ATE431733T1 - Pharmazeutische zusammensetzung enthaltend epothilone - Google Patents

Pharmazeutische zusammensetzung enthaltend epothilone

Info

Publication number: ATE431733T1
Authority: AT; Austria
Prior art keywords: pharmaceutical composition; composition containing; containing epothilones; epothilones; pharmaceutical
Prior art date: 1998-02-05

Application number

AT99907491T

Other languages

English (en)

Inventor

Hoogevest Peter Van

Original Assignee

Novartis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-05

Filing date

1999-02-03

Publication date

2009-06-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26313062&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE431733(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-02-05 Priority claimed from GBGB9802451.6A external-priority patent/GB9802451D0/en

1998-06-24 Priority claimed from GBGB9813646.8A external-priority patent/GB9813646D0/en

1999-02-03 Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh

2009-06-15 Application granted granted Critical

2009-06-15 Publication of ATE431733T1 publication Critical patent/ATE431733T1/de

Links

229930013356 epothilone Natural products 0.000 title 1
HESCAJZNRMSMJG-KKQRBIROSA-N epothilone A Chemical compound C/C([C@@H]1C[C@@H]2O[C@@H]2CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 HESCAJZNRMSMJG-KKQRBIROSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Inorganic Chemistry (AREA)
Organic Chemistry (AREA)
Dermatology (AREA)
Biochemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT99907491T 1998-02-05 1999-02-03 Pharmazeutische zusammensetzung enthaltend epothilone ATE431733T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9802451.6A GB9802451D0 (en)	1998-02-05	1998-02-05	Organic compounds
GBGB9813646.8A GB9813646D0 (en)	1998-06-24	1998-06-24	Organic compounds
PCT/EP1999/000702 WO1999039694A2 (en)	1998-02-05	1999-02-03	Compositions containing organic compounds

Publications (1)

Publication Number	Publication Date
ATE431733T1 true ATE431733T1 (de)	2009-06-15

Family

ID=26313062

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99907491T ATE431733T1 (de)	1998-02-05	1999-02-03	Pharmazeutische zusammensetzung enthaltend epothilone

Country Status (36)

Country	Link
US (5)	US20030203876A1 (de)
EP (1)	EP1052974B1 (de)
JP (2)	JP4644364B2 (de)
KR (3)	KR20080016756A (de)
CN (2)	CN100396276C (de)
AR (1)	AR017979A1 (de)
AT (1)	ATE431733T1 (de)
AU (1)	AU753519B2 (de)
BE (1)	BE1012140A3 (de)
BR (1)	BR9907647B1 (de)
CA (1)	CA2320182C (de)
CL (1)	CL2003002786A1 (de)
CO (1)	CO4920246A1 (de)
CY (1)	CY1109311T1 (de)
CZ (1)	CZ303168B6 (de)
DE (1)	DE69940904D1 (de)
DK (1)	DK1052974T3 (de)
ES (1)	ES2324378T3 (de)
FR (1)	FR2774909B1 (de)
HU (1)	HUP0101564A3 (de)
ID (1)	ID26549A (de)
IL (2)	IL137550A0 (de)
IT (1)	IT1313549B1 (de)
MX (1)	MXPA00007681A (de)
MY (1)	MY125921A (de)
NO (2)	NO329376B1 (de)
NZ (1)	NZ506389A (de)
PE (1)	PE20000272A1 (de)
PL (1)	PL201329B1 (de)
PT (1)	PT1052974E (de)
RU (1)	RU2214246C2 (de)
SI (1)	SI1052974T1 (de)
SK (2)	SK287487B6 (de)
TR (1)	TR200002299T2 (de)
TW (1)	TW457095B (de)
WO (1)	WO1999039694A2 (de)

Families Citing this family (54)

