ATE425263T1 - Multiplex-oligonukleotidaddition und zielamplifikation - Google Patents
Multiplex-oligonukleotidaddition und zielamplifikationInfo
- Publication number
- ATE425263T1 ATE425263T1 AT02803690T AT02803690T ATE425263T1 AT E425263 T1 ATE425263 T1 AT E425263T1 AT 02803690 T AT02803690 T AT 02803690T AT 02803690 T AT02803690 T AT 02803690T AT E425263 T1 ATE425263 T1 AT E425263T1
- Authority
- AT
- Austria
- Prior art keywords
- templates
- target amplification
- multiplex oligonucleotide
- oligonucleotide addition
- appending
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 2
- 230000003321 amplification Effects 0.000 title abstract 2
- 238000003199 nucleic acid amplification method Methods 0.000 title abstract 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 230000037452 priming Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
- C12Q1/6855—Ligating adaptors
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33169301P | 2001-11-19 | 2001-11-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE425263T1 true ATE425263T1 (de) | 2009-03-15 |
Family
ID=23294970
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02803690T ATE425263T1 (de) | 2001-11-19 | 2002-11-19 | Multiplex-oligonukleotidaddition und zielamplifikation |
| AT02803689T ATE540127T1 (de) | 2001-11-19 | 2002-11-19 | Multiplex pcr |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02803689T ATE540127T1 (de) | 2001-11-19 | 2002-11-19 | Multiplex pcr |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7510829B2 (de) |
| EP (2) | EP1453979B1 (de) |
| JP (2) | JP2005509433A (de) |
| CN (2) | CN100396788C (de) |
| AT (2) | ATE425263T1 (de) |
| AU (2) | AU2002366099A1 (de) |
| CA (2) | CA2467460A1 (de) |
| DE (1) | DE60231543D1 (de) |
| WO (2) | WO2003044177A2 (de) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110151438A9 (en) * | 2001-11-19 | 2011-06-23 | Affymetrix, Inc. | Methods of Analysis of Methylation |
| WO2003044177A2 (en) * | 2001-11-19 | 2003-05-30 | Parallele Bioscience, Inc. | Multiplex pcr |
| JP2006500959A (ja) * | 2002-09-30 | 2006-01-12 | パラレル バイオサイエンス， インコーポレイテッド | 動的サンプリング結合によるポリヌクレオチド合成および標識化 |
| US20060141498A1 (en) * | 2003-09-25 | 2006-06-29 | Affymetrix, Inc. | Methods for fragmenting nucleic acid |
| NZ546903A (en) * | 2003-10-13 | 2009-06-26 | Genaco Biomedical Products Inc | Method and kit for primer based amplification of nucleic acids |
| US8029454B2 (en) | 2003-11-05 | 2011-10-04 | Baxter International Inc. | High convection home hemodialysis/hemofiltration and sorbent system |
| WO2005049848A2 (en) | 2003-11-12 | 2005-06-02 | Geneohm Sciences, Inc. | Nucleic acid hybridization methods |
| WO2006005081A2 (en) * | 2004-06-30 | 2006-01-12 | Applera Corporation | Compositions and methods for identifying nucleotides in polynucleotide sequences |
| AU2006259565B2 (en) | 2005-06-15 | 2011-01-06 | Complete Genomics, Inc. | Single molecule arrays for genetic and chemical analysis |
| US8137936B2 (en) * | 2005-11-29 | 2012-03-20 | Macevicz Stephen C | Selected amplification of polynucleotides |
