2016-11-08 The George Washington University Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry
EP2422354B1 (de) * 2009-04-21 2020-12-16 Excellims Corporation Verfahren und vorrichtung für intelligent gesteuertes spektrometer
EP2422199B1 (de) 2009-04-23 2018-07-25 Siemens Healthcare Diagnostics Inc. Monomere und dimere formen von adiponectin-rezeptorfragmenten sowie verwendungsverfahren dafür
SG10201706002XA (en) 2009-05-20 2017-08-30 Xyleco Inc Bioprocessing
EP2435827A1 (de) * 2009-05-29 2012-04-04 The Board of Regents of The University of Texas System Peptoidliganden zur isolierung und behandlung von t-autoimmunzellen
CA2764153C (en) * 2009-06-02 2021-07-27 The Board Of Regents Of The University Of Texas System Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases
KR101099089B1 (ko) 2009-06-12 2011-12-27 한국항공대학교산학협력단 다층 버스 바를 이용한 미세입자 분류기 및 그 제조방법
ES2581178T3 (es) 2009-07-29 2016-09-01 Pharnext Nuevas herramientas de diagnóstico para enfermedad de Alzheimer
DE102009040186A1 (de) * 2009-09-07 2011-03-24 Dionex Benelux B.V. Chromatografieverfahren
TW201124726A (en) 2009-10-16 2011-07-16 Univ Texas Compositions and methods for producing coded peptoid libraries
US8415619B2 (en) 2009-11-13 2013-04-09 University of Glascgow Methods and systems for mass spectrometry
US8304248B2 (en) 2009-11-16 2012-11-06 Torres Anthony R Protein separation via ion-exchange chromatography and associated methods, systems, and devices
EP2513137B1 (de) 2009-12-17 2018-02-28 Children's Medical Center Corporation Aus saposin-a gewonnene peptide und verwendungen davon
CA2784919A1 (en) 2010-01-26 2011-07-26 Banyan Biomarkers, Inc. Compositions and methods relating to argininosuccinate synthetase
US20110229921A1 (en) 2010-03-18 2011-09-22 Abbott Laboratories METHODS OF ASSAYING URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (uNGAL) IN THE PROGNOSIS OF CADAVERIC KIDNEY TRANSPLANT FUNCTION IN A PATIENT, INCLUDING A PATIENT DIAGNOSED WITH DELAYED GRAFT FUNCTION (DGF), A METHOD OF ASSAYING uNGAL IN THE ASSESSMENT OF RISK OF DGF IN A PATIENT DIAGNOSED WITH EARLY GRAFT FUNCTION (EGF), AND RELATED KITS
WO2013040142A2 (en) 2011-09-16 2013-03-21 Iogenetics, Llc Bioinformatic processes for determination of peptide binding
WO2011119484A1 (en) 2010-03-23 2011-09-29 Iogenetics, Llc Bioinformatic processes for determination of peptide binding
WO2011139721A1 (en) 2010-04-27 2011-11-10 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
AU2011252883B2 (en) 2010-05-14 2015-09-10 Abbvie Inc. IL-1 binding proteins
WO2011149943A1 (en) 2010-05-24 2011-12-01 Ventana Midical Systems, Inc. Method for differentiation of non-small cellung carcinoma
US9551714B2 (en) 2010-06-25 2017-01-24 Abbott Laboratories Materials and methods for assay of anti-hepatitis C virus (HCV) antibodies
WO2012006500A2 (en) 2010-07-08 2012-01-12 Abbott Laboratories Monoclonal antibodies against hepatitis c virus core protein
UY33492A (es) 2010-07-09 2012-01-31 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
NZ707637A (en) 2010-07-19 2016-09-30 Otago Innovation Ltd Signal biomarkers
US8735546B2 (en) 2010-08-03 2014-05-27 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
CN103517990A (zh) 2010-10-07 2014-01-15 通用医疗公司 癌症生物标志物
EP2628013B1 (de) 2010-10-14 2019-06-12 The Johns Hopkins University Biomarker für gehirnverletzungen
US20120115244A1 (en) 2010-11-09 2012-05-10 Abbott Laboratories Materials and methods for immunoassay of pterins
DE102010054767B4 (de) * 2010-12-16 2013-02-21 Previpharma Ag Verfahren zur Trennung, Aufkonzentration und/oder Reinigung von (Blut)Plasmaprotein, Viren oder Virenbestandteilen
WO2012121775A2 (en) 2010-12-21 2012-09-13 Abbott Laboratories Dual variable domain immunoglobulins and uses thereof
CA2766675A1 (en) * 2011-02-07 2012-08-07 Laboratory Corporation Of America Holdings Methods and systems for multiplex analysis of biomolecules by liquid chromatography-mass spectrometry
KR20140026410A (ko) 2011-03-15 2014-03-05 유니버시티 오브 유타 리서치 파운데이션 혈관 관련 황반병증 및 이의 증상을 진단 및 치료하는 방법
EP2699906B1 (de) 2011-04-20 2017-11-29 Access Medical Systems, Ltd. Cyclische amplifikation lumineszenter polymere
JP2014518624A (ja) 2011-05-12 2014-08-07 ザ・ジョンズ・ホプキンス・ユニバーシティー ニューログラニン診断キットのためのアッセイ試薬
US9024254B2 (en) 2011-06-03 2015-05-05 Purdue Research Foundation Enclosed desorption electrospray ionization probes and method of use thereof
CN103765212A (zh) 2011-06-27 2014-04-30 杰克逊实验室 治疗癌症和自体免疫性疾病的方法和组合物
US9966162B2 (en) * 2011-10-10 2018-05-08 Siemens Medical Solutions Usa, Inc. Metal halide scintillators with reduced hygroscopicity and method of making the same
US10378060B2 (en) 2011-10-14 2019-08-13 Dana-Farber Cancer Institute, Inc. ZNF365/ZFP365 biomarker predictive of anti-cancer response
BR112014009810A2 (pt) 2011-10-24 2017-04-25 Abbvie Inc imunoligantes biespecíficos dirigidos contra tnf e il-17
EP2771360A1 (de) 2011-10-24 2014-09-03 AbbVie Inc. Gegen sclerostin gerchtet immunbinder
KR102035877B1 (ko) 2011-11-14 2019-10-23 알파시그마 에스.피.에이. 우울증이 있는 대상체를 위한 치료 양생법 선택을 위한 검정법 및 치료 방법
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
CA2860226C (en) 2011-12-22 2022-10-18 Randolph S. Watnick Saposin-a derived peptides and uses thereof
US8993248B2 (en) 2011-12-31 2015-03-31 Abbott Laboratories Truncated human vitamin D binding protein and mutation and fusion thereof and related materials and methods of use
LT2800578T (lt) 2012-01-05 2019-02-11 Boston Medical Center Corporation Slit-robo signalo perdavimas, skirtas inkstų ligos diagnozavimui ir gydymui
NZ629074A (en) 2012-01-20 2016-09-30 Adelaide Res & Innovation Pty Biomarkers for gastric cancer and uses thereof
EP3418397B1 (de) 2012-01-24 2020-10-07 CD Diagnostics, Inc. System zum nachweis einer infektion in der synovialflüssigkeit
WO2013119763A1 (en) 2012-02-07 2013-08-15 Intuitive Biosciences, Inc. Mycobacterium tuberculosis specific peptides for detection of infection or immunization in non-human primates
WO2013141716A1 (en) 2012-03-20 2013-09-26 Christopher Joseph Pemberton Biomarkers
WO2013148373A1 (en) 2012-03-28 2013-10-03 Genentech, Inc. Anti-hcmv idiotypic antibodies and uses thereof
US9758829B2 (en) 2012-06-22 2017-09-12 Htg Molecular Diagnostics, Inc. Molecular malignancy in melanocytic lesions
TW201402608A (zh) 2012-07-12 2014-01-16 Abbvie Inc Il-1結合蛋白質
EP2875518A1 (de) 2012-07-18 2015-05-27 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Neues klassifizierungsverfahren für spektraldaten
CA2884737A1 (en) 2012-08-16 2014-02-20 The Trustees Of Columbia University In The City Of New York Diagnostic markers of indolent prostate cancer
AU2013202668B2 (en) 2012-12-24 2014-12-18 Adelaide Research & Innovation Pty Ltd Inhibition of cancer growth and metastasis
EP2943775A4 (de) * 2013-01-10 2016-11-16 Bio Rad Laboratories Chromatografiesystem mit led-basierter lichtquelle
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
EP2972337B1 (de) * 2013-03-13 2018-11-21 The Government of the United States of America, as represented by the Secretary of the Navy Nanoplasmonisches bildgebungsverfahren zur räumlich-zeitlichen abbildung von einzelzellsekretionen in echtzeit
JP6505076B2 (ja) 2013-03-14 2019-04-24 アボット・ラボラトリーズAbbott Laboratories Hcv抗原−抗体組み合わせアッセイおよびこれに使用するための方法および組成物
EP2970947A4 (de) 2013-03-14 2016-10-12 Abbott Lab Rekombinante hcv-ns3-antigene und mutanten für den verbesserten nachweis von antikörpern
CN105308457B (zh) 2013-03-14 2018-07-10 斯坦福大学托管董事会 检测供体特异性抗体的方法和用于实施所述方法的系统
CN105378099B (zh) 2013-03-14 2021-05-11 雅培制药有限公司 Hcv核心脂质结合结构域单克隆抗体
US9157910B2 (en) 2013-03-15 2015-10-13 Abbott Laboratories Assay with increased dynamic range
US9005901B2 (en) 2013-03-15 2015-04-14 Abbott Laboratories Assay with internal calibration