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US6537579B1 (en) *	1993-02-22	2003-03-25	American Bioscience, Inc.	Compositions and methods for administration of pharmacologically active compounds
DE59609305D1 (de)	1995-11-17	2002-07-11	Biotechnolog Forschung Gmbh	Epothilon-Derivate und deren Herstellung
ATE267197T1 (de)	1996-11-18	2004-06-15	Biotechnolog Forschung Gmbh	Epothilon d, dessen herstellung und dessen verwendung als cytostatisches mittel bzw. als pflanzenschutzmittel
EP1386922B1 (de)	1996-12-03	2012-04-11	Sloan-Kettering Institute For Cancer Research	Synthese von Epitholonen, Zwischenprodukte, Analoga und ihre Verwendung
US6204388B1 (en)	1996-12-03	2001-03-20	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
US6605599B1 (en)	1997-07-08	2003-08-12	Bristol-Myers Squibb Company	Epothilone derivatives
US6365749B1 (en)	1997-12-04	2002-04-02	Bristol-Myers Squibb Company	Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
GB9802451D0 (en) *	1998-02-05	1998-04-01	Ciba Geigy Ag	Organic compounds
FR2775187B1 (fr) *	1998-02-25	2003-02-21	Novartis Ag	Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
US6498257B1 (en)	1998-04-21	2002-12-24	Bristol-Myers Squibb Company	2,3-olefinic epothilone derivatives
US6399638B1 (en)	1998-04-21	2002-06-04	Bristol-Myers Squibb Company	12,13-modified epothilone derivatives
US6410301B1 (en)	1998-11-20	2002-06-25	Kosan Biosciences, Inc.	Myxococcus host cells for the production of epothilones
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US6518421B1 (en)	2000-03-20	2003-02-11	Bristol-Myers Squibb Company	Process for the preparation of epothilone analogs
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US8618085B2 (en) *	2000-04-28	2013-12-31	Koasn Biosciences Incorporated	Therapeutic formulations of desoxyepothilones
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SK8552003A3 (en)	2001-01-25	2004-06-08	Bristol Myers Squibb Co	Parenteral formulation containing epothilone analogs
NZ526871A (en) *	2001-01-25	2006-01-27	Bristol Myers Squibb Co	Pharmaceutical dosage forms of epothilones for oral administration
CA2434526C (en) *	2001-01-25	2011-11-01	Bristol Myers Squibb Company	Methods of administering epothilone analogs for the treatment of cancer
DE60225666T2 (de)	2001-01-25	2009-04-16	Bristol-Myers Squibb Co.	Verfahren zur herstellung von pharmazeutischen zusammensetzungen enthaltend epothilon-analoga zur krebsbehandlung
US6893859B2 (en)	2001-02-13	2005-05-17	Kosan Biosciences, Inc.	Epothilone derivatives and methods for making and using the same
EE200300397A (et)	2001-02-20	2003-12-15	Bristol-Myers Squibb Company	Epotilooni derivaadid refraktaarsete kasvajate raviks
IL156988A0 (en)	2001-02-20	2004-02-08	Bristol Myers Squibb Co	Pharmaceutical compositions containing epothilone derivatives
ATE554756T1 (de)	2001-03-14	2012-05-15	Bristol Myers Squibb Co	Kombination aus epothilon-analog und chemotherapeutika zur behandlung von proliferativen erkrankungen
EP1372650B1 (de) *	2001-03-19	2008-11-19	Novartis AG	Kombinationen, ein antidiarrhoikum und epothilon oder ein epothilonderivat enthaltend
