ATE423990T1 - Verfahren und zusammensetzungen zur behandlung von uveitis - Google Patents
Verfahren und zusammensetzungen zur behandlung von uveitisInfo
- Publication number
- ATE423990T1 ATE423990T1 AT05780059T AT05780059T ATE423990T1 AT E423990 T1 ATE423990 T1 AT E423990T1 AT 05780059 T AT05780059 T AT 05780059T AT 05780059 T AT05780059 T AT 05780059T AT E423990 T1 ATE423990 T1 AT E423990T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions
- methods
- uveitis
- treating uveitis
- treatment
- Prior art date
Links
- 206010046851 Uveitis Diseases 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 108091034117 Oligonucleotide Proteins 0.000 abstract 2
- 208000002691 Choroiditis Diseases 0.000 abstract 1
- 206010022941 Iridocyclitis Diseases 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 201000007407 panuveitis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
- C12N2310/151—Nucleic acids forming more than 2 strands, e.g. TFOs more than 3 strands, e.g. tetrads, H-DNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56927604P | 2004-05-06 | 2004-05-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE423990T1 true ATE423990T1 (de) | 2009-03-15 |
Family
ID=35395815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05780059T ATE423990T1 (de) | 2004-05-06 | 2005-05-05 | Verfahren und zusammensetzungen zur behandlung von uveitis |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8895521B2 (de) |
| EP (1) | EP1751612B1 (de) |
| JP (1) | JP5014122B2 (de) |
| CN (1) | CN1989439B (de) |
| AT (1) | ATE423990T1 (de) |
| AU (2) | AU2005247341B2 (de) |
| CA (1) | CA2565714C (de) |
| DE (1) | DE602005012948D1 (de) |
| MX (1) | MXPA06012915A (de) |
| WO (1) | WO2005115359A2 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002353783A1 (en) | 2001-09-24 | 2003-04-07 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | SUPPRESSORS OF CpG OLIGONUCLEOTIDES AND METHODS OF USE |
| AU2003263963A1 (en) | 2002-08-01 | 2004-02-23 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | Method of treating inflammatory arthropathies with suppressors of cpg oligonucleotides |
| US8043622B2 (en) | 2002-10-08 | 2011-10-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating inflammatory lung disease with suppressors of CpG oligonucleotides |
| US20160106717A1 (en) | 2004-09-24 | 2016-04-21 | Gen Pharma Holdings LLC | Cai-based systems and methods for the localized treatment of uveitis |
| RU2311173C1 (ru) * | 2006-02-27 | 2007-11-27 | Яхья Хаджибикарович Вышегуров | Способ лечения эндофтальмитов и увеитов неясной и вирусной этиологии |
| EP2278979A4 (de) * | 2008-05-21 | 2012-09-26 | Us Gov Health & Human Serv | Verfahren zur behandlung von pneumokoniose mit oligodesoxynukleotiden |
| JO3417B1 (ar) | 2010-01-08 | 2019-10-20 | Regeneron Pharma | الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r |
| ES2870458T3 (es) * | 2010-12-21 | 2021-10-27 | Index Pharmaceuticals Ab | Oligonucleótidos biológicamente activos capaces de modular el sistema inmunitario |
| EP2468867A1 (de) * | 2010-12-21 | 2012-06-27 | Index Pharmaceuticals AB | Verfahren zur Identifizierung biologisch aktiver Oligonukleotide zur Modulation des Immunsystems |
| WO2016061378A1 (en) * | 2014-10-16 | 2016-04-21 | Gen Pharma Holdings, Llc | Cai-based systems and methods for the localized treatment of uveitis |
| SG11201803654TA (en) | 2015-11-03 | 2018-05-30 | Sanofi Biotechnology | Compositions comprising il6r antibodies for the treatment of uveitis and macular edema and methods of using same |
| EP3468605A4 (de) | 2016-06-08 | 2020-01-08 | President and Fellows of Harvard College | Manipulierter viraler vektor zur reduzierung von induktion von entzündungs- und immunreaktionen |
| AU2018364542A1 (en) | 2017-11-08 | 2020-04-16 | President And Fellows Of Harvard College | Compositions and methods for inhibiting viral vector-induced inflammatory responses |
| CN111801419A (zh) * | 2017-12-15 | 2020-10-20 | 拜耳动物保健有限责任公司 | 免疫刺激性寡核苷酸 |
| US20210060017A1 (en) * | 2018-02-27 | 2021-03-04 | Shilpa Medicare Ltd | Methotrexate ophthalmic solution |
| MA53481A (fr) | 2018-08-29 | 2021-07-07 | Regeneron Pharma | Méthodes et compositions pour le traitement de sujets ayant une polyarthrite rhumatoïde |
| JP7542543B2 (ja) | 2019-01-31 | 2024-08-30 | サノフィ・バイオテクノロジー | 若年性特発性関節炎を治療するための抗ｉｌ－６受容体抗体 |
| CN114651010A (zh) | 2019-04-24 | 2022-06-21 | 赛诺菲生物技术公司 | 类风湿性关节炎的诊断和治疗方法 |
| KR20230061198A (ko) | 2019-06-04 | 2023-05-08 | 사노피 바이오테크놀로지 | 류마티스성 관절염을 갖는 대상체에서 통증을 치료하기 위한 조성물 및 방법 |