JP6381629B2 (ja) 2013-03-20 2018-08-29 コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. 前立腺癌の放射線療法のための臨床決定支援(cds)
ES2832756T3 (es) 2013-04-15 2021-06-11 Becton Dickinson Co Dispositivo de toma de muestra de fluido biológico
CA3210220A1 (en) 2013-05-10 2014-11-13 Johns Hopkins University Compositions for ovarian cancer assessment having improved specificity
ES3043076T3 (en) 2013-07-12 2025-11-24 Areteia Therapeutics Inc Treating elevated levels of eosinophils and/or basophils
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
WO2015009907A1 (en) 2013-07-17 2015-01-22 The Johns Hopkins University A multi-protein biomarker assay for brain injury detection and outcome
WO2015023786A1 (en) 2013-08-13 2015-02-19 Knopp Biosciences Llc Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders
ES2871556T3 (es) 2013-08-13 2021-10-29 Knopp Biosciences Llc Composiciones y métodos para el tratamiento de la urticaria crónica
WO2015047958A1 (en) * 2013-09-24 2015-04-02 Entopsis Detectable arrays, systems for diagnosis, and methods of making and using the same
WO2015073709A2 (en) 2013-11-14 2015-05-21 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Detection of atherosclerotic cardiovascular disease risk and heart failure risk
ES2837437T3 (es) 2013-12-20 2021-06-30 Univ Lausanne Usos diagnósticos, pronósticos y terapéuticos de ARN largos no codificantes para cardiopatías y medicina regenerativa
US10398772B2 (en) 2014-01-08 2019-09-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Ras pathways as markers of protection against HIV and methods to improve vaccine efficacy
WO2015164743A2 (en) 2014-04-24 2015-10-29 Dana-Farber Cancer Institute, Inc. Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response
EP3760208B1 (de) 2014-06-25 2024-05-29 The General Hospital Corporation Targeting von humanem satellit ii (hsatii)
WO2015200833A2 (en) 2014-06-27 2015-12-30 Abbott Laboratories COMPOSITIONS AND METHODS FOR DETECTING HUMAN PEGIVIRUS 2 (HPgV-2)
CZ305831B6 (cs) 2014-09-16 2016-03-30 Petr Novák Způsob modifikace povrchů bílkovinami pro prekoncentraci analytu pro desorpčně- ionizační techniky hmotnostní spektrometrie a imunochemické eseje
WO2016044697A1 (en) 2014-09-19 2016-03-24 The Johns Hopkins University Biomarkers of cognitive dysfunction
JP7065610B6 (ja) 2014-10-24 2022-06-06 コーニンクレッカ フィリップス エヌ ヴェ 複数の細胞シグナル伝達経路活性を用いる治療応答の医学的予後及び予測
ES2857953T3 (es) 2014-10-24 2021-09-29 Koninklijke Philips Nv Pronóstico médico y predicción de la respuesta al tratamiento usando las actividades de múltiples rutas de señalización celular
ES2833543T3 (es) 2014-10-24 2021-06-15 Koninklijke Philips Nv Evaluación de la actividad de la ruta de señalización celular de TGF usando modelos matemáticos de la expresión de genes diana
ES2828713T3 (es) 2014-10-29 2021-05-27 Abbott Lab Ensayos de detección de anticuerpos anti-VHC objeto usando péptidos de captura NS3
US11543411B2 (en) 2014-12-05 2023-01-03 Prelude Corporation DCIS recurrence and invasive breast cancer
GB2535835B (en) * 2014-12-17 2019-09-04 Micromass Ltd A two-dimensional separation and imaging technique for the rapid analysis of biological samples
US9607816B2 (en) 2014-12-17 2017-03-28 Micromass Uk Limited Two-dimensional separation and imaging technique for the rapid analysis of biological samples
WO2016134365A1 (en) 2015-02-20 2016-08-25 The Johns Hopkins University Biomarkers of myocardial injury
US10048256B2 (en) * 2015-03-18 2018-08-14 Bio-Rad Laboratories, Inc. Sample analysis systems and methods
KR101821747B1 (ko) * 2015-05-13 2018-01-24 한국과학기술연구원 고속 액체 크로마토그래피 장치 및 이를 이용한 물질 스크리닝 방법
WO2016183585A1 (en) 2015-05-14 2016-11-17 Joslin Diabetes Center, Inc. Retinol-binding protein 3 (rbp3) as a protective factor in non-diabetic retinal degeneration
CA2992139A1 (en) 2015-07-10 2017-01-19 West Virginia University Markers of stroke and stroke severity
CA2994416A1 (en) 2015-08-04 2017-02-09 Cd Diagnostics, Inc. Methods for detecting adverse local tissue reaction (altr) necrosis
US11450409B2 (en) 2015-08-14 2022-09-20 Innosign B.V. Determination of NFkB pathway activity using unique combination of target genes
US10527613B2 (en) 2015-11-10 2020-01-07 The Board Of Trustees Of The Leland Stanford Junior University Biomarker detection methods and systems and kits for practicing same
EP3387154A4 (de) 2015-12-09 2019-05-15 Intuitive Biosciences, Inc. Automatisiertes silberveredelungssystem
US11998540B2 (en) 2015-12-11 2024-06-04 The General Hospital Corporation Compositions and methods for treating drug-tolerant glioblastoma
CN105590079B (zh) * 2015-12-23 2018-02-16 上海百傲科技股份有限公司 一种多张生物芯片透射信号连续自动识读的方法及设备
WO2017123933A1 (en) 2016-01-15 2017-07-20 Massachusetts Eye And Ear Infirmary Secreted p-glycoprotein is a non-invasive biomarker of chronic rhinosinusitis
US11306362B2 (en) 2016-02-08 2022-04-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Gene signature predictive of hepatocellular carcinoma response to transcatheter arterial chemoembolization (TACE)
US20200200735A9 (en) 2016-02-22 2020-06-25 Ursure, Inc. System and method for detecting therapeutic agents to monitor adherence to a treatment regimen
EP3532496A1 (de) 2016-10-28 2019-09-04 Banyan Biomarkers, Inc. Antikörper gegen ubiquitin c-terminale hydrolase l1 (uch-l1) und gliales fibrilläres saures protein (gfap) und verwandte verfahren
JP7132233B2 (ja) 2016-11-11 2022-09-06 アセンダント ディーエックス, エルエルシー 全身型若年性特発性関節炎および川崎病を診断および識別するための組成物および方法
EP4553501A3 (de) * 2016-12-30 2025-09-03 Università degli Studi di Bari "Aldo Moro" Verfahren zur biofunktionalisierung einer gate-elektrode eines feldeffekttransistorsensors mit einer sam und blockierung nichtspezifischer bindung
CN110167967B (zh) 2017-01-18 2022-08-05 豪夫迈·罗氏有限公司 针对抗pd-l1抗体的独特型抗体及其用途
US12135330B2 (en) 2017-03-31 2024-11-05 Charles River Laboratories International, Inc. Articles and methods involving detection of binding
CN107315851B (zh) * 2017-05-19 2020-06-23 中国科学院长春光学精密机械与物理研究所 一种宽光谱极紫外多层膜的鲁棒性膜系设计方法
CN107024436A (zh) * 2017-05-27 2017-08-08 北京环境特性研究所 一种分析药物对细胞作用点的方法
CA3071783A1 (en) 2017-08-16 2019-02-21 Michael D. Howell Compositions and methods for treatment of atopic dermatitis and treatment selection
WO2019060907A1 (en) 2017-09-25 2019-03-28 Fred Hutchinson Cancer Research Center HIGH PERFORMANCE TARGETED IN SITU PANGENOMIC PROFILING
US12276670B2 (en) 2017-09-29 2025-04-15 The General Hospital Corporation Methods for identifying and treating adrenomyeloneuropathy (AMN)
EP3461915A1 (de) 2017-10-02 2019-04-03 Koninklijke Philips N.V. Beurteilung der aktivität von zellulären jak-stat1/2-signalisierungspfaden mittels mathematischer modellierung der zielgenexpression
EP3461916A1 (de) 2017-10-02 2019-04-03 Koninklijke Philips N.V. Beurteilung der zellulären jak-stat3-signalisierungspfadaktivität mittels mathematischer modellierung der zielgenexpression
EP3502279A1 (de) 2017-12-20 2019-06-26 Koninklijke Philips N.V. Beurteilung der aktivität von zellulären mapk-ap 1-signalisierungspfaden mittels mathematischer modellierung der zielgenexpression
KR101921628B1 (ko) * 2018-01-15 2018-11-26 한국과학기술연구원 고속 액체 크로마토그래피 장치 및 이를 이용한 물질 스크리닝 방법
US20210213041A1 (en) 2018-02-06 2021-07-15 The General Hospital Corporation Repeat rna as biomarkers of tumor immune response
CN108715844A (zh) * 2018-04-11 2018-10-30 河北工业大学 一种仿生矿化固定化酶和辅因子的制备方法及仿生矿化固定化酶和辅因子
BR112020024715A2 (pt) 2018-06-04 2021-03-23 Avon Products. Inc. biomarcadores proteicos para identificar e tratar o envelhecimento da pele e afecções cutâneas
WO2020056338A1 (en) 2018-09-14 2020-03-19 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer
EP3677693A1 (de) 2019-01-03 2020-07-08 Ecole Polytechnique Federale De Lausanne (EPFL) EPFL-TTO Transpochimäre gentranskripte (tcgts) als krebsbiomarker
