DK1052974T3 - Farmaceutisk sammensætning indeholdende epothilon - Google Patents

Farmaceutisk sammensætning indeholdende epothilon

Info

Publication number
DK1052974T3
DK1052974T3 DK99907491T DK99907491T DK1052974T3 DK 1052974 T3 DK1052974 T3 DK 1052974T3 DK 99907491 T DK99907491 T DK 99907491T DK 99907491 T DK99907491 T DK 99907491T DK 1052974 T3 DK1052974 T3 DK 1052974T3
Authority
DK
Denmark
Prior art keywords
pharmaceutical composition
composition containing
containing epothilone
epothilone
pharmaceutical
Prior art date
Application number
DK99907491T
Other languages
English (en)
Inventor
Hoogevest Peter Van
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26313062&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1052974(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9802451.6A external-priority patent/GB9802451D0/en
Priority claimed from GBGB9813646.8A external-priority patent/GB9813646D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK1052974T3 publication Critical patent/DK1052974T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK99907491T 1998-02-05 1999-02-03 Farmaceutisk sammensætning indeholdende epothilon DK1052974T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9802451.6A GB9802451D0 (en) 1998-02-05 1998-02-05 Organic compounds
GBGB9813646.8A GB9813646D0 (en) 1998-06-24 1998-06-24 Organic compounds
PCT/EP1999/000702 WO1999039694A2 (en) 1998-02-05 1999-02-03 Compositions containing organic compounds

Publications (1)

Publication Number Publication Date
DK1052974T3 true DK1052974T3 (da) 2009-08-10

Family

ID=26313062

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99907491T DK1052974T3 (da) 1998-02-05 1999-02-03 Farmaceutisk sammensætning indeholdende epothilon

Country Status (36)

Country Link
US (5) US20030203876A1 (da)
EP (1) EP1052974B1 (da)
JP (2) JP4644364B2 (da)
KR (3) KR20080016756A (da)
CN (2) CN100396276C (da)
AR (1) AR017979A1 (da)
AT (1) ATE431733T1 (da)
AU (1) AU753519B2 (da)
BE (1) BE1012140A3 (da)
BR (1) BR9907647B1 (da)
CA (1) CA2320182C (da)
CL (1) CL2003002786A1 (da)
CO (1) CO4920246A1 (da)
CY (1) CY1109311T1 (da)
CZ (1) CZ303168B6 (da)
DE (1) DE69940904D1 (da)
DK (1) DK1052974T3 (da)
ES (1) ES2324378T3 (da)
FR (1) FR2774909B1 (da)
HU (1) HUP0101564A3 (da)
ID (1) ID26549A (da)
IL (2) IL137550A0 (da)
IT (1) IT1313549B1 (da)
MX (1) MXPA00007681A (da)
MY (1) MY125921A (da)
NO (2) NO329376B1 (da)
NZ (1) NZ506389A (da)
PE (1) PE20000272A1 (da)
PL (1) PL201329B1 (da)
PT (1) PT1052974E (da)
RU (1) RU2214246C2 (da)
SI (1) SI1052974T1 (da)
SK (2) SK287487B6 (da)
TR (1) TR200002299T2 (da)
TW (1) TW457095B (da)
WO (1) WO1999039694A2 (da)