| WO2007092538A2 (en) * | 2006-02-07 | 2007-08-16 | President And Fellows Of Harvard College | Methods for making nucleotide probes for sequencing and synthesis |
| EP2589668A1 (de) | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Analyse seltener Zellen mittels Probentrennung und DNA-Etiketten |
| EP2029779A4 (de) | 2006-06-14 | 2010-01-20 | Living Microsystems Inc | Verwendung hoch paralleler snp-genotypisierung zur fötalen diagnose |
| US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
| CN100427607C (zh) * | 2006-09-19 | 2008-10-22 | 南京师范大学 | 一种克隆新基因的试剂盒及其应用方法 |
| US7902345B2 (en) | 2006-12-05 | 2011-03-08 | Sequenom, Inc. | Detection and quantification of biomolecules using mass spectrometry |
| US7862999B2 (en) | 2007-01-17 | 2011-01-04 | Affymetrix, Inc. | Multiplex targeted amplification using flap nuclease |
| US20080293589A1 (en) * | 2007-05-24 | 2008-11-27 | Affymetrix, Inc. | Multiplex locus specific amplification |
| US9404150B2 (en) | 2007-08-29 | 2016-08-02 | Sequenom, Inc. | Methods and compositions for universal size-specific PCR |
| US9388457B2 (en) * | 2007-09-14 | 2016-07-12 | Affymetrix, Inc. | Locus specific amplification using array probes |
| US8716190B2 (en) | 2007-09-14 | 2014-05-06 | Affymetrix, Inc. | Amplification and analysis of selected targets on solid supports |
| US8114276B2 (en) | 2007-10-24 | 2012-02-14 | Baxter International Inc. | Personal hemodialysis system |
| US8592150B2 (en) | 2007-12-05 | 2013-11-26 | Complete Genomics, Inc. | Methods and compositions for long fragment read sequencing |
| US20090233809A1 (en) * | 2008-03-04 | 2009-09-17 | Affymetrix, Inc. | Resequencing methods for identification of sequence variants |
| US9068209B2 (en) | 2008-05-14 | 2015-06-30 | British Columbia Cancer Agency Branch | Gene synthesis by convergent assembly of oligonucleotide subsets |
| US20100279295A1 (en) * | 2009-03-18 | 2010-11-04 | Sequenom, Inc. | Use of thermostable endonucleases for generating reporter molecules |
| EP2425240A4 (de) | 2009-04-30 | 2012-12-12 | Good Start Genetics Inc | Verfahren und zusammensetzung zur bewertung genetischer marker |
| US12129514B2 (en) | 2009-04-30 | 2024-10-29 | Molecular Loop Biosolutions, Llc | Methods and compositions for evaluating genetic markers |
| US20110111462A1 (en) * | 2009-11-06 | 2011-05-12 | Stephen Picone | Composition and Method for Synthesizing a Deoxyribonucleotide Chain Using a Double Stranded Nucleic Acid Complex with a Thermostable Polymerase |
| EP2504448B1 (de) * | 2009-11-25 | 2016-10-19 | Bio-Rad Laboratories, Inc. | Verfahren und zusammensetzung zur erkennung von genetischem material |
| CN101956023B (zh) * | 2010-09-16 | 2012-10-31 | 西南大学 | 检测十种主要柑桔病害病原的基因芯片 |
| CN102399864A (zh) * | 2010-09-16 | 2012-04-04 | 上海迦美生物科技有限公司 | 基于引物保护解除的甲基化dna的检测方法 |
| US9163281B2 (en) | 2010-12-23 | 2015-10-20 | Good Start Genetics, Inc. | Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction |
| EP2673380B1 (de) | 2011-02-09 | 2018-12-12 | Bio-Rad Laboratories, Inc. | Analyse von nukleinsäuren |
| US8759036B2 (en) | 2011-03-21 | 2014-06-24 | Affymetrix, Inc. | Methods for synthesizing pools of probes |