WO2020198232A1 (en) 2019-03-25 2020-10-01 Massachusetts Eye And Ear Infirmary Methods and compositions to treat and diagnose diseases or pathologies associated with inflammation of the sinuses and nasal cavity
WO2020231774A1 (en) * 2019-05-10 2020-11-19 Quest Diagnostics Investments Llc MULTIPLEX ASSAY FOR DETERMINING THE ß-AMYLOID 42/40 RATIO IN HUMAN PLASMA SPECIMENS
KR20240137114A (ko) 2019-08-05 2024-09-19 시어 인코퍼레이티드 샘플 제조, 데이터 생성, 및 단백질 코로나 분석을 위한 시스템 및 방법
AU2020353178A1 (en) 2019-09-27 2022-04-14 Regeneron Pharmaceuticals, Inc. Hydrophobic interaction chromatography-coupled native mass spectrometry for antibody analysis
US12116637B2 (en) 2020-07-24 2024-10-15 The Regents Of The University Of Michigan Compositions and methods for detecting and treating high grade subtypes of uterine cancer
US20230375552A1 (en) 2020-09-29 2023-11-23 The Johns Hopkins University Integrated proteomic biomarkers for the detection of aggressive prostate cancer
EP4229222A2 (de) 2020-10-19 2023-08-23 Dana-Farber Cancer Institute, Inc. Keimbahnbiomarker einer klinischen reaktion und nutzen für eine immuncheckpoint-inhibitortherapie
US12426782B2 (en) 2020-11-06 2025-09-30 The Board Of Trustees Of The Leland Stanford Junior University Systems and temporal alignment methods for evaluation of gestational age and time to delivery
CA3209638A1 (en) 2021-02-25 2022-09-01 Lung Therapeutics, Inc. Biomarkers for the treatment of interstitial lung disease
CN117597583A (zh) * 2021-03-18 2024-02-23 康博国际有限公司 检测和定量体液样品的大量分子生物标志物的方法和系统
US20240247264A1 (en) 2021-05-28 2024-07-25 Centre Hospitalier Universitaire Vaudois (C.H.U.V.) NOVEL lncRNA CONTROLLING CARDIAC FIBROSIS
WO2023122723A1 (en) 2021-12-23 2023-06-29 The Broad Institute, Inc. Panels and methods for diagnosing and treating lung cancer
JP7804498B2 (ja) * 2022-03-18 2026-01-22 住友理工株式会社 ポリイソプレンの質量分析方法
US20230305019A1 (en) * 2022-03-28 2023-09-28 The Board Of Trustees Of The Leland Stanford Junior University Microprobe-capture in-emitter elution-electrospray ionization
CN115078570B (zh) * 2022-05-30 2024-05-28 郑州大学第一附属医院 Tau蛋白639位硫氰酸氨基酸修饰在快速质谱法检测阿尔茨海默症中的应用
KR20250121000A (ko) 2022-11-08 2025-08-11 더 브리검 앤드 우먼즈 하스피털, 인크. 생체액 내 ORF1p의 검출을 위한 초민감도 검정
WO2025106804A1 (en) 2023-11-16 2025-05-22 Massachusetts Institute Of Technology Compositions and methods for characterizing hepatocyte stress
WO2025217069A1 (en) 2024-04-08 2025-10-16 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for treating cardiotoxicity
WO2026096383A1 (en) 2024-10-28 2026-05-07 The Broad Institute, Inc. Compositions and methods for inducing phagocytosis

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL291000A (de) * 1962-04-02
US3288604A (en) * 1964-09-03 1966-11-29 Xerox Corp Imaging method using an element having a glass overcoating
US3669841A (en) * 1970-02-11 1972-06-13 Monsanto Co Attachment of enzymes to siliceous materials
US3896661A (en) * 1974-01-09 1975-07-29 Stanford Research Inst Method of coupling thin layer chromatograph with mass spectrometer
DE2654057B1 (de) * 1976-11-29 1978-04-27 Varian Mat Gmbh Verfahren zur Ionisierung von organischen Substanzen,sowie dieses Verfahren benutzendes Analysegeraet
US4126554A (en) 1977-09-02 1978-11-21 Analtech, Inc. Selectively marked thin-layer chromatographic plate
US4313906A (en) 1979-08-17 1982-02-02 Whatman, Inc. Two dimensional two phase thin layer chromatography plate and method
US4313908A (en) 1980-10-20 1982-02-02 Exxon Research & Engineering Co. Catalytic reactor having bed bypass
US4752562A (en) 1981-01-23 1988-06-21 Baxter Travenol Laboratories, Inc. Detection of serum antibody and surface antigen by radial partition immunoassay
US4444879A (en) * 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
DE3125335A1 (de) 1981-06-27 1983-01-13 Alfred Prof. Dr. 4400 Münster Benninghoven Verfahren zur analyse von gasen und fluessigkeiten