US6800653B2 (en)	2001-06-01	2004-10-05	Bristol-Myers Squibb Compnay	Epothilone derivatives
AU2008203233B2 (en) *	2001-07-19	2010-04-29	Novartis Ag	Combinations comprising epothilones and pharmaceutical uses thereof
TWI315982B (en)	2001-07-19	2009-10-21	Novartis Ag	Combinations comprising epothilones and pharmaceutical uses thereof
AU2003235761A1 (en)	2002-01-14	2003-07-24	Novartis Ag	Combinations comprising epothilones and anti-metabolites
US7211593B2 (en)	2002-03-12	2007-05-01	Bristol-Myers Squibb Co.	C12-cyano epothilone derivatives
TW200403994A (en)	2002-04-04	2004-03-16	Bristol Myers Squibb Co	Oral administration of EPOTHILONES
TW200400191A (en)	2002-05-15	2004-01-01	Bristol Myers Squibb Co	Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives
US20050271669A1 (en) *	2002-06-10	2005-12-08	Hohneker John A	Combinations comprising epothilones and pharmaceutical uses thereof
WO2003105828A1 (en)	2002-06-14	2003-12-24	Bristol-Myers Squibb Company	Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
ATE350383T1 (de)	2002-08-23	2007-01-15	Sloan Kettering Inst Cancer	Synthese von epothilonen, zwischenprodukte dafür, analoga und deren verwendungen
US7649006B2 (en)	2002-08-23	2010-01-19	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
HRP20050278A2 (en)	2002-09-23	2005-10-31	Bristol-Myers Squibb Company	Methods for the preparation, isolation and purification of epothilone b, and x-ray crystal structures of epothilone b
JP2006504743A (ja)	2002-10-09	2006-02-09	コーザンバイオサイエンシスインコーポレイテッド	治療製剤
ES2279139T3 (es) *	2002-10-15	2007-08-16	Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College	Uso de los derivados de epotilona para el tratamiento del hiperparatiroidismo.
ATE452888T1 (de)	2002-11-07	2010-01-15	Kosan Biosciences Inc	Trans-9,10-dehydroepothilon c und d, analoga davon und verfahren zu deren herstellung
KR20060122819A (ko) *	2003-10-09	2006-11-30	코산 바이오사이언시즈, 인코포레이티드	치료학적 제형
CN1867343A (zh) *	2003-10-09	2006-11-22	高山生物科学股份有限公司	治疗制剂
US20050171167A1 (en) *	2003-11-04	2005-08-04	Haby Thomas A.	Process and formulation containing epothilones and analogs thereof
US7655442B2 (en)	2004-01-29	2010-02-02	Eisai R&D Management Co., Ltd.	Method for stabilizing macrolide compounds
US20060121511A1 (en)	2004-11-30	2006-06-08	Hyerim Lee	Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents
EP1674098A1 (de)	2004-12-23	2006-06-28	Schering Aktiengesellschaft	Stabile, unbedenkliche parenterale Formulierungen von hochreaktiven organischen Arzneimitteln mit niedriger oder keiner wässrigen Löslichkeit
CN100409846C (zh) *	2005-11-22	2008-08-13	菏泽睿鹰制药集团有限公司	一种埃坡霉素b脂质体制剂及应用
CN101506217B (zh)	2006-08-16	2012-09-05	诺瓦提斯公司	埃坡霉素b的晶型及在药物组合物中的用途
EP2210584A1 (de)	2009-01-27	2010-07-28	Bayer Schering Pharma Aktiengesellschaft	Stabile Polymerzusammensetzung mit einem Epothilon und einem amphiphilischen Blockpolymer
CN101642453B (zh) *	2009-09-15	2011-03-16	湖南迪诺制药有限公司	一种含有埃坡霉素b的药物制剂
GB201505347D0 (en) *	2015-03-27	2015-05-13	Salupont Consulting Ltd	Sterilisation of s-nitrosothiols
ES3024636T3 (en) *	2017-09-27	2025-06-04	Novartis Ag	Parenteral formulation comprising siponimod

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1999
- 1999-02-03 KR KR1020087003239A patent/KR20080016756A/ko not_active Ceased
- 1999-02-03 MX MXPA00007681A patent/MXPA00007681A/es active IP Right Grant
- 1999-02-03 SK SK5020-2009A patent/SK287487B6/sk not_active IP Right Cessation
- 1999-02-03 ID IDW20001472A patent/ID26549A/id unknown
- 1999-02-03 AT AT99907491T patent/ATE431733T1/de active
- 1999-02-03 NZ NZ506389A patent/NZ506389A/en not_active IP Right Cessation
- 1999-02-03 TR TR2000/02299T patent/TR200002299T2/xx unknown
- 1999-02-03 JP JP2000530194A patent/JP4644364B2/ja not_active Expired - Fee Related
- 1999-02-03 AU AU27226/99A patent/AU753519B2/en not_active Ceased
- 1999-02-03 EP EP99907491A patent/EP1052974B1/de not_active Revoked
- 1999-02-03 MY MYPI99000384A patent/MY125921A/en unknown
- 1999-02-03 CN CNB998036722A patent/CN100396276C/zh not_active Expired - Fee Related
- 1999-02-03 RU RU2000123171/14A patent/RU2214246C2/ru not_active IP Right Cessation
- 1999-02-03 PT PT99907491T patent/PT1052974E/pt unknown
- 1999-02-03 ES ES99907491T patent/ES2324378T3/es not_active Expired - Lifetime
- 1999-02-03 AR ARP990100446A patent/AR017979A1/es not_active Application Discontinuation
- 1999-02-03 WO PCT/EP1999/000702 patent/WO1999039694A2/en not_active Ceased
- 1999-02-03 KR KR1020057022710A patent/KR20060002022A/ko not_active Ceased
- 1999-02-03 PL PL342629A patent/PL201329B1/pl unknown
- 1999-02-03 IL IL13755099A patent/IL137550A0/xx unknown
- 1999-02-03 HU HU0101564A patent/HUP0101564A3/hu unknown
- 1999-02-03 SI SI9931034T patent/SI1052974T1/sl unknown
- 1999-02-03 SK SK1170-2000A patent/SK287775B6/sk not_active IP Right Cessation
- 1999-02-03 CA CA002320182A patent/CA2320182C/en not_active Expired - Fee Related
- 1999-02-03 KR KR1020007008399A patent/KR100669174B1/ko not_active Expired - Fee Related
- 1999-02-03 CN CNA2004100058263A patent/CN1623543A/zh active Pending
- 1999-02-03 BR BRPI9907647-0A patent/BR9907647B1/pt not_active IP Right Cessation
- 1999-02-03 DE DE69940904T patent/DE69940904D1/de not_active Expired - Lifetime
- 1999-02-03 TW TW088101639A patent/TW457095B/zh not_active IP Right Cessation
- 1999-02-03 CZ CZ20002834A patent/CZ303168B6/cs not_active IP Right Cessation
- 1999-02-03 DK DK99907491T patent/DK1052974T3/da active
- 1999-02-04 CO CO99006429D patent/CO4920246A1/es unknown
- 1999-02-04 IT IT1999MI000208A patent/IT1313549B1/it active
- 1999-02-04 BE BE9900077A patent/BE1012140A3/fr active
- 1999-02-04 PE PE1999000092A patent/PE20000272A1/es not_active Application Discontinuation
- 1999-02-05 FR FR9901356A patent/FR2774909B1/fr not_active Expired - Fee Related
2000
- 2000-07-27 IL IL137550A patent/IL137550A/en not_active IP Right Cessation
- 2000-08-03 NO NO20003930A patent/NO329376B1/no not_active IP Right Cessation
2003
- 2003-04-09 US US10/410,376 patent/US20030203876A1/en not_active Abandoned
- 2003-12-30 CL CL200302786A patent/CL2003002786A1/es unknown
2006
- 2006-01-31 US US11/343,827 patent/US20060127423A1/en not_active Abandoned
- 2006-11-13 US US11/598,506 patent/US20070060627A1/en not_active Abandoned
2008
- 2008-05-20 US US12/123,639 patent/US20080221065A1/en not_active Abandoned
2009
- 2009-08-12 CY CY20091100866T patent/CY1109311T1/el unknown
- 2009-12-08 JP JP2009278624A patent/JP2010090147A/ja active Pending
2010
- 2010-03-04 NO NO20100302A patent/NO20100302L/no unknown
2011
- 2011-02-04 US US13/020,907 patent/US20110124691A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AU753519B2 (en)	2002-10-17
CN1292683A (zh)	2001-04-25
HK1033809A1 (en)	2001-09-28
JP2002502810A (ja)	2002-01-29
IL137550A (en)	2010-06-30
DK1052974T3 (da)	2009-08-10
CA2320182C (en)	2008-11-25
KR100669174B1 (ko)	2007-01-17
SK11702000A3 (sk)	2001-01-18
WO1999039694A2 (en)	1999-08-12
HUP0101564A2 (hu)	2001-11-28
TW457095B (en)	2001-10-01
CN100396276C (zh)	2008-06-25
SK287775B6 (sk)	2011-09-05
MXPA00007681A (es)	2003-07-14
NO20003930D0 (no)	2000-08-03
EP1052974B1 (de)	2009-05-20
SI1052974T1 (sl)	2009-10-31
IT1313549B1 (it)	2002-09-09
BR9907647A (pt)	2000-11-14
RU2214246C2 (ru)	2003-10-20
ITMI990208A1 (it)	2000-08-04
ES2324378T3 (es)	2009-08-05
CY1109311T1 (el)	2014-07-02
BE1012140A3 (fr)	2000-05-02
WO1999039694A3 (en)	1999-09-23
US20060127423A1 (en)	2006-06-15
IL137550A0 (en)	2001-07-24
ID26549A (id)	2001-01-18
JP2010090147A (ja)	2010-04-22
FR2774909B1 (fr)	2000-07-28
JP4644364B2 (ja)	2011-03-02
NZ506389A (en)	2003-07-25
CL2003002786A1 (es)	2005-02-04
NO20100302L (no)	2000-10-04
KR20060002022A (ko)	2006-01-06
PL342629A1 (en)	2001-06-18
US20070060627A1 (en)	2007-03-15
BR9907647B1 (pt)	2014-04-01
EP1052974A2 (de)	2000-11-22
KR20080016756A (ko)	2008-02-21
PE20000272A1 (es)	2000-04-17
FR2774909A1 (fr)	1999-08-20
PT1052974E (pt)	2009-08-07
AU2722699A (en)	1999-08-23
CO4920246A1 (es)	2000-05-29
AR017979A1 (es)	2001-10-24
PL201329B1 (pl)	2009-03-31
CN1623543A (zh)	2005-06-08
US20030203876A1 (en)	2003-10-30
CA2320182A1 (en)	1999-08-12
US20080221065A1 (en)	2008-09-11
US20110124691A1 (en)	2011-05-26
DE69940904D1 (de)	2009-07-02
TR200002299T2 (tr)	2000-11-21
KR20010040534A (ko)	2001-05-15
CZ303168B6 (cs)	2012-05-09
HUP0101564A3 (en)	2002-06-28
CZ20002834A3 (cs)	2000-11-15
NO329376B1 (no)	2010-10-04
MY125921A (en)	2006-08-30
NO20003930L (no)	2000-10-04
SK287487B6 (sk)	2010-11-08

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