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DE59609305D1 (de) 1995-11-17 2002-07-11 Biotechnolog Forschung Gmbh Epothilon-Derivate und deren Herstellung
ATE267197T1 (de) 1996-11-18 2004-06-15 Biotechnolog Forschung Gmbh Epothilon d, dessen herstellung und dessen verwendung als cytostatisches mittel bzw. als pflanzenschutzmittel
EP1386922B1 (en) 1996-12-03 2012-04-11 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereof, analogues and uses thereof
US6204388B1 (en) 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6605599B1 (en) 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
US6365749B1 (en) 1997-12-04 2002-04-02 Bristol-Myers Squibb Company Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
GB9802451D0 (en) * 1998-02-05 1998-04-01 Ciba Geigy Ag Organic compounds
FR2775187B1 (fr) * 1998-02-25 2003-02-21 Novartis Ag Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
US6498257B1 (en) 1998-04-21 2002-12-24 Bristol-Myers Squibb Company 2,3-olefinic epothilone derivatives
US6399638B1 (en) 1998-04-21 2002-06-04 Bristol-Myers Squibb Company 12,13-modified epothilone derivatives
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US8618085B2 (en) * 2000-04-28 2013-12-31 Koasn Biosciences Incorporated Therapeutic formulations of desoxyepothilones
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SK8552003A3 (en) 2001-01-25 2004-06-08 Bristol Myers Squibb Co Parenteral formulation containing epothilone analogs
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US6893859B2 (en) 2001-02-13 2005-05-17 Kosan Biosciences, Inc. Epothilone derivatives and methods for making and using the same
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IL156988A0 (en) 2001-02-20 2004-02-08 Bristol Myers Squibb Co Pharmaceutical compositions containing epothilone derivatives
ATE554756T1 (de) 2001-03-14 2012-05-15 Bristol Myers Squibb Co Kombination aus epothilon-analog und chemotherapeutika zur behandlung von proliferativen erkrankungen
EP1372650B1 (en) * 2001-03-19 2008-11-19 Novartis AG Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative
US6800653B2 (en) 2001-06-01 2004-10-05 Bristol-Myers Squibb Compnay Epothilone derivatives
AU2008203233B2 (en) * 2001-07-19 2010-04-29 Novartis Ag Combinations comprising epothilones and pharmaceutical uses thereof
TWI315982B (en) 2001-07-19 2009-10-21 Novartis Ag Combinations comprising epothilones and pharmaceutical uses thereof
AU2003235761A1 (en) 2002-01-14 2003-07-24 Novartis Ag Combinations comprising epothilones and anti-metabolites
US7211593B2 (en) 2002-03-12 2007-05-01 Bristol-Myers Squibb Co. C12-cyano epothilone derivatives
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US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
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ES2279139T3 (es) * 2002-10-15 2007-08-16 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Uso de los derivados de epotilona para el tratamiento del hiperparatiroidismo.
ATE452888T1 (de) 2002-11-07 2010-01-15 Kosan Biosciences Inc Trans-9,10-dehydroepothilon c und d, analoga davon und verfahren zu deren herstellung
KR20060122819A (ko) * 2003-10-09 2006-11-30 코산 바이오사이언시즈, 인코포레이티드 치료학적 제형
CN1867343A (zh) * 2003-10-09 2006-11-22 高山生物科学股份有限公司 治疗制剂
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Also Published As

Publication number Publication date
AU753519B2 (en) 2002-10-17
CN1292683A (zh) 2001-04-25
HK1033809A1 (en) 2001-09-28
JP2002502810A (ja) 2002-01-29
IL137550A (en) 2010-06-30
CA2320182C (en) 2008-11-25
KR100669174B1 (ko) 2007-01-17
SK11702000A3 (sk) 2001-01-18
WO1999039694A2 (en) 1999-08-12
HUP0101564A2 (hu) 2001-11-28
TW457095B (en) 2001-10-01
CN100396276C (zh) 2008-06-25
SK287775B6 (sk) 2011-09-05
MXPA00007681A (es) 2003-07-14
NO20003930D0 (no) 2000-08-03
EP1052974B1 (en) 2009-05-20
SI1052974T1 (sl) 2009-10-31
IT1313549B1 (it) 2002-09-09
BR9907647A (pt) 2000-11-14
RU2214246C2 (ru) 2003-10-20
ITMI990208A1 (it) 2000-08-04
ES2324378T3 (es) 2009-08-05
CY1109311T1 (el) 2014-07-02
BE1012140A3 (fr) 2000-05-02
WO1999039694A3 (en) 1999-09-23
US20060127423A1 (en) 2006-06-15
IL137550A0 (en) 2001-07-24
ID26549A (id) 2001-01-18
JP2010090147A (ja) 2010-04-22
FR2774909B1 (fr) 2000-07-28
JP4644364B2 (ja) 2011-03-02
NZ506389A (en) 2003-07-25
CL2003002786A1 (es) 2005-02-04
NO20100302L (no) 2000-10-04
KR20060002022A (ko) 2006-01-06
PL342629A1 (en) 2001-06-18
US20070060627A1 (en) 2007-03-15
BR9907647B1 (pt) 2014-04-01
EP1052974A2 (en) 2000-11-22
KR20080016756A (ko) 2008-02-21
PE20000272A1 (es) 2000-04-17
FR2774909A1 (fr) 1999-08-20
PT1052974E (pt) 2009-08-07
AU2722699A (en) 1999-08-23
CO4920246A1 (es) 2000-05-29
AR017979A1 (es) 2001-10-24
PL201329B1 (pl) 2009-03-31
CN1623543A (zh) 2005-06-08
US20030203876A1 (en) 2003-10-30
ATE431733T1 (de) 2009-06-15
CA2320182A1 (en) 1999-08-12
US20080221065A1 (en) 2008-09-11
US20110124691A1 (en) 2011-05-26
DE69940904D1 (de) 2009-07-02
TR200002299T2 (tr) 2000-11-21
KR20010040534A (ko) 2001-05-15
CZ303168B6 (cs) 2012-05-09
HUP0101564A3 (en) 2002-06-28
CZ20002834A3 (cs) 2000-11-15
NO329376B1 (no) 2010-10-04
MY125921A (en) 2006-08-30
NO20003930L (no) 2000-10-04
SK287487B6 (sk) 2010-11-08

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