SE8200442L (sv) * 1982-01-27 1983-07-28 Forsvarets Forsknings Forfarande vid detektion av organiska molekyler, sasom biomolekyler
JPS6042653A (ja) * 1983-08-17 1985-03-06 Shionogi & Co Ltd クロマトグラフィ−・プレ−ト
US4489477A (en) * 1984-02-23 1984-12-25 Northern Telecom Limited Method for screening laser diodes
JPS61187237A (ja) * 1985-02-14 1986-08-20 Toshiba Corp パタ−ン形成方法
US4820648A (en) * 1985-08-21 1989-04-11 Spectros Limited Methods for use in the mass analysis of chemical samples
JPS6251144A (ja) * 1985-08-29 1987-03-05 Hitachi Ltd 質量分析計
US4988879A (en) * 1987-02-24 1991-01-29 The Board Of Trustees Of The Leland Stanford Junior College Apparatus and method for laser desorption of molecules for quantitation
JPH07111427B2 (ja) 1987-10-13 1995-11-29 テラピン テクノロジーズ,インコーポレイテッド 免疫診断薬を製造する方法
US4963263A (en) 1988-03-24 1990-10-16 Terrapin Technologies, Inc. Method of identity analyte-binding peptides
US5133866A (en) 1988-03-24 1992-07-28 Terrapin Technologies, Inc. Method to identify analyte-bending ligands
US5300425A (en) 1987-10-13 1994-04-05 Terrapin Technologies, Inc. Method to produce immunodiagnostic reagents
US5338659A (en) 1991-04-02 1994-08-16 Terrapin Technologies, Inc. Method for determining analyte concentration by cross-reactivity profiling
US4891321A (en) * 1987-10-21 1990-01-02 Hubscher Thomas T Apparatus for performing determinations of immune reactants in biological fluids
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
HUT63587A (en) * 1988-03-24 1993-09-28 Terrapin Tech Inc Paralogic affinity-chromatography
US5340474A (en) 1988-03-24 1994-08-23 Terrapin Technologies, Inc. Panels of analyte-binding ligands
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5037611A (en) * 1988-11-29 1991-08-06 Icr Research Associates, Inc. Sample handling technique
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
GB2235529B (en) 1989-08-23 1993-07-28 Finnigan Mat Ltd Method of preparing samples for laser spectrometry analysis
GB2236186B (en) 1989-08-22 1994-01-05 Finnigan Mat Gmbh Process and device for laser desorption of analyte molecular ions, especially of biomolecules
US5045694A (en) 1989-09-27 1991-09-03 The Rockefeller University Instrument and method for the laser desorption of ions in mass spectrometry
US5035022A (en) * 1989-12-08 1991-07-30 Joseph Iuliano Device for applying coatings to objects having irregular shapes and/or diverse surfaces
US5366862A (en) * 1990-02-14 1994-11-22 Receptor Laboratories, Inc. Method for generating and screening useful peptides
US5288644A (en) * 1990-04-04 1994-02-22 The Rockefeller University Instrument and method for the sequencing of genome
DK0600866T3 (da) 1990-06-01 1998-03-09 Chiron Corp Præparater og fremgangsmåder til identifikation af biologisk aktive molekyler
IE66205B1 (en) 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5135627A (en) 1990-10-15 1992-08-04 Soane Technologies, Inc. Mosaic microcolumns, slabs, and separation media for electrophoresis and chromatography
US5308749A (en) * 1991-01-25 1994-05-03 Eastman Kodak Company Method of preparing biologically active reagents from succinimide-containing polymers, analytical element and methods of use
AU662148B2 (en) 1991-04-10 1995-08-24 Scripps Research Institute, The Heterodimeric receptor libraries using phagemids
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5382793A (en) * 1992-03-06 1995-01-17 Hewlett-Packard Company Laser desorption ionization mass monitor (LDIM)
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5372719A (en) 1992-03-30 1994-12-13 Perseptive Biosystems, Inc. Molecular imaging
US6271037B1 (en) 1992-05-29 2001-08-07 The Rockefeller University Method and product for the sequence determination of peptides using a mass spectrometer