| GB2492042B (en) * | 2011-05-11 | 2020-04-15 | Agilent Technologies Inc | Selector probes for nucleic acid analysis comprising at each end a non-adjacent target specific region |
| EP2768983A4 (de) | 2011-10-17 | 2015-06-03 | Good Start Genetics Inc | Analyseverfahren |
| CN108611398A (zh) | 2012-01-13 | 2018-10-02 | Data生物有限公司 | 通过新一代测序进行基因分型 |
| US8209130B1 (en) | 2012-04-04 | 2012-06-26 | Good Start Genetics, Inc. | Sequence assembly |
| US8812422B2 (en) | 2012-04-09 | 2014-08-19 | Good Start Genetics, Inc. | Variant database |
| US10227635B2 (en) | 2012-04-16 | 2019-03-12 | Molecular Loop Biosolutions, Llc | Capture reactions |
| EP2890814B1 (de) * | 2012-08-30 | 2019-11-13 | Gen-Probe Incorporated | Mehrphasige nukleinsäureamplifikation |
| US8778609B1 (en) | 2013-03-14 | 2014-07-15 | Good Start Genetics, Inc. | Methods for analyzing nucleic acids |
| EP3005200A2 (de) | 2013-06-03 | 2016-04-13 | Good Start Genetics, Inc. | Verfahren und systeme zur speicherung von sequenzlesedaten |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| CN105555972B (zh) | 2013-07-25 | 2020-07-31 | 伯乐生命医学产品有限公司 | 遗传测定 |
| US10851414B2 (en) | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
| WO2015057565A1 (en) | 2013-10-18 | 2015-04-23 | Good Start Genetics, Inc. | Methods for assessing a genomic region of a subject |
| GB2520765A (en) | 2013-12-02 | 2015-06-03 | Vanadis Diagnostics Ab | Multiplex detection of nucleic acids |
| GB2520763A (en) | 2013-12-02 | 2015-06-03 | Vanadis Diagnostics Ab | Nucleic acid probe and method of detecting genomic fragments |
| WO2015175530A1 (en) | 2014-05-12 | 2015-11-19 | Gore Athurva | Methods for detecting aneuploidy |
| EP2983297A1 (de) * | 2014-08-08 | 2016-02-10 | Thomson Licensing | Codeerzeugungsverfahren, Codeerzeugungsvorrichtung und computerlesbares Speichermedium |
| US10174383B2 (en) | 2014-08-13 | 2019-01-08 | Vanadis Diagnostics | Method of estimating the amount of a methylated locus in a sample |
| EP3180445A1 (de) * | 2014-08-14 | 2017-06-21 | Life Technologies Corporation | Multiplex-transkriptomanalyse |
| WO2016025818A1 (en) | 2014-08-15 | 2016-02-18 | Good Start Genetics, Inc. | Systems and methods for genetic analysis |
| US11408024B2 (en) | 2014-09-10 | 2022-08-09 | Molecular Loop Biosciences, Inc. | Methods for selectively suppressing non-target sequences |
| JP2017536087A (ja) | 2014-09-24 | 2017-12-07 | グッド スタート ジェネティクス， インコーポレイテッド | 遺伝子アッセイのロバストネスを増大させるためのプロセス制御 |
| US9441268B2 (en) * | 2014-11-26 | 2016-09-13 | Roche Molecular Systems, Inc. | Detecting single nucleotide polymorphism using overlapping hydrolysis probes |
| US10066259B2 (en) | 2015-01-06 | 2018-09-04 | Good Start Genetics, Inc. | Screening for structural variants |
| WO2016149694A1 (en) * | 2015-03-19 | 2016-09-22 | Quandx Inc. | Ided double-stranded probes for detection of nucleic acid and uses of same |
| ES2963242T3 (es) | 2015-09-18 | 2024-03-25 | Vanadis Diagnostics | Conjunto de sondas para analizar una muestra de ADN y método para utilizar el mismo |
| JP6941680B2 (ja) | 2016-10-24 | 2021-09-29 | ジェネインフォセック、インコーポレイテッド | 核酸内に存在する情報の秘匿化 |
| US11661624B2 (en) | 2017-03-30 | 2023-05-30 | Pioneer Hi-Bred International, Inc. | Methods of identifying and characterizing gene editing variations in nucleic acids |
| US11441174B2 (en) | 2017-06-02 | 2022-09-13 | Affymetrix, Inc. | Array-based methods for analysing mixed samples using differently labelled allele-specific probes |
| CN110914448A (zh) | 2017-06-02 | 2020-03-24 | 昂飞股份有限公司 | 使用差异性标记的等位基因特异性探针分析混合样品的基于阵列的方法 |
| CN107385052B (zh) * | 2017-08-08 | 2020-10-30 | 中国林业科学研究院热带林业研究所 | 用于鉴定桉树无性系的str引物及其应用 |
| CN111918965A (zh) * | 2018-04-28 | 2020-11-10 | 深圳华大生命科学研究院 | 一种胎儿游离核酸的富集方法及其应用 |
| CN108660146B (zh) * | 2018-05-22 | 2019-03-19 | 南京诺唯赞生物科技有限公司 | 一种提高PCR片段兼容性与效率的Topo1连接方法 |
| EP3836967A4 (de) | 2018-07-30 | 2022-06-15 | ReadCoor, LLC | Verfahren und systeme zur probenverarbeitung oder -analyse |
| WO2020056004A1 (en) | 2018-09-11 | 2020-03-19 | The Board Of Trustees Of The Lelandstanford Junior University | Methods and systems for multiplex gene amplification from ultra-low dna input amounts and uses thereof |
| CN115362264A (zh) | 2020-01-29 | 2022-11-18 | 10X基因组学有限公司 | 用于分析物检测的组合物和方法 |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US588731A (en) * | 1897-08-24 | Slate-sprinkler | ||
| TW205070B (de) | 1986-06-30 | 1993-05-01 | Takeda Pharm Industry Co Ltd | |
| US5185243A (en) | 1988-08-25 | 1993-02-09 | Syntex (U.S.A.) Inc. | Method for detection of specific nucleic acid sequences |
| CA1339731C (en) * | 1988-10-12 | 1998-03-17 | Charles T. Caskey | Multiplex genomic dna amplification for deletion detection |
| US5508178A (en) | 1989-01-19 | 1996-04-16 | Rose; Samuel | Nucleic acid amplification using single primer |
| GB8920097D0 (en) * | 1989-09-06 | 1989-10-18 | Ici Plc | Amplification processes |
| US5595891A (en) | 1990-07-19 | 1997-01-21 | Behringwerke Ag | Method for producing a polynucleotide for use in single primer amplification |
| US5439793A (en) | 1990-07-19 | 1995-08-08 | Syntex (U.S.A.) Inc. | Method for producing a polynucleotide having an intramolecularly base-paired structure |
| HU223760B1 (hu) | 1991-09-24 | 2005-01-28 | Keygene N.V. | Szelektív restrikciós fragmentumsokszorosítás, általános módszer DNS-fingerprint analízisére |
| US5612199A (en) | 1991-10-11 | 1997-03-18 | Behringwerke Ag | Method for producing a polynucleotide for use in single primer amplification |
| US5731171A (en) * | 1993-07-23 | 1998-03-24 | Arch Development Corp. | Sequence independent amplification of DNA |
| US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US5834252A (en) | 1995-04-18 | 1998-11-10 | Glaxo Group Limited | End-complementary polymerase reaction |
| US5928905A (en) * | 1995-04-18 | 1999-07-27 | Glaxo Group Limited | End-complementary polymerase reaction |
| US5851770A (en) * | 1994-04-25 | 1998-12-22 | Variagenics, Inc. | Detection of mismatches by resolvase cleavage using a magnetic bead support |
| CA2195562A1 (en) * | 1994-08-19 | 1996-02-29 | Pe Corporation (Ny) | Coupled amplification and ligation method |
| US5491063A (en) | 1994-09-01 | 1996-02-13 | Hoffmann-La Roche Inc. | Methods for in-solution quenching of fluorescently labeled oligonucleotide probes |
| US5846719A (en) | 1994-10-13 | 1998-12-08 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
| US5565340A (en) | 1995-01-27 | 1996-10-15 | Clontech Laboratories, Inc. | Method for suppressing DNA fragment amplification during PCR |
| US5830655A (en) * | 1995-05-22 | 1998-11-03 | Sri International | Oligonucleotide sizing using cleavable primers |
| US5882856A (en) | 1995-06-07 | 1999-03-16 | Genzyme Corporation | Universal primer sequence for multiplex DNA amplification |
| US5728526A (en) | 1995-06-07 | 1998-03-17 | Oncor, Inc. | Method for analyzing a nucleotide sequence |
| JP3790797B2 (ja) | 1995-07-11 | 2006-06-28 | フォーファス | グリコシラーゼによる候補座位のヌクレオチド配列の検出 |
| US5888731A (en) * | 1995-08-30 | 1999-03-30 | Visible Genetics Inc. | Method for identification of mutations using ligation of multiple oligonucleotide probes |
| US6458530B1 (en) | 1996-04-04 | 2002-10-01 | Affymetrix Inc. | Selecting tag nucleic acids |
| CA2255774C (en) * | 1996-05-29 | 2008-03-18 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
| WO1999049293A2 (en) | 1998-03-24 | 1999-09-30 | Boston Probes, Inc. | Methods, kits and compositions pertaining to detection complexes |
| GB9812768D0 (en) | 1998-06-13 | 1998-08-12 | Zeneca Ltd | Methods |
| US6355422B1 (en) * | 1998-06-24 | 2002-03-12 | City Of Hope | Single tube PCR assay for detection of chromosomal mutations: application to the inversion hotspot in the factor VIII gene including optional use of subcycling PCR |
| US6743605B1 (en) | 1998-06-24 | 2004-06-01 | Enzo Life Sciences, Inc. | Linear amplification of specific nucleic acid sequences |
| US6410278B1 (en) | 1998-11-09 | 2002-06-25 | Eiken Kagaku Kabushiki Kaisha | Process for synthesizing nucleic acid |
| US20020119448A1 (en) | 1999-06-23 | 2002-08-29 | Joseph A. Sorge | Methods of enriching for and identifying polymorphisms |
| CA2379132C (en) | 1999-07-14 | 2011-05-31 | Packard Bioscience Company | Method for multiplexed analysis of a plurality of target nucleic acid sequences in a sample |
| US6528254B1 (en) | 1999-10-29 | 2003-03-04 | Stratagene | Methods for detection of a target nucleic acid sequence |
| US7118860B2 (en) * | 1999-10-29 | 2006-10-10 | Stratagene California | Methods for detection of a target nucleic acid by capture |
| GB9927576D0 (en) | 1999-11-23 | 2000-01-19 | Univ Birmingham | Novel assay |
| US6207424B1 (en) * | 1999-11-23 | 2001-03-27 | Maxim Biotech, Inc. | Self-primed amplification system |
| AU2001238068A1 (en) | 2000-02-07 | 2001-08-14 | Illumina, Inc. | Nucleic acid detection methods using universal priming |
| WO2001094625A2 (en) | 2000-06-06 | 2001-12-13 | Tm Bioscience Corporation | Capture moieties for nucleic acids and uses thereof |
| EP1330547A4 (de) | 2000-10-04 | 2005-01-19 | Univ Leland Stanford Junior | Renaturierung, reassoziierung, assoziierung und hybridisierung von nukleinsäuremolekülen |
