ATE430127T1 - Hif hydroxylase-inhibitoren zur anämiebehandlung - Google Patents

Hif hydroxylase-inhibitoren zur anämiebehandlung

Info

Publication number
ATE430127T1
ATE430127T1 AT03712396T AT03712396T ATE430127T1 AT E430127 T1 ATE430127 T1 AT E430127T1 AT 03712396 T AT03712396 T AT 03712396T AT 03712396 T AT03712396 T AT 03712396T AT E430127 T1 ATE430127 T1 AT E430127T1
Authority
AT
Austria
Prior art keywords
hydroxylase inhibitors
hif hydroxylase
anemia treatment
treatment
activity
Prior art date
Application number
AT03712396T
Other languages
English (en)
Inventor
Christopher J Schofield
Patrick H Maxwell
Christopher W Pugh
Peter J Ratcliffe
Original Assignee
Isis Innovation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9933457&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE430127(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Isis Innovation filed Critical Isis Innovation
Application granted granted Critical
Publication of ATE430127T1 publication Critical patent/ATE430127T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
AT03712396T 2002-03-21 2003-03-21 Hif hydroxylase-inhibitoren zur anämiebehandlung ATE430127T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0206711.4A GB0206711D0 (en) 2002-03-21 2002-03-21 HIF Inhibitor
PCT/GB2003/001239 WO2003080566A2 (en) 2002-03-21 2003-03-21 Hif hydroxylase inhibitors

Publications (1)

Publication Number Publication Date
ATE430127T1 true ATE430127T1 (de) 2009-05-15

Family

ID=9933457

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03712396T ATE430127T1 (de) 2002-03-21 2003-03-21 Hif hydroxylase-inhibitoren zur anämiebehandlung

Country Status (13)

Country Link
US (2) US20050227948A1 (de)
EP (2) EP1485347B1 (de)
JP (1) JP2005520859A (de)
CN (6) CN101199503A (de)
AT (1) ATE430127T1 (de)
AU (2) AU2003216857B2 (de)
CA (1) CA2479881A1 (de)
DE (1) DE60327428D1 (de)
ES (1) ES2322992T3 (de)
GB (1) GB0206711D0 (de)
MX (1) MXPA04009155A (de)
PL (1) PL205110B1 (de)
WO (1) WO2003080566A2 (de)

