ATE423990T1 - Verfahren und zusammensetzungen zur behandlung von uveitis - Google Patents
Verfahren und zusammensetzungen zur behandlung von uveitisInfo
- Publication number
- ATE423990T1 ATE423990T1 AT05780059T AT05780059T ATE423990T1 AT E423990 T1 ATE423990 T1 AT E423990T1 AT 05780059 T AT05780059 T AT 05780059T AT 05780059 T AT05780059 T AT 05780059T AT E423990 T1 ATE423990 T1 AT E423990T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions
- methods
- uveitis
- treating uveitis
- treatment
- Prior art date
Links
- 206010046851 Uveitis Diseases 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 108091034117 Oligonucleotide Proteins 0.000 abstract 2
- 208000002691 Choroiditis Diseases 0.000 abstract 1
- 206010022941 Iridocyclitis Diseases 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 201000007407 panuveitis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
- C12N2310/151—Nucleic acids forming more than 2 strands, e.g. TFOs more than 3 strands, e.g. tetrads, H-DNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56927604P | 2004-05-06 | 2004-05-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE423990T1 true ATE423990T1 (de) | 2009-03-15 |
Family
ID=35395815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05780059T ATE423990T1 (de) | 2004-05-06 | 2005-05-05 | Verfahren und zusammensetzungen zur behandlung von uveitis |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8895521B2 (de) |
| EP (1) | EP1751612B1 (de) |
| JP (1) | JP5014122B2 (de) |
| CN (1) | CN1989439B (de) |
| AT (1) | ATE423990T1 (de) |
| AU (2) | AU2005247341B2 (de) |
| CA (1) | CA2565714C (de) |
| DE (1) | DE602005012948D1 (de) |
| MX (1) | MXPA06012915A (de) |
| WO (1) | WO2005115359A2 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003027313A2 (en) | 2001-09-24 | 2003-04-03 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | SUPPRESSORS OF CpG OLIGONUCLEOTIDES AND METHODS OF USE |
| EP1575504A4 (de) | 2002-08-01 | 2009-11-04 | Us Gov Health & Human Serv | Verfahren zur behandlung von entzündlichen arthropathien mit suppressoren der cpg-oligonucleotide |
| US8043622B2 (en) | 2002-10-08 | 2011-10-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating inflammatory lung disease with suppressors of CpG oligonucleotides |
| US20160106717A1 (en) | 2004-09-24 | 2016-04-21 | Gen Pharma Holdings LLC | Cai-based systems and methods for the localized treatment of uveitis |
| RU2311173C1 (ru) * | 2006-02-27 | 2007-11-27 | Яхья Хаджибикарович Вышегуров | Способ лечения эндофтальмитов и увеитов неясной и вирусной этиологии |
| WO2009143292A2 (en) * | 2008-05-21 | 2009-11-26 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating pneumoconiosis with oligodeoxynucleotides |
| JO3417B1 (ar) | 2010-01-08 | 2019-10-20 | Regeneron Pharma | الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r |
| US9157919B2 (en) * | 2010-12-21 | 2015-10-13 | Index Pharmaceuticals Ab | Method for identifying biologically active oligonucleotides capable of modulating the immune system |
| EP2468867A1 (de) * | 2010-12-21 | 2012-06-27 | Index Pharmaceuticals AB | Verfahren zur Identifizierung biologisch aktiver Oligonukleotide zur Modulation des Immunsystems |
| WO2016061378A1 (en) * | 2014-10-16 | 2016-04-21 | Gen Pharma Holdings, Llc | Cai-based systems and methods for the localized treatment of uveitis |
| WO2017079443A1 (en) | 2015-11-03 | 2017-05-11 | Sanofi Biotechnology | Compositions comprising il6r antibodies for the treatment of uveitis and macular edema and methods of using same |
| JP7034951B2 (ja) | 2016-06-08 | 2022-03-14 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 操作されたウイルスベクターは炎症および免疫応答の誘導を低減する |
| JP2021502381A (ja) | 2017-11-08 | 2021-01-28 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ウイルスベクター誘発性炎症反応を阻害するための組成物および方法 |
| CR20200260A (es) * | 2017-12-15 | 2020-08-01 | Bayer Animal Health Gmbh | Composiciones inmunoestimulantes |
| US20210060017A1 (en) * | 2018-02-27 | 2021-03-04 | Shilpa Medicare Ltd | Methotrexate ophthalmic solution |
| SG11202101674QA (en) | 2018-08-29 | 2021-03-30 | Regeneron Pharma | Methods and compositions for treating subjects having rheumatoid arthritis |
| MA54861A (fr) | 2019-01-31 | 2021-12-08 | Regeneron Pharma | Anticorps anti-récepteur de l'il6 pour traiter l'arthrite idiopathique juvénile |
| SG11202111742QA (en) | 2019-04-24 | 2021-11-29 | Sanofi Biotechnology | Methods of diagnosis and treatment of rheumatoid arthritis |
| CA3142710A1 (en) | 2019-06-04 | 2020-12-10 | Sanofi Biotechnology | Compositions and methods for treating pain in subjects with rheumatoid arthritis |
