ATE423770T1 - Benzoyltetrahydropyridine als glyt-1-inhibitoren - Google Patents

Benzoyltetrahydropyridine als glyt-1-inhibitoren

Info

Publication number
ATE423770T1
ATE423770T1 AT05820269T AT05820269T ATE423770T1 AT E423770 T1 ATE423770 T1 AT E423770T1 AT 05820269 T AT05820269 T AT 05820269T AT 05820269 T AT05820269 T AT 05820269T AT E423770 T1 ATE423770 T1 AT E423770T1
Authority
AT
Austria
Prior art keywords
benzoyltetrahydropyridines
glyt
inhibitors
Prior art date
Application number
AT05820269T
Other languages
English (en)
Inventor
Synese Jolidon
Robert Narquizian
Roger Norcross
Emmanuel Pinard
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE423770T1 publication Critical patent/ATE423770T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT05820269T 2005-01-04 2005-12-27 Benzoyltetrahydropyridine als glyt-1-inhibitoren ATE423770T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05100027 2005-01-04

Publications (1)

Publication Number Publication Date
ATE423770T1 true ATE423770T1 (de) 2009-03-15

Family

ID=36118130

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05820269T ATE423770T1 (de) 2005-01-04 2005-12-27 Benzoyltetrahydropyridine als glyt-1-inhibitoren

Country Status (19)

Country Link
US (1) US7485637B2 (de)
EP (1) EP1836168B1 (de)
JP (1) JP4738421B2 (de)
KR (1) KR100957280B1 (de)
CN (1) CN101111477B (de)
AR (1) AR052553A1 (de)
AT (1) ATE423770T1 (de)
AU (1) AU2005324109B2 (de)
BR (1) BRPI0519746A2 (de)
CA (1) CA2594260A1 (de)
DE (1) DE602005012997D1 (de)
ES (1) ES2319220T3 (de)
IL (1) IL184206A (de)
MX (1) MX2007008043A (de)
NO (1) NO20073275L (de)
RU (1) RU2007124546A (de)
TW (1) TW200635898A (de)
WO (1) WO2006072432A1 (de)
ZA (1) ZA200705383B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007263083B2 (en) * 2006-06-22 2012-10-04 F. Hoffmann-La Roche Ag Substituted phenyl methanone derivatives
JP6034215B2 (ja) * 2013-02-19 2016-11-30 株式会社東芝 紙葉類処理装置

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2423847A1 (de) * 1973-05-28 1975-01-02 Ciba Geigy Ag Neue sulfamoylbenzoesaeureamide
DE2533604A1 (de) 1975-07-26 1977-02-10 Bayer Ag 2-substituierte 5-trifluormethyl1,3,4-thiadiazole, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide und insektizide
DE2611705A1 (de) * 1976-03-18 1977-09-22 Josef Dipl Chem Dr Rer N Klosa N-5-(nitrofurfuryliden-)-1-amino- hydantoin enthaltende kristalloesungsmittel
US4122083A (en) * 1978-01-16 1978-10-24 E. R. Squibb & Sons, Inc. 1,2,3,4-Tetrahydropyrido[4',3':4.5]thiazolo-[3,2-a]benzimidazoles
US4436002A (en) 1981-12-11 1984-03-13 Hughes Tool Company Reversal mechanism for power tong
IT1176613B (it) 1984-08-14 1987-08-18 Ravizza Spa Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione
RU2124511C1 (ru) 1993-05-14 1999-01-10 Фармасьютикал Ко., Лтд Производные пиперазина
TW498067B (en) * 1996-07-19 2002-08-11 Hoffmann La Roche 4-hydroxy-piperidine derivatives
EE200000482A (et) 1998-03-06 2002-02-15 Janssen Pharmaceutica N.V. Glütsiini ülekannet pärssiva ühendi kasutamine ravimi valmistamiseks, ühend, seda sisaldav kompositsioon ning meetod ühendi ja kompositsiooni valmistamiseks
KR20010032967A (ko) 1998-03-06 2001-04-25 디르크 반테 글리신 수송 저해제
US20030216385A1 (en) * 2000-05-19 2003-11-20 Takahiko Tobe Triazole derivatives
GB0021419D0 (en) 2000-08-31 2000-10-18 Oxford Glycosciences Uk Ltd Compounds
GB0106661D0 (en) 2001-03-16 2001-05-09 Pfizer Ltd Pharmaceutically active compounds
WO2003004480A2 (en) 2001-07-02 2003-01-16 Novo Nordisk A/S Substituted piperazine and diazepanes as histamine h3 receptor agonists
WO2003035602A1 (en) 2001-10-25 2003-05-01 Sankyo Company, Limited Lipid modulators
EP1458689B1 (de) * 2001-12-20 2007-04-11 H. Lundbeck A/S Aryloxyphenyl und arylsulfanylphenylderivate
JP2006512404A (ja) 2002-10-22 2006-04-13 グラクソ　グループ　リミテッド Ｈ３受容体リガンドとしてのアリールオキシアルキルアミン誘導体
PT1594840E (pt) * 2003-02-17 2007-01-31 Hoffmann La Roche Derivados de piperidina-benzenossulfonamida
NZ544820A (en) * 2003-08-11 2009-02-28 Hoffmann La Roche Piperazine with or-substituted phenyl group and their use as GlyT1 inhibitors
CN100522171C (zh) * 2003-09-09 2009-08-05 弗·哈夫曼-拉罗切有限公司 作为甘氨酸摄取抑制剂、用于治疗精神病的1-苯甲酰基哌嗪衍生物
EP1663232B1 (de) * 2003-09-09 2007-10-03 F. Hoffmann-La Roche Ag 1-(2-amino-benzoyl)-piperazin-derivate als glycin-aufnahmehemmer zur behandlung von psychosen
PL1828154T3 (pl) * 2004-12-09 2009-10-30 Hoffmann La Roche Pochodne fenylopiperazynometanonu
MX2007006896A (es) * 2004-12-15 2007-06-26 Hoffmann La Roche Fenil-metanonas bi- y triciclicas sustituidas como inhibidores del transportador 1 de glicina (glyt-1) para el tratamiento de la enfermedad de alzheimer.
CN101360711A (zh) * 2005-11-23 2009-02-04 阿斯利康(瑞典)有限公司 L-苯丙氨酸衍生物及其作为整联蛋白拮抗剂的用途

Also Published As

Publication number Publication date
JP4738421B2 (ja) 2011-08-03
ES2319220T3 (es) 2009-05-05
MX2007008043A (es) 2007-07-16
IL184206A (en) 2011-09-27
KR20070094953A (ko) 2007-09-27
KR100957280B1 (ko) 2010-05-12
US20060148797A1 (en) 2006-07-06
RU2007124546A (ru) 2009-02-20
ZA200705383B (en) 2008-09-25
EP1836168B1 (de) 2009-02-25
AU2005324109B2 (en) 2011-01-20
NO20073275L (no) 2007-07-31
AR052553A1 (es) 2007-03-21
CA2594260A1 (en) 2006-07-13
EP1836168A1 (de) 2007-09-26
WO2006072432A1 (en) 2006-07-13
US7485637B2 (en) 2009-02-03
CN101111477B (zh) 2010-05-26
DE602005012997D1 (de) 2009-04-09
IL184206A0 (en) 2007-10-31
JP2008526794A (ja) 2008-07-24
TW200635898A (en) 2006-10-16
BRPI0519746A2 (pt) 2009-03-10
AU2005324109A1 (en) 2006-07-13
CN101111477A (zh) 2008-01-23

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