| CN111870607A (zh) * | 2020-07-09 | 2020-11-03 | 温州医科大学 | 盐酸米诺环素作为制备治疗自身免疫性葡萄膜炎药物的应用及其治疗方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469863A (en) * | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US5023243A (en) * | 1981-10-23 | 1991-06-11 | Molecular Biosystems, Inc. | Oligonucleotide therapeutic agent and method of making same |
| WO1983001451A1 (en) | 1981-10-23 | 1983-04-28 | Molecular Biosystems Inc | Oligonucleotide therapeutic agent and methods of making same |
| US6153595A (en) * | 1990-08-16 | 2000-11-28 | Isis Pharmaceuticals Inc. | Composition and method for treatment of CMV infections |
| WO1995026204A1 (en) * | 1994-03-25 | 1995-10-05 | Isis Pharmaceuticals, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
| WO1996002555A1 (en) | 1994-07-15 | 1996-02-01 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US7094766B1 (en) * | 1995-06-06 | 2006-08-22 | Trustees Of Boston University | Use of locally applied DNA fragments |
| WO1998008861A1 (en) * | 1996-08-29 | 1998-03-05 | Millennium Pharmaceuticals, Inc. | Rp compositions and therapeutic and diagnostic uses therefor |
| US5856462A (en) | 1996-09-10 | 1999-01-05 | Hybridon Incorporated | Oligonucleotides having modified CpG dinucleosides |
| SI9820003A (sl) * | 1997-01-17 | 1999-06-30 | Icn Pharmaceuticals, Inc. | Zdravljenje bolezni povezano s citokini |
| WO1998037919A1 (en) | 1997-02-28 | 1998-09-03 | University Of Iowa Research Foundation | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS |
| AU753688B2 (en) | 1997-03-10 | 2002-10-24 | Ottawa Civic Loeb Research Institute | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| AU7690898A (en) | 1997-05-20 | 1998-12-11 | Ottawa Civic Hospital Loeb Research Institute | Vectors and methods for immunization or therapeutic protocols |
| US6218371B1 (en) | 1998-04-03 | 2001-04-17 | University Of Iowa Research Foundation | Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines |
| US7244710B2 (en) * | 2002-05-21 | 2007-07-17 | Zengen, Inc. | Treatment of ophthalmic infections using antimicrobial peptides |
| US7585847B2 (en) * | 2000-02-03 | 2009-09-08 | Coley Pharmaceutical Group, Inc. | Immunostimulatory nucleic acids for the treatment of asthma and allergy |
| AU2001251115A1 (en) * | 2000-03-31 | 2001-10-15 | Trustees Of Boston University | Use of locally applied dna fragments |
| AU2002236495B2 (en) * | 2000-11-29 | 2006-05-11 | Allergan, Inc. | Intraocular implants for preventing transplant rejection in the eye |
| AU2002353783A1 (en) * | 2001-09-24 | 2003-04-07 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | SUPPRESSORS OF CpG OLIGONUCLEOTIDES AND METHODS OF USE |
| US7084157B2 (en) * | 2002-05-17 | 2006-08-01 | Rajeev Raut | Ophthalmic pharmaceutical compositions and methods for treating ocular inflammation |
| AU2003263963A1 (en) | 2002-08-01 | 2004-02-23 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | Method of treating inflammatory arthropathies with suppressors of cpg oligonucleotides |
| US8043622B2 (en) * | 2002-10-08 | 2011-10-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating inflammatory lung disease with suppressors of CpG oligonucleotides |
-
2005
- 2005-05-05 CA CA2565714A patent/CA2565714C/en not_active Expired - Fee Related
- 2005-05-05 US US11/579,518 patent/US8895521B2/en not_active Expired - Fee Related
- 2005-05-05 MX MXPA06012915A patent/MXPA06012915A/es active IP Right Grant
- 2005-05-05 CN CN2005800203908A patent/CN1989439B/zh not_active Expired - Fee Related
- 2005-05-05 WO PCT/US2005/015761 patent/WO2005115359A2/en not_active Ceased
- 2005-05-05 EP EP05780059A patent/EP1751612B1/de not_active Expired - Lifetime
- 2005-05-05 AU AU2005247341A patent/AU2005247341B2/en not_active Ceased
- 2005-05-05 AT AT05780059T patent/ATE423990T1/de not_active IP Right Cessation
- 2005-05-05 JP JP2007511612A patent/JP5014122B2/ja not_active Expired - Fee Related
- 2005-05-05 DE DE602005012948T patent/DE602005012948D1/de not_active Expired - Lifetime
-
2008
- 2008-08-05 AU AU2008203509A patent/AU2008203509B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2565714A1 (en) | 2005-12-08 |
| WO2005115359A2 (en) | 2005-12-08 |
| JP5014122B2 (ja) | 2012-08-29 |
| AU2005247341B2 (en) | 2008-05-08 |
| EP1751612B1 (de) | 2009-02-25 |
| AU2008203509B2 (en) | 2010-05-13 |
| US20090082288A1 (en) | 2009-03-26 |
| EP1751612A2 (de) | 2007-02-14 |
| AU2008203509A1 (en) | 2008-08-28 |
| CN1989439B (zh) | 2010-12-29 |
| DE602005012948D1 (de) | 2009-04-09 |
| JP2007536258A (ja) | 2007-12-13 |
| US8895521B2 (en) | 2014-11-25 |
| AU2005247341A1 (en) | 2005-12-08 |
| WO2005115359A3 (en) | 2006-04-27 |
| CN1989439A (zh) | 2007-06-27 |
| MXPA06012915A (es) | 2007-03-01 |
| CA2565714C (en) | 2014-12-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |