ATE427935T1 - Spiro isobenzofurane als neuropeptid y rezeptor antagonisten - Google Patents

Spiro isobenzofurane als neuropeptid y rezeptor antagonisten

Info

Publication number: ATE427935T1
Authority: AT; Austria
Prior art keywords: alk; optionally substituted; aryl; nhalk; oalk
Prior art date: 2001-08-07

Application number

AT02755790T

Other languages

English (en)

Inventor

Takehiro Fukami

Katsumasa Nonoshita

Takeshi Sagara

Hiroyuki Kishino

Original Assignee

Banyu Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-07

Filing date

2002-08-02

Publication date

2009-04-15

2002-08-02 Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd

2009-04-15 Application granted granted Critical

2009-04-15 Publication of ATE427935T1 publication Critical patent/ATE427935T1/de

Links

150000002509 isobenzofuranes Chemical class 0.000 title 1
239000002660 neuropeptide Y receptor antagonist Substances 0.000 title 1
125000003118 aryl group Chemical group 0.000 abstract 5
125000001475 halogen functional group Chemical group 0.000 abstract 3
125000002947 alkylene group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000004438 haloalkoxy group Chemical group 0.000 abstract 2
125000001188 haloalkyl group Chemical group 0.000 abstract 2
125000001072 heteroaryl group Chemical group 0.000 abstract 2
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
150000003413 spiro compounds Chemical class 0.000 abstract 2
101500025005 Homo sapiens Neuropeptide Y Proteins 0.000 abstract 1
208000001953 Hypotension Diseases 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000001195 anabolic effect Effects 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
230000001539 anorectic effect Effects 0.000 abstract 1
230000002075 anti-alcohol Effects 0.000 abstract 1
230000001773 anti-convulsant effect Effects 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
230000003178 anti-diabetic effect Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000002402 anti-lipaemic effect Effects 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
239000003472 antidiabetic agent Substances 0.000 abstract 1
229960003965 antiepileptics Drugs 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
230000000949 anxiolytic effect Effects 0.000 abstract 1
125000000732 arylene group Chemical group 0.000 abstract 1
238000003556 assay Methods 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
206010061428 decreased appetite Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
XKWCTHKJQNUFOQ-HRPSIEBRSA-N gtpl1504 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 XKWCTHKJQNUFOQ-HRPSIEBRSA-N 0.000 abstract 1
125000005549 heteroarylene group Chemical group 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
208000021822 hypotensive Diseases 0.000 abstract 1
230000001077 hypotensive effect Effects 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 1
230000000324 neuroprotective effect Effects 0.000 abstract 1
230000001777 nootropic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940125725 tranquilizer Drugs 0.000 abstract 1
239000003204 tranquilizing agent Substances 0.000 abstract 1
230000002936 tranquilizing effect Effects 0.000 abstract 1

Classifications

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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Addiction (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Hospice & Palliative Care (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT02755790T 2001-08-07 2002-08-02 Spiro isobenzofurane als neuropeptid y rezeptor antagonisten ATE427935T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2001239567		2001-08-07

Publications (1)

Publication Number	Publication Date
ATE427935T1 true ATE427935T1 (de)	2009-04-15

Family

ID=19070298

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02755790T ATE427935T1 (de)	2001-08-07	2002-08-02	Spiro isobenzofurane als neuropeptid y rezeptor antagonisten

Country Status (18)

Country	Link
US (1)	US7205417B2 (de)
EP (1)	EP1415986B1 (de)
JP (1)	JP4341404B2 (de)
KR (1)	KR20040023731A (de)
CN (1)	CN1538956A (de)
AT (1)	ATE427935T1 (de)
AU (1)	AU2002323787B2 (de)
BR (1)	BR0211740A (de)
CA (1)	CA2456599A1 (de)
DE (1)	DE60231880D1 (de)
EA (1)	EA006964B1 (de)
HU (1)	HUP0401108A2 (de)
IL (1)	IL160139A0 (de)
MX (1)	MXPA04001144A (de)
NO (1)	NO20040534L (de)
PL (1)	PL367983A1 (de)
WO (1)	WO2003014083A1 (de)
ZA (1)	ZA200400091B (de)

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2002
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- 2002-08-02 WO PCT/JP2002/007922 patent/WO2003014083A1/ja not_active Ceased
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- 2002-08-02 CN CNA028153073A patent/CN1538956A/zh active Pending
- 2002-08-02 PL PL02367983A patent/PL367983A1/xx not_active Application Discontinuation
- 2002-08-02 EP EP02755790A patent/EP1415986B1/de not_active Expired - Lifetime
- 2002-08-02 DE DE60231880T patent/DE60231880D1/de not_active Expired - Lifetime
- 2002-08-02 US US10/485,955 patent/US7205417B2/en not_active Expired - Fee Related
- 2002-08-02 IL IL16013902A patent/IL160139A0/xx unknown
- 2002-08-02 HU HU0401108A patent/HUP0401108A2/hu unknown
- 2002-08-02 KR KR10-2004-7001947A patent/KR20040023731A/ko not_active Withdrawn
- 2002-08-02 MX MXPA04001144A patent/MXPA04001144A/es unknown
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2004
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Publication number	Publication date
KR20040023731A (ko)	2004-03-18
EP1415986B1 (de)	2009-04-08
DE60231880D1 (de)	2009-05-20
EA200400288A1 (ru)	2004-12-30
AU2002323787B2 (en)	2008-04-24
EA006964B1 (ru)	2006-06-30
PL367983A1 (en)	2005-03-21
HUP0401108A2 (hu)	2004-09-28
MXPA04001144A (es)	2004-07-08
WO2003014083A1 (en)	2003-02-20
JP4341404B2 (ja)	2009-10-07
US20040259890A1 (en)	2004-12-23
CA2456599A1 (en)	2003-02-20
NO20040534L (no)	2004-03-23
IL160139A0 (en)	2004-06-20
BR0211740A (pt)	2004-09-28
JPWO2003014083A1 (ja)	2004-11-25
EP1415986A4 (de)	2005-11-02
EP1415986A1 (de)	2004-05-06
CN1538956A (zh)	2004-10-20
US7205417B2 (en)	2007-04-17
ZA200400091B (en)	2005-06-07

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