WO1994002225A1 (en) 1992-07-27 1994-02-03 Terrapin Technologies, Inc. Sorbent families
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
AU689755B2 (en) 1992-09-22 1998-04-09 Biofocus Discovery Limited Recombinant viruses displaying a nonviral polypeptide on their external surface
US5376249A (en) 1992-11-25 1994-12-27 Perseptive Biosystems, Inc. Analysis utilizing isoelectric focusing
CA2153387A1 (en) 1993-01-07 1994-07-21 Hubert Koester Dna sequencing by mass spectrometry
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
CA2158642A1 (en) 1993-03-19 1994-09-29 Hubert Koster Dna sequencing by mass spectrometry via exonuclease degradation
US5356784A (en) 1993-03-30 1994-10-18 Terrapin Technologies, Inc. Determination of concentration by affinity titration
US20020037517A1 (en) * 1993-05-28 2002-03-28 Hutchens T. William Methods for sequencing biopolymers
US6020208A (en) * 1994-05-27 2000-02-01 Baylor College Of Medicine Systems for surface-enhanced affinity capture for desorption and detection of analytes
WO1994028418A1 (en) * 1993-05-28 1994-12-08 Baylor College Of Medicine Method and apparatus for desorption and ionization of analytes
DE69431719T2 (de) 1993-06-25 2003-09-18 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Hybridisierung und sequenzierung von nukleinsäuren
US5496545A (en) * 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
GB9317193D0 (en) * 1993-08-18 1993-10-06 Zeneca Ltd Method
CN1132586C (zh) * 1993-09-09 2003-12-31 罗拉斯医疗公司 来自胆汁的免疫调节组合物、其制备方法及其用途
DE69433180T2 (de) 1993-10-26 2004-06-24 Affymetrix, Inc., Santa Clara Felder von nukleinsaeuresonden auf biologischen chips
US6071610A (en) * 1993-11-12 2000-06-06 Waters Investments Limited Enhanced resolution matrix-laser desorption and ionization TOF-MS sample surface
US5587293A (en) 1994-01-06 1996-12-24 Terrapin Technologies, Inc. Method to identify binding partners
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5538897A (en) 1994-03-14 1996-07-23 University Of Washington Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases
US5834195A (en) * 1994-03-23 1998-11-10 The Penn State Research Foundation Method for identifying members of combinatorial libraries
US5502022A (en) * 1994-05-16 1996-03-26 Biosepra, Inc. Chromatography adsorbents utilizing mercapto heterocyclic ligands
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5498545A (en) * 1994-07-21 1996-03-12 Vestal; Marvin L. Mass spectrometer system and method for matrix-assisted laser desorption measurements
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US6030917A (en) * 1996-07-23 2000-02-29 Symyx Technologies, Inc. Combinatorial synthesis and analysis of organometallic compounds and catalysts
US6440745B1 (en) * 1994-10-18 2002-08-27 Symyx Technologies Combinatorial synthesis and screening of organometallic compounds and catalysts
US6004617A (en) * 1994-10-18 1999-12-21 The Regents Of The University Of California Combinatorial synthesis of novel materials
US5985356A (en) * 1994-10-18 1999-11-16 The Regents Of The University Of California Combinatorial synthesis of novel materials
US6419881B1 (en) * 1994-10-18 2002-07-16 Symyx Technologies, Inc. Combinatorial arrays of organometallic compounds and catalysts
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US6207369B1 (en) * 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
ATE273384T1 (de) * 1995-04-06 2004-08-15 Regeneron Pharma Tie-2 liganden, herstellungsverfahren und verwendung
US5741462A (en) * 1995-04-25 1998-04-21 Irori Remotely programmable matrices with memories
US5624711A (en) * 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5770272A (en) * 1995-04-28 1998-06-23 Massachusetts Institute Of Technology Matrix-bearing targets for maldi mass spectrometry and methods of production thereof
WO1996036986A1 (en) 1995-05-19 1996-11-21 Perseptive Biosystems, Inc. Methods and apparatus for sequencing polymers with a statistical certainty using mass spectrometry