| CN111870607A (zh) * | 2020-07-09 | 2020-11-03 | 温州医科大学 | 盐酸米诺环素作为制备治疗自身免疫性葡萄膜炎药物的应用及其治疗方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469863A (en) * | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US5023243A (en) * | 1981-10-23 | 1991-06-11 | Molecular Biosystems, Inc. | Oligonucleotide therapeutic agent and method of making same |
| DE3280400D1 (de) | 1981-10-23 | 1992-06-04 | Molecular Biosystems Inc | Oligonukleotides heilmittel und dessen herstellungsverfahren. |
| US6153595A (en) | 1990-08-16 | 2000-11-28 | Isis Pharmaceuticals Inc. | Composition and method for treatment of CMV infections |
| WO1995026204A1 (en) * | 1994-03-25 | 1995-10-05 | Isis Pharmaceuticals, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
| EP1167379A3 (de) | 1994-07-15 | 2004-09-08 | University Of Iowa Research Foundation | Immunomodulatorische Oligonukleotide |
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| WO2001074342A2 (en) | 2000-03-31 | 2001-10-11 | Trustees Of Boston University | Use of locally applied dna fragments |
| US7094766B1 (en) * | 1995-06-06 | 2006-08-22 | Trustees Of Boston University | Use of locally applied DNA fragments |
| AU4163797A (en) | 1996-08-29 | 1998-03-19 | Millennium Pharmaceuticals, Inc. | (rp) compositions and therapeutic and diagnostic uses therefor |
| US5856462A (en) | 1996-09-10 | 1999-01-05 | Hybridon Incorporated | Oligonucleotides having modified CpG dinucleosides |
| EP0998293A4 (de) * | 1997-01-17 | 2002-07-17 | Icn Pharmaceuticals | Behandlungen von zytokin-bedingten krankheiten |
| WO1998037919A1 (en) | 1997-02-28 | 1998-09-03 | University Of Iowa Research Foundation | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS |
| DK1005368T3 (da) | 1997-03-10 | 2010-01-04 | Ottawa Hospital Res Inst | Anvendelse af nukleinsyrer, der indeholder ikke-metyleret CpG dinukleotid i kombination med alun som hjælpestoffer |
| EP1003531B1 (de) | 1997-05-20 | 2007-08-22 | Ottawa Health Research Institute | Verfahren zur Herstellung von Nukleinsäurekonstrukten |
| AU760549B2 (en) | 1998-04-03 | 2003-05-15 | University Of Iowa Research Foundation, The | Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines |
| US7244710B2 (en) * | 2002-05-21 | 2007-07-17 | Zengen, Inc. | Treatment of ophthalmic infections using antimicrobial peptides |
| US7585847B2 (en) * | 2000-02-03 | 2009-09-08 | Coley Pharmaceutical Group, Inc. | Immunostimulatory nucleic acids for the treatment of asthma and allergy |
| EP1339438B1 (de) * | 2000-11-29 | 2005-10-19 | Allergan Inc. | Verhinderung von transplantatabstossung im auge |
| WO2003027313A2 (en) * | 2001-09-24 | 2003-04-03 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | SUPPRESSORS OF CpG OLIGONUCLEOTIDES AND METHODS OF USE |
| US7084157B2 (en) * | 2002-05-17 | 2006-08-01 | Rajeev Raut | Ophthalmic pharmaceutical compositions and methods for treating ocular inflammation |
| EP1575504A4 (de) | 2002-08-01 | 2009-11-04 | Us Gov Health & Human Serv | Verfahren zur behandlung von entzündlichen arthropathien mit suppressoren der cpg-oligonucleotide |
| US8043622B2 (en) * | 2002-10-08 | 2011-10-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating inflammatory lung disease with suppressors of CpG oligonucleotides |
-
2005
- 2005-05-05 CN CN2005800203908A patent/CN1989439B/zh not_active Expired - Fee Related
- 2005-05-05 JP JP2007511612A patent/JP5014122B2/ja not_active Expired - Fee Related
- 2005-05-05 US US11/579,518 patent/US8895521B2/en not_active Expired - Fee Related
- 2005-05-05 EP EP05780059A patent/EP1751612B1/de not_active Expired - Lifetime
- 2005-05-05 WO PCT/US2005/015761 patent/WO2005115359A2/en not_active Ceased
- 2005-05-05 CA CA2565714A patent/CA2565714C/en not_active Expired - Fee Related
- 2005-05-05 DE DE602005012948T patent/DE602005012948D1/de not_active Expired - Lifetime
- 2005-05-05 MX MXPA06012915A patent/MXPA06012915A/es active IP Right Grant
- 2005-05-05 AT AT05780059T patent/ATE423990T1/de not_active IP Right Cessation
- 2005-05-05 AU AU2005247341A patent/AU2005247341B2/en not_active Ceased
-
2008
- 2008-08-05 AU AU2008203509A patent/AU2008203509B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005247341A1 (en) | 2005-12-08 |
| MXPA06012915A (es) | 2007-03-01 |
| CN1989439B (zh) | 2010-12-29 |
| CA2565714C (en) | 2014-12-23 |
| US20090082288A1 (en) | 2009-03-26 |
| AU2008203509B2 (en) | 2010-05-13 |
| CA2565714A1 (en) | 2005-12-08 |
| AU2005247341B2 (en) | 2008-05-08 |
| DE602005012948D1 (de) | 2009-04-09 |
| WO2005115359A2 (en) | 2005-12-08 |
| JP2007536258A (ja) | 2007-12-13 |
| EP1751612A2 (de) | 2007-02-14 |
| US8895521B2 (en) | 2014-11-25 |
| AU2008203509A1 (en) | 2008-08-28 |
| EP1751612B1 (de) | 2009-02-25 |
| JP5014122B2 (ja) | 2012-08-29 |
| WO2005115359A3 (en) | 2006-04-27 |
| CN1989439A (zh) | 2007-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |