BRPI0519746A2 - benzoil tetraidro piridina como inibidores de glyt-1 - Google Patents
benzoil tetraidro piridina como inibidores de glyt-1Info
- Publication number
- BRPI0519746A2 BRPI0519746A2 BRPI0519746-5A BRPI0519746A BRPI0519746A2 BR PI0519746 A2 BRPI0519746 A2 BR PI0519746A2 BR PI0519746 A BRPI0519746 A BR PI0519746A BR PI0519746 A2 BRPI0519746 A2 BR PI0519746A2
- Authority
- BR
- Brazil
- Prior art keywords
- lower alkyl
- glyt
- inhibitors
- halogen
- substituted
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- BECCUPAXNMKZJU-UHFFFAOYSA-N 3,4-dihydro-2h-pyridin-1-yl(phenyl)methanone Chemical compound C=1C=CC=CC=1C(=O)N1CCCC=C1 BECCUPAXNMKZJU-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 damage Chemical group 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
BENZOIL TETRAIDRO PIRIDINA COMO INIBIDORES DE GLYT-1. A presente invenção refere-se a compostos da fórmula geral (I) onde R¹ um heterociclo não-aromático ou OR'; R' é alquila inferior, alquila inferior substituído com halogênio ou é -(CH~ 2~)~ n~-cicIo alquila; R² é NO~ 2~, CN ou SO~ 2~R"; R" é alquila inferior; Ar é fenila, opcionalmente substituído com halogênio, dano, alquila inferior substituído com halogênio ou SO~ 2~R"; n é 0,1 ou2; e a sais de adição ácida farmaceuticamente ativos e a seu uso no tratamento de distúrbios neurológicos e neuropsiquiátricos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05100027 | 2005-01-04 | ||
| PCT/EP2005/014052 WO2006072432A1 (en) | 2005-01-04 | 2005-12-27 | Benzoyl-tetrahydropyridine as glyt-1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0519746A2 true BRPI0519746A2 (pt) | 2009-03-10 |
Family
ID=36118130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0519746-5A BRPI0519746A2 (pt) | 2005-01-04 | 2005-12-27 | benzoil tetraidro piridina como inibidores de glyt-1 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7485637B2 (pt) |
| EP (1) | EP1836168B1 (pt) |
| JP (1) | JP4738421B2 (pt) |
| KR (1) | KR100957280B1 (pt) |
| CN (1) | CN101111477B (pt) |
| AR (1) | AR052553A1 (pt) |
| AT (1) | ATE423770T1 (pt) |
| AU (1) | AU2005324109B2 (pt) |
| BR (1) | BRPI0519746A2 (pt) |
| CA (1) | CA2594260A1 (pt) |
| DE (1) | DE602005012997D1 (pt) |
| ES (1) | ES2319220T3 (pt) |
| IL (1) | IL184206A (pt) |
| MX (1) | MX2007008043A (pt) |
| NO (1) | NO20073275L (pt) |
| RU (1) | RU2007124546A (pt) |
| TW (1) | TW200635898A (pt) |
| WO (1) | WO2006072432A1 (pt) |
| ZA (1) | ZA200705383B (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4937347B2 (ja) * | 2006-06-22 | 2012-05-23 | エフ．ホフマン−ラ ロシュ アーゲー | 置換フェニルメタノン誘導体 |
| JP6034215B2 (ja) * | 2013-02-19 | 2016-11-30 | 株式会社東芝 | 紙葉類処理装置 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2423847A1 (de) | 1973-05-28 | 1975-01-02 | Ciba Geigy Ag | Neue sulfamoylbenzoesaeureamide |
| DE2533604A1 (de) | 1975-07-26 | 1977-02-10 | Bayer Ag | 2-substituierte 5-trifluormethyl1,3,4-thiadiazole, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide und insektizide |
| DE2611705A1 (de) | 1976-03-18 | 1977-09-22 | Josef Dipl Chem Dr Rer N Klosa | N-5-(nitrofurfuryliden-)-1-amino- hydantoin enthaltende kristalloesungsmittel |
| US4122083A (en) | 1978-01-16 | 1978-10-24 | E. R. Squibb & Sons, Inc. | 1,2,3,4-Tetrahydropyrido[4',3':4.5]thiazolo-[3,2-a]benzimidazoles |
| US4436002A (en) | 1981-12-11 | 1984-03-13 | Hughes Tool Company | Reversal mechanism for power tong |
| IT1176613B (it) | 1984-08-14 | 1987-08-18 | Ravizza Spa | Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione |
| RU2124511C1 (ru) | 1993-05-14 | 1999-01-10 | Фармасьютикал Ко., Лтд | Производные пиперазина |
| TW498067B (en) * | 1996-07-19 | 2002-08-11 | Hoffmann La Roche | 4-hydroxy-piperidine derivatives |
| HRP20000524A2 (en) | 1998-03-06 | 2001-02-28 | Janssen Pharmaceutica Nv | Gylcine transport inhibitors |
| SK13082000A3 (sk) | 1998-03-06 | 2001-03-12 | Janssen Pharmaceutica N. V. | Inhibítory prenosu glycínu, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie |
| US20030216385A1 (en) * | 2000-05-19 | 2003-11-20 | Takahiko Tobe | Triazole derivatives |
| GB0021419D0 (en) | 2000-08-31 | 2000-10-18 | Oxford Glycosciences Uk Ltd | Compounds |
| GB0106661D0 (en) | 2001-03-16 | 2001-05-09 | Pfizer Ltd | Pharmaceutically active compounds |
| AU2002344951A1 (en) | 2001-07-02 | 2003-01-21 | Boehringer Ingelheim International Gmbh | Substituted piperazine and diazepanes as histamine h3 receptor agonists |
| WO2003035602A1 (en) | 2001-10-25 | 2003-05-01 | Sankyo Company, Limited | Lipid modulators |
| WO2003053942A1 (en) * | 2001-12-20 | 2003-07-03 | H. Lundbeck A/S | Aryloxyphenyl and arylsulfanylphenyl derivatives |
| JP2006512404A (ja) | 2002-10-22 | 2006-04-13 | グラクソ グループ リミテッド | Ｈ３受容体リガンドとしてのアリールオキシアルキルアミン誘導体 |
| SI1594840T1 (sl) | 2003-02-17 | 2006-12-31 | Hoffmann La Roche | Derivati piperidin-benzensulfonamida |
| SI1656361T1 (sl) | 2003-08-11 | 2008-04-30 | Hoffmann La Roche | Piperazin z OR-substituirano fenilno skupino in njuna uporaba kot zaviralca GLYT1 |
| PT1663232E (pt) | 2003-09-09 | 2007-12-12 | Hoffmann La Roche | Derivados de 1- (2-amino-benzol) -piperazina como inibidores de absorção de glicina para o tratamento de psicoses |
| CN100522171C (zh) | 2003-09-09 | 2009-08-05 | 弗·哈夫曼-拉罗切有限公司 | 作为甘氨酸摄取抑制剂、用于治疗精神病的1-苯甲酰基哌嗪衍生物 |
| WO2006061135A1 (en) * | 2004-12-09 | 2006-06-15 | F. Hoffmann-La Roche Ag | Phenyl-piperazin methanone derivatives |
| ATE457989T1 (de) * | 2004-12-15 | 2010-03-15 | Hoffmann La Roche | Bi- und trizyklische substituierte phenyl- methanone als inhibitoren von glycin-i (glyt-1)- transportern zur behandlung der alzheimer- krankheit |
| US20090137601A1 (en) * | 2005-11-23 | 2009-05-28 | Astrazeneca Ab | L-Phenylalanine Derivatives |
-
2005
- 2005-12-13 US US11/302,403 patent/US7485637B2/en not_active Expired - Fee Related
- 2005-12-27 AT AT05820269T patent/ATE423770T1/de active
- 2005-12-27 RU RU2007124546/04A patent/RU2007124546A/ru not_active Application Discontinuation
- 2005-12-27 AU AU2005324109A patent/AU2005324109B2/en not_active Ceased
- 2005-12-27 CA CA002594260A patent/CA2594260A1/en not_active Abandoned
- 2005-12-27 EP EP05820269A patent/EP1836168B1/en not_active Expired - Lifetime
- 2005-12-27 WO PCT/EP2005/014052 patent/WO2006072432A1/en not_active Ceased
- 2005-12-27 MX MX2007008043A patent/MX2007008043A/es active IP Right Grant
- 2005-12-27 DE DE602005012997T patent/DE602005012997D1/de not_active Expired - Lifetime
- 2005-12-27 JP JP2007549822A patent/JP4738421B2/ja not_active Expired - Fee Related
- 2005-12-27 CN CN2005800476568A patent/CN101111477B/zh not_active Expired - Fee Related
- 2005-12-27 ES ES05820269T patent/ES2319220T3/es not_active Expired - Lifetime
- 2005-12-27 KR KR1020077017900A patent/KR100957280B1/ko not_active Expired - Fee Related
- 2005-12-27 BR BRPI0519746-5A patent/BRPI0519746A2/pt not_active IP Right Cessation
-
2006
- 2006-01-02 TW TW095100092A patent/TW200635898A/zh unknown
- 2006-01-03 AR ARP060100011A patent/AR052553A1/es unknown
-
2007
- 2007-06-25 IL IL184206A patent/IL184206A/en active IP Right Grant
- 2007-06-27 NO NO20073275A patent/NO20073275L/no not_active Application Discontinuation
- 2007-07-02 ZA ZA200705383A patent/ZA200705383B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005324109B2 (en) | 2011-01-20 |
| ZA200705383B (en) | 2008-09-25 |
| TW200635898A (en) | 2006-10-16 |
| US20060148797A1 (en) | 2006-07-06 |
| WO2006072432A1 (en) | 2006-07-13 |
| DE602005012997D1 (de) | 2009-04-09 |
| NO20073275L (no) | 2007-07-31 |
| KR20070094953A (ko) | 2007-09-27 |
| ES2319220T3 (es) | 2009-05-05 |
| US7485637B2 (en) | 2009-02-03 |
| JP2008526794A (ja) | 2008-07-24 |
| IL184206A0 (en) | 2007-10-31 |
| ATE423770T1 (de) | 2009-03-15 |
| IL184206A (en) | 2011-09-27 |
| CN101111477A (zh) | 2008-01-23 |
| JP4738421B2 (ja) | 2011-08-03 |
| RU2007124546A (ru) | 2009-02-20 |
| EP1836168B1 (en) | 2009-02-25 |
| CN101111477B (zh) | 2010-05-26 |
| AU2005324109A1 (en) | 2006-07-13 |
| EP1836168A1 (en) | 2007-09-26 |
| MX2007008043A (es) | 2007-07-16 |
| KR100957280B1 (ko) | 2010-05-12 |
| AR052553A1 (es) | 2007-03-21 |
| CA2594260A1 (en) | 2006-07-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014. |