| US6350580B1 (en) | 2000-10-11 | 2002-02-26 | Stratagene | Methods for detection of a target nucleic acid using a probe comprising secondary structure |
| IE20000887A1 (en) | 2000-11-03 | 2002-12-11 | Univ College Cork Nat Univ Ie | Method for the amplification and optional characterisation of nucleic acids |
| JP4422963B2 (ja) | 2001-01-25 | 2010-03-03 | ルミネックス モレキュラー ダイアグノスティックス， インク． | 標識および標識補体として使用するための非クロス交雑しているポリヌクレオチドのファミリー、製品、ならびにその使用方法 |
| WO2002070751A1 (en) | 2001-03-02 | 2002-09-12 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Pcr method |
| WO2003044177A2 (en) | 2001-11-19 | 2003-05-30 | Parallele Bioscience, Inc. | Multiplex pcr |
-
2002
- 2002-11-19 WO PCT/US2002/037238 patent/WO2003044177A2/en not_active Ceased
- 2002-11-19 CN CNB028265912A patent/CN100396788C/zh not_active Expired - Fee Related
- 2002-11-19 AU AU2002366099A patent/AU2002366099A1/en not_active Abandoned
- 2002-11-19 AT AT02803690T patent/ATE425263T1/de not_active IP Right Cessation
- 2002-11-19 CA CA002467460A patent/CA2467460A1/en not_active Abandoned
- 2002-11-19 JP JP2003545802A patent/JP2005509433A/ja active Pending
- 2002-11-19 EP EP02803689A patent/EP1453979B1/de not_active Expired - Lifetime
- 2002-11-19 US US10/300,285 patent/US7510829B2/en not_active Expired - Fee Related
- 2002-11-19 WO PCT/US2002/037239 patent/WO2003044216A2/en not_active Ceased
- 2002-11-19 AT AT02803689T patent/ATE540127T1/de active
- 2002-11-19 EP EP02803690A patent/EP1456416B1/de not_active Expired - Lifetime
- 2002-11-19 JP JP2003545837A patent/JP2005509440A/ja active Pending
- 2002-11-19 US US10/300,311 patent/US7208295B2/en not_active Expired - Lifetime
- 2002-11-19 CA CA002467577A patent/CA2467577A1/en not_active Abandoned
- 2002-11-19 DE DE60231543T patent/DE60231543D1/de not_active Expired - Fee Related
- 2002-11-19 CN CNA028265955A patent/CN1697882A/zh active Pending
- 2002-11-19 AU AU2002366098A patent/AU2002366098A1/en not_active Abandoned
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2007
- 2007-04-24 US US11/739,654 patent/US7754451B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003044177A2 (en) | 2003-05-30 |
| US7754451B2 (en) | 2010-07-13 |
| AU2002366099A1 (en) | 2003-06-10 |
| CN1697882A (zh) | 2005-11-16 |
| CN100396788C (zh) | 2008-06-25 |
| EP1453979A2 (de) | 2004-09-08 |
| EP1453979A4 (de) | 2005-12-28 |
| CA2467460A1 (en) | 2003-05-30 |
| EP1453979B1 (de) | 2012-01-04 |
| EP1456416A4 (de) | 2006-01-11 |
| DE60231543D1 (de) | 2009-04-23 |
| EP1456416B1 (de) | 2009-03-11 |
| US20090004701A1 (en) | 2009-01-01 |
| AU2002366098A1 (en) | 2003-06-10 |
| WO2003044177A3 (en) | 2003-08-28 |
| US20030104459A1 (en) | 2003-06-05 |
| WO2003044216A3 (en) | 2003-08-14 |
| CA2467577A1 (en) | 2003-05-30 |
| WO2003044216A2 (en) | 2003-05-30 |
| US7510829B2 (en) | 2009-03-31 |
| CN1610758A (zh) | 2005-04-27 |
| EP1456416A2 (de) | 2004-09-15 |
| JP2005509433A (ja) | 2005-04-14 |
| ATE540127T1 (de) | 2012-01-15 |
| JP2005509440A (ja) | 2005-04-14 |
| US7208295B2 (en) | 2007-04-24 |
| US20030096291A1 (en) | 2003-05-22 |
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