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US8124582B2 (en) 2002-12-06 2012-02-28 Fibrogen, Inc. Treatment of diabetes
US7618940B2 (en) 2002-12-06 2009-11-17 Fibrogen, Inc. Fat regulation
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US20050170019A1 (en) * 2003-10-22 2005-08-04 Fred Hutchinson Cancer Research Center Methods, compositions and devices for inducing stasis in cells
US20050136125A1 (en) * 2003-10-22 2005-06-23 Roth Mark B. Methods, compositions and devices for inducing stasis in cells, tissues, organs, and organisms
EP1733030A2 (de) 2004-03-26 2006-12-20 Isis Innovation Limited Tests zur identifizierung von modulatoren der hydroxylierung von ankyrin-repeat-proteinen durch 2-oxoglutarat-abhängige oxygenase und verfahren zur verwendung davon
PL1676591T3 (pl) * 2004-11-24 2018-12-31 Lifescan, Inc. Kompozycje i sposoby tworzenia unaczynionego środowiska dla przeszczepu komórkowego
US8822535B2 (en) * 2005-04-20 2014-09-02 Fred Hutchinson Cancer Research Center Methods, compositions and articles of manufacture for enhancing survivability of cells, tissues, organs, and organisms
DE102005019712A1 (de) * 2005-04-28 2006-11-09 Bayer Healthcare Ag Dipyridyl-dihydropyrazolone und ihre Verwendung
GB0519605D0 (en) 2005-09-26 2005-11-02 Isis Innovation Assay
WO2007090068A2 (en) 2006-01-27 2007-08-09 Fibrogen, Inc. Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (hif)
EP2016078B1 (de) 2006-04-04 2016-06-15 Fibrogen, Inc. Pyrrolo- und thiazolopyridinverbindungen als hif-modulatoren
AU2008241503A1 (en) * 2007-04-18 2008-10-30 Merck Sharp & Dohme Corp. Novel 1,8-naphthyridine compounds
AU2008319229A1 (en) * 2007-11-02 2009-05-07 Fibrogen, Inc. Methods for reducing blood pressure
US8269008B2 (en) 2007-12-03 2012-09-18 Fibrogen, Inc. Oxazolopyridine and isoxazolopyridine derivatives for use in the treatment of HIF-mediated conditions
EP2252619B1 (de) 2008-01-11 2013-10-09 Fibrogen, Inc. Isothiazolpyridinderivate als modulatoren der hif-(hypoxia-inducible-factor-)aktivität
US8324405B2 (en) 2008-02-05 2012-12-04 Fibrogen, Inc. Chromene derivatives and use thereof as HIF hydroxylase activity inhibitors
WO2009134847A1 (en) * 2008-04-30 2009-11-05 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
GB0809262D0 (en) 2008-05-21 2008-06-25 Isis Innovation Assay
US8217043B2 (en) 2008-08-20 2012-07-10 Fibrogen, Inc. Compounds and methods for their use
CN102272117B (zh) 2008-11-14 2015-06-17 菲布罗根有限公司 作为hif羟化酶抑制剂的苯并噻喃衍生物
EP2553086B1 (de) 2010-03-31 2017-04-19 The Scripps Research Institute Umprogrammierung von zellen
CN103608346B (zh) 2011-02-02 2016-06-15 菲布罗根有限公司 作为缺氧诱导因子(hif)羟化酶抑制剂的萘啶衍生物
GB201102659D0 (en) 2011-02-15 2011-03-30 Isis Innovation Assay
GB201113101D0 (en) 2011-07-28 2011-09-14 Isis Innovation Assay
US9446031B2 (en) 2012-01-18 2016-09-20 National University Of Singapore Compositions and methods for neovascularization
US20150018384A1 (en) * 2012-03-09 2015-01-15 Fibrogen, Inc. Treatment for high cholesterol
WO2014116849A1 (en) 2013-01-24 2014-07-31 Fibrogen, Inc. Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid
WO2017120349A1 (en) * 2016-01-05 2017-07-13 The Trustees Of Columbia University In The City Of New York Compositions and methods for regulating activity of inhibitor of dna binding-2 (id2) protein
US20220409606A1 (en) * 2017-06-15 2022-12-29 The Trustees Of Columbia University In The City Of New York Treatment of neurodegeneration via reprogramming metabolism by inhibiting phd
WO2021216530A1 (en) 2020-04-20 2021-10-28 Akebia Therapeutics, Inc. Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer
WO2022150623A1 (en) 2021-01-08 2022-07-14 Akebia Therapeutics, Inc. Compounds and composition for the treatment of anemia
WO2022251563A1 (en) 2021-05-27 2022-12-01 Keryx Biopharmaceuticals, Inc. Pediatric formulations of ferric citrate

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Also Published As

Publication number Publication date
AU2003216857B2 (en) 2009-06-11
AU2009202216A1 (en) 2009-06-25
GB0206711D0 (en) 2002-05-01
AU2003216857A1 (en) 2003-10-08
CN101199502A (zh) 2008-06-18
EP2065366A2 (de) 2009-06-03
EP2065366A3 (de) 2009-09-02
CN101199503A (zh) 2008-06-18
CN101199512A (zh) 2008-06-18
CN101199537A (zh) 2008-06-18
MXPA04009155A (es) 2004-11-26
WO2003080566A2 (en) 2003-10-02
US20050227948A1 (en) 2005-10-13
CN100369891C (zh) 2008-02-20
JP2005520859A (ja) 2005-07-14
DE60327428D1 (de) 2009-06-10
US7662854B2 (en) 2010-02-16
ES2322992T3 (es) 2009-07-03
CN1653040A (zh) 2005-08-10
CA2479881A1 (en) 2003-10-02
US20070066576A1 (en) 2007-03-22
EP1485347A2 (de) 2004-12-15
PL205110B1 (pl) 2010-03-31
EP1485347B1 (de) 2009-04-29
PL371515A1 (en) 2005-06-27
WO2003080566A3 (en) 2003-12-11
CN101199501A (zh) 2008-06-18

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