WO1996037777A1 (en) 1995-05-23 1996-11-28 Nelson Randall W Mass spectrometric immunoassay
DE69635242T2 (de) 1995-06-07 2006-05-18 Arizona Board Of Regents, Tempe Probengeber für massenspektrometrie
US6316266B1 (en) * 1995-06-07 2001-11-13 Arizona State University Board Of Regents Sample presentation apparatus for mass spectrometry
US6093541A (en) * 1995-06-07 2000-07-25 Arizona State University Board Of Regents Mass spectrometer having a derivatized sample presentation apparatus
US6004770A (en) * 1995-06-07 1999-12-21 Arizona State University Board Of Regents Sample presentation apparatus for mass spectrometry
WO1997006068A1 (fr) 1995-08-04 1997-02-20 Charles Faraud S.A. Dispositif d'emballage et de stockage de plats prepares
GB9517926D0 (en) * 1995-09-01 1995-11-01 Biocine Spa Binding protein
WO1997009068A2 (en) * 1995-09-01 1997-03-13 University Of Washington Interactive molecular conjugates
GB9518429D0 (en) * 1995-09-08 1995-11-08 Pharmacia Biosensor A rapid method for providing kinetic and structural data in molecular interaction analysis
US5705813A (en) * 1995-11-01 1998-01-06 Hewlett-Packard Company Integrated planar liquid handling system for maldi-TOF MS
US5716825A (en) * 1995-11-01 1998-02-10 Hewlett Packard Company Integrated nucleic acid analysis system for MALDI-TOF MS
US5808300A (en) * 1996-05-10 1998-09-15 Board Of Regents, The University Of Texas System Method and apparatus for imaging biological samples with MALDI MS
US5780232A (en) 1996-05-28 1998-07-14 Atom Sciences, Inc. DNA sequencing, mapping, and diagnostic processes using hybridization and stable isotope labels of DNA
US6660159B1 (en) * 1996-06-07 2003-12-09 Immunivest Corporation Magnetic separation apparatus and methods
US6790366B2 (en) * 1996-06-07 2004-09-14 Immunivest Corporation Magnetic separation apparatus and methods
US6136182A (en) * 1996-06-07 2000-10-24 Immunivest Corporation Magnetic devices and sample chambers for examination and manipulation of cells
JP3996644B2 (ja) * 1996-06-07 2007-10-24 イムニベスト・コーポレイション 外部及び内部勾配を有する磁気分離
US6441901B2 (en) * 1996-07-23 2002-08-27 Symyx Technologies, Inc. Optical systems and methods for rapid screening of libraries of different materials
US5821060A (en) 1996-08-02 1998-10-13 Atom Sciences, Inc. DNA sequencing, mapping, and diagnostic processes using hybridization chips and unlabeled DNA
CA2267897C (en) * 1996-10-09 2005-12-06 Symyx Technologies Infrared spectroscopy and imaging of libraries
US5854486A (en) * 1996-12-27 1998-12-29 R. T. Hodgson Method and apparatus for MALDI mass spectrometry
US5882496A (en) * 1997-02-27 1999-03-16 The Regents Of The University Of California Porous silicon structures with high surface area/specific pore size
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US6207370B1 (en) * 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
US6127005A (en) * 1999-01-08 2000-10-03 Rutgers University Method of thermally glazing an article
WO2000054309A1 (en) * 1999-03-09 2000-09-14 The Scripps Research Institute Improved desorption/ionization of analytes from porous light-absorbing semiconductor
DE19937438C2 (de) * 1999-08-07 2001-09-13 Bruker Daltonik Gmbh Kopplung Dünnschicht-Chromatographie und Massenspektrometrie (TLC/MS)
US7299134B2 (en) * 2001-02-16 2007-11-20 Bio-Rad Laboratories, Inc. Method for correlating gene expression profiles with protein expression profiles
US7155127B2 (en) * 2001-08-15 2006-12-26 Nippon Telegraph And Telephone Corporation Optical communication system, optical communication unit, and optical transceiving package
US6977517B2 (en) * 2002-05-20 2005-12-20 Finisar Corporation Laser production and product qualification via accelerated life testing based on statistical modeling

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